NO830399L - Fremgangsmaate ved fremstilling av nye carbacycliner - Google Patents

Fremgangsmaate ved fremstilling av nye carbacycliner

Info

Publication number
NO830399L
NO830399L NO830399A NO830399A NO830399L NO 830399 L NO830399 L NO 830399L NO 830399 A NO830399 A NO 830399A NO 830399 A NO830399 A NO 830399A NO 830399 L NO830399 L NO 830399L
Authority
NO
Norway
Prior art keywords
carbacyclines
procedure
manufacture
new
atoms
Prior art date
Application number
NO830399A
Other languages
English (en)
Other versions
NO155729C (no
NO155729B (no
Inventor
Werner Skuballa
Bernd Raduechel
Helmut Vorbrueggen
Jorge Casals-Stenzel
Gerda Mannesmann
Michael Harold Town
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of NO830399L publication Critical patent/NO830399L/no
Publication of NO155729B publication Critical patent/NO155729B/no
Publication of NO155729C publication Critical patent/NO155729C/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/72Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/005Analogues or derivatives having the five membered ring replaced by other rings
    • C07C405/0075Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
    • C07C405/0083Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/57Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
    • C07C45/59Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in five-membered rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/78Separation; Purification; Stabilisation; Use of additives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40Esters thereof
    • C07F9/4003Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4015Esters of acyclic unsaturated acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Ink Jet Recording Methods And Recording Media Thereof (AREA)
  • Lubricants (AREA)
  • Medicinal Preparation (AREA)
NO830399A 1982-02-08 1983-02-07 Analogifremgangsmaate ved fremstilling av nye, terapeutisk aktive carbacycliner. NO155729C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19823204443 DE3204443A1 (de) 1982-02-08 1982-02-08 Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Publications (3)

Publication Number Publication Date
NO830399L true NO830399L (no) 1983-08-09
NO155729B NO155729B (no) 1987-02-09
NO155729C NO155729C (no) 1987-05-20

Family

ID=6155190

Family Applications (1)

Application Number Title Priority Date Filing Date
NO830399A NO155729C (no) 1982-02-08 1983-02-07 Analogifremgangsmaate ved fremstilling av nye, terapeutisk aktive carbacycliner.

Country Status (19)

Country Link
EP (1) EP0086404B1 (no)
JP (1) JPH0611728B2 (no)
AT (1) ATE24487T1 (no)
AU (1) AU567867B2 (no)
CA (1) CA1215362A (no)
CS (1) CS235307B2 (no)
DD (1) DD207901A5 (no)
DE (2) DE3204443A1 (no)
DK (1) DK156563C (no)
ES (1) ES8400384A1 (no)
FI (1) FI78064C (no)
GR (1) GR77967B (no)
HU (1) HU191197B (no)
IE (1) IE54554B1 (no)
IL (1) IL67839A0 (no)
NO (1) NO155729C (no)
NZ (1) NZ203115A (no)
SU (1) SU1145926A3 (no)
ZA (1) ZA83851B (no)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3225287A1 (de) * 1982-07-02 1984-01-05 Schering AG, 1000 Berlin und 4709 Bergkamen Neue carbacyclinamide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3408699A1 (de) * 1984-03-08 1985-09-12 Schering AG, 1000 Berlin und 4709 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4927963A (en) * 1989-04-28 1990-05-22 Syntex (U.S.A.) Inc. Novel processes for the synthesis of certain bicyclo(4.2.0)octane derivatives with valuable therapeutic properties
DE4135193C1 (no) * 1991-10-22 1993-03-11 Schering Ag Berlin Und Bergkamen, 1000 Berlin, De

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2845770A1 (de) * 1978-10-19 1980-04-30 Schering Ag Neue prostacyclin-derivate und verfahren zu ihrer herstellung
CA1201712A (en) * 1980-02-28 1986-03-11 Paul A. Aristoff Carbacyclin analogs
DE3104044A1 (de) * 1981-02-02 1982-08-26 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue prostacyclin-derivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel

Also Published As

Publication number Publication date
ATE24487T1 (de) 1987-01-15
DE3368609D1 (en) 1987-02-05
ES519627A0 (es) 1983-11-16
NO155729C (no) 1987-05-20
HU191197B (en) 1987-01-28
ES8400384A1 (es) 1983-11-16
IL67839A0 (en) 1983-06-15
CA1215362A (en) 1986-12-16
DE3204443A1 (de) 1983-08-18
DD207901A5 (de) 1984-03-21
DK52383D0 (da) 1983-02-08
FI830414L (fi) 1983-08-09
SU1145926A3 (ru) 1985-03-15
GR77967B (no) 1984-09-25
DK156563C (da) 1990-01-29
AU1118083A (en) 1983-08-18
EP0086404B1 (de) 1986-12-30
DK156563B (da) 1989-09-11
JPS58146531A (ja) 1983-09-01
CS235307B2 (en) 1985-05-15
IE830246L (en) 1983-08-08
FI830414A0 (fi) 1983-02-07
JPH0611728B2 (ja) 1994-02-16
IE54554B1 (en) 1989-11-22
EP0086404A1 (de) 1983-08-24
NO155729B (no) 1987-02-09
FI78064C (fi) 1989-06-12
AU567867B2 (en) 1987-12-10
DK52383A (da) 1983-08-09
NZ203115A (en) 1986-03-14
ZA83851B (en) 1983-10-26
FI78064B (fi) 1989-02-28

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