ES8304570A1 - Procedimiento para la obtencion de 5-diazacicloalquil-imidazo(2,1-b) (1,3,5) benzotiadiazepinas. - Google Patents

Procedimiento para la obtencion de 5-diazacicloalquil-imidazo(2,1-b) (1,3,5) benzotiadiazepinas.

Info

Publication number
ES8304570A1
ES8304570A1 ES513638A ES513638A ES8304570A1 ES 8304570 A1 ES8304570 A1 ES 8304570A1 ES 513638 A ES513638 A ES 513638A ES 513638 A ES513638 A ES 513638A ES 8304570 A1 ES8304570 A1 ES 8304570A1
Authority
ES
Spain
Prior art keywords
alkyl
halogeno
sulfamoyl
hydrogen
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES513638A
Other languages
English (en)
Other versions
ES513638A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES513638A0 publication Critical patent/ES513638A0/es
Publication of ES8304570A1 publication Critical patent/ES8304570A1/es
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84Sulfur atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Polymerisation Methods In General (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE 5-DIAZACICLOALQUIL-IMIDAZO 2,1-B 1,3,5 BENZOTIADIAZEPINAS, ASI COMO DE SUS N- Y/O S-OXIDOS, DERIVADOS CUATERNARIOS DE ALQUILO INFERIOR Y SALES, DE FORMULA (I), EN LA QUE PH ES 1,2-FENILENO SUSTITUIDO O SIN SUSTITUIR; R, R Y R PUEDEN SER VARIOS TIPOS DE RADICALES; Y C<MH <M Y C<NH <N SON ALQUILENO C <- . CONSISTE EN LA REACCION DE CIERRE DE ANILLO, BAJO CONDICIONES DESHIDRATANTES O DESHIDROSULFURANTES, DE UN COMPUESTO DE FORMULA (II), EN LA QUE Z ES OXIGENO, AZUFRE O NH; Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE EFECTUA EN UN DISOLVENTE INERTE, EN PRESENCIA DE HALUROS Y/O OXIHALUROS DE FOSFORO O HALUROS DE CIANO. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SUS PROPIEDADES NEUROLEPTICAS.
ES513638A 1980-06-12 1982-07-01 Procedimiento para la obtencion de 5-diazacicloalquil-imidazo(2,1-b) (1,3,5) benzotiadiazepinas. Expired ES8304570A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US15867180A 1980-06-12 1980-06-12

Publications (2)

Publication Number Publication Date
ES513638A0 ES513638A0 (es) 1983-03-01
ES8304570A1 true ES8304570A1 (es) 1983-05-16

Family

ID=22569177

Family Applications (2)

Application Number Title Priority Date Filing Date
ES502949A Granted ES502949A0 (es) 1980-06-12 1981-06-11 Procedimiento para la obtencion de nuevas 5-diazacicloalquil-imidazo (2,1-b)(1,3,5) benzotiadiazepinas
ES513638A Expired ES8304570A1 (es) 1980-06-12 1982-07-01 Procedimiento para la obtencion de 5-diazacicloalquil-imidazo(2,1-b) (1,3,5) benzotiadiazepinas.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES502949A Granted ES502949A0 (es) 1980-06-12 1981-06-11 Procedimiento para la obtencion de nuevas 5-diazacicloalquil-imidazo (2,1-b)(1,3,5) benzotiadiazepinas

Country Status (20)

Country Link
EP (1) EP0042354B1 (es)
JP (1) JPS57118589A (es)
KR (2) KR840002145B1 (es)
AT (1) ATE16935T1 (es)
AU (1) AU538864B2 (es)
CA (1) CA1163630A (es)
DD (1) DD160535A5 (es)
DE (1) DE3173184D1 (es)
DK (1) DK255281A (es)
ES (2) ES502949A0 (es)
FI (1) FI69310C (es)
GB (1) GB2077727B (es)
GR (1) GR78222B (es)
HU (1) HU185128B (es)
IE (1) IE52043B1 (es)
IL (1) IL63079A (es)
NO (1) NO811977L (es)
NZ (1) NZ197392A (es)
PT (1) PT73173B (es)
ZA (1) ZA813930B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4459232A (en) * 1981-12-07 1984-07-10 Ciba-Geigy Corporation Imidazo[1,2-c][1,3]benzodiazepines
FI824170L (fi) * 1981-12-07 1983-06-08 Ciba Geigy Ag Imidazobensodiazepiner, foerfarande foer deras framstaellning, dessa foereningar innehaollande farmaceutiska preparat och deras anvaendning
US4460587A (en) * 1981-12-07 1984-07-17 Ciba-Geigy Corporation 5-Diazacycloalkyl imidazo[1,2-c][1,3]benzodiazepines
US4507311A (en) * 1981-12-07 1985-03-26 Ciba-Geigy Corporation Imidazo[1,2-c][1,3]benzodiazepines
US4460508A (en) * 1981-12-07 1984-07-17 Ciba-Geigy Corporation 5-Diazacycloalkylimidazo[1,2-c][1,3]benzodiazepines
US4595535A (en) * 1983-06-06 1986-06-17 Ciba-Geigy Corporation Diazacycloalkyl-1,2,4-triazolo[2,3-c][1,3]benzodiazepines useful as neuroleptic and/or antihistaminic agents

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2349064A1 (de) * 1973-09-29 1975-04-10 Basf Ag 1,3-diazacycloalkeno- eckige klammer auf 1,2-d eckige klammer zu -benzo- eckige klammer auf f eckige klammer zu -1,3,4- thiadiazepine
IT7851496A0 (it) * 1977-10-31 1978-10-13 Sandoz Ag Menti pirazinobenzossazepine loro preparazione e loro impiego quali medica

Also Published As

Publication number Publication date
CA1163630A (en) 1984-03-13
ES513638A0 (es) 1983-03-01
EP0042354A2 (de) 1981-12-23
AU538864B2 (en) 1984-08-30
ZA813930B (en) 1982-06-30
JPS57118589A (en) 1982-07-23
HU185128B (en) 1984-12-28
GB2077727A (en) 1981-12-23
EP0042354B1 (de) 1985-12-11
DE3173184D1 (en) 1986-01-23
ATE16935T1 (de) 1985-12-15
ES8300761A1 (es) 1982-11-01
GB2077727B (en) 1984-03-07
DK255281A (da) 1981-12-13
FI811771L (fi) 1981-12-13
IE811302L (en) 1981-12-12
FI69310C (fi) 1986-01-10
ES502949A0 (es) 1982-11-01
DD160535A5 (de) 1983-09-07
PT73173B (de) 1983-04-29
KR840002145B1 (ko) 1984-11-23
IE52043B1 (en) 1987-05-27
IL63079A0 (en) 1981-09-13
NO811977L (no) 1981-12-14
KR850000614B1 (ko) 1985-05-01
EP0042354A3 (en) 1982-02-24
IL63079A (en) 1985-06-30
GR78222B (es) 1984-09-26
NZ197392A (en) 1984-03-30
KR850001467A (ko) 1985-03-18
KR830006313A (ko) 1983-09-20
AU7164181A (en) 1981-12-17
FI69310B (fi) 1985-09-30
PT73173A (de) 1981-07-01

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