DK162988C - Substituerede 3-(4-phenyl-1-piperazinyl)ethylquinazolin-2,4-(1h,3h)dioner, fremstilling deraf samt praeparater indeholdende samme - Google Patents

Substituerede 3-(4-phenyl-1-piperazinyl)ethylquinazolin-2,4-(1h,3h)dioner, fremstilling deraf samt praeparater indeholdende samme

Info

Publication number
DK162988C
DK162988C DK465086A DK465086A DK162988C DK 162988 C DK162988 C DK 162988C DK 465086 A DK465086 A DK 465086A DK 465086 A DK465086 A DK 465086A DK 162988 C DK162988 C DK 162988C
Authority
DK
Denmark
Prior art keywords
ethylquinazoline
diones
piperazinyl
phenyl
substituted
Prior art date
Application number
DK465086A
Other languages
Danish (da)
English (en)
Other versions
DK465086D0 (da
DK465086A (da
DK162988B (da
Inventor
Victor T Bandurco
Charles F Schwender
Robert Falotico
Alfonso J Tobia
Original Assignee
Ortho Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Pharma Corp filed Critical Ortho Pharma Corp
Publication of DK465086D0 publication Critical patent/DK465086D0/da
Publication of DK465086A publication Critical patent/DK465086A/da
Publication of DK162988B publication Critical patent/DK162988B/da
Application granted granted Critical
Publication of DK162988C publication Critical patent/DK162988C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C07D239/96—Two oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK465086A 1985-09-30 1986-09-29 Substituerede 3-(4-phenyl-1-piperazinyl)ethylquinazolin-2,4-(1h,3h)dioner, fremstilling deraf samt praeparater indeholdende samme DK162988C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/782,241 US4711883A (en) 1985-09-30 1985-09-30 Substituted 3-(4-phenyl-1-piperazinyl)alkylquinazolin-2,4-(1H,3H) diones, methods of preparation, compositions and method of use
US78224185 1985-09-30

Publications (4)

Publication Number Publication Date
DK465086D0 DK465086D0 (da) 1986-09-29
DK465086A DK465086A (da) 1987-03-31
DK162988B DK162988B (da) 1992-01-06
DK162988C true DK162988C (da) 1992-06-01

Family

ID=25125457

Family Applications (3)

Application Number Title Priority Date Filing Date
DK465086A DK162988C (da) 1985-09-30 1986-09-29 Substituerede 3-(4-phenyl-1-piperazinyl)ethylquinazolin-2,4-(1h,3h)dioner, fremstilling deraf samt praeparater indeholdende samme
DK109891A DK109891A (da) 1985-09-30 1991-06-10 3-(2-chlorethyl)quinazolin-2,4-dioner samt fremgangsmaade til fremstilling deraf
DK911135A DK113591D0 (da) 1985-09-30 1991-06-13 3-oe2-chlorethylaaquinazolin-2,4-dioner samt fremgangsmaade til fremstilling deraf

Family Applications After (2)

Application Number Title Priority Date Filing Date
DK109891A DK109891A (da) 1985-09-30 1991-06-10 3-(2-chlorethyl)quinazolin-2,4-dioner samt fremgangsmaade til fremstilling deraf
DK911135A DK113591D0 (da) 1985-09-30 1991-06-13 3-oe2-chlorethylaaquinazolin-2,4-dioner samt fremgangsmaade til fremstilling deraf

Country Status (15)

Country Link
US (1) US4711883A (es)
EP (1) EP0219259A3 (es)
JP (1) JPS62111970A (es)
KR (1) KR870003098A (es)
AU (1) AU583949B2 (es)
CA (1) CA1290334C (es)
DK (3) DK162988C (es)
ES (1) ES2001809A6 (es)
FI (1) FI863910A (es)
GR (1) GR862452B (es)
HU (1) HUT43590A (es)
IL (1) IL80184A0 (es)
NO (1) NO863870L (es)
PT (1) PT83458B (es)
ZA (1) ZA867424B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL90879A0 (en) * 1988-09-02 1990-02-09 Janssen Pharmaceutica Nv 3-piperidinyl-indazole derivatives,their preparation and antihypertensive compositions containing them
PL166839B1 (en) * 1990-04-24 1995-06-30 Dresden Arzneimittel Method of obtaining novel 3-(mercaptoalkyl)-quinazolino-(1h,3h)-diones-2,4
IE913473A1 (en) * 1990-10-15 1992-04-22 Fujisawa Pharmaceutical Co Quinazoline derivatives and their preparation
KR100817538B1 (ko) * 2006-07-05 2008-03-27 한국화학연구원 신규 치환된―１ｈ―퀴나졸린―２,４―디온 유도체, 이의제조방법 및 이를 함유하는 약학적 조성물
NZ595263A (en) 2009-02-26 2013-06-28 Compositions, synthesis, and methods of utilizing arylpiperazine derivatives
EP3180318B1 (en) * 2014-08-11 2019-02-20 Hydra Biosciences, Inc. Quinazoline-2,4(1h,3h)-dione derivatives as trcp5 modulators for the treatment of neuropsychiatric disorders
CN111848528B (zh) * 2019-04-29 2022-03-11 北京嘉林药业股份有限公司 一种预防和/或治疗癌症的化合物及其制备方法和应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU612466A (en) * 1966-05-26 1967-11-30 Miles Laboratories Inc. V Product and process
US3819630A (en) * 1972-08-21 1974-06-25 R Parcell 3-(1-piperazinylalkyl)-2,4-quinazolinedione compounds and methods for their production
JPS58159480A (ja) * 1982-03-17 1983-09-21 Chugai Pharmaceut Co Ltd 新規なフエニルピペラジン誘導体
JPS60222467A (ja) * 1984-04-17 1985-11-07 Mitsubishi Chem Ind Ltd キナゾリン誘導体およびそれらの酸付加塩
JPS6187675A (ja) * 1984-10-05 1986-05-06 Mitsubishi Chem Ind Ltd キナゾリン誘導体およびその酸付加塩
JPS61161268A (ja) * 1985-01-08 1986-07-21 Mitsubishi Chem Ind Ltd フエニルピペラジン誘導体
US4639518A (en) * 1984-09-24 1987-01-27 Ortho Pharmaceutical Corporation Substituted quinazolinediones

Also Published As

Publication number Publication date
ZA867424B (en) 1988-04-27
DK109891D0 (da) 1991-06-10
DK465086D0 (da) 1986-09-29
NO863870D0 (no) 1986-09-29
EP0219259A3 (en) 1988-01-20
EP0219259A2 (en) 1987-04-22
PT83458B (en) 1988-10-31
DK113591A (da) 1991-06-13
AU6321186A (en) 1987-04-02
AU583949B2 (en) 1989-05-11
PT83458A (en) 1986-10-01
FI863910A (fi) 1987-03-31
HUT43590A (en) 1987-11-30
NO863870L (no) 1987-03-31
CA1290334C (en) 1991-10-08
JPS62111970A (ja) 1987-05-22
DK465086A (da) 1987-03-31
KR870003098A (ko) 1987-04-15
GR862452B (en) 1987-01-27
DK109891A (da) 1991-06-10
DK162988B (da) 1992-01-06
US4711883A (en) 1987-12-08
IL80184A0 (en) 1986-12-31
ES2001809A6 (es) 1988-06-16
FI863910A0 (fi) 1986-09-29
DK113591D0 (da) 1991-06-13

Similar Documents

Publication Publication Date Title
IT1185687B (it) Ombrellone sospeso.
DK214687D0 (da) Thienopyrimidin-2,4-dionderivater samt mellempro- dukter ved fremstillingen deraf
NL940006I2 (nl) 1,2-Benzuisoxazol-3-yl-en 1,2-benzisothiazol-3-yl-derivaten.
IT1215651B (it) Agenti cardiotonici antitrombogenici immidazochinolinici.
DK140382A (da) Tetrahydrophthalimider og deres anvendelse,samt fremgangsmaadetil fremstilling deraf
DK198387D0 (da) 1-hydroxy-2-pyridoner, deres fremstilling og anvendelse samt ved fremgangsmaaden anvendelige mellemprodukter og disses fremstilling
FI872547A (fi) 3-(substituerad tio)-2 -benzoyl-cycklohex-2-enoner.
FI885424A0 (fi) Diacylderivat av 4-(trialkylbensyl) -piperazinylfoereningar.
DE3774902D1 (de) Automatisch gesteuerte verstaerkungseinrichtung.
DK158522C (da) Beta-amylase, samt fremstilling og anvendelse deraf
FI864596A0 (fi) Kardiotoniska heterocykliska oxazoloner.
DK162988C (da) Substituerede 3-(4-phenyl-1-piperazinyl)ethylquinazolin-2,4-(1h,3h)dioner, fremstilling deraf samt praeparater indeholdende samme
NO166286C (no) Fremgangsmaate for fremstilling av en invers mikrolateks, samt anvendelse av en slik mikrolateks.
FI862642A0 (fi) 3-(substituerade) propenylaminotiazol-yl-kefalosporansyror och deras estrar.
DK326085A (da) 4-amino-2-phenylquinoliner, deres fremstilling og anvendelse samt ved fremstillingen anvendelige mellemprodukter
DK184679A (da) Substituerede 1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepiner fremgangsmaade til deres fremstilling samt deres anvendelse
FI861329A0 (fi) Anvaendning av 4-(isoxazolyl)-tiazol-2-oxaminsyraderivat.
DK687787D0 (da) Carbamoyloxylabdaner, deres fremstilling og anvendelse samt ved fremstillingen anvendelige mellemprodukter
FI865019A0 (fi) Skaeranordning foer pappersbana.
FI841284A (fi) Anordning foer samtidig styrning av luftfloedesmaengden och blaossnabbheten i en reglerbar luftfloedesmaengden om omfattande luftkonditioneringsinstallation.
ATE48275T1 (de) Cardiotonische heterocyclocarbonyl- und acetylthiazolone.
DE3670085D1 (de) 2-(1-hydroxy-2,2,6,6-tetraalkyl-piperidin-4-yloxy)-dibenzodioxaphosphepine und dibenzodioxaphosphocine.
FI854545A0 (fi) Foerfarande foer tillverkning av botten av en vaeska och en vaeska tillverkad enligt foerfarandet.
AR224380A1 (es) Nuevas fenil(3,4-sustituidas)-hidrazoaldoximas y sus derivados dotadas de actividad fungicida
BR6400672U (pt) Porta-rotulos,rotulo e conjunto dos mesmos