GB2077727B - Imidazo-(2,1-b)-(1,3,5)-benzothiadiazepines - Google Patents
Imidazo-(2,1-b)-(1,3,5)-benzothiadiazepinesInfo
- Publication number
- GB2077727B GB2077727B GB8117623A GB8117623A GB2077727B GB 2077727 B GB2077727 B GB 2077727B GB 8117623 A GB8117623 A GB 8117623A GB 8117623 A GB8117623 A GB 8117623A GB 2077727 B GB2077727 B GB 2077727B
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- halogeno
- sulfamoyl
- hydrogen
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Polymerisation Methods In General (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
The invention concerns the compounds of the Formula I <IMAGE> wherein each of R1 and R2 is hydrogen, alkyl, alkanoyl, halogeno, cyano, carboxy, carbalkoxy, carbamoyl, sulfamoyl, mono- or di-alkyl-(carbamoyl or sulfamoyl); Ph is 1,2-phenylene, unsubstituted or substituted by up to two identical or different members selected from alkyl, alkoxy, alkylthio, halogeno, trifluoromethyl, sulfamoyl, mono- or di-alkylsulfamoyl; each of CmH2m and CnH2n is alkylene separating both nitrogen atoms by 2 or 3 carbon atoms, and R3 is hydrogen, alkyl, alkanoyl, alkoxycarbonyl, phenyl-alkoxycarbonyl or hydroxyalkyl, wherein the hydroxy group is separated from the nitrogen atom by at least 2 carbon atoms; their N- and/or S-oxides, and alkyl quaternary derivatives thereof salts of all these compounds. The compounds exhibit neuroleptic activity. They are prepared by condensing a compound of the general Formula III or a salt thereof with a compound of the general Formula IV <IMAGE> wherein X is halogeno, alkoxy, alkylthio, cyanato or thiocyanato; Y is hydrogen or an alkali metal; p is an integer from 0 to 2, and the remaining symbols have the meaning given for formula I.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15867180A | 1980-06-12 | 1980-06-12 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GB2077727A GB2077727A (en) | 1981-12-23 |
| GB2077727B true GB2077727B (en) | 1984-03-07 |
Family
ID=22569177
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB8117623A Expired GB2077727B (en) | 1980-06-12 | 1981-06-09 | Imidazo-(2,1-b)-(1,3,5)-benzothiadiazepines |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0042354B1 (en) |
| JP (1) | JPS57118589A (en) |
| KR (2) | KR840002145B1 (en) |
| AT (1) | ATE16935T1 (en) |
| AU (1) | AU538864B2 (en) |
| CA (1) | CA1163630A (en) |
| DD (1) | DD160535A5 (en) |
| DE (1) | DE3173184D1 (en) |
| DK (1) | DK255281A (en) |
| ES (2) | ES502949A0 (en) |
| FI (1) | FI69310C (en) |
| GB (1) | GB2077727B (en) |
| GR (1) | GR78222B (en) |
| HU (1) | HU185128B (en) |
| IE (1) | IE52043B1 (en) |
| IL (1) | IL63079A (en) |
| NO (1) | NO811977L (en) |
| NZ (1) | NZ197392A (en) |
| PT (1) | PT73173B (en) |
| ZA (1) | ZA813930B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4507311A (en) * | 1981-12-07 | 1985-03-26 | Ciba-Geigy Corporation | Imidazo[1,2-c][1,3]benzodiazepines |
| FI824170L (en) * | 1981-12-07 | 1983-06-08 | Ciba Geigy Ag | IMMEDAZOBENSODIAZEPINER, FOERFARANDE FOER DERAS FRAMSTAELLNING, DESSA FOERENINGAR INNEHAOLLANDE PHARMACEUTICAL PREPARATION OCH DERAS ANVAENDNING |
| US4460508A (en) * | 1981-12-07 | 1984-07-17 | Ciba-Geigy Corporation | 5-Diazacycloalkylimidazo[1,2-c][1,3]benzodiazepines |
| US4460587A (en) * | 1981-12-07 | 1984-07-17 | Ciba-Geigy Corporation | 5-Diazacycloalkyl imidazo[1,2-c][1,3]benzodiazepines |
| US4459232A (en) * | 1981-12-07 | 1984-07-10 | Ciba-Geigy Corporation | Imidazo[1,2-c][1,3]benzodiazepines |
| US4595535A (en) * | 1983-06-06 | 1986-06-17 | Ciba-Geigy Corporation | Diazacycloalkyl-1,2,4-triazolo[2,3-c][1,3]benzodiazepines useful as neuroleptic and/or antihistaminic agents |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2349064A1 (en) * | 1973-09-29 | 1975-04-10 | Basf Ag | 1,3-DIAZACYCLOALKENO- SQUARE BRACKET ON 1,2-SQUARE BRACKET TO -BENZO- SQUARE BRACKET ON SQUARE BRACKET TO -1,3,4- THIADIAZEPINE |
| IT7851496A0 (en) * | 1977-10-31 | 1978-10-13 | Sandoz Ag | PYRAZINOBENZOXAZEPINES THEIR PREPARATION AND THEIR MEDICAL USE |
-
1981
- 1981-05-30 JP JP56083705A patent/JPS57118589A/en active Pending
- 1981-06-08 FI FI811771A patent/FI69310C/en not_active IP Right Cessation
- 1981-06-09 EP EP81810228A patent/EP0042354B1/en not_active Expired
- 1981-06-09 AT AT81810228T patent/ATE16935T1/en not_active IP Right Cessation
- 1981-06-09 DE DE8181810228T patent/DE3173184D1/en not_active Expired
- 1981-06-09 GB GB8117623A patent/GB2077727B/en not_active Expired
- 1981-06-10 GR GR65189A patent/GR78222B/el unknown
- 1981-06-10 CA CA000379490A patent/CA1163630A/en not_active Expired
- 1981-06-11 NO NO811977A patent/NO811977L/en unknown
- 1981-06-11 ZA ZA813930A patent/ZA813930B/en unknown
- 1981-06-11 IE IE1302/81A patent/IE52043B1/en unknown
- 1981-06-11 DD DD81230728A patent/DD160535A5/en unknown
- 1981-06-11 ES ES502949A patent/ES502949A0/en active Granted
- 1981-06-11 DK DK255281A patent/DK255281A/en not_active Application Discontinuation
- 1981-06-11 PT PT73173A patent/PT73173B/en unknown
- 1981-06-11 NZ NZ197392A patent/NZ197392A/en unknown
- 1981-06-11 IL IL63079A patent/IL63079A/en unknown
- 1981-06-11 AU AU71641/81A patent/AU538864B2/en not_active Ceased
- 1981-06-11 HU HU811736A patent/HU185128B/en unknown
- 1981-06-12 KR KR1019810002117A patent/KR840002145B1/en active IP Right Grant
-
1982
- 1982-07-01 ES ES513638A patent/ES8304570A1/en not_active Expired
-
1984
- 1984-07-26 KR KR1019840004435A patent/KR850000614B1/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| IL63079A0 (en) | 1981-09-13 |
| EP0042354A3 (en) | 1982-02-24 |
| AU538864B2 (en) | 1984-08-30 |
| NO811977L (en) | 1981-12-14 |
| HU185128B (en) | 1984-12-28 |
| ES8300761A1 (en) | 1982-11-01 |
| IE52043B1 (en) | 1987-05-27 |
| DE3173184D1 (en) | 1986-01-23 |
| AU7164181A (en) | 1981-12-17 |
| PT73173A (en) | 1981-07-01 |
| FI811771L (en) | 1981-12-13 |
| IE811302L (en) | 1981-12-12 |
| ES8304570A1 (en) | 1983-05-16 |
| ES502949A0 (en) | 1982-11-01 |
| DK255281A (en) | 1981-12-13 |
| PT73173B (en) | 1983-04-29 |
| GR78222B (en) | 1984-09-26 |
| EP0042354A2 (en) | 1981-12-23 |
| KR840002145B1 (en) | 1984-11-23 |
| CA1163630A (en) | 1984-03-13 |
| KR850000614B1 (en) | 1985-05-01 |
| FI69310C (en) | 1986-01-10 |
| NZ197392A (en) | 1984-03-30 |
| KR830006313A (en) | 1983-09-20 |
| DD160535A5 (en) | 1983-09-07 |
| ATE16935T1 (en) | 1985-12-15 |
| GB2077727A (en) | 1981-12-23 |
| ES513638A0 (en) | 1983-03-01 |
| KR850001467A (en) | 1985-03-18 |
| EP0042354B1 (en) | 1985-12-11 |
| FI69310B (en) | 1985-09-30 |
| JPS57118589A (en) | 1982-07-23 |
| ZA813930B (en) | 1982-06-30 |
| IL63079A (en) | 1985-06-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PCNP | Patent ceased through non-payment of renewal fee |