NO863870L - Substituerte 3-(4-fenyl-1-piperazinyl)alkylkinazolin-2,4-(1h,3h)dioner og fremgangsmaate for deres fremstilling. - Google Patents

Substituerte 3-(4-fenyl-1-piperazinyl)alkylkinazolin-2,4-(1h,3h)dioner og fremgangsmaate for deres fremstilling.

Info

Publication number
NO863870L
NO863870L NO863870A NO863870A NO863870L NO 863870 L NO863870 L NO 863870L NO 863870 A NO863870 A NO 863870A NO 863870 A NO863870 A NO 863870A NO 863870 L NO863870 L NO 863870L
Authority
NO
Norway
Prior art keywords
compound
formula
acid
piperazinyl
dione
Prior art date
Application number
NO863870A
Other languages
English (en)
Norwegian (no)
Other versions
NO863870D0 (no
Inventor
Victor T Bandurco
Charles F Schwender
Robert Falotico
Alfonso J Tobia
Original Assignee
Ortho Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Pharma Corp filed Critical Ortho Pharma Corp
Publication of NO863870D0 publication Critical patent/NO863870D0/no
Publication of NO863870L publication Critical patent/NO863870L/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72Quinazolines; Hydrogenated quinazolines
    • C07D239/95Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C07D239/96Two oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO863870A 1985-09-30 1986-09-29 Substituerte 3-(4-fenyl-1-piperazinyl)alkylkinazolin-2,4-(1h,3h)dioner og fremgangsmaate for deres fremstilling. NO863870L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/782,241 US4711883A (en) 1985-09-30 1985-09-30 Substituted 3-(4-phenyl-1-piperazinyl)alkylquinazolin-2,4-(1H,3H) diones, methods of preparation, compositions and method of use

Publications (2)

Publication Number Publication Date
NO863870D0 NO863870D0 (no) 1986-09-29
NO863870L true NO863870L (no) 1987-03-31

Family

ID=25125457

Family Applications (1)

Application Number Title Priority Date Filing Date
NO863870A NO863870L (no) 1985-09-30 1986-09-29 Substituerte 3-(4-fenyl-1-piperazinyl)alkylkinazolin-2,4-(1h,3h)dioner og fremgangsmaate for deres fremstilling.

Country Status (15)

Country Link
US (1) US4711883A (es)
EP (1) EP0219259A3 (es)
JP (1) JPS62111970A (es)
KR (1) KR870003098A (es)
AU (1) AU583949B2 (es)
CA (1) CA1290334C (es)
DK (3) DK162988C (es)
ES (1) ES2001809A6 (es)
FI (1) FI863910A (es)
GR (1) GR862452B (es)
HU (1) HUT43590A (es)
IL (1) IL80184A0 (es)
NO (1) NO863870L (es)
PT (1) PT83458B (es)
ZA (1) ZA867424B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL90879A0 (en) * 1988-09-02 1990-02-09 Janssen Pharmaceutica Nv 3-piperidinyl-indazole derivatives,their preparation and antihypertensive compositions containing them
PL166839B1 (en) * 1990-04-24 1995-06-30 Dresden Arzneimittel Method of obtaining novel 3-(mercaptoalkyl)-quinazolino-(1h,3h)-diones-2,4
IE913473A1 (en) * 1990-10-15 1992-04-22 Fujisawa Pharmaceutical Co Quinazoline derivatives and their preparation
KR100817538B1 (ko) * 2006-07-05 2008-03-27 한국화학연구원 신규 치환된―1h―퀴나졸린―2,4―디온 유도체, 이의제조방법 및 이를 함유하는 약학적 조성물
NZ595263A (en) 2009-02-26 2013-06-28 Compositions, synthesis, and methods of utilizing arylpiperazine derivatives
EP3180318B1 (en) * 2014-08-11 2019-02-20 Hydra Biosciences, Inc. Quinazoline-2,4(1h,3h)-dione derivatives as trcp5 modulators for the treatment of neuropsychiatric disorders
CN111848528B (zh) * 2019-04-29 2022-03-11 北京嘉林药业股份有限公司 一种预防和/或治疗癌症的化合物及其制备方法和应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU612466A (en) * 1966-05-26 1967-11-30 Miles Laboratories Inc. V Product and process
US3819630A (en) * 1972-08-21 1974-06-25 R Parcell 3-(1-piperazinylalkyl)-2,4-quinazolinedione compounds and methods for their production
JPS58159480A (ja) * 1982-03-17 1983-09-21 Chugai Pharmaceut Co Ltd 新規なフエニルピペラジン誘導体
JPS60222467A (ja) * 1984-04-17 1985-11-07 Mitsubishi Chem Ind Ltd キナゾリン誘導体およびそれらの酸付加塩
JPS6187675A (ja) * 1984-10-05 1986-05-06 Mitsubishi Chem Ind Ltd キナゾリン誘導体およびその酸付加塩
JPS61161268A (ja) * 1985-01-08 1986-07-21 Mitsubishi Chem Ind Ltd フエニルピペラジン誘導体
US4639518A (en) * 1984-09-24 1987-01-27 Ortho Pharmaceutical Corporation Substituted quinazolinediones

Also Published As

Publication number Publication date
ZA867424B (en) 1988-04-27
DK109891D0 (da) 1991-06-10
DK465086D0 (da) 1986-09-29
NO863870D0 (no) 1986-09-29
EP0219259A3 (en) 1988-01-20
EP0219259A2 (en) 1987-04-22
PT83458B (en) 1988-10-31
DK113591A (da) 1991-06-13
AU6321186A (en) 1987-04-02
AU583949B2 (en) 1989-05-11
PT83458A (en) 1986-10-01
FI863910A (fi) 1987-03-31
HUT43590A (en) 1987-11-30
CA1290334C (en) 1991-10-08
DK162988C (da) 1992-06-01
JPS62111970A (ja) 1987-05-22
DK465086A (da) 1987-03-31
KR870003098A (ko) 1987-04-15
GR862452B (en) 1987-01-27
DK109891A (da) 1991-06-10
DK162988B (da) 1992-01-06
US4711883A (en) 1987-12-08
IL80184A0 (en) 1986-12-31
ES2001809A6 (es) 1988-06-16
FI863910A0 (fi) 1986-09-29
DK113591D0 (da) 1991-06-13

Similar Documents

Publication Publication Date Title
US4001238A (en) 1,3,4-oxadiazole amides
US4001237A (en) Oxazole, isoxazole, thiazole and isothiazole amides
US3669968A (en) Trialkoxy quinazolines
US3971783A (en) 4-Aminoquinazoline derivatives as cardiac stimulants
AU648394B2 (en) 4-aryl-thiazole or imidazole derivatives
IE46652B1 (en) 4-amino-6,7-dimethoxy-2(4-(1,2,3-thiadiazole carbonyl)-pioerazin-1-yl)quinazolines
DK158838B (da) Quinazolinderivater, en fremgangsmaade til fremstilling deraf, farmaceutiske praeparater indeholdende derivater samt anvendelse af derivaterne til fremstilling af medikamenter
US4960773A (en) Xanthine derivatives
NO863870L (no) Substituerte 3-(4-fenyl-1-piperazinyl)alkylkinazolin-2,4-(1h,3h)dioner og fremgangsmaate for deres fremstilling.
EA008249B1 (ru) Новые пролекарства (n-2-пиридил-n-2-гидроксикарбонилэтил)амида 1-метил-2-(4-амидинофениламинометил)бензимидазол-5-илкарбоновой кислоты, их получение и их применение в качестве лекарственных средств
FI85468C (fi) Foerfarande foer framstaellning av ett terapeutiskt anvaendbart bensazepinsulfonamidderivat.
US5158953A (en) 2-substituted methyl-2,3-dihydroimidazo[1,2-c]quinazolin-5(6H)-ones (thiones), the preparation and use thereof
US4668787A (en) 5,6-dialkoxy-4-imino-2(1H)quinazolinone derivatives
HU176110B (en) Process for producing thiourea- and guanidine derivatives
US3454574A (en) Novel halo-substituted tetrahydro-quinazolines
US4258188A (en) 2-(1-Piperazinyl)-cycloheptimidazole derivatives
US4929616A (en) Novel basic-substituted 5-halo-thienoisothiazol-3(2H)-one 1,1-dioxides, a process for the preparation thereof, and pharmaceutical preparations containing these compounds
US3470185A (en) 2-(piperazino)methyl-2,3-dihydro-benzofurans
EP0338346B1 (en) Quinoxaline derivatives and antiulcer agents
EP0551527A1 (en) Pyrroloazepine derivative
DK149364B (da) Analogifremgangsmaade til fremstilling af 5-(chlorphenyl)-6h-1,3,4-thiadiazin-2-aminer
CA1274830A (en) Intermediates useful for preparing substituted 3-(4- phenyl-1-piperazinyl)alkylquinazolin-2,4-(1h,3h) diones
CS228944B2 (en) Production of 4-piperazinyl 1-4-phenylquinazoline derivatives
JP3265083B2 (ja) 2−[2−(置換アミノ)ベンジルチオ]−5,6,7,8−テトラヒドロ−4(3h)−キナゾリノン誘導体
US3856796A (en) Hydroxyalkyl-substituted-amino-quinolines and nitrates thereof