NO813446L - 1,5-bis(1,4-benzodioksin-2yl)-3-azapentan-1,5-dioler, fremgangsmaate til deres fremstilling, farmasoeytiske preparater inneholdende disse forbindelser samt deres terapeutiske anvendelse - Google Patents
1,5-bis(1,4-benzodioksin-2yl)-3-azapentan-1,5-dioler, fremgangsmaate til deres fremstilling, farmasoeytiske preparater inneholdende disse forbindelser samt deres terapeutiske anvendelseInfo
- Publication number
- NO813446L NO813446L NO813446A NO813446A NO813446L NO 813446 L NO813446 L NO 813446L NO 813446 A NO813446 A NO 813446A NO 813446 A NO813446 A NO 813446A NO 813446 L NO813446 L NO 813446L
- Authority
- NO
- Norway
- Prior art keywords
- benzodioxin
- dihydro
- compound
- mixture
- formula
- Prior art date
Links
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- 238000000034 method Methods 0.000 title claims description 25
- 238000002360 preparation method Methods 0.000 title claims description 9
- -1 1,4-BENZODIOXIN-2YL Chemical class 0.000 title description 11
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- 150000003839 salts Chemical class 0.000 claims description 32
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- 238000006243 chemical reaction Methods 0.000 claims description 15
- 239000007858 starting material Substances 0.000 claims description 15
- 238000010992 reflux Methods 0.000 claims description 13
- 125000002252 acyl group Chemical group 0.000 claims description 11
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- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- ZDHXKXAHOVTTAH-UHFFFAOYSA-N trichlorosilane Chemical compound Cl[SiH](Cl)Cl ZDHXKXAHOVTTAH-UHFFFAOYSA-N 0.000 description 1
- 239000005052 trichlorosilane Substances 0.000 description 1
- DTQVDTLACAAQTR-UHFFFAOYSA-N trifluoroacetic acid Substances OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- 238000002211 ultraviolet spectrum Methods 0.000 description 1
- 150000003672 ureas Chemical class 0.000 description 1
- NLVXSWCKKBEXTG-UHFFFAOYSA-N vinylsulfonic acid Chemical compound OS(=O)(=O)C=C NLVXSWCKKBEXTG-UHFFFAOYSA-N 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/196,503 US4313955A (en) | 1980-10-14 | 1980-10-14 | 1,5-Bis(1,4-benzodioxin-2-yl)-3-azapentane-1,5-diols |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO813446L true NO813446L (no) | 1982-04-15 |
Family
ID=22725667
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO813446A NO813446L (no) | 1980-10-14 | 1981-10-13 | 1,5-bis(1,4-benzodioksin-2yl)-3-azapentan-1,5-dioler, fremgangsmaate til deres fremstilling, farmasoeytiske preparater inneholdende disse forbindelser samt deres terapeutiske anvendelse |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US4313955A (hu) |
| EP (1) | EP0050585B1 (hu) |
| JP (1) | JPS5795982A (hu) |
| KR (1) | KR830007618A (hu) |
| AR (1) | AR227441A1 (hu) |
| AT (1) | ATE9694T1 (hu) |
| AU (1) | AU548164B2 (hu) |
| DD (1) | DD201678A5 (hu) |
| DE (1) | DE3166503D1 (hu) |
| DK (1) | DK454181A (hu) |
| ES (3) | ES8303403A1 (hu) |
| FI (1) | FI813154L (hu) |
| GB (1) | GB2085008B (hu) |
| GR (1) | GR75089B (hu) |
| HU (1) | HU187378B (hu) |
| IE (1) | IE51645B1 (hu) |
| IL (1) | IL64033A (hu) |
| NO (1) | NO813446L (hu) |
| NZ (1) | NZ198619A (hu) |
| PT (1) | PT73812B (hu) |
| ZA (1) | ZA817048B (hu) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4380653A (en) * | 1980-10-14 | 1983-04-19 | Ciba-Geigy Corporation | 1,5-Bis-(1,4-benzodioxin-2-yl)-3-azapentane-1,5-diols |
| US4471128A (en) * | 1981-09-08 | 1984-09-11 | Ciba-Geigy Corporation | 1,5-Bis-(1,4-benzodioxin-2-yl)-3-azapentane-1,5-diols |
| CA1337429C (en) * | 1983-12-05 | 1995-10-24 | Guy Rosalia Eugene Van Lommen | Derivatives of 2,2'-iminobisethanol |
| US4654362A (en) * | 1983-12-05 | 1987-03-31 | Janssen Pharmaceutica, N.V. | Derivatives of 2,2'-iminobisethanol |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1038333A (en) * | 1963-02-13 | 1966-08-10 | Ici Ltd | Pharmaceutical compositions |
| US4187313A (en) * | 1978-01-30 | 1980-02-05 | Ciba-Geigy Corporation | 2-Aminoethyl-1,4-benzodioxans |
| US4261907A (en) * | 1978-01-30 | 1981-04-14 | Ciba-Geigy Corporation | Stereospecific process |
| DE2827801A1 (de) * | 1978-06-24 | 1980-01-10 | Kali Chemie Pharma Gmbh | Neue n tief 1 -benzoyl-n tief 2 -phenyl-1,3-diaminopropan-2-ole, verfahren zu deren herstellung und arzneimittel |
| US4212808A (en) * | 1979-03-09 | 1980-07-15 | Ciba-Geigy Corporation | 2-Oxiranyl-1,4-benzodioxans |
-
1980
- 1980-10-14 US US06/196,503 patent/US4313955A/en not_active Expired - Lifetime
-
1981
- 1981-10-08 EP EP81810403A patent/EP0050585B1/de not_active Expired
- 1981-10-08 DE DE8181810403T patent/DE3166503D1/de not_active Expired
- 1981-10-08 AT AT81810403T patent/ATE9694T1/de not_active IP Right Cessation
- 1981-10-09 GR GR66245A patent/GR75089B/el unknown
- 1981-10-12 GB GB8130712A patent/GB2085008B/en not_active Expired
- 1981-10-12 FI FI813154A patent/FI813154L/fi not_active Application Discontinuation
- 1981-10-12 IL IL64033A patent/IL64033A/xx unknown
- 1981-10-13 IE IE2399/81A patent/IE51645B1/en unknown
- 1981-10-13 NO NO813446A patent/NO813446L/no unknown
- 1981-10-13 AU AU76290/81A patent/AU548164B2/en not_active Ceased
- 1981-10-13 HU HU812953A patent/HU187378B/hu unknown
- 1981-10-13 PT PT73812A patent/PT73812B/pt unknown
- 1981-10-13 ES ES506212A patent/ES8303403A1/es not_active Expired
- 1981-10-13 ZA ZA817048A patent/ZA817048B/xx unknown
- 1981-10-13 NZ NZ198619A patent/NZ198619A/en unknown
- 1981-10-13 DK DK454181A patent/DK454181A/da not_active Application Discontinuation
- 1981-10-13 AR AR287078A patent/AR227441A1/es active
- 1981-10-14 JP JP56162905A patent/JPS5795982A/ja active Pending
- 1981-10-14 KR KR1019810003878A patent/KR830007618A/ko unknown
- 1981-10-14 DD DD81234081A patent/DD201678A5/de unknown
-
1982
- 1982-10-06 ES ES516272A patent/ES516272A0/es active Granted
-
1983
- 1983-11-30 ES ES527677A patent/ES8600282A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FI813154L (fi) | 1982-04-15 |
| PT73812A (en) | 1981-11-01 |
| DK454181A (da) | 1982-04-15 |
| IL64033A0 (en) | 1982-01-31 |
| ES527677A0 (es) | 1985-10-01 |
| ATE9694T1 (de) | 1984-10-15 |
| IE812399L (en) | 1982-04-14 |
| IE51645B1 (en) | 1987-01-21 |
| AU548164B2 (en) | 1985-11-28 |
| ES8502437A1 (es) | 1985-01-01 |
| KR830007618A (ko) | 1983-11-04 |
| GB2085008B (en) | 1984-04-18 |
| NZ198619A (en) | 1985-07-31 |
| US4313955A (en) | 1982-02-02 |
| ES506212A0 (es) | 1983-02-01 |
| PT73812B (en) | 1983-06-20 |
| GR75089B (hu) | 1984-07-13 |
| ES8600282A1 (es) | 1985-10-01 |
| EP0050585B1 (de) | 1984-10-03 |
| DD201678A5 (de) | 1983-08-03 |
| AU7629081A (en) | 1982-04-22 |
| JPS5795982A (en) | 1982-06-15 |
| ES8303403A1 (es) | 1983-02-01 |
| ES516272A0 (es) | 1985-01-01 |
| EP0050585A1 (de) | 1982-04-28 |
| AR227441A1 (es) | 1982-10-29 |
| GB2085008A (en) | 1982-04-21 |
| DE3166503D1 (en) | 1984-11-08 |
| ZA817048B (en) | 1982-09-29 |
| IL64033A (en) | 1984-08-31 |
| HU187378B (en) | 1985-12-28 |
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