AU1509192A - Phosphono/biaryl substituted dipeptide derivatives - Google Patents

Phosphono/biaryl substituted dipeptide derivatives

Info

Publication number
AU1509192A
AU1509192A AU15091/92A AU1509192A AU1509192A AU 1509192 A AU1509192 A AU 1509192A AU 15091/92 A AU15091/92 A AU 15091/92A AU 1509192 A AU1509192 A AU 1509192A AU 1509192 A AU1509192 A AU 1509192A
Authority
AU
Australia
Prior art keywords
phosphono
dipeptide derivatives
biaryl substituted
substituted dipeptide
biaryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU15091/92A
Other versions
AU655252B2 (en
Inventor
Stephane De Lombaert
Mark D Erion
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Publication of AU1509192A publication Critical patent/AU1509192A/en
Application granted granted Critical
Publication of AU655252B2 publication Critical patent/AU655252B2/en
Assigned to NOVARTIS AG reassignment NOVARTIS AG Request to Amend Deed and Register Assignors: CIBA-GEIGY AG
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms
    • C07F9/655345—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a five-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU15091/92A 1991-05-01 1992-04-23 Phosphono/biaryl substituted dipeptide derivatives Ceased AU655252B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/694,533 US5155100A (en) 1991-05-01 1991-05-01 Phosphono/biaryl substituted dipeptide derivatives
US694533 1991-05-01

Publications (2)

Publication Number Publication Date
AU1509192A true AU1509192A (en) 1992-11-05
AU655252B2 AU655252B2 (en) 1994-12-08

Family

ID=24789228

Family Applications (1)

Application Number Title Priority Date Filing Date
AU15091/92A Ceased AU655252B2 (en) 1991-05-01 1992-04-23 Phosphono/biaryl substituted dipeptide derivatives

Country Status (15)

Country Link
US (1) US5155100A (en)
EP (1) EP0511940A3 (en)
JP (1) JPH05170792A (en)
KR (1) KR920021578A (en)
AU (1) AU655252B2 (en)
CA (1) CA2067592A1 (en)
FI (1) FI921884A (en)
HU (1) HUT61032A (en)
IE (1) IE921401A1 (en)
IL (1) IL101633A (en)
MX (1) MX9201953A (en)
NO (1) NO921719L (en)
NZ (1) NZ242546A (en)
TW (1) TW208704B (en)
ZA (1) ZA923164B (en)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5177064A (en) * 1990-07-13 1993-01-05 University Of Florida Targeted drug delivery via phosphonate derivatives
US5294632A (en) * 1991-05-01 1994-03-15 Ciba-Geigy Corporation Phosphono/biaryl substituted dipetide derivatives
US5250522A (en) * 1992-10-09 1993-10-05 Ciba-Geigy Corporation Phosphono/biaryl substituted amino acid derivatives
US5273990A (en) * 1992-09-03 1993-12-28 Ciba-Geigy Corporation Phosphono substituted tetrazole derivatives
JP3130938B2 (en) * 1991-10-22 2001-01-31 オーストリア・タバクヴェルケ・アクチエンゲゼルシャフトヴォマー・オーシュターライヒッシェ・タバコレジー Cigarette filter
JPH05148277A (en) * 1991-11-05 1993-06-15 Banyu Pharmaceut Co Ltd Aminophosphonic acid derivative
IT1266570B1 (en) * 1993-07-30 1997-01-09 Zambon Spa DERIVATIVES OF PROPANAMIDE N-ETEROARYL SUBSTITUTES USEFUL IN THE TREATMENT OF CARDIOVASCULAR DISEASES
WO1995013817A1 (en) * 1993-11-18 1995-05-26 Smithkline Beecham Corporation Endothelin converting enzyme inhibitors
IT1274673B (en) * 1994-04-14 1997-07-24 Zambon Spa PHOSPHONIC ACID DERIVATIVES HELPFUL IN THE TREATMENT OF CARIOIOVASCULAR DISEASES
IT1270260B (en) * 1994-06-21 1997-04-29 Zambon Spa PHOSPHONIC ACID DERIVATIVES FOR METALLOPEPTIDASE INHIBITIVE ACTIVITIES
US5583123A (en) * 1994-12-22 1996-12-10 Ciba-Geigy Corporation Certain tetrazole derivatives
US5635103A (en) 1995-01-20 1997-06-03 The Procter & Gamble Company Bleaching compositions and additives comprising bleach activators having alpha-modified lactam leaving-groups
US5550119A (en) * 1995-03-02 1996-08-27 Ciba-Geigy Corporation Phosphono substituted tetrazole derivatives as ECE inhibitors
AU7211696A (en) * 1995-09-27 1997-04-17 Ciba-Geigy Ag Treatment of chronic progressive renal failure
JP3973748B2 (en) * 1998-01-14 2007-09-12 花王株式会社 Hair growth inhibitor
HUP0200662A3 (en) * 1999-03-29 2004-07-28 Bristol Myers Squibb Company P Use of composition containing vasopeptidase to treat angina pectoris
JP2007191446A (en) * 2006-01-20 2007-08-02 Sumitomo Chemical Co Ltd Biphenylmethylhydantoin compound, method for producing the same and method for producing biphenylalanine compound using the same
WO2007083774A1 (en) * 2006-01-17 2007-07-26 Sumitomo Chemical Company, Limited Biphenylmethylhydantoin compound, method for producing same, and method for producing biphenylalanine using same
TW200838501A (en) 2007-02-02 2008-10-01 Theravance Inc Dual-acting antihypertensive agents
JP2008260755A (en) * 2007-03-20 2008-10-30 Sumitomo Chemical Co Ltd Method for retrieving l-biphenylalanine compound salt, and method for retrieving biphenylalanine ester compound using the same
TWI448284B (en) 2007-04-24 2014-08-11 Theravance Inc Dual-acting antihypertensive agents
TWI406850B (en) 2007-06-05 2013-09-01 Theravance Inc Dual-acting benzoimidazole antihypertensive agents
US7834041B2 (en) 2007-09-07 2010-11-16 Theravance, Inc. Dual-acting antihypertensive agents
JP2011506459A (en) 2007-12-11 2011-03-03 セラヴァンス， インコーポレーテッド Dual acting benzimidazole derivatives and their use as antihypertensive agents
WO2009134741A1 (en) 2008-04-29 2009-11-05 Theravance, Inc. Dual-acting antihypertensive agents
US7863309B2 (en) 2008-07-24 2011-01-04 Theravance, Inc. Dual-acting antihypertensive agents
WO2011005674A1 (en) 2009-07-07 2011-01-13 Theravance, Inc. Dual-acting pyrazole antihypertensive agents
ES2441419T3 (en) 2009-07-22 2014-02-04 Theravance, Inc. Oxazole-based double-acting antihypertensive agents
WO2011090929A1 (en) 2010-01-19 2011-07-28 Theravance, Inc. Dual-acting thiophene, pyrrole, thiazole and furan antihypertensive agents
US8993631B2 (en) 2010-11-16 2015-03-31 Novartis Ag Method of treating contrast-induced nephropathy
SG190432A1 (en) 2010-12-15 2013-07-31 Theravance Inc Neprilysin inhibitors
AR084290A1 (en) 2010-12-15 2013-05-08 Theravance Inc NEPRILISIN INHIBITORS, METHODS FOR THEIR PREPARATION AND INTERMEDIARIES USED THEREOF, PHARMACEUTICAL COMPOSITIONS THAT INCLUDE THEM AND THEIR USE IN THE MANUFACTURE OF MEDICINES TO TREAT DISEASES MEDIATED BY THE NEP INHIBITION
CA2825737C (en) 2011-02-17 2018-11-13 Theravance, Inc. Substituted aminobutyric derivatives as neprilysin inhibitors
EP2675792B1 (en) 2011-02-17 2016-01-06 Theravance Biopharma R&D IP, LLC Substituted aminobutyric derivatives as neprilysin inhibitors
WO2012166389A1 (en) 2011-05-31 2012-12-06 Theravance, Inc. Neprilysin inhibitors
CN103596928B (en) 2011-05-31 2017-02-15 施万生物制药研发Ip有限责任公司 Neprilysin inhibitors
EP2714660B1 (en) 2011-05-31 2018-09-26 Theravance Biopharma R&D IP, LLC Neprilysin inhibitors
TWI560172B (en) 2011-11-02 2016-12-01 Theravance Biopharma R&D Ip Llc Neprilysin inhibitors
ES2609810T3 (en) 2012-05-31 2017-04-24 Theravance Biopharma R&D Ip, Llc Nitric oxide donor neprilysin inhibitors
JP6162230B2 (en) 2012-06-08 2017-07-12 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー Neprilysin inhibitor
CN104470521B (en) 2012-06-08 2017-04-12 施万生物制药研发Ip有限责任公司 Neprilysin inhibitors
DK2882716T3 (en) 2012-08-08 2017-03-06 Theravance Biopharma R&D Ip Llc Neprilysin inhibitors
UY35144A (en) 2012-11-20 2014-06-30 Novartis Ag APELINE SYNTHETIC LINEAR MIMETICS FOR THE CARDIAC INSUFFICIENCY TREATMENT
NZ710574A (en) 2013-02-14 2017-11-24 Novartis Ag Substituted bisphenyl butanoic phosphonic acid derivatives as nep (neutral endopeptidase) inhibitors
CA2902456A1 (en) 2013-03-05 2014-09-12 Theravance Biopharma R&D Ip, Llc Neprilysin inhibitors
US9340582B2 (en) 2013-07-25 2016-05-17 Novartis Ag Bioconjugates of synthetic apelin polypeptides
WO2015013168A1 (en) 2013-07-25 2015-01-29 Novartis Ag Cyclic polypeptides for the treatment of heart failure
US9593110B2 (en) 2014-01-30 2017-03-14 Theravence Biopharma R&D IP, LLC Neprilysin inhibitors
CN105960398A (en) 2014-01-30 2016-09-21 施万生物制药研发Ip有限责任公司 5-biphenyl-4-heteroarylcarbonylamino-pentanoic acid derivatives as neprilysin inhibitors
CA2972871A1 (en) 2015-01-23 2016-07-28 Novartis Ag Synthetic apelin fatty acid conjugates with improved half-life
RU2726623C2 (en) 2015-02-11 2020-07-15 ТЕРЕВАНС БАЙОФАРМА Ар энд Ди АйПи, ЭлЭлСи (2s,4r)-5-(5'-chloro-2'-fluorobiphenyl-4-yl)-4-(ethoxyoxalylamino)-2-hydroxymethyl-2-methylpentanoic acid
SI3259255T1 (en) 2015-02-19 2021-04-30 Theravance Biopharma R&D Ip, Llc (2r,4r)-5-(5'-chloro-2'-fluorobiphenyl-4-yl)-2-hydroxy-4-((5-methyloxazole-2-carbonyl)amino)pentanoic acid
AU2017229466C1 (en) 2016-03-08 2021-02-11 Theravance Biopharma R&D Ip, Llc Crystalline(2S,4R)-5-(5'-chloro-2'-fluoro-[1,1'-biphenyl]-4-YL)-2-(ethoxymethyl)-4-(3-hydroxyisoxazole-5-carboxamido)-2-methylpentanoic acid and uses thereof
EP3887388A1 (en) 2018-11-27 2021-10-06 Novartis AG Cyclic peptides as proprotein convertase subtilisin/kexin type 9 (pcsk9) inhibitors for the treatment of metabolic disorders
WO2020110008A1 (en) 2018-11-27 2020-06-04 Novartis Ag Cyclic pentamer compounds as proprotein convertase subtilisin/kexin type 9 (pcsk9) inhibitors for the treatment of metabolic disorder
UY38485A (en) 2018-11-27 2020-06-30 Novartis Ag CYCLIC TETRAMER COMPOUNDS AS PROPROTEIN CONVERTASE SUBTILISIN / KEXIN TYPE 9 (PCSK9) INHIBITORS, METHOD OF TREATMENT, USE AND PREPARATION
WO2023084449A1 (en) 2021-11-12 2023-05-19 Novartis Ag Diaminocyclopentylpyridine derivatives for the treatment of a disease or disorder

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE141930C (en) * 1900-01-01
US4053505A (en) * 1976-01-05 1977-10-11 Monsanto Company Preparation of n-phosphonomethyl glycine
CY1406A (en) * 1980-12-18 1988-04-22 Schering Corp Substituted dipeptides, processes for their preparation and pharmaceutical compositions containing them and their use in the inhibition of enkephalinase
US4721726A (en) * 1980-12-18 1988-01-26 Schering Corporation Substituted dipeptides as inhibitors of enkephalinases
FR2518088B1 (en) * 1981-12-16 1987-11-27 Roques Bernard NOVEL AMINO ACID DERIVATIVES AND THEIR THERAPEUTIC APPLICATION
DK31784A (en) * 1983-01-28 1984-07-29 Schering Corp PHOSPHOUS AMID COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE, AND PROCEDURES FOR THE PREPARATION OF THE COMPOUNDS
US4939261A (en) * 1984-06-08 1990-07-03 Ciba-Geigy Corporation N-substituted butyramide derivatives useful for treatment of conditions responsive to inhibition of enkephalinase
EP0225292A3 (en) * 1985-12-06 1988-11-30 Ciba-Geigy Ag Certain n-substituted butyramide derivatives
US4749688A (en) * 1986-06-20 1988-06-07 Schering Corporation Use of neutral metalloendopeptidase inhibitors in the treatment of hypertension
CA1337400C (en) * 1987-06-08 1995-10-24 Norma G. Delaney Inhibitors of neutral endopeptidase
US4963539A (en) * 1987-09-10 1990-10-16 E. R. Squibb & Sons, Inc. Phosphonate and phosphonamide endopeptidase inhibitors
GB8726714D0 (en) * 1987-11-14 1987-12-16 Beecham Group Plc Compounds
EP0401963A1 (en) * 1989-04-13 1990-12-12 Beecham Group p.l.c. Phosphonopeptides with collagenase inhibiting activity
FR2652087B1 (en) * 1989-09-15 1993-10-15 Bioprojet Ste Civile AMINO ACID DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATIONS.

Also Published As

Publication number Publication date
HUT61032A (en) 1992-11-30
CA2067592A1 (en) 1992-11-02
NO921719D0 (en) 1992-04-30
EP0511940A3 (en) 1993-11-03
MX9201953A (en) 1992-11-01
FI921884A0 (en) 1992-04-27
NO921719L (en) 1992-11-02
IL101633A0 (en) 1992-12-30
IE921401A1 (en) 1992-11-04
AU655252B2 (en) 1994-12-08
HU9201430D0 (en) 1992-07-28
ZA923164B (en) 1992-11-25
KR920021578A (en) 1992-12-18
EP0511940A2 (en) 1992-11-04
US5155100A (en) 1992-10-13
FI921884A (en) 1992-11-02
JPH05170792A (en) 1993-07-09
NZ242546A (en) 1994-08-26
TW208704B (en) 1993-07-01
IL101633A (en) 1996-03-31

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