NO342258B1 - 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-oner, fremgangsmåte for fremstilling derav og farmasøytiske preparater inneholdende slike - Google Patents

2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-oner, fremgangsmåte for fremstilling derav og farmasøytiske preparater inneholdende slike Download PDF

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Publication number
NO342258B1
NO342258B1 NO20082069A NO20082069A NO342258B1 NO 342258 B1 NO342258 B1 NO 342258B1 NO 20082069 A NO20082069 A NO 20082069A NO 20082069 A NO20082069 A NO 20082069A NO 342258 B1 NO342258 B1 NO 342258B1
Authority
NO
Norway
Prior art keywords
substituted
phenyl
methoxy
unsubstituted
pyridin
Prior art date
Application number
NO20082069A
Other languages
English (en)
Norwegian (no)
Other versions
NO20082069L (no
Inventor
Daniel J Poon
Teresa E Pick
Christopher Mcbride
Paul A Renhowe
Timothy D Machajewski
Cynthia M Shafer
William Antonios-Mccrea
Brandon M Doughan
Barry H Levine
Yi Xia
Maureen Mckenna
X Michael Wang
Kris Mendenhall
Yasheen Zhou
Baoqing Gong
Dan Gu
John Dolan
John Tulinsky
Kristin Brinner
Zhenhai Gao
Paul A Barsanti
Xiaodong Lin
Abran Costales
Alice Rico
Nathan Brammeier
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of NO20082069L publication Critical patent/NO20082069L/no
Publication of NO342258B1 publication Critical patent/NO342258B1/no

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/86—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
NO20082069A 2005-09-30 2008-04-30 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-oner, fremgangsmåte for fremstilling derav og farmasøytiske preparater inneholdende slike NO342258B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US72279605P 2005-09-30 2005-09-30
US83688606P 2006-08-09 2006-08-09
PCT/US2006/038181 WO2007041362A1 (en) 2005-09-30 2006-09-28 2-amino-7,8-dihydro-6h-pyrido[4,3-d] pyrimidin-5-ones

Publications (2)

Publication Number Publication Date
NO20082069L NO20082069L (no) 2008-06-09
NO342258B1 true NO342258B1 (no) 2018-04-30

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
NO20082069A NO342258B1 (no) 2005-09-30 2008-04-30 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-oner, fremgangsmåte for fremstilling derav og farmasøytiske preparater inneholdende slike

Country Status (31)

Country Link
US (2) US7671059B2 (https=)
EP (1) EP1928875B1 (https=)
JP (2) JP5036002B2 (https=)
KR (1) KR101311757B1 (https=)
AR (1) AR058072A1 (https=)
AT (1) ATE514694T1 (https=)
AU (1) AU2006297124B2 (https=)
BR (1) BRPI0616701A2 (https=)
CA (1) CA2624253C (https=)
CR (1) CR9846A (https=)
CY (1) CY1112028T1 (https=)
DK (1) DK1928875T3 (https=)
EA (1) EA016152B1 (https=)
EC (1) ECSP088324A (https=)
GE (1) GEP20115231B (https=)
HR (1) HRP20110655T1 (https=)
IL (1) IL190446A0 (https=)
JO (1) JO2783B1 (https=)
MA (1) MA29885B1 (https=)
ME (1) ME01952B (https=)
MY (1) MY143604A (https=)
NO (1) NO342258B1 (https=)
NZ (1) NZ566914A (https=)
PE (1) PE20070621A1 (https=)
PL (1) PL1928875T3 (https=)
PT (1) PT1928875E (https=)
RS (1) RS51795B (https=)
SM (1) SMAP200800029A (https=)
TN (1) TNSN08143A1 (https=)
TW (1) TWI373471B (https=)
WO (1) WO2007041362A1 (https=)

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CL2007002994A1 (es) * 2006-10-19 2008-02-08 Wyeth Corp Compuestos derivados heterociclicos que contienen sulfamoilo, inhibidores de hsp90; composicion farmaceutica; y uso para el tratamiento del cancer, tal como cancer de mama, de colon y prostata, entre otros.
CN101225083A (zh) * 2007-01-16 2008-07-23 北京摩力克科技有限公司 四氢喹唑啉酮类化合物及其用于制备治疗和预防病毒性疾病的药物的用途
GB2449293A (en) 2007-05-17 2008-11-19 Evotec Compounds having Hsp90 inhibitory activity
SG187502A1 (en) 2008-02-01 2013-02-28 Takeda Pharmaceutical Oxim derivatives as hsp90 inhibitors
EP2334379A2 (en) 2008-09-26 2011-06-22 INSERM (Institut National de la Santé et de la Recherche Médicale) Host cell kinases as targets for antiviral therapies against hcv infection
EP2370103B1 (en) * 2008-11-28 2016-03-23 Novartis AG Pharmaceutical combinations comprising an isoxazole derived hsp90-inhibitor and the her2 inhibitor trastuzumab
BRPI0924107A2 (pt) 2008-11-28 2019-09-24 Novartis Ag inibidores de hsp90 para tratamento terapêutico
MA32934B1 (fr) * 2008-11-28 2012-01-02 Novartis Ag Combinaisons inhibitrices hsp90
AR075180A1 (es) * 2009-01-29 2011-03-16 Novartis Ag Formulaciones orales solidas de una pirido-pirimidinona
AR077405A1 (es) 2009-07-10 2011-08-24 Sanofi Aventis Derivados del indol inhibidores de hsp90, composiciones que los contienen y utilizacion de los mismos para el tratamiento del cancer
FR2949467B1 (fr) 2009-09-03 2011-11-25 Sanofi Aventis Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation
MX2012004846A (es) * 2009-10-29 2012-10-05 Genosco Inhibidores de cinasa.
WO2012104823A2 (en) 2011-02-04 2012-08-09 Novartis Ag Pyridopyrimidinone compounds in the treatment of neurodegenerative diseases
RU2624493C2 (ru) 2011-10-14 2017-07-04 Новартис Аг 2-КАРБОКСАМИД ЦИКЛОАМИНО ПРОИЗВОДНЫЕ МОЧЕВИНЫ В КОМБИНАЦИИ С ИНГИБИТОРАМИ Hsp90 ДЛЯ ЛЕЧЕНИЯ ПРОЛИФЕРАТИВНЫХ ЗАБОЛЕВАНИЙ
ITTO20111013A1 (it) 2011-11-03 2013-05-04 Dac Srl Composti farmaceutici
CN103664938A (zh) * 2012-09-12 2014-03-26 山东亨利医药科技有限责任公司 含有嘧啶并环的syk抑制剂
EP2916841A1 (en) 2012-11-07 2015-09-16 Novartis AG Combination therapy
US9677907B2 (en) * 2013-03-14 2017-06-13 Itron Inc Intelligent receptacle
GB201306610D0 (en) * 2013-04-11 2013-05-29 Almac Discovery Ltd Pharmaceutical compounds
RU2657783C2 (ru) 2013-09-30 2018-06-15 Тайхо Фармасьютикал Ко., Лтд. Комбинированная терапия с использованием азабициклосоединения для ракового заболевания
EP3189051A1 (en) * 2014-09-02 2017-07-12 Pierre Fabre Médicament Isoquinolinone derivatives useful in the treatment of cancer
KR20160035411A (ko) * 2014-09-23 2016-03-31 주식회사 오스코텍 LRRK2 (Leucine Rich Repeat Kinase 2) 키나제 억제제로서의 피리도피리미딘 유도체 화합물
KR101653560B1 (ko) * 2016-02-02 2016-09-12 한국화학연구원 신규한 화합물 또는 이의 약학적으로 허용가능한 염, 및 이를 유효성분으로 함유하는 인플루엔자 바이러스 감염으로 인한 질환의 예방 또는 치료용 약학적 조성물
RU2629599C1 (ru) * 2016-09-28 2017-08-30 Государственное бюджетное учреждение здравоохранения Московской области "Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского" (ГБУЗ МО МОНИКИ им. М.Ф. Владимирского) Способ химиолучевого лечения опухолей прямой кишки и анального канала
KR20250007021A (ko) 2017-06-09 2025-01-13 추가이 세이야쿠 가부시키가이샤 N-치환 아미노산을 포함하는 펩타이드의 합성 방법
CN115916752B (zh) * 2020-06-26 2025-05-06 日本农药株式会社 芳基四氢吡啶衍生物或其盐类、和含有该化合物的杀虫剂及其使用方法
EP4310084A4 (en) * 2021-03-08 2025-06-25 Jinan University Pyridopyrimidine-based compound and use thereof
WO2026027375A1 (de) 2024-07-29 2026-02-05 Bayer Aktiengesellschaft Hydroxy-dihydropyridinon carboxamide als schädlingsbekämpfungsmittel

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EP0188094A2 (en) * 1984-12-14 1986-07-23 Mitsui Petrochemical Industries, Ltd. Quinazoline derivatives and antihypertensive preparations containing same as effective components

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DE60206363T2 (de) * 2001-02-12 2006-07-06 F. Hoffmann-La Roche Ag 6-substituierte pyridopyrimidine
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WO2006045010A2 (en) 2004-10-20 2006-04-27 Resverlogix Corp. Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases
WO2006074293A2 (en) * 2005-01-07 2006-07-13 President And Fellows Of Harvard College Bicyclic dihydropyrimidines as eg5 inhibitors
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EP0188094A2 (en) * 1984-12-14 1986-07-23 Mitsui Petrochemical Industries, Ltd. Quinazoline derivatives and antihypertensive preparations containing same as effective components

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Also Published As

Publication number Publication date
KR20080057318A (ko) 2008-06-24
WO2007041362A1 (en) 2007-04-12
EA016152B1 (ru) 2012-02-28
MY143604A (en) 2011-06-15
ECSP088324A (es) 2008-04-28
KR101311757B1 (ko) 2013-09-26
US20070123546A1 (en) 2007-05-31
EA200800992A1 (ru) 2008-10-30
US20100004237A1 (en) 2010-01-07
NO20082069L (no) 2008-06-09
AR058072A1 (es) 2008-01-23
TWI373471B (en) 2012-10-01
JP2009510108A (ja) 2009-03-12
CY1112028T1 (el) 2015-11-04
NZ566914A (en) 2011-09-30
ME01952B (en) 2011-12-31
EP1928875A1 (en) 2008-06-11
CA2624253A1 (en) 2007-04-12
ATE514694T1 (de) 2011-07-15
PT1928875E (pt) 2011-09-06
HRP20110655T1 (hr) 2011-10-31
PL1928875T3 (pl) 2011-11-30
GEP20115231B (en) 2011-06-10
DK1928875T3 (da) 2011-10-03
CA2624253C (en) 2015-06-16
US7671059B2 (en) 2010-03-02
MA29885B1 (fr) 2008-10-03
EP1928875B1 (en) 2011-06-29
AU2006297124A1 (en) 2007-04-12
RS51795B (sr) 2011-12-31
BRPI0616701A2 (pt) 2011-06-28
HK1118823A1 (en) 2009-02-20
CR9846A (es) 2008-08-01
JP5036002B2 (ja) 2012-09-26
PE20070621A1 (es) 2007-09-06
JP2012158611A (ja) 2012-08-23
IL190446A0 (en) 2008-11-03
JO2783B1 (en) 2014-03-15
TNSN08143A1 (en) 2009-07-14
SMP200800029B (it) 2008-05-07
SMAP200800029A (it) 2008-05-07
AU2006297124B2 (en) 2011-12-08
TW200728304A (en) 2007-08-01

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