NO762352L - - Google Patents
Info
- Publication number
- NO762352L NO762352L NO762352A NO762352A NO762352L NO 762352 L NO762352 L NO 762352L NO 762352 A NO762352 A NO 762352A NO 762352 A NO762352 A NO 762352A NO 762352 L NO762352 L NO 762352L
- Authority
- NO
- Norway
- Prior art keywords
- prolinamide
- pyroglutamyl
- glucose
- insulin
- animals
- Prior art date
Links
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 9
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 9
- VLJNHYLEOZPXFW-BYPYZUCNSA-N L-prolinamide Chemical compound NC(=O)[C@@H]1CCCN1 VLJNHYLEOZPXFW-BYPYZUCNSA-N 0.000 claims description 7
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- QOSSAOTZNIDXMA-UHFFFAOYSA-N Dicylcohexylcarbodiimide Chemical compound C1CCCCC1N=C=NC1CCCCC1 QOSSAOTZNIDXMA-UHFFFAOYSA-N 0.000 claims description 4
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 4
- 230000008878 coupling Effects 0.000 claims description 4
- 238000010168 coupling process Methods 0.000 claims description 4
- 238000005859 coupling reaction Methods 0.000 claims description 4
- 239000000376 reactant Substances 0.000 claims description 4
- 238000006243 chemical reaction Methods 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims description 2
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims description 2
- GKQLYSROISKDLL-UHFFFAOYSA-N EEDQ Chemical compound C1=CC=C2N(C(=O)OCC)C(OCC)C=CC2=C1 GKQLYSROISKDLL-UHFFFAOYSA-N 0.000 claims 1
- -1 L-pyroglutamyl Chemical group 0.000 claims 1
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 16
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 9
- 241001465754 Metazoa Species 0.000 description 9
- 239000008103 glucose Substances 0.000 description 9
- 102000004877 Insulin Human genes 0.000 description 8
- 108090001061 Insulin Proteins 0.000 description 8
- 229940125396 insulin Drugs 0.000 description 8
- 238000012360 testing method Methods 0.000 description 7
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 5
- ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 description 4
- 241000699670 Mus sp. Species 0.000 description 4
- ODHCTXKNWHHXJC-UHFFFAOYSA-N acide pyroglutamique Natural products OC(=O)C1CCC(=O)N1 ODHCTXKNWHHXJC-UHFFFAOYSA-N 0.000 description 4
- 238000007446 glucose tolerance test Methods 0.000 description 4
- 230000004044 response Effects 0.000 description 4
- 241000700159 Rattus Species 0.000 description 3
- 201000001421 hyperglycemia Diseases 0.000 description 3
- 238000010348 incorporation Methods 0.000 description 3
- 230000032683 aging Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 210000004556 brain Anatomy 0.000 description 2
- 230000006735 deficit Effects 0.000 description 2
- 230000037406 food intake Effects 0.000 description 2
- 230000006362 insulin response pathway Effects 0.000 description 2
- 229910052740 iodine Inorganic materials 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 210000001685 thyroid gland Anatomy 0.000 description 2
- ADFXKUOMJKEIND-UHFFFAOYSA-N 1,3-dicyclohexylurea Chemical compound C1CCCCC1NC(=O)NC1CCCCC1 ADFXKUOMJKEIND-UHFFFAOYSA-N 0.000 description 1
- JVLRBIADOALMLB-UHFFFAOYSA-N 2-ethoxy-1,2-dihydroquinoline Chemical compound C1=CC=C2C=CC(OCC)NC2=C1 JVLRBIADOALMLB-UHFFFAOYSA-N 0.000 description 1
- DJRPCZOTIKTSSC-UHFFFAOYSA-N 3-[[2,4-bis(sulfanylidene)-1,3-thiazinan-5-yl]diazenyl]-5-chloro-2-hydroxybenzenesulfonic acid Chemical compound OC1=C(C=C(C=C1N=NC1C(NC(SC1)=S)=S)Cl)S(=O)(=O)O DJRPCZOTIKTSSC-UHFFFAOYSA-N 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 208000017701 Endocrine disease Diseases 0.000 description 1
- 206010018429 Glucose tolerance impaired Diseases 0.000 description 1
- 125000000899 L-alpha-glutamyl group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C([H])([H])C([H])([H])C(O[H])=O 0.000 description 1
- 125000000174 L-prolyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(*)=O 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 238000001367 Mood's median test Methods 0.000 description 1
- 238000011785 NMRI mouse Methods 0.000 description 1
- 208000001280 Prediabetic State Diseases 0.000 description 1
- 230000006819 RNA synthesis Effects 0.000 description 1
- 125000003368 amide group Chemical group 0.000 description 1
- 238000005915 ammonolysis reaction Methods 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 230000019522 cellular metabolic process Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000007822 coupling agent Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000000921 elemental analysis Methods 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 125000004494 ethyl ester group Chemical group 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000007903 gelatin capsule Substances 0.000 description 1
- 230000034659 glycolysis Effects 0.000 description 1
- 230000002710 gonadal effect Effects 0.000 description 1
- 210000002216 heart Anatomy 0.000 description 1
- 230000013632 homeostatic process Effects 0.000 description 1
- 230000003914 insulin secretion Effects 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000002438 mitochondrial effect Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 150000004682 monohydrates Chemical class 0.000 description 1
- 238000000655 nuclear magnetic resonance spectrum Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 201000009104 prediabetes syndrome Diseases 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000001243 protein synthesis Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 239000012429 reaction media Substances 0.000 description 1
- 239000003488 releasing hormone Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06173—Dipeptides with the first amino acid being heterocyclic and Glp-amino acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Obesity (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB28678/75A GB1492640A (en) | 1975-07-08 | 1975-07-08 | L-pyroglutamyl-l-prolinamide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO762352L true NO762352L (ja) | 1977-01-11 |
Family
ID=10279404
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO762352A NO762352L (ja) | 1975-07-08 | 1976-07-06 |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US4077951A (ja) |
| JP (1) | JPS5210267A (ja) |
| AR (1) | AR209498A1 (ja) |
| AT (1) | AT351689B (ja) |
| AU (1) | AU500396B2 (ja) |
| BE (1) | BE843855A (ja) |
| BG (1) | BG24801A3 (ja) |
| CA (1) | CA1058186A (ja) |
| CS (1) | CS194241B2 (ja) |
| DD (1) | DD126726A5 (ja) |
| DE (1) | DE2630757C2 (ja) |
| DK (1) | DK305876A (ja) |
| ES (1) | ES449624A1 (ja) |
| FI (1) | FI761970A (ja) |
| FR (1) | FR2316944A1 (ja) |
| GB (1) | GB1492640A (ja) |
| GR (1) | GR60849B (ja) |
| HU (1) | HU174650B (ja) |
| IL (1) | IL49991A (ja) |
| IN (1) | IN145074B (ja) |
| NL (1) | NL7607446A (ja) |
| NO (1) | NO762352L (ja) |
| PT (1) | PT65324B (ja) |
| RO (1) | RO69885A (ja) |
| SE (1) | SE402282B (ja) |
| SU (1) | SU624572A3 (ja) |
| ZA (1) | ZA764046B (ja) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4483991A (en) * | 1983-01-17 | 1984-11-20 | American Home Products Corporation | Hypotensive agents |
| JP2513197B2 (ja) * | 1986-01-21 | 1996-07-03 | 日本新薬株式会社 | ピログルタミド誘導体 |
| FR2597100A1 (fr) * | 1986-01-21 | 1987-10-16 | Nippon Shinyaku Co Ltd | Derives du pyroglutamide |
| CA1320734C (en) * | 1986-02-04 | 1993-07-27 | Suntory Limited | Pyrrolidineamide derivative of acylamino acid and pharmaceutical composition containing the same |
| US5198458A (en) * | 1986-02-04 | 1993-03-30 | Suntory Limited | Pyrrolidineamide derivatives of acylamino acid and pharmaceutical composition containing the same |
| IT1202426B (it) * | 1987-01-26 | 1989-02-09 | Poli Ind Chimica Spa | Derivato di acido tiazolidin-4-carbossilico,sua preparazione e composizioni farmaceutiche che lo contengono |
| DE3712365A1 (de) * | 1987-04-11 | 1988-10-27 | Hoechst Ag | Neue 2-acylpyrrolidin-derivate, verfahren zu ihrer herstellung, sie enthaltende mittel sowie deren verwendung |
| DE3712364A1 (de) * | 1987-04-11 | 1988-10-27 | Hoechst Ag | Neue pyrrolidin-2-(1,3-dicarbonyl)-derivate, verfahren zu ihrer herstellung, sie enthaltende mittel sowie deren verwendung |
| IT1230706B (it) * | 1989-02-10 | 1991-10-29 | Poli Ind Chimica Spa | Derivati dell'acido 3 piroglutamoil tiazolidin 4 carbossilico e loro proprieta' farmacologiche. |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3135748A (en) * | 1960-05-27 | 1964-06-02 | Little Inc A | Heterocyclic substituted carbodhmides and method of preparation |
| CH420187A (de) * | 1961-07-14 | 1966-09-15 | Sandoz Ag | Verfahren zur Herstellung eines bisher unbekannten Polypeptides |
| DE2423389A1 (de) * | 1974-05-14 | 1975-12-04 | Hoechst Ag | Arzneimittel mit psychotroper wirkung und verfahren zu ihrer herstellung |
-
1975
- 1975-07-08 GB GB28678/75A patent/GB1492640A/en not_active Expired
-
1976
- 1976-07-06 SE SE7607717A patent/SE402282B/xx unknown
- 1976-07-06 DK DK305876A patent/DK305876A/da unknown
- 1976-07-06 NO NO762352A patent/NO762352L/no unknown
- 1976-07-06 NL NL7607446A patent/NL7607446A/xx not_active Application Discontinuation
- 1976-07-06 FI FI761970A patent/FI761970A/fi not_active Application Discontinuation
- 1976-07-07 FR FR7621219A patent/FR2316944A1/fr active Granted
- 1976-07-07 RO RO7686867A patent/RO69885A/ro unknown
- 1976-07-07 BE BE1007488A patent/BE843855A/xx not_active IP Right Cessation
- 1976-07-07 AR AR263885A patent/AR209498A1/es active
- 1976-07-07 CA CA256,544A patent/CA1058186A/en not_active Expired
- 1976-07-07 ZA ZA764046A patent/ZA764046B/xx unknown
- 1976-07-07 IN IN1201/CAL/76A patent/IN145074B/en unknown
- 1976-07-07 AU AU15655/76A patent/AU500396B2/en not_active Expired
- 1976-07-07 AT AT495076A patent/AT351689B/de not_active IP Right Cessation
- 1976-07-07 US US05/703,299 patent/US4077951A/en not_active Expired - Lifetime
- 1976-07-07 BG BG7600033694A patent/BG24801A3/xx unknown
- 1976-07-07 IL IL49991A patent/IL49991A/xx unknown
- 1976-07-07 CS CS764509A patent/CS194241B2/cs unknown
- 1976-07-07 PT PT65324A patent/PT65324B/pt unknown
- 1976-07-07 ES ES449624A patent/ES449624A1/es not_active Expired
- 1976-07-08 GR GR51220A patent/GR60849B/el unknown
- 1976-07-08 SU SU762381705A patent/SU624572A3/ru active
- 1976-07-08 DD DD193757A patent/DD126726A5/xx unknown
- 1976-07-08 JP JP51081428A patent/JPS5210267A/ja active Granted
- 1976-07-08 DE DE2630757A patent/DE2630757C2/de not_active Expired
- 1976-07-08 HU HU76UE74A patent/HU174650B/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL49991A0 (en) | 1976-09-30 |
| AT351689B (de) | 1979-08-10 |
| CA1058186A (en) | 1979-07-10 |
| SE7607717L (sv) | 1977-01-09 |
| IL49991A (en) | 1979-03-12 |
| FR2316944B1 (ja) | 1979-03-23 |
| BE843855A (fr) | 1977-01-07 |
| DE2630757A1 (de) | 1977-01-27 |
| JPS5210267A (en) | 1977-01-26 |
| ES449624A1 (es) | 1977-07-01 |
| AU500396B2 (en) | 1979-05-17 |
| BG24801A3 (en) | 1978-05-12 |
| SE402282B (sv) | 1978-06-26 |
| RO69885A (ro) | 1981-11-04 |
| AR209498A1 (es) | 1977-04-29 |
| DK305876A (da) | 1977-01-09 |
| AU1565576A (en) | 1978-01-12 |
| FI761970A (ja) | 1977-01-09 |
| NL7607446A (nl) | 1977-01-11 |
| PT65324B (en) | 1978-01-05 |
| GR60849B (en) | 1978-08-31 |
| ZA764046B (en) | 1977-05-25 |
| JPS6131118B2 (ja) | 1986-07-17 |
| US4077951A (en) | 1978-03-07 |
| IN145074B (ja) | 1978-08-19 |
| PT65324A (en) | 1976-08-01 |
| SU624572A3 (ru) | 1978-09-15 |
| GB1492640A (en) | 1977-11-23 |
| ATA495076A (de) | 1979-01-15 |
| FR2316944A1 (fr) | 1977-02-04 |
| HU174650B (hu) | 1980-02-28 |
| DD126726A5 (ja) | 1977-08-10 |
| CS194241B2 (en) | 1979-11-30 |
| DE2630757C2 (de) | 1985-01-10 |
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