NO900831L - Fremgangsmaate for fremstilling av piperidinforbindelser. - Google Patents

Fremgangsmaate for fremstilling av piperidinforbindelser.

Info

Publication number
NO900831L
NO900831L NO90900831A NO900831A NO900831L NO 900831 L NO900831 L NO 900831L NO 90900831 A NO90900831 A NO 90900831A NO 900831 A NO900831 A NO 900831A NO 900831 L NO900831 L NO 900831L
Authority
NO
Norway
Prior art keywords
piperide
compounds
procedure
preparation
alkynyl
Prior art date
Application number
NO90900831A
Other languages
English (en)
Norwegian (no)
Other versions
NO900831D0 (no
Inventor
Per Sauerberg
Preben H Olesen
Charles H Mitch
Original Assignee
Ferrosan As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DK82589A external-priority patent/DK82589A/da
Priority claimed from DK231589A external-priority patent/DK231589D0/da
Application filed by Ferrosan As filed Critical Ferrosan As
Publication of NO900831D0 publication Critical patent/NO900831D0/no
Publication of NO900831L publication Critical patent/NO900831L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
NO90900831A 1989-02-22 1990-02-21 Fremgangsmaate for fremstilling av piperidinforbindelser. NO900831L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK82589A DK82589A (da) 1989-02-22 1989-02-22 Piperidinforbindelser, deres fremstilling og anvendelse
DK231589A DK231589D0 (da) 1989-05-12 1989-05-12 Piperidinforbindelser og deres fremstilling og anvendelse

Publications (2)

Publication Number Publication Date
NO900831D0 NO900831D0 (no) 1990-02-21
NO900831L true NO900831L (no) 1990-08-23

Family

ID=26064725

Family Applications (2)

Application Number Title Priority Date Filing Date
NO90900831A NO900831L (no) 1989-02-22 1990-02-21 Fremgangsmaate for fremstilling av piperidinforbindelser.
NO900830A NO179639C (no) 1989-02-22 1990-02-21 Analogifremgangsmåte for fremstilling av terapeutisk aktive, substituerte piperidinforbindelser

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO900830A NO179639C (no) 1989-02-22 1990-02-21 Analogifremgangsmåte for fremstilling av terapeutisk aktive, substituerte piperidinforbindelser

Country Status (22)

Country Link
US (5) US5043345A (fr)
EP (2) EP0384285A3 (fr)
JP (2) JPH02255680A (fr)
KR (1) KR0163763B1 (fr)
CN (1) CN1028105C (fr)
AR (1) AR247565A1 (fr)
AT (1) ATE123030T1 (fr)
AU (2) AU629302B2 (fr)
CA (2) CA2010578C (fr)
DE (1) DE69019550T2 (fr)
DK (1) DK0384288T3 (fr)
ES (1) ES2072323T3 (fr)
FI (2) FI95704C (fr)
GR (1) GR3017062T3 (fr)
HU (2) HU221623B1 (fr)
IE (1) IE69672B1 (fr)
IL (2) IL93352A (fr)
NO (2) NO900831L (fr)
NZ (1) NZ232615A (fr)
PH (1) PH26465A (fr)
PT (2) PT93241B (fr)
RU (1) RU2042676C1 (fr)

Families Citing this family (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0372125A1 (fr) * 1988-11-08 1990-06-13 Akzo N.V. Dérivés de thiazole et d'oxazole
US5328925A (en) * 1989-02-22 1994-07-12 Novo Nordisk A/S Piperidine compounds and their use
US5260311A (en) * 1989-02-22 1993-11-09 Novo Nordisk A/S Piperidine compounds and their use
US5264444A (en) * 1989-02-22 1993-11-23 Novo Nordisk A/S Piperidine compounds and use
US5043345A (en) * 1989-02-22 1991-08-27 Novo Nordisk A/S Piperidine compounds and their preparation and use
EP0459568A3 (en) * 1990-05-31 1992-09-30 Merck Sharp & Dohme Ltd. Substituted oxadiazoles and thiadiazoles for use in the treatment of glaucoma and novel compounds having such use
DK198490D0 (da) * 1990-08-21 1990-08-21 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling og anvendelse
USRE35822E (en) * 1990-08-21 1998-06-09 Novo Nordisk A/S Heterocyclic compounds
DK198390D0 (da) * 1990-08-21 1990-08-21 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling og anvendelse
US5376668A (en) * 1990-08-21 1994-12-27 Novo Nordisk A/S Heterocyclic compounds
DK198590D0 (da) * 1990-08-21 1990-08-21 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling og anvendelse
US5418240A (en) * 1990-08-21 1995-05-23 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
US5527813A (en) * 1990-08-21 1996-06-18 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
ES2113939T3 (es) * 1990-11-29 1998-05-16 Allergan Inc Uso de derivados de piridina en el tratamiento de la hipertension ocular.
EP0492903A1 (fr) * 1990-12-21 1992-07-01 MERCK SHARP & DOHME LTD. Pyrazines, pyrimidines et pyridazines substitués utiles dans le traitement de glaucome
IE922270A1 (en) * 1991-07-26 1993-01-27 Akzo Nv Pyrazole derivatives
US5641791A (en) * 1991-08-13 1997-06-24 Novo Nordisk A.S Heterocyclic compounds and their preparation and use
US5175166A (en) * 1991-08-27 1992-12-29 The University Of Toledo Muscarinic agonists
WO1993014089A1 (fr) * 1992-01-13 1993-07-22 Novo Nordisk A/S Composes heterocycliques, leur preparation et leur utilisation
US5244906A (en) * 1992-01-23 1993-09-14 Dowelanco Insect control with substituted oxadiazole and thiadiazole compounds
AU678186B2 (en) * 1992-10-23 1997-05-22 Merck Sharp & Dohme Limited Dopamine receptor subtype ligands
KR100339115B1 (ko) * 1993-06-04 2002-11-07 노보 노르디스크 에이/에스 결정성3-(4-헥실옥시-1,2,5-티아디아졸-3-일)-1,2,5,6-테트라하이드로-1-메틸피리딘(+)l-하이드로겐타르트레이트,이의제조방법및이를포함하는약제학적조성물
US5753683A (en) * 1993-08-19 1998-05-19 Novo Nordisk A/S Antipsychotic method
CZ285030B6 (cs) * 1993-08-19 1999-05-12 Novo Nordisk A/S Použití thiadiazolových a oxadiazolových sloučenin pro výrobu farmaceutického prostředku a farmacetický prostředek pro léčení schizofrenie nebo schizofrenních nemocí
US5545638A (en) * 1993-12-21 1996-08-13 Novo Nordisk A/S Method of treating gastrointestinal motility disorders
IL112024A (en) * 1993-12-21 1999-07-14 Novo Nordisk As Pharmaceutical compositions comprising tetrahydropyridine derivatives substituted with oxadiazole or thiadiazole for treating gastrointestinal motility disorders
US5665745A (en) * 1994-10-24 1997-09-09 Eli Lilly And Company Heterocyclic compounds and their preparation and use
US5998404A (en) * 1994-10-24 1999-12-07 Eli Lilly And Company Heterocyclic compounds and their use
US5605908A (en) * 1994-10-24 1997-02-25 Eli Lilly And Company Heterocyclic compounds and their use
US5488056A (en) * 1994-10-31 1996-01-30 Eli Lilly And Company Method for treating anxiety
EP0709094B1 (fr) * 1994-10-31 2000-04-05 Eli Lilly And Company Tétrahydropyridine oxadiazole ou thiadiazole pour traiter l'anxiété
US5484794A (en) * 1994-11-09 1996-01-16 Eli Lilly And Company Method for treating anxiety
US5574028A (en) * 1994-10-31 1996-11-12 Eli Lilly And Company Method for treating anxiety
US5726193A (en) * 1994-10-31 1998-03-10 Eli Lilly And Company Method for treating anxiety
US5565475A (en) * 1994-11-08 1996-10-15 Muhlhauser; Mark A. Method of treating urinary bladder dysfunctions with 3-tetrahydropyridine derivatives
US5612351A (en) * 1994-11-08 1997-03-18 Novo Nordisk A/S Method of treating urinary bladder dysfunctions
TW304167B (fr) * 1995-01-30 1997-05-01 Lilly Co Eli
US5605701A (en) * 1995-02-17 1997-02-25 Eli Lilly And Company Transdermal formulation
US5763457A (en) * 1995-11-13 1998-06-09 Eli Lilly And Company Method for treating anxiety
US5852037A (en) * 1995-11-13 1998-12-22 Eli Lilly And Company Method for treating anxiety
WO1997020819A1 (fr) * 1995-12-06 1997-06-12 Eli Lilly And Company Compositions de traitement de la douleur
NZ324594A (en) * 1995-12-07 1999-09-29 Lilly Co Eli A method and composition for treating pain using a composition comprising an azacyclic azabicyclic or tetrahydropyridine compound and an analgesic
GB9603755D0 (en) * 1996-02-22 1996-04-24 Pfizer Ltd Therapeutic agents
EP0912183A4 (fr) * 1996-04-23 1999-08-04 Lilly Co Eli Composes heterocycliques
AU2991397A (en) * 1996-04-23 1997-11-12 Eli Lilly And Company Heterocyclic compounds
WO1997040045A1 (fr) * 1996-04-24 1997-10-30 Novo Nordisk A/S Composes heterocycliques, preparation et utilisation
EP0821959A3 (fr) * 1996-08-01 1998-09-16 Eli Lilly And Company Utilisation de la 3-(4-hexyloxy-1,2,5-thiadiazol-3-yl)-1,2,5,6-tétrahydro-1-méthylpyridine pour traiter le sevrage à la nicotine
US6090829A (en) * 1996-08-01 2000-07-18 Eli Lilly And Company Method for treating excessive aggression
EP0821957A3 (fr) * 1996-08-01 1998-04-22 Eli Lilly And Company Utilisation de la 3-(4-hexyloxy-1,2,5-thiadiazol-3-yl)-1,2,5,6-tétrahydro-1-méthylpyridine (xanoméline) pour traiter l'abus de drogues
US6043258A (en) * 1996-08-01 2000-03-28 Eli Lilly And Company Method for treating disruptive behavior disorders with xanomeline
US6117890A (en) * 1996-08-01 2000-09-12 Eli Lilly And Company Method for treating bipolar disorder
PT821955E (pt) * 1996-08-01 2002-07-31 Lilly Co Eli Uso de 3-(4-hexiloxi-1,2,5-tiadiazol-3-il)-1,2,5,6-tetrahidro-1-metilpiridina (xanomelina) para o tratamento da doenca bipolar
EP0821958A3 (fr) * 1996-08-01 1998-07-08 Eli Lilly And Company Utilisation de la 3-(4-hexyloxy-1,2,5-thiadiazol-3-yl)-1,2,5,6-tétrahydro-1-méthylpyridine (xanoméline) pour traiter l'agressivité excessive
EP0821956A1 (fr) * 1996-08-01 1998-02-04 Eli Lilly And Company Méthode de traitement de troubles disruptifs de comportement
EP0821954A1 (fr) * 1996-08-01 1998-02-04 Eli Lilly And Company Méthode de traitement d'arriération mentale
WO1998017214A1 (fr) * 1996-10-23 1998-04-30 Eli Lilly And Company Procede de traitement d'une demence provoquee par le syndrome d'immunodeficit acquis
ES2227836T3 (es) 1997-05-29 2005-04-01 H. Lundbeck A/S Tratamiento de esquizofrenia y psicosis.
US6034108A (en) * 1997-07-28 2000-03-07 Eli Lilly And Company Method for treating mental retardation
US6528529B1 (en) 1998-03-31 2003-03-04 Acadia Pharmaceuticals Inc. Compounds with activity on muscarinic receptors
US6096767A (en) 1999-01-22 2000-08-01 The University Of Toledo Muscarinic receptor agonists
US6211204B1 (en) 1999-01-22 2001-04-03 University Of Toledo Muscarinic receptor agonists
US6376675B2 (en) 1999-01-22 2002-04-23 The University Of Toledo Muscarinic receptor agonists
US20040023951A1 (en) * 2001-06-18 2004-02-05 Bymaster Franklin Porter Combination therapy for treatment of psychoses
US7678363B2 (en) * 2005-08-26 2010-03-16 Braincells Inc Methods of treating psychiatric conditions comprising administration of muscarinic agents in combination with SSRIs
EP2258358A3 (fr) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenèse avec un inhibiteur de l'acetylcholinestérase
CN1821243B (zh) * 2005-08-30 2010-12-08 北京大学 取代的吡啶类m1受体激动剂、其制备方法及其用途
EP1940389A2 (fr) 2005-10-21 2008-07-09 Braincells, Inc. Modulation de la neurogenese par inhibition de la pde
US20070112017A1 (en) 2005-10-31 2007-05-17 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20090012101A1 (en) * 2005-12-27 2009-01-08 University Of Toledo Mucarinic Agonists and Methods of Use Thereof
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
MX2008014320A (es) 2006-05-09 2009-03-25 Braincells Inc Neurogenesis mediada por el receptor de 5-hidroxitriptamina.
AU2007249399A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
JP2010502722A (ja) 2006-09-08 2010-01-28 ブレインセルス，インコーポレイティド ４−アシルアミノピリジン誘導体を含む組み合わせ
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
EP2296471A4 (fr) 2008-05-15 2012-03-14 Univ Toledo Agonistes muscariniques servant de stimulateurs cognitifs
WO2010099217A1 (fr) 2009-02-25 2010-09-02 Braincells, Inc. Modulation de neurogenèse à l'aide de combinaisons de d-cyclosérine
ES2742728T3 (es) 2009-07-22 2020-02-17 PureTech Health LLC Composiciones para el tratamiento de trastornos mejorados por la activación del receptor muscarínico
US10265311B2 (en) 2009-07-22 2019-04-23 PureTech Health LLC Methods and compositions for treatment of disorders ameliorated by muscarinic receptor activation
WO2012068161A1 (fr) 2010-11-15 2012-05-24 Agenebio, Inc. Dérivés de pyridazine, compositions et méthodes de traitement d'une déficience cognitive
US9549928B2 (en) 2011-04-29 2017-01-24 The University Of Toledo Muscarinic agonists as enhancers of cognitive flexibility
EP3083569B1 (fr) 2013-12-20 2022-01-26 Agenebio, Inc. Dérivés de benzodiazépine, compositions et procédés de traitement de la déficience cognitive
CA2990004C (fr) 2015-06-19 2024-04-23 Agenebio, Inc. Derives de benzodiazepine, compositions et methodes de traitement de la deficience cognitive
US20180250270A1 (en) 2015-09-11 2018-09-06 Chase Pharmaceuticals Corporation Muscarinic combination and its use for combating hypocholinergic disorders of the central nervous system
US11505555B2 (en) 2016-12-19 2022-11-22 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
US20180170941A1 (en) 2016-12-19 2018-06-21 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
EA202190076A1 (ru) 2018-06-19 2021-09-22 Эйджинбайо, Инк. Производные бензодиазепина, композиции и способы лечения когнитивных нарушений
AU2019346626B2 (en) 2018-09-28 2022-06-02 Karuna Therapeutics, Inc. Compositions and methods for treating disorders ameliorated by muscarinic receptor activation
WO2021097427A1 (fr) 2019-11-15 2021-05-20 Karuna Therapeutics, Inc. Dérivés de xanoméline et méthodes de traitement de troubles neurologiques
CN115974863A (zh) * 2021-10-14 2023-04-18 南京迈诺威医药科技有限公司 占诺美林衍生物的苹果酸盐、a晶型及其制备方法和用途
WO2024039886A1 (fr) 2022-08-19 2024-02-22 Agenebio, Inc. Dérivés de benzoazépine, compositions et méthodes de traitement de déficience cognitive

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ219646A (en) * 1986-03-27 1990-10-26 Merck Sharp & Dohme Oxadiazole derivatives of azacyclics for treating cns disorders
IL83275A (en) * 1986-09-08 1994-02-27 Novo Nordisk As Compounds 1,2, 4-Oxadiazolyl Pipridine Transformed, their preparation and pharmaceutical preparations containing them
US5017618A (en) * 1987-03-16 1991-05-21 University Of Florida Labile derivatives of ketone analogs of 3-substituted-1-alkylamino-2-propanols and their use as beta-adrenergic blockers
GB8714789D0 (en) * 1987-06-24 1987-07-29 Lundbeck & Co As H Heterocyclic compounds
NZ225999A (en) * 1987-09-10 1992-04-28 Merck Sharp & Dohme Azacyclic- or azabicyclic-substituted thiadiazole derivatives and pharmaceutical compositions
IE63906B1 (en) * 1987-11-13 1995-06-14 Novo Nordisk As Azabicyclic compounds and their preparation and use
NZ227841A (en) * 1988-02-12 1991-08-27 Merck Sharp & Dohme Heterocyclic compounds with at least two non-condensed five membered rings and pharmaceutical compositions
DK162892C (da) * 1988-07-04 1992-05-11 Novo Nordisk As 1,2,5,6-tetrahydropyridinforbindelser, deres fremstilling og farmaceutiske praeparater indeholdende disse
US5328925A (en) * 1989-02-22 1994-07-12 Novo Nordisk A/S Piperidine compounds and their use
US5043345A (en) * 1989-02-22 1991-08-27 Novo Nordisk A/S Piperidine compounds and their preparation and use
US5264444A (en) * 1989-02-22 1993-11-23 Novo Nordisk A/S Piperidine compounds and use
US5260311A (en) * 1989-02-22 1993-11-09 Novo Nordisk A/S Piperidine compounds and their use
DK198390D0 (da) * 1990-08-21 1990-08-21 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling og anvendelse
DK198490D0 (da) * 1990-08-21 1990-08-21 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling og anvendelse
US5175166A (en) * 1991-08-27 1992-12-29 The University Of Toledo Muscarinic agonists

Also Published As

Publication number Publication date
CA2010578A1 (fr) 1990-08-22
AU629302B2 (en) 1992-10-01
EP0384288B1 (fr) 1995-05-24
NZ232615A (en) 1992-06-25
AU4999790A (en) 1990-08-30
CN1028105C (zh) 1995-04-05
IE900504L (en) 1990-08-22
IL93423A0 (en) 1990-11-29
NO179639C (no) 1996-11-20
FI900886A0 (fi) 1990-02-22
CA2010579A1 (fr) 1990-08-22
HU221623B1 (hu) 2002-12-28
US5712297A (en) 1998-01-27
IL93352A (en) 1994-08-26
HU211705A9 (en) 1995-12-28
EP0384285A3 (fr) 1991-04-24
EP0384288A3 (fr) 1991-04-10
PH26465A (en) 1992-07-27
CN1045104A (zh) 1990-09-05
NO900830L (no) 1990-08-23
HU900884D0 (en) 1990-05-28
PT93241A (pt) 1990-08-31
AR247565A1 (es) 1995-01-31
PT93241B (pt) 1996-01-31
IL93352A0 (en) 1990-11-29
JP2921578B2 (ja) 1999-07-19
IE69672B1 (en) 1996-10-02
US5041455A (en) 1991-08-20
KR0163763B1 (ko) 1998-12-01
AU4999690A (en) 1990-08-30
US5284859A (en) 1994-02-08
US5559138A (en) 1996-09-24
JPH02255680A (ja) 1990-10-16
DE69019550D1 (de) 1995-06-29
DE69019550T2 (de) 1995-10-05
EP0384288A2 (fr) 1990-08-29
EP0384285A2 (fr) 1990-08-29
ES2072323T3 (es) 1995-07-16
FI95704C (fi) 1996-03-11
CA2010578C (fr) 2000-05-23
DK0384288T3 (da) 1995-10-02
HUT58326A (en) 1992-02-28
FI95704B (fi) 1995-11-30
NO900831D0 (no) 1990-02-21
FI900887A0 (fi) 1990-02-22
JPH02255679A (ja) 1990-10-16
PT93242A (pt) 1990-08-31
US5043345A (en) 1991-08-27
KR910015569A (ko) 1991-09-30
ATE123030T1 (de) 1995-06-15
GR3017062T3 (en) 1995-11-30
NO900830D0 (no) 1990-02-21
NO179639B (no) 1996-08-12
RU2042676C1 (ru) 1995-08-27

Similar Documents

Publication Publication Date Title
NO900831L (no) Fremgangsmaate for fremstilling av piperidinforbindelser.
IE850042L (en) Disubstituted piperidines
NO171788C (no) Analogifremgangsmaate ved fremstilling av terapeutisk aktive fosfinsyrederivater
MX9306831A (es) Nuevos compuestos heterociclicos.
PT87754A (pt) Process for the preparation of new amino acid derivatives
DK162519C (da) Dihydropyridazinonderivater og fremgangsmaade til fremstilling deraf samt farmaceutisk praeparat indeholdende forbindelserne
NO163568C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive kinolonkarboksylsyrederivater.
NO161564C (no) Analogifremgangsmaate ved fremstilling av terapeutisk aktive beta-carbolin-3-oxadiazolylderivater.
AU2868689A (en) Use of 1,4-disubstituted-piperidinyl compounds in the manufacture of a medicament for the treatment of insomnia
EP0270093A3 (fr) Dérivés de lactame, leurs procédé de préparation, compositions pharmaceutiques les contenant et leur application à la fabrication de médicaments à propriétés thérapeutiques
ES2045067T3 (es) Procedimiento para preparar nuevos compuestos de tiazol.
FI880716A (fi) Menetelmä terapeuttisesti käyttökelpoisten aryylipiperatsinyylialkyleenifenyylisubstituoitujen heterosyklisten yhdisteiden valmistamiseksi
ATE101040T1 (de) Derivate und analoge von pyrimidon zur behandlung von asthma und bestimmte hautkrankheiten.
NO842417L (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive fenylalkyl-(piperazinyl eller homopiperazinyl)-alkyl-(urinstoff eller tiourinstoff)-derivater
GR1002384B (el) Μεθοδος παρασκευης παραγωγων υποκατεστημενου στυρολιου.
DK148288A (da) N-phenethylaminoalkyl-benzamid-forbindelser, deres anvendelse til fremstilling af antiarrhythmia-laegemidler og farmaceutiske praeparater indeholdende forbindelserne
ES2016305B3 (es) Compuestos de piperazina, procedimiento para prepararlos y composicion farmaceutica y su uso.
ES552782A0 (es) Un procedimiento para preparar un compuesto de n-fenil-trans-4-guanidincometilciclohexanocarboxamida.
IT7967658A0 (it) 2 4 etil i pipera inil 4 fenilchinoline procedimento per la loro prepara ione e composizioni farmaceutiche contenenti tali composti
ATE141507T1 (de) Verwendung von aminosteroiden zur herstellung von pharmazeutischen zubereitungen
AU1586588A (en) Fungicidal derivatives of propenoic acid and processes for their preparation
IE811212L (en) Substituted phenoxy-aminopropanol derivatives
ES8601990A1 (es) Un procedimiento para preparar 2-arilimidazo (4,5-c) piridi-nas.
SE8300711L (sv) Mjoldrygealkaloider, forfarande for framstellning derav liksom farmaceutiska beredningar innehallande dessa foreningar
GB8515212D0 (en) Thiazolidine derivatives