NO873639L - Analogifremgangsmaate for fremstilling av terapeutisk aktive 3-brom-2,6-dimetoksybenzamider. - Google Patents
Analogifremgangsmaate for fremstilling av terapeutisk aktive 3-brom-2,6-dimetoksybenzamider.Info
- Publication number
- NO873639L NO873639L NO873639A NO873639A NO873639L NO 873639 L NO873639 L NO 873639L NO 873639 A NO873639 A NO 873639A NO 873639 A NO873639 A NO 873639A NO 873639 L NO873639 L NO 873639L
- Authority
- NO
- Norway
- Prior art keywords
- acid
- hydroxy
- acid addition
- addition salts
- formula
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 11
- 238000002360 preparation method Methods 0.000 title claims description 5
- 230000001225 therapeutic effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims description 21
- 239000002253 acid Substances 0.000 claims description 14
- 150000003839 salts Chemical class 0.000 claims description 11
- 238000004519 manufacturing process Methods 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 9
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 8
- 239000007858 starting material Substances 0.000 claims description 7
- 239000000460 chlorine Substances 0.000 claims description 4
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- 229910052739 hydrogen Inorganic materials 0.000 claims description 4
- 239000001257 hydrogen Substances 0.000 claims description 4
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 3
- 229910052731 fluorine Inorganic materials 0.000 claims description 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 3
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- 125000003277 amino group Chemical group 0.000 claims description 2
- 239000011737 fluorine Substances 0.000 claims description 2
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- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 30
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- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 238000009499 grossing Methods 0.000 description 1
- 229960003878 haloperidol Drugs 0.000 description 1
- 150000002431 hydrogen Chemical class 0.000 description 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
- 229940071870 hydroiodic acid Drugs 0.000 description 1
- JBFYUZGYRGXSFL-UHFFFAOYSA-N imidazolide Chemical compound C1=C[N-]C=N1 JBFYUZGYRGXSFL-UHFFFAOYSA-N 0.000 description 1
- 239000003701 inert diluent Substances 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229940098779 methanesulfonic acid Drugs 0.000 description 1
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000004899 motility Effects 0.000 description 1
- 230000001095 motoneuron effect Effects 0.000 description 1
- 230000004973 motor coordination Effects 0.000 description 1
- XRKQMIFKHDXFNQ-UHFFFAOYSA-N n-cyclohexyl-n-ethylcyclohexanamine Chemical compound C1CCCCC1N(CC)C1CCCCC1 XRKQMIFKHDXFNQ-UHFFFAOYSA-N 0.000 description 1
- 230000000701 neuroleptic effect Effects 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- LYGJENNIWJXYER-UHFFFAOYSA-N nitromethane Chemical compound C[N+]([O-])=O LYGJENNIWJXYER-UHFFFAOYSA-N 0.000 description 1
- 239000012074 organic phase Substances 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 229920002689 polyvinyl acetate Polymers 0.000 description 1
- 239000011118 polyvinyl acetate Substances 0.000 description 1
- 229940075065 polyvinyl acetate Drugs 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000010414 supernatant solution Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 108010072897 transcription factor Brn-2 Proteins 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 235000016788 valerian Nutrition 0.000 description 1
- 238000010626 work up procedure Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
- C07D225/04—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D225/08—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with two six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Anesthesiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19863629598 DE3629598A1 (de) | 1986-08-30 | 1986-08-30 | 3-brom-2,6-dimethoxibenzamide, ihre herstellung und verwendung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO873639D0 NO873639D0 (no) | 1987-08-28 |
| NO873639L true NO873639L (no) | 1988-03-01 |
Family
ID=6308588
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO873639A NO873639L (no) | 1986-08-30 | 1987-08-28 | Analogifremgangsmaate for fremstilling av terapeutisk aktive 3-brom-2,6-dimetoksybenzamider. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5006533A (fr) |
| EP (1) | EP0258800A3 (fr) |
| JP (1) | JPS6393767A (fr) |
| KR (1) | KR880002835A (fr) |
| AU (1) | AU593131B2 (fr) |
| DD (1) | DD264435A5 (fr) |
| DE (1) | DE3629598A1 (fr) |
| DK (1) | DK452087A (fr) |
| FI (1) | FI873739A (fr) |
| HU (1) | HU203750B (fr) |
| IL (1) | IL83682A0 (fr) |
| NO (1) | NO873639L (fr) |
| PH (1) | PH24810A (fr) |
| PT (1) | PT85600B (fr) |
| SU (1) | SU1549483A3 (fr) |
| ZA (1) | ZA876423B (fr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102993197B (zh) * | 2012-12-27 | 2015-09-02 | 蕾硕医药化工（长沙）有限公司 | 托品酮衍生物及其制备方法和应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE411118B (sv) * | 1978-03-23 | 1979-12-03 | Astra Laekemedel Ab | Ett forfarande for framstellning av 2,6-dialkoxibensamider med terapentiska egenskaper |
| IL59004A0 (en) * | 1978-12-30 | 1980-03-31 | Beecham Group Ltd | Substituted benzamides their preparation and pharmaceutical compositions containing them |
| US4321378A (en) * | 1979-01-16 | 1982-03-23 | Delalande S.A. | 8-(5-Pyrimidinecarboxamide)nor-tropane derivatives |
| EP0095262B1 (fr) * | 1982-05-11 | 1986-12-03 | Beecham Group Plc | Dérivés de l'azabicycloalkane, leur préparation et médicaments les contenant |
| DE3340629A1 (de) * | 1983-11-10 | 1985-05-23 | Boehringer Ingelheim KG, 6507 Ingelheim | Basisch substituierte 2,6-dimethoxibenzamide, deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zu ihrer herstellung |
-
1986
- 1986-08-30 DE DE19863629598 patent/DE3629598A1/de not_active Withdrawn
-
1987
- 1987-08-20 PH PH35700A patent/PH24810A/en unknown
- 1987-08-26 EP EP87112366A patent/EP0258800A3/fr not_active Ceased
- 1987-08-27 PT PT85600A patent/PT85600B/pt not_active IP Right Cessation
- 1987-08-28 NO NO873639A patent/NO873639L/no unknown
- 1987-08-28 IL IL83682A patent/IL83682A0/xx unknown
- 1987-08-28 DK DK452087A patent/DK452087A/da not_active Application Discontinuation
- 1987-08-28 HU HU873792A patent/HU203750B/hu not_active IP Right Cessation
- 1987-08-28 JP JP62214969A patent/JPS6393767A/ja active Pending
- 1987-08-28 ZA ZA876423A patent/ZA876423B/xx unknown
- 1987-08-28 AU AU77666/87A patent/AU593131B2/en not_active Ceased
- 1987-08-28 FI FI873739A patent/FI873739A/fi not_active IP Right Cessation
- 1987-08-28 DD DD87306461A patent/DD264435A5/de not_active IP Right Cessation
- 1987-08-28 SU SU874203239A patent/SU1549483A3/ru active
- 1987-08-29 KR KR870009498A patent/KR880002835A/ko not_active Application Discontinuation
-
1989
- 1989-11-22 US US07/440,917 patent/US5006533A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0258800A3 (fr) | 1989-08-16 |
| FI873739A (fi) | 1988-03-01 |
| FI873739A0 (fi) | 1987-08-28 |
| NO873639D0 (no) | 1987-08-28 |
| AU7766687A (en) | 1988-03-03 |
| DK452087A (da) | 1988-03-01 |
| HUT46324A (en) | 1988-10-28 |
| DK452087D0 (da) | 1987-08-28 |
| US5006533A (en) | 1991-04-09 |
| HU203750B (en) | 1991-09-30 |
| PH24810A (en) | 1990-10-30 |
| IL83682A0 (en) | 1988-01-31 |
| JPS6393767A (ja) | 1988-04-25 |
| PT85600B (pt) | 1990-05-31 |
| AU593131B2 (en) | 1990-02-01 |
| DE3629598A1 (de) | 1988-03-03 |
| PT85600A (de) | 1987-09-01 |
| EP0258800A2 (fr) | 1988-03-09 |
| KR880002835A (ko) | 1988-05-11 |
| DD264435A5 (de) | 1989-02-01 |
| SU1549483A3 (ru) | 1990-03-07 |
| ZA876423B (en) | 1989-04-26 |
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