NO910510L - Kontrastmiddel oppbygd av polyaldehyder. - Google Patents
Kontrastmiddel oppbygd av polyaldehyder.Info
- Publication number
- NO910510L NO910510L NO91910510A NO910510A NO910510L NO 910510 L NO910510 L NO 910510L NO 91910510 A NO91910510 A NO 91910510A NO 910510 A NO910510 A NO 910510A NO 910510 L NO910510 L NO 910510L
- Authority
- NO
- Norway
- Prior art keywords
- appropriate
- polyaldehydes
- contractor
- constructed
- coupling agents
- Prior art date
Links
- 229920001744 Polyaldehyde Polymers 0.000 title 1
- 239000007822 coupling agent Substances 0.000 abstract 2
- 239000004094 surface-active agent Substances 0.000 abstract 2
- 239000004971 Cross linker Substances 0.000 abstract 1
- 239000000654 additive Substances 0.000 abstract 1
- 150000001299 aldehydes Chemical class 0.000 abstract 1
- 229920002988 biodegradable polymer Polymers 0.000 abstract 1
- 239000004621 biodegradable polymer Substances 0.000 abstract 1
- 239000002961 echo contrast media Substances 0.000 abstract 1
- 239000007789 gas Substances 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 229920002521 macromolecule Polymers 0.000 abstract 1
- 239000011859 microparticle Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G6/00—Condensation polymers of aldehydes or ketones only
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/225—Microparticles, microcapsules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5094—Microcapsules containing magnetic carrier material, e.g. ferrite for drug targeting
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2984—Microcapsule with fluid core [includes liposome]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2984—Microcapsule with fluid core [includes liposome]
- Y10T428/2985—Solid-walled microcapsule from synthetic polymer
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2991—Coated
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Acoustics & Sound (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Phenolic Resins Or Amino Resins (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Manufacturing Of Micro-Capsules (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4004430A DE4004430A1 (de) | 1990-02-09 | 1990-02-09 | Aus polyaldehyden aufgebaute kontrastmittel |
Publications (3)
Publication Number | Publication Date |
---|---|
NO910510D0 NO910510D0 (no) | 1991-02-08 |
NO910510L true NO910510L (no) | 1991-08-12 |
NO300916B1 NO300916B1 (no) | 1997-08-18 |
Family
ID=6400056
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO910510A NO300916B1 (no) | 1990-02-09 | 1991-02-08 | Gassholdige hulpartikler |
Country Status (17)
Country | Link |
---|---|
US (1) | US5501863A (no) |
EP (1) | EP0441468B1 (no) |
JP (1) | JP3363912B2 (no) |
AT (1) | ATE142507T1 (no) |
AU (1) | AU649996B2 (no) |
CA (1) | CA2036107A1 (no) |
DE (2) | DE4004430A1 (no) |
DK (1) | DK0441468T3 (no) |
ES (1) | ES2094192T3 (no) |
FI (1) | FI910596A (no) |
GR (1) | GR3021206T3 (no) |
HU (1) | HUT61490A (no) |
IE (1) | IE76315B1 (no) |
NO (1) | NO300916B1 (no) |
NZ (1) | NZ237060A (no) |
PT (1) | PT96691B (no) |
ZA (1) | ZA91961B (no) |
Families Citing this family (113)
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US5425366A (en) * | 1988-02-05 | 1995-06-20 | Schering Aktiengesellschaft | Ultrasonic contrast agents for color Doppler imaging |
US6088613A (en) | 1989-12-22 | 2000-07-11 | Imarx Pharmaceutical Corp. | Method of magnetic resonance focused surgical and therapeutic ultrasound |
US5585112A (en) | 1989-12-22 | 1996-12-17 | Imarx Pharmaceutical Corp. | Method of preparing gas and gaseous precursor-filled microspheres |
US5580575A (en) | 1989-12-22 | 1996-12-03 | Imarx Pharmaceutical Corp. | Therapeutic drug delivery systems |
US5922304A (en) | 1989-12-22 | 1999-07-13 | Imarx Pharmaceutical Corp. | Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents |
US6001335A (en) | 1989-12-22 | 1999-12-14 | Imarx Pharmaceutical Corp. | Contrasting agents for ultrasonic imaging and methods for preparing the same |
US5469854A (en) | 1989-12-22 | 1995-11-28 | Imarx Pharmaceutical Corp. | Methods of preparing gas-filled liposomes |
US5776429A (en) | 1989-12-22 | 1998-07-07 | Imarx Pharmaceutical Corp. | Method of preparing gas-filled microspheres using a lyophilized lipids |
US20020150539A1 (en) * | 1989-12-22 | 2002-10-17 | Unger Evan C. | Ultrasound imaging and treatment |
US6551576B1 (en) | 1989-12-22 | 2003-04-22 | Bristol-Myers Squibb Medical Imaging, Inc. | Container with multi-phase composition for use in diagnostic and therapeutic applications |
US5656211A (en) | 1989-12-22 | 1997-08-12 | Imarx Pharmaceutical Corp. | Apparatus and method for making gas-filled vesicles of optimal size |
US6146657A (en) | 1989-12-22 | 2000-11-14 | Imarx Pharmaceutical Corp. | Gas-filled lipid spheres for use in diagnostic and therapeutic applications |
US5542935A (en) | 1989-12-22 | 1996-08-06 | Imarx Pharmaceutical Corp. | Therapeutic delivery systems related applications |
US6613306B1 (en) | 1990-04-02 | 2003-09-02 | Bracco International B.V. | Ultrasound contrast agents and methods of making and using them |
US6989141B2 (en) * | 1990-05-18 | 2006-01-24 | Bracco International B.V. | Ultrasound contrast agents and methods of making and using them |
US20010024638A1 (en) * | 1992-11-02 | 2001-09-27 | Michel Schneider | Stable microbubble suspensions as enhancement agents for ultrasound echography and dry formulations thereof |
US5445813A (en) * | 1992-11-02 | 1995-08-29 | Bracco International B.V. | Stable microbubble suspensions as enhancement agents for ultrasound echography |
US20040208826A1 (en) * | 1990-04-02 | 2004-10-21 | Bracco International B.V. | Ultrasound contrast agents and methods of making and using them |
US7083778B2 (en) * | 1991-05-03 | 2006-08-01 | Bracco International B.V. | Ultrasound contrast agents and methods of making and using them |
USRE39146E1 (en) | 1990-04-02 | 2006-06-27 | Bracco International B.V. | Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof |
IN172208B (no) | 1990-04-02 | 1993-05-01 | Sint Sa | |
US5578292A (en) | 1991-11-20 | 1996-11-26 | Bracco International B.V. | Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof |
AU636481B2 (en) * | 1990-05-18 | 1993-04-29 | Bracco International B.V. | Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography |
US20030194376A1 (en) * | 1990-05-18 | 2003-10-16 | Bracco International B.V. | Ultrasound contrast agents and methods of making and using them |
GB9106673D0 (en) * | 1991-03-28 | 1991-05-15 | Hafslund Nycomed As | Improvements in or relating to contrast agents |
GB9106686D0 (en) * | 1991-03-28 | 1991-05-15 | Hafslund Nycomed As | Improvements in or relating to contrast agents |
US5205290A (en) | 1991-04-05 | 1993-04-27 | Unger Evan C | Low density microspheres and their use as contrast agents for computed tomography |
US5874062A (en) | 1991-04-05 | 1999-02-23 | Imarx Pharmaceutical Corp. | Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents |
US5993805A (en) * | 1991-04-10 | 1999-11-30 | Quadrant Healthcare (Uk) Limited | Spray-dried microparticles and their use as therapeutic vehicles |
GB9107628D0 (en) * | 1991-04-10 | 1991-05-29 | Moonbrook Limited | Preparation of diagnostic agents |
MX9205298A (es) | 1991-09-17 | 1993-05-01 | Steven Carl Quay | Medios gaseosos de contraste de ultrasonido y metodo para seleccionar gases para usarse como medios de contraste de ultrasonido |
US6723303B1 (en) | 1991-09-17 | 2004-04-20 | Amersham Health, As | Ultrasound contrast agents including protein stabilized microspheres of perfluoropropane, perfluorobutane or perfluoropentane |
US5409688A (en) * | 1991-09-17 | 1995-04-25 | Sonus Pharmaceuticals, Inc. | Gaseous ultrasound contrast media |
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US5871710A (en) * | 1992-09-04 | 1999-02-16 | The General Hospital Corporation | Graft co-polymer adducts of platinum (II) compounds |
US5718884A (en) * | 1992-09-16 | 1998-02-17 | Nycomed Imaging As | Microbubble-based contrast agents with crosslinked and reduced proteinaceous shells |
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US6383470B1 (en) | 1992-09-26 | 2002-05-07 | Thomas Fritzsch | Microparticle preparations made of biodegradable copolymers |
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US6107102A (en) * | 1995-06-07 | 2000-08-22 | Regents Of The University Of California | Therapeutic microdevices and methods of making and using same |
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AU6636000A (en) * | 1999-08-13 | 2001-03-13 | Point Biomedical Corporation | Hollow microspheres with controlled fragility for medical use |
EP1202671A4 (en) | 1999-08-13 | 2004-11-10 | Point Biomedical Corp | MICROPARTICLES USEFUL AS ULTRASONIC CONTRAST AGENTS FOR THE LYMPHATIC SYSTEM |
DE60121925T2 (de) * | 2000-03-22 | 2007-03-01 | The Secretary Of State For Defence, Salisbury | Arzneimittel zur verabreichung an schleimhäute |
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US6919068B2 (en) * | 2002-05-17 | 2005-07-19 | Point Biomedical Corporation | Method of preparing gas-filled polymer matrix microparticles useful for echographic imaging |
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FR2850385B1 (fr) * | 2003-01-29 | 2007-04-20 | Inst Gustave Roussy Igr | Microparticules echogenes, servant notamment comme agent de contraste pour l'exploration ultrasonique et/ou comme emboles pour le detections ultrasoniques |
US20040185108A1 (en) * | 2003-03-18 | 2004-09-23 | Short Robert E. | Method of preparing gas-filled polymer matrix microparticles useful for delivering drug |
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US7025726B2 (en) | 2004-01-22 | 2006-04-11 | The Regents Of The University Of Nebraska | Detection of endothelial dysfunction by ultrasonic imaging |
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JP2010540499A (ja) * | 2007-09-26 | 2010-12-24 | ディーエスエム アイピー アセッツ ビー.ブイ. | 架橋ポリマーを含む微粒子 |
US20120108514A1 (en) | 2009-07-09 | 2012-05-03 | University Of Iowa Research Foundation | Long acting atrial natriuretic peptide (la-anp) and methods for use thereof |
CN107090028A (zh) | 2011-08-30 | 2017-08-25 | 梅约医学教育与研究基金会 | 利钠多肽 |
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GB2017125B (en) * | 1978-03-17 | 1982-07-21 | California Inst Of Techn | Polyglutaraldehyde synthesis and protein bonding substrates |
US4267234A (en) * | 1978-03-17 | 1981-05-12 | California Institute Of Technology | Polyglutaraldehyde synthesis and protein bonding substrates |
US4276885A (en) * | 1979-05-04 | 1981-07-07 | Rasor Associates, Inc | Ultrasonic image enhancement |
US4349530A (en) * | 1980-12-11 | 1982-09-14 | The Ohio State University | Implants, microbeads, microcapsules, preparation thereof and method of administering a biologically-active substance to an animal |
US4438239A (en) * | 1981-03-30 | 1984-03-20 | California Institute Of Technology | Microsphere coated substrate containing reactive aldehyde groups |
US4413070A (en) * | 1981-03-30 | 1983-11-01 | California Institute Of Technology | Polyacrolein microspheres |
US4678814A (en) * | 1981-03-30 | 1987-07-07 | California Institute Of Technology | Polyacrolein microspheres |
IL63220A (en) * | 1981-07-01 | 1985-09-29 | Yeda Res & Dev | Process for production of polyacrolein microspheres |
IL65131A0 (en) * | 1982-02-28 | 1982-04-30 | Yeda Res & Dev | Process for the production of agarose-polyaldehyde beads and their biological applications |
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US4826689A (en) * | 1984-05-21 | 1989-05-02 | University Of Rochester | Method for making uniformly sized particles from water-insoluble organic compounds |
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US4937081A (en) * | 1988-01-14 | 1990-06-26 | Daicel Chemical Industries Ltd. | Process for producing porous, spherical particles |
WO1989006978A1 (en) * | 1988-02-05 | 1989-08-10 | Schering Aktiengesellschaft Berlin Und Bergkamen | Ultrasonic contrast agents, process for producing them and their use as diagnostic and therapeutic agents |
US5019400A (en) * | 1989-05-01 | 1991-05-28 | Enzytech, Inc. | Very low temperature casting of controlled release microspheres |
US5049403A (en) * | 1989-10-12 | 1991-09-17 | Horsk Hydro A.S. | Process for the preparation of surface modified solid substrates |
-
1990
- 1990-02-09 DE DE4004430A patent/DE4004430A1/de not_active Withdrawn
-
1991
- 1991-02-05 JP JP03521891A patent/JP3363912B2/ja not_active Expired - Fee Related
- 1991-02-07 FI FI910596A patent/FI910596A/fi not_active Application Discontinuation
- 1991-02-07 PT PT96691A patent/PT96691B/pt not_active IP Right Cessation
- 1991-02-08 HU HU91427A patent/HUT61490A/hu unknown
- 1991-02-08 ZA ZA91961A patent/ZA91961B/xx unknown
- 1991-02-08 NO NO910510A patent/NO300916B1/no not_active IP Right Cessation
- 1991-02-11 AU AU70982/91A patent/AU649996B2/en not_active Ceased
- 1991-02-11 IE IE43491A patent/IE76315B1/en not_active IP Right Cessation
- 1991-02-11 AT AT91250038T patent/ATE142507T1/de not_active IP Right Cessation
- 1991-02-11 DE DE59108153T patent/DE59108153D1/de not_active Expired - Lifetime
- 1991-02-11 ES ES91250038T patent/ES2094192T3/es not_active Expired - Lifetime
- 1991-02-11 NZ NZ237060A patent/NZ237060A/en unknown
- 1991-02-11 DK DK91250038.6T patent/DK0441468T3/da active
- 1991-02-11 EP EP91250038A patent/EP0441468B1/de not_active Expired - Lifetime
- 1991-02-11 CA CA002036107A patent/CA2036107A1/en not_active Abandoned
-
1995
- 1995-01-17 US US08/373,467 patent/US5501863A/en not_active Expired - Fee Related
-
1996
- 1996-09-30 GR GR960402562T patent/GR3021206T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
HU910427D0 (en) | 1991-08-28 |
IE76315B1 (en) | 1997-10-22 |
JP3363912B2 (ja) | 2003-01-08 |
FI910596A (fi) | 1991-08-10 |
US5501863A (en) | 1996-03-26 |
NO300916B1 (no) | 1997-08-18 |
NZ237060A (en) | 1994-11-25 |
ZA91961B (en) | 1991-11-27 |
JPH059132A (ja) | 1993-01-19 |
DE4004430A1 (de) | 1991-08-14 |
IE910434A1 (en) | 1991-08-14 |
PT96691A (pt) | 1991-10-31 |
CA2036107A1 (en) | 1991-08-10 |
DK0441468T3 (no) | 1997-02-10 |
FI910596A0 (fi) | 1991-02-07 |
EP0441468A3 (en) | 1992-05-27 |
AU649996B2 (en) | 1994-06-09 |
ES2094192T3 (es) | 1997-01-16 |
EP0441468B1 (de) | 1996-09-11 |
ATE142507T1 (de) | 1996-09-15 |
PT96691B (pt) | 1998-07-31 |
GR3021206T3 (en) | 1996-12-31 |
HUT61490A (en) | 1993-01-28 |
EP0441468A2 (de) | 1991-08-14 |
AU7098291A (en) | 1991-10-17 |
NO910510D0 (no) | 1991-02-08 |
DE59108153D1 (de) | 1996-10-17 |
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