NO811977L - Imidazobenzotiadiazepiner, fremgangsmaate til deres fremstilling, farmasoeytiske preparater inneholdende disse forbindelser, samt deres terapeutiske anvendelse - Google Patents
Imidazobenzotiadiazepiner, fremgangsmaate til deres fremstilling, farmasoeytiske preparater inneholdende disse forbindelser, samt deres terapeutiske anvendelseInfo
- Publication number
- NO811977L NO811977L NO811977A NO811977A NO811977L NO 811977 L NO811977 L NO 811977L NO 811977 A NO811977 A NO 811977A NO 811977 A NO811977 A NO 811977A NO 811977 L NO811977 L NO 811977L
- Authority
- NO
- Norway
- Prior art keywords
- compound
- lower alkyl
- hydrogen
- compounds
- phenylene
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims abstract description 102
- 238000000034 method Methods 0.000 title claims description 19
- 238000002360 preparation method Methods 0.000 title claims description 6
- 239000000825 pharmaceutical preparation Substances 0.000 title description 4
- 230000001225 therapeutic effect Effects 0.000 title description 2
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 48
- -1 cyano, carboxy Chemical group 0.000 claims abstract description 41
- 150000003839 salts Chemical class 0.000 claims abstract description 39
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 37
- 239000001257 hydrogen Substances 0.000 claims abstract description 37
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims abstract description 14
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims abstract description 13
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 12
- 125000001589 carboacyl group Chemical group 0.000 claims abstract description 11
- 125000004433 nitrogen atom Chemical group N* 0.000 claims abstract description 11
- 229910052783 alkali metal Chemical group 0.000 claims abstract description 10
- 150000001340 alkali metals Chemical group 0.000 claims abstract description 10
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract description 10
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims abstract description 9
- 125000002030 1,2-phenylene group Chemical group [H]C1=C([H])C([*:1])=C([*:2])C([H])=C1[H] 0.000 claims abstract description 8
- 125000003545 alkoxy group Chemical group 0.000 claims abstract description 8
- 125000004414 alkyl thio group Chemical group 0.000 claims abstract description 7
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 6
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims abstract description 6
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims abstract description 4
- 125000000858 thiocyanato group Chemical group *SC#N 0.000 claims abstract description 4
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- 125000001651 cyanato group Chemical group [*]OC#N 0.000 claims abstract description 3
- 150000002431 hydrogen Chemical class 0.000 claims description 18
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- 239000000047 product Substances 0.000 claims description 11
- 125000002252 acyl group Chemical group 0.000 claims description 7
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 7
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 7
- 125000005740 oxycarbonyl group Chemical group [*:1]OC([*:2])=O 0.000 claims description 7
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- 150000002148 esters Chemical class 0.000 claims description 6
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 4
- 239000000126 substance Substances 0.000 claims description 4
- 125000001424 substituent group Chemical group 0.000 claims description 4
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- 230000008569 process Effects 0.000 claims description 3
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- 125000003118 aryl group Chemical group 0.000 description 3
- 239000003054 catalyst Substances 0.000 description 3
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- CYQAYERJWZKYML-UHFFFAOYSA-N phosphorus pentasulfide Chemical compound S1P(S2)(=S)SP3(=S)SP1(=S)SP2(=S)S3 CYQAYERJWZKYML-UHFFFAOYSA-N 0.000 description 1
- OXNIZHLAWKMVMX-UHFFFAOYSA-N picric acid Chemical class OC1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-N 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
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- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- NTTOTNSKUYCDAV-UHFFFAOYSA-N potassium hydride Chemical compound [KH] NTTOTNSKUYCDAV-UHFFFAOYSA-N 0.000 description 1
- 229910000105 potassium hydride Inorganic materials 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- TVDSBUOJIPERQY-UHFFFAOYSA-N prop-2-yn-1-ol Chemical compound OCC#C TVDSBUOJIPERQY-UHFFFAOYSA-N 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 210000001747 pupil Anatomy 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 229940107700 pyruvic acid Drugs 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
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- 229960004889 salicylic acid Drugs 0.000 description 1
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- 238000007086 side reaction Methods 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 239000012419 sodium bis(2-methoxyethoxy)aluminum hydride Substances 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 229910000104 sodium hydride Inorganic materials 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
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- 239000003381 stabilizer Substances 0.000 description 1
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- 239000008117 stearic acid Substances 0.000 description 1
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- BDHFUVZGWQCTTF-UHFFFAOYSA-N sulfonic acid Chemical compound OS(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-N 0.000 description 1
- 150000003458 sulfonic acid derivatives Chemical class 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- ZWZVWGITAAIFPS-UHFFFAOYSA-N thiophosgene Chemical compound ClC(Cl)=S ZWZVWGITAAIFPS-UHFFFAOYSA-N 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- NLVXSWCKKBEXTG-UHFFFAOYSA-N vinylsulfonic acid Chemical compound OS(=O)(=O)C=C NLVXSWCKKBEXTG-UHFFFAOYSA-N 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Polymerisation Methods In General (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15867180A | 1980-06-12 | 1980-06-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO811977L true NO811977L (no) | 1981-12-14 |
Family
ID=22569177
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO811977A NO811977L (no) | 1980-06-12 | 1981-06-11 | Imidazobenzotiadiazepiner, fremgangsmaate til deres fremstilling, farmasoeytiske preparater inneholdende disse forbindelser, samt deres terapeutiske anvendelse |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0042354B1 (hu) |
| JP (1) | JPS57118589A (hu) |
| KR (2) | KR840002145B1 (hu) |
| AT (1) | ATE16935T1 (hu) |
| AU (1) | AU538864B2 (hu) |
| CA (1) | CA1163630A (hu) |
| DD (1) | DD160535A5 (hu) |
| DE (1) | DE3173184D1 (hu) |
| DK (1) | DK255281A (hu) |
| ES (2) | ES502949A0 (hu) |
| FI (1) | FI69310C (hu) |
| GB (1) | GB2077727B (hu) |
| GR (1) | GR78222B (hu) |
| HU (1) | HU185128B (hu) |
| IE (1) | IE52043B1 (hu) |
| IL (1) | IL63079A (hu) |
| NO (1) | NO811977L (hu) |
| NZ (1) | NZ197392A (hu) |
| PT (1) | PT73173B (hu) |
| ZA (1) | ZA813930B (hu) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4459232A (en) * | 1981-12-07 | 1984-07-10 | Ciba-Geigy Corporation | Imidazo[1,2-c][1,3]benzodiazepines |
| FI824170L (fi) * | 1981-12-07 | 1983-06-08 | Ciba Geigy Ag | Imidazobensodiazepiner, foerfarande foer deras framstaellning, dessa foereningar innehaollande farmaceutiska preparat och deras anvaendning |
| US4460587A (en) * | 1981-12-07 | 1984-07-17 | Ciba-Geigy Corporation | 5-Diazacycloalkyl imidazo[1,2-c][1,3]benzodiazepines |
| US4507311A (en) * | 1981-12-07 | 1985-03-26 | Ciba-Geigy Corporation | Imidazo[1,2-c][1,3]benzodiazepines |
| US4460508A (en) * | 1981-12-07 | 1984-07-17 | Ciba-Geigy Corporation | 5-Diazacycloalkylimidazo[1,2-c][1,3]benzodiazepines |
| US4595535A (en) * | 1983-06-06 | 1986-06-17 | Ciba-Geigy Corporation | Diazacycloalkyl-1,2,4-triazolo[2,3-c][1,3]benzodiazepines useful as neuroleptic and/or antihistaminic agents |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2349064A1 (de) * | 1973-09-29 | 1975-04-10 | Basf Ag | 1,3-diazacycloalkeno- eckige klammer auf 1,2-d eckige klammer zu -benzo- eckige klammer auf f eckige klammer zu -1,3,4- thiadiazepine |
| IT7851496A0 (it) * | 1977-10-31 | 1978-10-13 | Sandoz Ag | Menti pirazinobenzossazepine loro preparazione e loro impiego quali medica |
-
1981
- 1981-05-30 JP JP56083705A patent/JPS57118589A/ja active Pending
- 1981-06-08 FI FI811771A patent/FI69310C/fi not_active IP Right Cessation
- 1981-06-09 GB GB8117623A patent/GB2077727B/en not_active Expired
- 1981-06-09 DE DE8181810228T patent/DE3173184D1/de not_active Expired
- 1981-06-09 EP EP81810228A patent/EP0042354B1/de not_active Expired
- 1981-06-09 AT AT81810228T patent/ATE16935T1/de not_active IP Right Cessation
- 1981-06-10 GR GR65189A patent/GR78222B/el unknown
- 1981-06-10 CA CA000379490A patent/CA1163630A/en not_active Expired
- 1981-06-11 ZA ZA813930A patent/ZA813930B/xx unknown
- 1981-06-11 DD DD81230728A patent/DD160535A5/de unknown
- 1981-06-11 DK DK255281A patent/DK255281A/da not_active Application Discontinuation
- 1981-06-11 HU HU811736A patent/HU185128B/hu unknown
- 1981-06-11 NZ NZ197392A patent/NZ197392A/en unknown
- 1981-06-11 ES ES502949A patent/ES502949A0/es active Granted
- 1981-06-11 IL IL63079A patent/IL63079A/xx unknown
- 1981-06-11 IE IE1302/81A patent/IE52043B1/en unknown
- 1981-06-11 AU AU71641/81A patent/AU538864B2/en not_active Ceased
- 1981-06-11 NO NO811977A patent/NO811977L/no unknown
- 1981-06-11 PT PT73173A patent/PT73173B/pt unknown
- 1981-06-12 KR KR1019810002117A patent/KR840002145B1/ko active IP Right Grant
-
1982
- 1982-07-01 ES ES513638A patent/ES8304570A1/es not_active Expired
-
1984
- 1984-07-26 KR KR1019840004435A patent/KR850000614B1/ko active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| CA1163630A (en) | 1984-03-13 |
| ES513638A0 (es) | 1983-03-01 |
| EP0042354A2 (de) | 1981-12-23 |
| AU538864B2 (en) | 1984-08-30 |
| ZA813930B (en) | 1982-06-30 |
| JPS57118589A (en) | 1982-07-23 |
| HU185128B (en) | 1984-12-28 |
| GB2077727A (en) | 1981-12-23 |
| EP0042354B1 (de) | 1985-12-11 |
| DE3173184D1 (en) | 1986-01-23 |
| ATE16935T1 (de) | 1985-12-15 |
| ES8300761A1 (es) | 1982-11-01 |
| GB2077727B (en) | 1984-03-07 |
| DK255281A (da) | 1981-12-13 |
| FI811771L (fi) | 1981-12-13 |
| IE811302L (en) | 1981-12-12 |
| FI69310C (fi) | 1986-01-10 |
| ES502949A0 (es) | 1982-11-01 |
| DD160535A5 (de) | 1983-09-07 |
| PT73173B (de) | 1983-04-29 |
| KR840002145B1 (ko) | 1984-11-23 |
| IE52043B1 (en) | 1987-05-27 |
| ES8304570A1 (es) | 1983-05-16 |
| IL63079A0 (en) | 1981-09-13 |
| KR850000614B1 (ko) | 1985-05-01 |
| EP0042354A3 (en) | 1982-02-24 |
| IL63079A (en) | 1985-06-30 |
| GR78222B (hu) | 1984-09-26 |
| NZ197392A (en) | 1984-03-30 |
| KR850001467A (ko) | 1985-03-18 |
| KR830006313A (ko) | 1983-09-20 |
| AU7164181A (en) | 1981-12-17 |
| FI69310B (fi) | 1985-09-30 |
| PT73173A (de) | 1981-07-01 |
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