US3856796A - Hydroxyalkyl-substituted-amino-quinolines and nitrates thereof - Google Patents

Abstract

Disclosed are compounds of the class of quinolines substituted at the 2-, 3- or 4- position by an amino function bearing a hydroxyalkyl nitrate moiety, e.g. 4-(2-hydroxyethylpiperazino)quinoline nitrate. The compounds have various pharmacological activities in animals and are useful, for example, as hypotensive and anti-anginal agents. Also disclosed are the corresponding hydroxy intermediates which are useful in preparation of the nitrates and also as hypotensive and anti-anginal agents.

Description

llnited States Patent [19] Simpson Dec. 24, 1974 l-lltDROXYALKYL-SUBSTIITUTED-AMINO- QIUIINOLINES AND NITRATES THEREOF [75] Inventor: William R. Simpson, Mendham, NJ.

[73] Assignee: Sandal-Wander, llnc., Hanover, NJ.

[22] Filed: Sept. 25, 1972 [21] Appl. No.: 291,833

Related US. Application Data [63] Continuation-in-part of Ser. No. 245,308, April 19, 1972, abandoned, which is a continuation-in-part of Ser. No. 127,376, March 23, 1971, abandoned.

[52] US. Cl. 260/288 R, 260/283 R, 260/286 R, 260/268 BQ, 260/288 R, 260/289 R, 260/268 R, 260/286 Q, 424/258, 424/250 [51] int. Cl C07d 33/50 [58] Field of Search 260/288 R [56] References Cited UNITED STATES PATENTS 3,272,824 9/1966 Ebertino et al. 260/288 R Gabe] et a1 260/2565 R Cronin et a1. 260/268 C Primary Examiner-Donald G. Daus Assistant ExaminerMary C. Vaughn Attorney, Agent, or FirmGerald D. Sharkin; Richard E. Vila [57] ABSTRACT 22 Claims, No Drawings HYDROXYALKYL-SUBSTITUTED-AMINO- QUINOLINES AND NITRATES THEREOF This application is a continuation-in-part of copending application Ser. No. 245,308 filed Apr. 19, 1972 which in turn is a continuation-in-part of application Ser. No. 127,376, filed Mar..23, 1971, now both abandoned.

This invention relates to quinoline derivatives, and more particularly to pharmacologically active quinolines which are substituted at the 2-, 3- or 4- position by an amino function bearing a hydroxyalkyl nitrate moiety. The invention further relates to corresponding hydroxyalkyl substituted amino-quinolines useful as intermediates in preparation of said nitrates and also possessing pharmacological activity. The invention also relates to pharmaceutical methods and compositions utilizing said compounds.

The compounds of the invention may be represented by the structural formula I:

II Y/ /N\ N-R Y V V V i Y!!! I wherein R is from the group of a. 'CH2("CH2)"ONO2 CHZ(JJH -ONOz,

R is from the group of e. CH (-CH ),,-ONO when R is (a) as above de fined,

f. hydrogen, and

g. lower alkyl of l to 4 carbon atoms,

R is hydrogen, (CH ),,,CH or (C- H -),,ONO provided that one R (and only one) is other than hydrogen, that the sum of n and m does not exceed 7 and that the sum of n and y does not exceed 8, or

R and R, together with the 4- amino nitrogen attached to the quinoline ring form n is l to 7, preferably 3 to 5,

m is to 4,

x is 0 or 1,

y is l to 4,

z is l to 4, and each of Y, Y, Y and Y is hydrogen, halo of atomic weight of from l8 to 80, i.e., fluoro, chloro or bromo, lower alkoxy of l to 3 carbon atoms, e.g., methoxy or lower alkyl of l to 3 carbon atoms, e.g., methyl, or Y and Y together from methylenedioxy; provided that at least 2 of Y, Y', Y and Y' are hydrogen and further provided that when one of Y, Y, Y and Y' is halo then the others are hydrogen, or a l-lower alkyl(- C C )iodide, the l-trifluoromethyl iodide or the l- (w,w,w-trifluoro)ethyl iodide thereof.

A preferred method for preparation of the compounds of formula I involves in a Step A reaction the nitration of the corresponding hydroxy compound of formula II;

or a corresponding iodide thereof, wherein R and R are the nonnitrate bearing hydroxyalkyl substituents corresponding to R and R respectively, i.e.,:

R is from the group of:

R is from the group of:

e. CH (-CH ),,-OH when R is (a) as above defined,

f. hydrogen,

g. lower alkyl of l to 4 carbon atoms,

R, is hydrogen, (CH ),,,CH or (CH ,,OH, provided that one R,, is other than hydrogen, that the sum of n and m does not exceed 7 and that the sum of n and y does not exceed 8, or

R and R together with the 4- amino nitrogen attached to the quinoline ring form n, m, y and z and Y,Y, Y and Y are as defined.

The preparation of compounds I by Step A involves a nitration reaction which may be carried out in a manner known per se for nitrating hydroxyalkyl groups. A preferred method of conducting the nitration involves the reaction of a compound [I with nitric acid in pres ence of a carboxylic acid anhydride which is preferably of from 3 to 8 carbon atoms, more preferably acetic acid anhydride. The reaction may be suitably carried out in an organic solvent medium at temperatures in the range of from minus C. to plus 50C., preferably minus 5C. to plus 20C. The solvent medium for the reaction is preferably provided by employing a lower aliphatic carboxylic acid, e.g., acetic acid, although other well known organic solvents may be employed or the reaction may be carried out employing an excess of the carboxylic acid anhydride. The product compound I may be isolated from the reaction mixture of Step A by working up by established procedures.

A preferred method for preparation of compounds [I involves a Step B reaction of a corresponding haloquinazoline of formula [I]:

III

or a corresponding iodide thereof, wherein Y, Y, Y" and Y' are as defined and X is halo from the group of chloro or bromo, preferably chloro with a compound of formula IV:

wherein R and R are as defined.

The reaction of Step B is of known type and may be carried out in a conventional manner by subjecting a compound Ill to reaction with the compound at elevated temperatures which may be suitably in the range of 30C. to 180C., preferably 60C. to 160C. The reaction may be suitably carried out in an inert organic solvent which may be any of several of the well-known conventional solvents such as dioxane. A generally preferred solvent is isopropanol. Alternately, the reaction may be initiated and/or carried out in the inert liquid medium provided by employing an excess of compound IV when the compound is liquid at the reaction temperature or by fusion of solid reactants. An acid binding agent such as sodium carbonate may be also employed to advantage in the reaction, if desired. The reaction product compound Il may be isolated from the reaction mixture of Step B by established procedures.

However, the preferred procedures for the preparation of the iodides of the compounds of the formulae 1 and 11 involves reacting the corresponding compound of the formulae I and 11, respectively, with the iodides at temperatures in the range of from 20C. to 100C. The reaction may be carried out in inert organic solvents of conventional type but it is generally preferred to use an excess of the iodide as the sole solvent and conduct the reaction at the reflux temperature of the system.

The compounds of formula III and IV are either known or may be prepared from known materials by established procedures.

The compounds of the formulae 1 and Il may be produced in the form of acid addition salts and the pharmaceutically acceptable acid addition salts are also included within the scope of the invention. Such salts include the acid addition salts, e.g., the methane sulfonate, hydronitrate, hydrosulfonate, fumarate, hydrochloride and maleate. Such salts may be then readily converted to the free bases by conventional procedures. In preparing the free bases from the acid addition salt, it is also convenient to employ a buffer system, e.g., a system comprising a 1:1 molar mixture of acetic acid and sodium acetate, followed by working up by conventional procedures. The free bases may be readily converted into the hydronitrate and other acid addition salts by established procedures.

The compounds of the formula I and 11 (including their iodides) and their pharmaceutically acceptable acid addition salts, are useful because they possess pharmacological activity in animals. In particular, the compounds of the formulae I and II are useful as agents for the lowering of blood pressure, e.g. as hypotensive agents, as indicated on intravenous administration to the anesthetized dog in the Cannulated Blood Vessel Test. The compounds of formulae 1 and II are also useful as antianginal agents as indicated by effecting coronary dilation in the anesthetized dog on intravenous administration and measurement of blood flow through the anterior descending branch of the left coronary artery.

The compounds of formule I and 11 (including their iodides) are further useful as anti-arrhythmic agents, as

indicated by polygraph recordings on intravenous administration to the anesthetized dog given Oubain until the appearance of constantly occurring ventricular ectopic beats and then the test compound every two minutes until the arrhythmia reverts then the test compound every two minutes until the arrhythmia reverts to sinus rhythm.

For the above uses, the compounds of the formulae I and [I may be combined with a pharmaceutically acceptable carrier, and such other conventional adjuvants as may be necessary, and administered orally in such forms as tablets. capsules. elixirs, suspensions and the like or parenterally in the form of an injectable solution or suspension. For the above-mentioned uses, the dosage administered will, of course, vary depending upon the compounds used, the therapy desired and the mode of administration. However, for use as agents for the lowering of blood pressure, e.g. as hypotensive agents, and for use as anti-arrhythmic agents, satisfactory results in general are obtained with the compounds of the formulae 1 and II when administered at a daily dosage of from about 0.2 milligrams to about 100 milligrams per kilogram of body weight, preferably given in divided doses 2 to 4 times a day, or in sustained release form. For most larger mammals, the administration of from about 16 milligrams to about 500 milligrams of the compound per day provides satisfactory results and dosage forms suitable for internal administration comprise from about 4 milligrams to about 250 milligrams of the compound in admixture with a solid or liquid pharmaceutical carrier or diluent.

As anti-angina] agents, satisfactory results may be obtained with the compounds of the formulae 1 and 11 when administered at a daily dosage of from 0.2 to 100 milligrams per kilogram of body weight, given as required or in divided doses or in sustained release form. For most larger mammals, a dosage of from 16 to 500 milligrams, pro re nata, provides satisfactory results. As antianginal agents, the compounds are preferably administered orally and used to prophylactically prevent or minimize angina attacks at a daily dosage of 16 to 500 milligrams, or in divided doses of from 4 to 250 milligrams. The preferred anti-angina! compounds are those of the formula 1.

Various of the compounds of the invention as represented by the compounds of Examples 4(z-l 4(2-9) and 3(a) hereinafter also possess peripheral vasodilatory activity as indicated in dogs by the cannulated blood vessel test following intravenous administration, and are therefore also indicated for use as peripheral vasodilators. The indicated suitable modes of administration and daily dosage are the same as for the indicated hypotensive use, above.

The compounds of formula 11 (including their iodides) are also useful as anti-obesity agents as indicated by glucose transport tests carried out on male Wistar rats which are dosed orally with 10-150 milligrams per kilogram of body weight of the test compound after at least 20 hours of fasting. One hour after receiving the drug each animal is sacrificed and the upper small intestine is removed and washed with glucose-saline. A 5 cm. section of the intenstine is everted so that the nucosal surface is on the outside. One end of the segment is tied off and the center of the sac so formed is filled with oxygen saturated Krebs biocarbonate buffer. The other end is then closed and the sac is incubated in 10 ml. of oxygen saturated bicarbonate buffer for 60 minutes at 37C. Both the outside and inside solutions contain initially 0.3% of glucose. At the end of the incubation time, the glucose content of the outer (mucosal) and the inner (serosal) solution is determined using the standard Autoanalyzer procedure. Similar tests are run simultaneously with control animals. The percent inhibition of glucose transport 5 caused by the drug is calculated from the formula:

I: Mll c m X 100 where I percent inhibition;

S, glucose concentration (mg.%) of serosal fluid at the end of an experiment in the drug-treated animal;

S glucose concentration (mg.%) of serosal fluid at the end of an experiment in the control animal; l\/l,= glucose concentration (mg.%) of mucosal fluid at the end of an experiment in the drug-treated animal; and

M glucose concentration (mg.%) of mucosal fluid at the end of an experiment in the control animal.

The effective dosage of active ingredient employed for the treatment of obesity will vary depending on the particular compound employed and the severity of the condition being treated. However, in general, satisfactory results in the treatment of obesity are obtained when the compounds [I are administered at a daily dosage of from about 0.3 milligrams to about 150 milligrams per kilogram of animal body weight, preferably given in divided doses two to four times a day, or in sustained release form. For most large mammals, the total daily dosage is from about to 1,000 milligrams. Dos- 30 age forms suitable for internal use comprise from about 10 to about 500 milligrams of the active compound in intimate admixture with a solid or liquid pharmaceutically acceptable carrier or diluent.

The preferred anti-obesity agents of the formula H are those in which R is (a), (b), (c) and (d) as defined above with respect to compounds II, more preferably in other than iodide form with R being hydrogen and with the NR R moiety being at the 4-position. More particularly preferred as anti-obesity agents among R being (a), (b), (c) and (d) are those in which R is (d), usually with R being hydrogen and in other than iodide form, for example, the compound of Example 4(s) hereinafter.

For the above usages, oral administration with carriers may take place in such conventional forms as tablets, dispersible powders, granules, capsules, syrups and elixirs. Such compositions may be prepared according to any method known in the art for the manufacture of pharmaceutical compositions, and such compositions may contain one or more conventional adjuvants, such as sweetening agents, flavoring agents, coloring agents and preserving agents, in order to provide an elegant and palatable preparation. Tablets may contain the active ingredient in admixture with conventional pharmaceutical excipients, i.e., inert diluents such as calcium phosphate, calcium sulphate dihydrate, lactose and talc, granulating and disintegrating agents, e.g., starch and aliginic acid, binding agents, e.g., starch, gelatin, polyvinyl pyrrolidone and acacia, and lubricating agents, e.g., magnesium stearate, stearic acid and talc. The tablets may be uncoated or coated by known techniques to delay disintegration and adsorption in the gastro-intestinal tract and thereby provide a sustained action over a longer period. Similarly, suspensions, syrups and elixirs may contain the active ingredient in admixture with any of the conventional excipients utilized for the preparation of such compositions, e.g., suspending agents (methylcellulose, tragacanth and sodium alginate). wetting agents (lecithin. polvoxvethvlene stealngredients Weight Compound of the formula 1, eg. 4-(5hydroxypentyl) amino-7-methoxyquinoline nitrate maleate 50 Tragacanth l0 Corn starch 25 Lactose I975 Talcum l5 Magnesium stearate 2.5

A particularly preferred compound for the treatment of angina and/or arrhythmia is l-methyl-4-(5- hydroxypentyl)amino8-methoxyquinoline nitrate iodide and tablets containing 30 milligrams (instead of 50 milligrams) thereof may be formulated as given above for administration two to four times a day for use in such treatments.

In general, the compositions of the invention adapted for either oral or parenteral administration may contain 1 to by weight of the active ingredient in combination with the inert carrier, more usually 3 to 40%.

The following examples are given for the purpose of illustration only.

EXAMPLE I 2-[ 3-Bis(2-hydroxyethyl)aminopropyl]aminoquinoline dinitrate dihydrochloride STEP A: Preparation of 2-[3-bis(2- hydroxyethyl)aminopropyl]amino-quinoline.

A mixture of 5.05 g. of 2-chloroquinoline, 5.5g. of bis(2-hydroxyethyl)aminopropylamine and 3.0 g. of sodium carbonate is heated in 20 ml of refluxing isopropanol for 24 hours. The reaction mixture is then filtered, solvent removed in vacuo and the residue chromatographed over silica gel to obtain an oil of 2-[3- bis(2-hydroxyethyl)aminopropyl] amino-quinoline. STEP B: Preparation of 2-[3 bis(2- hydroxyethyl)aminopropyllamino-quinoline dinitrate dihydrochloride.

A solution of 5.0 g. of 2-[3-bis(2-hydroxyethyl- )aminopropyl] amino-quinoline in 5.0 g. of glacial acid is added slowly to a stirred cooled (5C.) mixture of 15.0 ml. of acetic anhydride and 5.0 ml. of 90% nitric acid. Stirring is continued for 20 minutes after addition and 500 ml. of diethyl ether added to obtain an oil which is added to an excess of cooled (0C.) aqueous ammonia solution. The resulting mixture is extracted with ethyl acetate, the organic phase dried and concentrated in vacuo to obtain an oil which is treated with a slight excess of hydrogen chloride in ethanol. Addition of diethyl ether yields a solid which is recrystallized from methanol/diethyl ether to obtain 2-[3-bis(2- hydroxyethyl)aminopropyl]amino-quinoline dinitrate dihvdrochloride. m.D. 112C. (decomo) STEP A: hydroxyethyl)aminopropyl]amino-quinoline EXAMPLE 2 Following the procedure of Example 1, the following compounds are prepared:

a. 2-[4-(2-hydroxyethyl)-l-pipera2ino]-quinoline. b. 2-[4-(2-hydroxyethyl)-1-pipera2ino1-quinoline nitrate dihydrochloride, m.p. 263C. (decomp.).

c. 2-(S-hydroxypentyl)amino-6,7-dimethoxyquinoline, m.p. l27-l28C. d. 2-(S-hydroxypentyl)amino-6,7-dimethoxyquinoline nitrate fumarate, m.p. l50152C.

e. 2-(2,3-dihydroxypropyl)amino-quinoline.

f. 2-(2,3-dihydroxypropyl)amino-quinoline dinitrate maleate, m.p. 124C. (decomp.).

g. 2-(S-hydroxypentyl)amino-quinoline.

h. 2-(5-hydroxypentyl)amino-quinoline nitrate hydrochloride, m.p. l 18.5-l20C.

i. 2-[4-(2hydroxyethyl)-l-pipera2ino[-6,7-

dimethoxyquinoline, m.p. l76177C.

j. 2-[4-(2-hydroxy)-l-piperazino]-6,7-dimethoxy- 2O quinoline nitrate dihydrochloride, m.p. 223226C. (decomp.).

EXAMPLE 3 4-[3-Bis(2-hydroxyethyl)aminopropyl]aminoquinoline dinitrate dihydrochloride Preparation of 4-[3-bis(2- A mixture of 5.0 g. of 4-chloroquinoline, 7.2 g. of bis- 8 d. 4-(5-hydroxypentyl)amino-6,7-dimethoxyquinoline nitrate hydrochloride. e. 4-(2,3-dihydroxypropyl)amino-quinoline. f. 4-(2,3-dihydroxypropyl)amino-quinoline dinitrate hydrochloride, m.p. 163C.

g. 4-[4-(2-hydroxyethyl)-l-pipera2inol-6,7-

dimethoxy-quinoline. h 4-[4-(2-hydroxyethyl-l-pipera2ino]-6.7-

n. 2-[4-(2-hydr0xyethyl)-l-piperazino]-6-methoxy-.

quinoline nitrate, maleate form, m.p. l3l-l32C. (decomp.).

o. 2-[3-bis(hydroxyethyl)aminopropyllamino-6- methoxy-quinoline, m.p. 9798.5C.

p. 2-[3-bis(2-hydroxyethyl)aminopropyllamino-6- methoxyquinoline dinitrate, dihydronitrate form, m.p. 124-125C. (decomp.).

q. 4-(5-hydroxypentyl)amino-8-methoxy-quinoline,

m.p. l38l40C.

r. 4-(5-hydroxypentyl)amino-8-methoxy-quinoline nitrate, hydronitrate form. m.p. 149C. (decomp.).

s. 4-[3-bis(2-hydroxyethyl)aminopropyl]amino-8 methoxyquinoline, m.p. l4l143C.

dihydrochloride, m.p. 125C. (decomp.).

t. 4-[3-bis(2-hydroxyethyl)aminopropyl]amino-8- methoxy-quinoline dinitrate difumarate form, m.p. l09-110C. (decomp.).

u. 2-[3-bis(2-hydroxyethyl)aminopropyl]amino-6,7-

dimethoxy-quinoline, m.p. 8890C.

v. 2-[3-bis(2-hydroxyethyl)aminopropyl]amino-6.7-

(2-hydroxyethyl)aminopropylamine, 3.0 g. of sodium carbonate and 25 ml. of isopropanol is heated in a pressure vessel at 150C. for 17 hours. The resulting mixture is diluted with chloroform, filtered and purified by filtering over silica gel to obtain an oil of 4-[3-bis(2- hydroxyethyl)aminopropyllamino-quinoline.

STEP B; Preparation f 4 [3- i 2. dimethoxy-quinoline dinitrate fumarate form, m.p. hydr0xyethyl)aminopropyl]amino-quinoline dinitrate P- dihydrochloride w. 2-[4-(2-hydroxyethyl)-l-pipera2ino]-6.7-

A solution of 5.0 g. of 4-[3-bis(2-hydroxyethyldimethoxyquinoline, m.p. l76-l77C. )aminopropyl] amino-quinoline in 5.0 g. of glacial y Y 'P P ll dimethoxyquinoline nitrate dihydrochloride, m.p. 223-226C. (decomp.).

3-[3-bis(2-hydroxyethyl)aminopropyllaminoquinoline.

3-[3-bis(2-hydroxyethyl)aminopropyllaminoquinoline dinitrate, as an oil, N.M.R. CH -ONO triplet 5 4.62 p.p.m., NH broad singlet 6 8.0 p.p.m., 1.R. ONO strong peaks 1.280 cm", 1,640 cm, 2-1. 4-[3-bis(2-hydroxyethyl)aminopropyl]amino-7- chloroquinoline, m.p. 105.5l07.5C. 2-2. 4-[3-bis(2-hydroxyethyl)aminopropyl1arnino-7- chlorodinitrate, trihydrochloride form, m.p.

acetic acid is added slowly to a mixture of 15 ml. of acetic anhydride and 5.0 ml. of 90% nitric acid with stirring at minus 5C. The resulting mixture is allowed y. to warm to plus 5C. and after standing for an additional 5 minutes it is treated with an excess of ice-cold 2. aqueous ammonia solution and then extracted with methylene chloride to obtain an amber oil which is dissolved in 5.0 ml. of ethanol and treated with a slight excess of hydrogen chloride in ethanol. Addition of diethyl ether yields a solid which is recrystallized from methanol/diethyl ether to obtain 4-[3-bis(2- hydroxyethyl) aminopropyl]amino-quin0line dinitrate compounds are prepared:

EXAMPLE 4 Following the procedure of Example 3 the following a. 4-[4-(2-hydroxyethyl)-l-pipera2ino]-quinoline.

b. 4-[4-(2-hydroxyethyl)-l-pipera2ino]-quinoline nitrate dihydronitrate, m.p. C. (decomp.).

c. 4-(5-hydroxypentyl)amino-6,7-dimethoxyquinoline maleate, m.p. 146-147C.

l40-142C. (decomp.).

2-3. 4-[4-(2-hydroxyethyl)-l-pipera2ino]-7-chloroquinoline. m.p. ll9-l2lC.

2-4. 4-[4-(2-hydroxyethyl)-1-piperazinol-7-chloroquinoline nitrate, dihydrochloride form, m.p. l50-l5lC.(decomp.).

2-5. 4-[3-bis(2-hydroxyethyl)aminopropyllamino-6- methoxyquinoline, dimaleate form, m.p. 144.5-l46C.

methoxyquinoline iodide, m.p. 889lC.

. l-methyl-4-(6-hydroxyhexyl)amino-8- methoxyquinoline nitrate iodide, m.p. 99100.5C.

. l-methyl-4-(7-hydr0xyheptyl)amino-7- chloroquinoline nitrate iodide. m.p. 135C.

t. l-methyl-4-(7-hydroxyheptyl)amino-7- methoxyquinoline nitrate iodide, m.p. 165C. (decomp.).

u. l-methyl-4-(7-hydroxyheptyl)amino-8- methoxyquinoline nitrate iodide, m.p. 8386C. v. l-trifluoromethyl-4-(5-hydroxypentyl)amino-8- methoxyquinoline nitrate iodide.

What is claimed is: 1. A compound of the formula:

wherein R is from the group of l-methyl-4-( 6-hydroxyhexyl )amino-8-r each of Y, Y, Y" and Y is hydrogen, halo of atomic weight of from 18 to 80, alkoxy of l to 3 carbon atoms or alkyl of l to 3 carbon atoms or Y and Y together form methylenedioxy, provided that at least 2 of Y, Y, Y" and Y are hydrogen and further provided that when one ofY, Y, Y and Y is halo then the others are hydrogen; or a pharmaceutically acceptable acid addition salt thereof.

2. A compound of claim 1 having the formula:

wherein Y, Y, Y, Y, R and R, are defined in claim 1.

3. A compound of claim 2 in which R is hydrogen.

4. A compound of claim 3 in which R is CH- 2( 2)- 2- 5. A compound of claim 3 in which R is CH. .(C- 2)11" l' 2( 2)!/' 2l2- 6. The compound of claim 4 in which n is 4, Y and Y are each methoxy and Y and Y" are each hydrogen.

7. The compound ofclaim 5 in which n is 2, y is l and each of Y, Y, Y and Y is hydrogen.

8. A compound of claim 3 in which R is 9. A compound of claim 8 in which R is -(CH- 2)y z- 10. The compound of claim 9 in which n and y are l and each of Y, y, Y and Y is hydrogen.

11. A compound of claim l having the formula:

wherein Y, Y, Y, Y, R and R are as defined in claim 1.

12. A compound of claim 11 in which R is hydrogen.

13. A compound of claim 12 in which R is -CH- 2( 2)n' 2- 14. A compound of claim 12 in which R is -CH 2)n l' 2(' 2)1/ 2- 15. The compound ofclaim 13 in which n is 4, Y and Y are each methoxy.

16. The compound of claim 14 in which n is 2, y is 1 and each of Y, Y, Y" and Y is hydrogen.

17. A compound of claim 12 in which R is 13 l4 18. A compound of claim 17 in which R is -(CH Y ONO I 2 I 19. The compound of claim 18 in which n and y are 1 and each of Y, Y. Y" and Y" are hydrogen. Y t N R 20. The compound of claim 14 in which n is 2, y is l, and each of Y, Y, Y" and Y' is hydrogen.

2ll.The compound of claim 13 in which n is 4, Y is I, m I methoxy and each of Y, Y" and Y is hydrogen. gf Y Y Y R and are as defined m 22. A compound of claim 1 having the formula:

Claims (22)

1. A COMPOUND OF THE FORMULA:

2. A compound of claim 1 having the formula:

3. A compound of claim 2 in which R1 is hydrogen.

4. A compound of claim 3 in which R is -CH2(-CH2)n-ONO2.

5. A compound of claim 3 in which R is -CH2(-CH2)n-N(-CH2(-CH2)y-ONO2)2.

6. The compound of claim 4 in which n is 4, Y and Y'' are each methoxy and Y'''' and Y'''''' are each hydrogen.

7. The compound of claim 5 in which n is 2, y is 1 and each of Y, Y'', Y'''' and Y'''''' is hydrogen.

8. A compound of claim 3 in which R is

9. A compound of claim 8 in which Ro is -(CH2)y-ONO2.

10. The compound of claim 9 in which n and y are 1 and each of Y, Y'', Y'''' and Y'''''' is hydrogen.

11. A compound of claim 1 having the formula:

12. A compound of claim 11 in which R1 is hydrogen.

13. A compound of claim 12 in which R is -CH2(-CH2)n-ONO2.

14. A compound of claim 12 in which R is -CH2(-CH2)n-N(-CH2(-CH2)y-ONO2.

15. The compound of claim 13 in which n is 4, Y and Y'' are each methoxy.

16. The compound of claim 14 in which n is 2, y is 1 and each of Y, Y'', Y'''' and Y'''''' is hydrogen.

17. A compound of claim 12 in which R is

18. A compound of claim 17 in which Ro is -(CH2)y-ONO2.

19. The compound of claim 18 in which n and y are 1 and each of Y, Y'', Y'''' and Y'''''' are hydrogen.

20. The compound of claim 14 in which n is 2, y is 1, and each of Y, Y'', Y'''' and Y'''''' is hydrogen.

21. The compound of claim 13 in which n is 4, Y'' is methoxy and each of Y, Y'''' and Y'''''' is hydrogen.

22. A compound of claim 1 having the formula: