DK109891A - 3-(2-chlorethyl)quinazolin-2,4-dioner samt fremgangsmaade til fremstilling deraf - Google Patents

3-(2-chlorethyl)quinazolin-2,4-dioner samt fremgangsmaade til fremstilling deraf Download PDF

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Publication number
DK109891A
DK109891A DK109891A DK109891A DK109891A DK 109891 A DK109891 A DK 109891A DK 109891 A DK109891 A DK 109891A DK 109891 A DK109891 A DK 109891A DK 109891 A DK109891 A DK 109891A
Authority
DK
Denmark
Prior art keywords
chlorethyl
diones
quinazoline
procedures
preparing
Prior art date
Application number
DK109891A
Other languages
English (en)
Other versions
DK109891D0 (da
Inventor
Victor T Bandurco
Charles F Schwender
Robert Falotico
Alfonso J Tobia
Original Assignee
Ortho Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Pharma Corp filed Critical Ortho Pharma Corp
Publication of DK109891D0 publication Critical patent/DK109891D0/da
Publication of DK109891A publication Critical patent/DK109891A/da

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72Quinazolines; Hydrogenated quinazolines
    • C07D239/95Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C07D239/96Two oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK109891A 1985-09-30 1991-06-10 3-(2-chlorethyl)quinazolin-2,4-dioner samt fremgangsmaade til fremstilling deraf DK109891A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/782,241 US4711883A (en) 1985-09-30 1985-09-30 Substituted 3-(4-phenyl-1-piperazinyl)alkylquinazolin-2,4-(1H,3H) diones, methods of preparation, compositions and method of use

Publications (2)

Publication Number Publication Date
DK109891D0 DK109891D0 (da) 1991-06-10
DK109891A true DK109891A (da) 1991-06-10

Family

ID=25125457

Family Applications (3)

Application Number Title Priority Date Filing Date
DK465086A DK162988C (da) 1985-09-30 1986-09-29 Substituerede 3-(4-phenyl-1-piperazinyl)ethylquinazolin-2,4-(1h,3h)dioner, fremstilling deraf samt praeparater indeholdende samme
DK109891A DK109891A (da) 1985-09-30 1991-06-10 3-(2-chlorethyl)quinazolin-2,4-dioner samt fremgangsmaade til fremstilling deraf
DK911135A DK113591D0 (da) 1985-09-30 1991-06-13 3-oe2-chlorethylaaquinazolin-2,4-dioner samt fremgangsmaade til fremstilling deraf

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK465086A DK162988C (da) 1985-09-30 1986-09-29 Substituerede 3-(4-phenyl-1-piperazinyl)ethylquinazolin-2,4-(1h,3h)dioner, fremstilling deraf samt praeparater indeholdende samme

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK911135A DK113591D0 (da) 1985-09-30 1991-06-13 3-oe2-chlorethylaaquinazolin-2,4-dioner samt fremgangsmaade til fremstilling deraf

Country Status (15)

Country Link
US (1) US4711883A (da)
EP (1) EP0219259A3 (da)
JP (1) JPS62111970A (da)
KR (1) KR870003098A (da)
AU (1) AU583949B2 (da)
CA (1) CA1290334C (da)
DK (3) DK162988C (da)
ES (1) ES2001809A6 (da)
FI (1) FI863910A (da)
GR (1) GR862452B (da)
HU (1) HUT43590A (da)
IL (1) IL80184A0 (da)
NO (1) NO863870L (da)
PT (1) PT83458B (da)
ZA (1) ZA867424B (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL90879A0 (en) * 1988-09-02 1990-02-09 Janssen Pharmaceutica Nv 3-piperidinyl-indazole derivatives,their preparation and antihypertensive compositions containing them
PL165856B1 (pl) * 1990-04-24 1995-02-28 Dresden Arzneimittel Sposób wytwarzania nowych 3-/merkaptoalkilo/-chinazolino-/1 H,3H/-dionów-2,4 PL
IE913473A1 (en) * 1990-10-15 1992-04-22 Fujisawa Pharmaceutical Co Quinazoline derivatives and their preparation
KR100817538B1 (ko) * 2006-07-05 2008-03-27 한국화학연구원 신규 치환된―1h―퀴나졸린―2,4―디온 유도체, 이의제조방법 및 이를 함유하는 약학적 조성물
WO2010099503A1 (en) 2009-02-26 2010-09-02 Reviva Pharmaceuticals, Inc. Compositions, synthesis, and methods of utilizing quinazolinedione derivatives
WO2016023826A1 (en) * 2014-08-11 2016-02-18 Hydra Biosciences, Inc. Quinazoline-2,4(1h,3h)-dione derivatives as trcp5 modulators for the treatment of neuropsychiatry disorders
CN111848528B (zh) * 2019-04-29 2022-03-11 北京嘉林药业股份有限公司 一种预防和/或治疗癌症的化合物及其制备方法和应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU612466A (en) * 1966-05-26 1967-11-30 Miles Laboratories Inc. V Product and process
US3819630A (en) * 1972-08-21 1974-06-25 R Parcell 3-(1-piperazinylalkyl)-2,4-quinazolinedione compounds and methods for their production
JPS58159480A (ja) * 1982-03-17 1983-09-21 Chugai Pharmaceut Co Ltd 新規なフエニルピペラジン誘導体
JPS60222467A (ja) * 1984-04-17 1985-11-07 Mitsubishi Chem Ind Ltd キナゾリン誘導体およびそれらの酸付加塩
JPS61161268A (ja) * 1985-01-08 1986-07-21 Mitsubishi Chem Ind Ltd フエニルピペラジン誘導体
JPS6187675A (ja) * 1984-10-05 1986-05-06 Mitsubishi Chem Ind Ltd キナゾリン誘導体およびその酸付加塩
US4639518A (en) * 1984-09-24 1987-01-27 Ortho Pharmaceutical Corporation Substituted quinazolinediones

Also Published As

Publication number Publication date
EP0219259A2 (en) 1987-04-22
DK109891D0 (da) 1991-06-10
DK162988C (da) 1992-06-01
GR862452B (en) 1987-01-27
DK465086A (da) 1987-03-31
FI863910A (fi) 1987-03-31
NO863870L (no) 1987-03-31
ES2001809A6 (es) 1988-06-16
AU583949B2 (en) 1989-05-11
HUT43590A (en) 1987-11-30
EP0219259A3 (en) 1988-01-20
ZA867424B (en) 1988-04-27
DK113591A (da) 1991-06-13
NO863870D0 (no) 1986-09-29
PT83458B (en) 1988-10-31
DK113591D0 (da) 1991-06-13
AU6321186A (en) 1987-04-02
DK162988B (da) 1992-01-06
CA1290334C (en) 1991-10-08
PT83458A (en) 1986-10-01
IL80184A0 (en) 1986-12-31
FI863910A0 (fi) 1986-09-29
DK465086D0 (da) 1986-09-29
JPS62111970A (ja) 1987-05-22
KR870003098A (ko) 1987-04-15
US4711883A (en) 1987-12-08

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