NO912860D0 - 3-(1,2,5,6-tetrahydropyridyl)-pyrrolopyridiner. - Google Patents

3-(1,2,5,6-tetrahydropyridyl)-pyrrolopyridiner.

Info

Publication number
NO912860D0
NO912860D0 NO1991912860A NO912860A NO912860D0 NO 912860 D0 NO912860 D0 NO 912860D0 NO 1991912860 A NO1991912860 A NO 1991912860A NO 912860 A NO912860 A NO 912860A NO 912860 D0 NO912860 D0 NO 912860D0
Authority
NO
Norway
Prior art keywords
alkyl
tetrahydropyridyl
alkoxy
formula
pyrrolopyridiner
Prior art date
Application number
NO1991912860A
Other languages
English (en)
Norwegian (no)
Other versions
NO912860L (no
Inventor
John Eugene Macor
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of NO912860D0 publication Critical patent/NO912860D0/no
Publication of NO912860L publication Critical patent/NO912860L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
NO91912860A 1989-01-20 1991-07-22 3-(1,2,5,6-tetrahydropyridyl)-pyrrolopyridiner. NO912860L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1989/000231 WO1990007926A1 (en) 1989-01-20 1989-01-20 3-(1,2,5,6-tetrahydropyridyl)-pyrrolopyridines

Publications (2)

Publication Number Publication Date
NO912860D0 true NO912860D0 (no) 1991-07-22
NO912860L NO912860L (no) 1991-07-22

Family

ID=22214793

Family Applications (1)

Application Number Title Priority Date Filing Date
NO91912860A NO912860L (no) 1989-01-20 1991-07-22 3-(1,2,5,6-tetrahydropyridyl)-pyrrolopyridiner.

Country Status (26)

Country Link
US (2) US5051412A (pl)
EP (1) EP0379314B1 (pl)
JP (1) JPH0751576B2 (pl)
KR (1) KR920010642B1 (pl)
CN (1) CN1025998C (pl)
AT (1) ATE103282T1 (pl)
CA (1) CA2008016A1 (pl)
CS (1) CS277611B6 (pl)
DD (2) DD298398A5 (pl)
DE (1) DE69007501T2 (pl)
DK (1) DK0379314T3 (pl)
EG (1) EG18945A (pl)
ES (1) ES2062319T3 (pl)
FI (1) FI94641C (pl)
HU (1) HU206349B (pl)
IE (1) IE62757B1 (pl)
IL (1) IL93041A (pl)
MX (1) MX19185A (pl)
MY (1) MY106305A (pl)
NO (1) NO912860L (pl)
NZ (1) NZ232166A (pl)
PL (2) PL287840A1 (pl)
PT (1) PT92889A (pl)
WO (1) WO1990007926A1 (pl)
YU (1) YU47553B (pl)
ZA (1) ZA90393B (pl)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990007926A1 (en) * 1989-01-20 1990-07-26 Pfizer Inc. 3-(1,2,5,6-tetrahydropyridyl)-pyrrolopyridines
US5451566A (en) * 1993-11-17 1995-09-19 Zeneca Limited Herbicidal pyrrolopyridine compounds
US6586458B1 (en) 1996-08-16 2003-07-01 Pozen Inc. Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs
EP1082958A3 (en) * 1996-11-15 2002-12-11 Eli Lilly And Company 5-HT1F agonists in chronic pain
ZA979961B (en) * 1996-11-15 1999-05-05 Lilly Co Eli 5-HT1F agonists
EP0875513A1 (en) * 1997-04-14 1998-11-04 Eli Lilly And Company Substituted heteroaromatic 5-HT 1F agonists
ZA989389B (en) * 1997-11-14 2000-04-14 Lilly Co Eli Pyrrolo [3,2-b] pyridine processes and intermediates.
US5905084A (en) * 1997-11-14 1999-05-18 Eli Lilly And Company 5-HTIF -agonists effective in treating migraine
US6476034B2 (en) 2000-02-22 2002-11-05 Bristol-Myers Squibb Company Antiviral azaindole derivatives
MXPA05006954A (es) 2002-12-26 2005-09-22 Pozen Inc Formas de dosificacion de capas multiples que contienen nsaids y triptanos.
KR20110137838A (ko) * 2003-11-21 2011-12-23 어레이 바이오파마 인크. Ａｋｔ 단백질 키나제 억제제
AU2005269387A1 (en) 2004-07-27 2006-02-09 Sgx Pharmaceuticals, Inc. Fused ring heterocycle kinase modulators
US7361764B2 (en) * 2004-07-27 2008-04-22 Sgx Pharmaceuticals, Inc. Pyrrolo-pyridine kinase modulators
US7626021B2 (en) * 2004-07-27 2009-12-01 Sgx Pharmaceuticals, Inc. Fused ring heterocycle kinase modulators
AU2005269386A1 (en) * 2004-07-27 2006-02-09 Sgx Pharmaceuticals, Inc. Pyrrolo-pyridine kinase modulators
US20060100432A1 (en) 2004-11-09 2006-05-11 Matiskella John D Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
US7851476B2 (en) 2005-12-14 2010-12-14 Bristol-Myers Squibb Company Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-YL)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-C]pyridin-3-YL]-1,2-dioxoethyl]-piperazine
US7807671B2 (en) 2006-04-25 2010-10-05 Bristol-Myers Squibb Company Diketo-piperazine and piperidine derivatives as antiviral agents
US8063050B2 (en) * 2006-07-06 2011-11-22 Array Biopharma Inc. Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
JP5268904B2 (ja) 2006-07-06 2013-08-21 アレイ バイオファーマ、インコーポレイテッド Ａｋｔプロテインキナーゼ阻害剤としてのシクロペンタ［ｄ］ピリミジン
SI2054418T1 (sl) 2006-07-06 2012-02-29 Array Biopharma Inc Dihidrotieno pirimidini kot AKT protein kinazni inhibitorji
ATE493418T1 (de) 2006-07-06 2011-01-15 Array Biopharma Inc Dihydrofuropyrimidine als akt- proteinkinaseinhibitoren
EP2114955B1 (en) * 2006-12-29 2013-02-13 Rigel Pharmaceuticals, Inc. Bridged bicyclic aryl and bridged bicyclic heteroaryl substituted triazoles useful as axl inhibitors
US8846683B2 (en) 2007-07-05 2014-09-30 Array Biopharma, Inc. Pyrimidyl cyclopentanes as Akt protein kinase inhibitors
MX2009014013A (es) * 2007-07-05 2010-01-28 Array Biopharma Inc Pirimidil ciclopentanos como inhibidores de la proteina cinasa akt.
US9409886B2 (en) 2007-07-05 2016-08-09 Array Biopharma Inc. Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
RU2486181C2 (ru) 2007-07-05 2013-06-27 Эррэй Биофарма Инк. Пиримидилциклопентаны как ингибиторы акт-протеинкиназ
MX2010007546A (es) * 2008-01-09 2010-09-30 Array Biopharma Inc Pirimidil ciclopentanos hidroxilados en forma de inhibidores de akt proteína quinasa.
JP5346345B2 (ja) * 2008-01-09 2013-11-20 アレイ バイオファーマ、インコーポレイテッド Ａｋｔタンパク質キナーゼ阻害剤としての水酸化されたピリミジルシクロペンタン類
JP5858789B2 (ja) 2009-01-16 2016-02-10 ライジェル ファーマシューティカルズ， インコーポレイテッド 転移性癌の予防、治療、または管理のための併用療法に用いるためのａｘｌ阻害薬
AP3631A (en) 2009-06-17 2016-03-08 Vertex Pharma Inhibitors of influenza viruses replication
WO2012083117A1 (en) 2010-12-16 2012-06-21 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
ES2688809T3 (es) 2011-04-01 2018-11-07 Genentech, Inc. Combinaciones de compuestos inhibidores de AKT y MEK para tratar el cáncer
ES2657750T3 (es) 2011-04-01 2018-03-06 Genentech, Inc. Combinación de compuesto inhibidor de AKT y vemurafenib para su uso en tratamientos terapéuticos
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
CA2891122C (en) 2012-11-14 2021-07-20 The Johns Hopkins University Methods and compositions for treating schizophrenia
RU2700415C1 (ru) 2013-11-13 2019-09-17 Вертекс Фармасьютикалз Инкорпорейтед Ингибиторы репликации вирусов гриппа
KR102338461B1 (ko) 2013-11-13 2021-12-13 버텍스 파마슈티칼스 인코포레이티드 인플루엔자 바이러스 복제 억제제의 제조 방법
EP3209663B1 (en) * 2014-10-23 2018-12-12 Janssen Pharmaceutica N.V. New pyrazolopyrimidine derivatives as nik inhibitors
WO2016062789A1 (en) 2014-10-23 2016-04-28 Janssen Pharmaceutica Nv New thienopyrimidine derivatives as nik inhibitors
WO2016183120A1 (en) 2015-05-13 2016-11-17 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
EP3294717B1 (en) 2015-05-13 2020-07-29 Vertex Pharmaceuticals Inc. Methods of preparing inhibitors of influenza viruses replication

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3272804A (en) * 1963-12-23 1966-09-13 Sterling Drug Inc Process and intermediates for preparing indoles
GB1141949A (en) * 1966-02-23 1969-02-05 Sterling Drug Inc 7-azaindole derivatives
IL48508A (en) * 1974-12-09 1979-10-31 Roussel Uclaf Pharmaceutical compositions comprising piperidylindole derivatives
FR2362628A1 (fr) * 1976-08-26 1978-03-24 Roussel Uclaf Nouveaux derives du piperidyl-indole et leurs sels, procede de preparation et application a titre de medicaments
FR2421899A1 (fr) * 1978-01-16 1979-11-02 Roussel Uclaf Nouveaux derives du tetrahydropyridinyl-indole et leurs sels, le procede de preparation et l'application a titre de medicaments de ces nouveaux produits
FR2444678A2 (fr) * 1978-12-22 1980-07-18 Roussel Uclaf Nouveau procede de preparation de derives du piperidyl-indole et de leurs sels
US5025096A (en) * 1985-08-22 1991-06-18 Mine Safety Appliances Company Preparation of indole and indole derivatives
WO1990007926A1 (en) * 1989-01-20 1990-07-26 Pfizer Inc. 3-(1,2,5,6-tetrahydropyridyl)-pyrrolopyridines

Also Published As

Publication number Publication date
MX19185A (es) 1993-12-01
CS26090A3 (en) 1992-02-19
US5169947A (en) 1992-12-08
DE69007501T2 (de) 1994-06-30
EP0379314B1 (en) 1994-03-23
KR920010642B1 (ko) 1992-12-12
CN1044465A (zh) 1990-08-08
FI913509A0 (fi) 1991-07-22
YU9990A (en) 1992-05-28
ES2062319T3 (es) 1994-12-16
CS277611B6 (en) 1993-03-17
JPH0751576B2 (ja) 1995-06-05
PT92889A (pt) 1990-07-31
JPH02247175A (ja) 1990-10-02
PL163626B1 (pl) 1994-04-29
DK0379314T3 (da) 1994-05-09
IL93041A (en) 1994-02-27
FI94641B (fi) 1995-06-30
WO1990007926A1 (en) 1990-07-26
PL287840A1 (en) 1991-07-15
IL93041A0 (en) 1990-11-05
YU47553B (sh) 1995-10-03
ZA90393B (en) 1991-08-28
ATE103282T1 (de) 1994-04-15
AU4867390A (en) 1990-07-26
PL283354A1 (en) 1991-08-12
MY106305A (en) 1995-04-29
DE69007501D1 (de) 1994-04-28
AU613259B2 (en) 1991-07-25
KR900011772A (ko) 1990-08-02
NO912860L (no) 1991-07-22
CN1025998C (zh) 1994-09-28
IE900210L (en) 1990-07-23
DD291559A5 (de) 1991-07-04
CA2008016A1 (en) 1990-07-20
HUT57762A (en) 1991-12-30
EP0379314A1 (en) 1990-07-25
EG18945A (en) 1994-09-29
US5051412A (en) 1991-09-24
HU206349B (en) 1992-10-28
FI94641C (fi) 1995-10-10
NZ232166A (en) 1992-10-28
IE62757B1 (en) 1995-02-22
DD298398A5 (de) 1992-02-20

Similar Documents

Publication Publication Date Title
ATE103282T1 (de) 3-(1,2,5,6-tetrahydropyridyl)-pyrrolopyridine.
PT77645A (en) Process for preparing epimeril aza homoerytheomycin a derivati-ves and intermediates therefor
FI945703A0 (fi) 3,4,4-trisybstituoitujen piperidinyyli-N-alkyylikarboksylaattien ja välituotteiden valmistus
ES8605821A1 (es) Un procedimiento para la preparacion de aciltripeptidos in- munoestimulantes
AU2215588A (en) Substituted cycloalkanols
GR3036754T3 (en) Use of isoxazole- and crotonamide derivatives for the manufacture of a medicament for the treatment of cancers
DE59300623D1 (de) Führung für den Schaft eines Offenend-Spinnrotors.
DE3768479D1 (de) 2,3-diaminoacrylonitrilderivate.
ZA200003035B (en) Compounds of 7-oxo-2,3,7,14-tetrahydro-1H-benzo[B]-pyrano[3,2-H] acridin carboxylate, a process for their preparation and pharmaceutical compositions containing them.
EP0116255A3 (en) Treatment of migraine with n-alkyl-piperidinyl benzoate derivatives
FI945750A (fi) 3-(fenyylialkyyliaminoalkyylioksi)-5-fenyylipyratsoli-yhdisteet sekä menetelmät ja välituotteet niiden valmistamiseksi ja näitä yhdisteitä sisältävät lääkeaineet
NL7705801A (en) Analgesic decahydro-isoquinolines - with 4A phenyl substits.
PT81324A (en) Process for the preparation of s-aralkyltrithiophosphonate having an insecticidal effect
IT1240836B (it) Impiego di attivatori dei canali potassici per la profilassi dell'asma
EP0171812A3 (en) Cephem derivatives
CS153685A1 (en) Treatment method of staple yarn spinned by rotor system
HUP9903171A2 (hu) Duloxetin alkalmazása figyelemcsökkenéssel/hiperaktivitással kapcsolatos rendellenességek kezelésére alkalmas gyógyászati készítmények előállítására
ES8609254A1 (es) Un procedimiento para preparar un derivado de piridinodicar-boxilato