ES8307779A1 - "un derivado de la piperazina". - Google Patents

"un derivado de la piperazina".

Info

Publication number
ES8307779A1
ES8307779A1 ES512518A ES512518A ES8307779A1 ES 8307779 A1 ES8307779 A1 ES 8307779A1 ES 512518 A ES512518 A ES 512518A ES 512518 A ES512518 A ES 512518A ES 8307779 A1 ES8307779 A1 ES 8307779A1
Authority
ES
Spain
Prior art keywords
lower alkyl
group
single bond
optionally
processes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES512518A
Other languages
English (en)
Other versions
ES512518A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kowa Co Ltd
Original Assignee
Kowa Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kowa Co Ltd filed Critical Kowa Co Ltd
Publication of ES512518A0 publication Critical patent/ES512518A0/es
Publication of ES8307779A1 publication Critical patent/ES8307779A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Indole Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

UN PROCESO PARA LA PRODUCCION DE UN DERIVADO DE LA PIPERAZINA. SE EFECTUA LA ESTERIFICACION DE UN 4-FENOL SUSTITUIDO CON UN ACIDO CARBOXILICO R<1-A-COOH PARA OBTENER EL COMPUESTO (I) EN QUE R<1 ES UN GRUPO INDOLILO QUE PUEDE SER SUSTITUIDO POR UNO O MAS GRUPOS ALQUILO INFERIOR Y/O ALCOXILO INFERIOR O GRUPO NAFTILO QUE PUEDE ESTAR PARCIALMENTE SATURADO; A ES ENLACE SIMPLE O UN GRUPO ALQUILENO; B ES UN ENLACE SIMPLE O UN GRUPO VINILENO; Q ES UN GRUPO -O-ALQUILENO O UN GRUPO -NH-ALQUILENO CUANDO P ES ENLACE SIMPLE, O UN ENLACE SIMPLE CUANDO P ES UN GRUPO VINILENO; R<2 ES UN GRUPO ALQUILO INFERIOR, MORFOLINO-ALQUILO-INFERIOR U OTROS.
ES512518A 1981-06-05 1982-05-25 "un derivado de la piperazina". Expired ES8307779A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56086569A JPS57203060A (en) 1981-06-05 1981-06-05 Piperazine derivative

Publications (2)

Publication Number Publication Date
ES512518A0 ES512518A0 (es) 1983-08-01
ES8307779A1 true ES8307779A1 (es) 1983-08-01

Family

ID=13890640

Family Applications (1)

Application Number Title Priority Date Filing Date
ES512518A Expired ES8307779A1 (es) 1981-06-05 1982-05-25 "un derivado de la piperazina".

Country Status (9)

Country Link
US (1) US4443603A (es)
EP (1) EP0067561A3 (es)
JP (1) JPS57203060A (es)
KR (1) KR840000532A (es)
AU (1) AU8413382A (es)
CA (1) CA1202627A (es)
DK (1) DK249782A (es)
ES (1) ES8307779A1 (es)
ZA (1) ZA823777B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU545463B2 (en) * 1982-06-25 1985-07-18 Kowa Co. Ltd. Benzoyl piperacine esters
JPS59139357A (ja) * 1983-01-28 1984-08-10 Torii Yakuhin Kk アミジン誘導体
JPS59212471A (ja) * 1983-05-19 1984-12-01 Kowa Co インド−ルカルボン酸ベンゾイルエステル
JPS59222484A (ja) * 1983-06-02 1984-12-14 Kowa Co テトラヒドロナフチルカルボン酸フエニルエステル誘導体
US4746737A (en) * 1985-07-26 1988-05-24 Kowa Co., Ltd. Phenyl guanidinobenzoate derivatives which have protease inhibitory activity
US5182284A (en) * 1990-01-26 1993-01-26 Taiho Pharmaceutical Co., Ltd. Piperazine compounds, processes for preparation thereof and medical uses thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3228961A (en) * 1963-05-22 1966-01-11 Egyt Gyogyszervegyeszeti Gyar Diethylamino and pyrrolidino lower alkyl esters of 3, 5-dimethoxy-4-butoxy and amyloxy benzoic acids
FR5342M (es) * 1966-03-08 1967-09-04
FR1543944A (fr) * 1967-03-10 1968-10-31 Bruneau & Cie Lab Dérivés amidés de l'acide salicylique et leur préparation
FR1544673A (fr) * 1967-05-26 1968-11-08 Esters indolylacétylsalicyliques
US3846430A (en) * 1968-01-12 1974-11-05 Bruneau & Cie Lab 1-(2-methoxy-phenyl)-4-{8 2-(4-fluoro-benzamido)-ethyl{9 -piperazine
FR2244518A1 (en) * 1973-08-10 1975-04-18 Delalande Sa N-sinapyl-N'-alkoxyalkyl or-aminocarbonylmethyl-piperazines - as vasodilators, diuretics, antihypertensive and antiulcer agents
FR2240734A1 (en) * 1973-08-13 1975-03-14 Delalande Sa N-(dihydro sinapyl) piperazine derivs - having antiulcer, hypertensive and diuretic props
FR2358145A1 (fr) * 1976-03-29 1978-02-10 Richard Sa Laboratoire M Nouveau medicament anti-inflammatoire, analgesique et antipyretique a base de (p-chlorobenzoyl-1 methyl-2 methoxy-5)-indole-3 acetate de p-acetamidophenol
IT1113364B (it) * 1979-05-10 1986-01-20 Montedison Spa N,n'-di-(idrossi-fenil)derivati della piperrazina e loro impiego come stabilizzanti per polimeri

Also Published As

Publication number Publication date
JPS57203060A (en) 1982-12-13
KR840000532A (ko) 1984-02-25
ES512518A0 (es) 1983-08-01
ZA823777B (en) 1983-04-27
EP0067561A3 (en) 1983-08-10
AU8413382A (en) 1982-12-09
CA1202627A (en) 1986-04-01
DK249782A (da) 1982-12-06
US4443603A (en) 1984-04-17
EP0067561A2 (en) 1982-12-22

Similar Documents

Publication Publication Date Title
UA41272C2 (uk) Естери тієнілкарбонової кислоти і аміноспиртів, їх продукти кватернізації і кислотно-адитивні солі та фармацевтична композиція
GB2124077B (en) Immunomodulating agent
ES429234A1 (es) Procedimiento para la preparacion de nuevas amidas de aci- dos n-(1-(omega-fenilalcohil)-piperidil-4)-n-(alfa-piridil)-carboxilicos.
GEP19970818B (en) Method of n-/2-/4-fluorphenyl/-1-methyl/-ethyl-n-methyl-n-propinylamine production
AU1395283A (en) 1-carboxyalkanoylindoline-2-carboxylic acid esters
ES8307779A1 (es) &#34;un derivado de la piperazina&#34;.
MY109628A (en) An improved proces for the preparation of substituted indoline derivatives
GB1535123A (en) Process for preparing n-(alpha-alkoxyethyl)carboxylic acid amides
ES8301931A1 (es) Un procedimiento para la preparacion de nuevos imidazoles.
ATE104661T1 (de) Thioformamid-derivate.
ES8104985A1 (es) Procedimiento para la preparacion de derivados de acido n-acil-amino
ATE18993T1 (de) Dibenzocycloheptenyliden-verbindungen zur verwendung bei der modulation der immunreaktion.
SE7407916L (es)
ES8304920A1 (es) Un procedimiento para preparar derivados de n-acil-n-hidroxi-a minoacidos.
ES8308870A1 (es) Procedimiento para la preparacion de derivados de acido 5-(4-fenil-1-piperidinil) metil-2,3-dihidro-2-oxo-1h-imidazol-4-carboxilico.
ES8301963A1 (es) Un procedimiento para preparacion de nuevas piperidinoquinazolinas.
ES556048A0 (es) Un procedimiento para la preparacion de un derivado de tiazolidina.
DK0412529T3 (da) Hidtil ukendte imidazolderivater, fremgangsmåde til fremstilling deraf og midler mod mavesår indeholdende disse
IL75430A (en) Pineapple ketone carbonate derivatives and their use as flavoring agents
ZA876073B (en) Dopamine-beta-hydroxylase inhibitors
JPS52133973A (en) Preparation of optically active lactam derivatives
ES8308874A1 (es) Procedimiento para preparar derivados de acido 5-aminometil-2,3-dihidro-2-oxo-1h-imidazol-4-carboxilico.
JPS5479270A (en) Preparation of 2-(aminomethyl) pyrrolidine
ES8200658A1 (es) Procedimiento para la preparacion de sales de alcohileter- isotiuronio
EP0117875A4 (en) METHOD FOR PRODUCING AZETIDINONE COMBS.