KR101311757B1 - 2-아미노-7,8-디히드로-6ｈ-피리도［4,3-ｄ］피리미딘-5-온 - Google Patents

2-아미노-7,8-디히드로-6ｈ-피리도［4,3-ｄ］피리미딘-5-온 Download PDF

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Publication number
KR101311757B1
KR101311757B1 KR1020087010134A KR20087010134A KR101311757B1 KR 101311757 B1 KR101311757 B1 KR 101311757B1 KR 1020087010134 A KR1020087010134 A KR 1020087010134A KR 20087010134 A KR20087010134 A KR 20087010134A KR 101311757 B1 KR101311757 B1 KR 101311757B1
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KR
South Korea
Prior art keywords
amino
pyrimidin
phenyl
methyl
fluoro
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Expired - Fee Related
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KR1020087010134A
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English (en)
Korean (ko)
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KR20080057318A (ko
Inventor
티모시 디. 마챠쥬스키
신시아 엠. 샤퍼
크리스토퍼 맥브라이드
윌리엄 안토니오스-맥크레아
브랜든 엠. 더간
배리 에이치. 레빈
이 시아
마우린 맥켄나
엑스. 마이클 왕
크리스 멘덴홀
야신 주
바오칭 공
단 구
존 돌란
존 투린스키
크리스틴 브린너
젠하이 가오
다니엘 푼
폴 에이. 바르산티
샤오동 린
아브란 코스테일스
앨리스 리코
나탄 브래미어
테레사 픽
폴 에이. 렌호웨
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노파르티스 아게
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/86—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020087010134A 2005-09-30 2006-09-28 2-아미노-7,8-디히드로-6ｈ-피리도［4,3-ｄ］피리미딘-5-온 Expired - Fee Related KR101311757B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US72279605P 2005-09-30 2005-09-30
US60/722,796 2005-09-30
US83688606P 2006-08-09 2006-08-09
US60/836,886 2006-08-09
PCT/US2006/038181 WO2007041362A1 (en) 2005-09-30 2006-09-28 2-amino-7,8-dihydro-6h-pyrido[4,3-d] pyrimidin-5-ones

Publications (2)

Publication Number Publication Date
KR20080057318A KR20080057318A (ko) 2008-06-24
KR101311757B1 true KR101311757B1 (ko) 2013-09-26

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Country Link
US (2) US7671059B2 (https=)
EP (1) EP1928875B1 (https=)
JP (2) JP5036002B2 (https=)
KR (1) KR101311757B1 (https=)
AR (1) AR058072A1 (https=)
AT (1) ATE514694T1 (https=)
AU (1) AU2006297124B2 (https=)
BR (1) BRPI0616701A2 (https=)
CA (1) CA2624253C (https=)
CR (1) CR9846A (https=)
CY (1) CY1112028T1 (https=)
DK (1) DK1928875T3 (https=)
EA (1) EA016152B1 (https=)
EC (1) ECSP088324A (https=)
GE (1) GEP20115231B (https=)
HR (1) HRP20110655T1 (https=)
IL (1) IL190446A0 (https=)
JO (1) JO2783B1 (https=)
MA (1) MA29885B1 (https=)
ME (1) ME01952B (https=)
MY (1) MY143604A (https=)
NO (1) NO342258B1 (https=)
NZ (1) NZ566914A (https=)
PE (1) PE20070621A1 (https=)
PL (1) PL1928875T3 (https=)
PT (1) PT1928875E (https=)
RS (1) RS51795B (https=)
SM (1) SMP200800029B (https=)
TN (1) TNSN08143A1 (https=)
TW (1) TWI373471B (https=)
WO (1) WO2007041362A1 (https=)

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CL2007002994A1 (es) * 2006-10-19 2008-02-08 Wyeth Corp Compuestos derivados heterociclicos que contienen sulfamoilo, inhibidores de hsp90; composicion farmaceutica; y uso para el tratamiento del cancer, tal como cancer de mama, de colon y prostata, entre otros.
CN101225083A (zh) * 2007-01-16 2008-07-23 北京摩力克科技有限公司 四氢喹唑啉酮类化合物及其用于制备治疗和预防病毒性疾病的药物的用途
GB2449293A (en) * 2007-05-17 2008-11-19 Evotec Compounds having Hsp90 inhibitory activity
ES2475206T3 (es) * 2008-02-01 2014-07-10 Takeda Pharmaceutical Company Limited Derivados de oxima como inhibidores de HSP90
JP2012503619A (ja) 2008-09-26 2012-02-09 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル Ｈｃｖ感染に対する抗ウイルス治療のための標的としての宿主細胞キナーゼ
CN105727297A (zh) * 2008-11-28 2016-07-06 诺华股份有限公司 包含hsp90抑制剂和mtor抑制剂的药物组合
MA32933B1 (fr) * 2008-11-28 2012-01-02 Novartis Ag Combinaison d'inhibiteurs de hspo90 et d'herceptine
BRPI0924107A2 (pt) * 2008-11-28 2019-09-24 Novartis Ag inibidores de hsp90 para tratamento terapêutico
AR075180A1 (es) * 2009-01-29 2011-03-16 Novartis Ag Formulaciones orales solidas de una pirido-pirimidinona
AR077405A1 (es) 2009-07-10 2011-08-24 Sanofi Aventis Derivados del indol inhibidores de hsp90, composiciones que los contienen y utilizacion de los mismos para el tratamiento del cancer
FR2949467B1 (fr) 2009-09-03 2011-11-25 Sanofi Aventis Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation
SG10201407012XA (en) * 2009-10-29 2014-11-27 Genosco Kinase inhibitors
WO2012104823A2 (en) 2011-02-04 2012-08-09 Novartis Ag Pyridopyrimidinone compounds in the treatment of neurodegenerative diseases
MX2014004559A (es) 2011-10-14 2014-08-01 Novartis Ag Derivados de 2-carboxamida cicloamino urea en combinacion con inhibidores de hsp90 para el tratamiento de enfermedades proliferativas.
ITTO20111013A1 (it) 2011-11-03 2013-05-04 Dac Srl Composti farmaceutici
CN103664938A (zh) * 2012-09-12 2014-03-26 山东亨利医药科技有限责任公司 含有嘧啶并环的syk抑制剂
WO2014074580A1 (en) 2012-11-07 2014-05-15 Novartis Ag Combination therapy
US9677907B2 (en) * 2013-03-14 2017-06-13 Itron Inc Intelligent receptacle
GB201306610D0 (en) * 2013-04-11 2013-05-29 Almac Discovery Ltd Pharmaceutical compounds
HUE053617T2 (hu) * 2013-09-30 2021-07-28 Taiho Pharmaceutical Co Ltd Kombinációs rákterápia azabiciklo vegyületet felhasználva
RU2690853C2 (ru) * 2014-09-02 2019-06-06 Пьер Фабр Медикамент Производные изохинолинона, полезные для лечения рака
KR20160035411A (ko) * 2014-09-23 2016-03-31 주식회사 오스코텍 LRRK2 (Leucine Rich Repeat Kinase 2) 키나제 억제제로서의 피리도피리미딘 유도체 화합물
KR101653560B1 (ko) * 2016-02-02 2016-09-12 한국화학연구원 신규한 화합물 또는 이의 약학적으로 허용가능한 염, 및 이를 유효성분으로 함유하는 인플루엔자 바이러스 감염으로 인한 질환의 예방 또는 치료용 약학적 조성물
RU2629599C1 (ru) * 2016-09-28 2017-08-30 Государственное бюджетное учреждение здравоохранения Московской области "Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского" (ГБУЗ МО МОНИКИ им. М.Ф. Владимирского) Способ химиолучевого лечения опухолей прямой кишки и анального канала
WO2018225851A1 (ja) 2017-06-09 2018-12-13 中外製薬株式会社 Ｎ－置換アミノ酸を含むペプチドの合成方法
CN115916752B (zh) * 2020-06-26 2025-05-06 日本农药株式会社 芳基四氢吡啶衍生物或其盐类、和含有该化合物的杀虫剂及其使用方法
AU2022234998B2 (en) * 2021-03-08 2025-04-10 Jinan University Pyridopyrimidine compounds and applications thereof
WO2026027375A1 (de) 2024-07-29 2026-02-05 Bayer Aktiengesellschaft Hydroxy-dihydropyridinon carboxamide als schädlingsbekämpfungsmittel

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EP0192783A1 (en) 1984-09-07 1986-09-03 Mitsui Petrochemical Industries, Ltd. 2-piperazinopyrimidine derivatives and process for their preparation
EP0278742A2 (en) 1987-02-11 1988-08-17 May & Baker Limited Cyclic diones

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DE60206363T2 (de) * 2001-02-12 2006-07-06 F. Hoffmann-La Roche Ag 6-substituierte pyridopyrimidine
DE102004018198A1 (de) * 2004-04-15 2005-11-03 Merck Patent Gmbh Sulfonamide
WO2006045010A2 (en) 2004-10-20 2006-04-27 Resverlogix Corp. Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases
US20100152206A1 (en) * 2005-01-07 2010-06-17 Ralph Mazitschek Bicyclic Dihydropyrimidines and Uses Thereof
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Patent Citations (2)

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EP0192783A1 (en) 1984-09-07 1986-09-03 Mitsui Petrochemical Industries, Ltd. 2-piperazinopyrimidine derivatives and process for their preparation
EP0278742A2 (en) 1987-02-11 1988-08-17 May & Baker Limited Cyclic diones

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TNSN08143A1 (en) 2009-07-14
EA200800992A1 (ru) 2008-10-30
ATE514694T1 (de) 2011-07-15
NO342258B1 (no) 2018-04-30
CY1112028T1 (el) 2015-11-04
SMAP200800029A (it) 2008-05-07
HK1118823A1 (en) 2009-02-20
TWI373471B (en) 2012-10-01
US7671059B2 (en) 2010-03-02
CR9846A (es) 2008-08-01
MA29885B1 (fr) 2008-10-03
DK1928875T3 (da) 2011-10-03
CA2624253C (en) 2015-06-16
NO20082069L (no) 2008-06-09
JP2012158611A (ja) 2012-08-23
ECSP088324A (es) 2008-04-28
US20070123546A1 (en) 2007-05-31
AU2006297124B2 (en) 2011-12-08
CA2624253A1 (en) 2007-04-12
MY143604A (en) 2011-06-15
PL1928875T3 (pl) 2011-11-30
JP5036002B2 (ja) 2012-09-26
US20100004237A1 (en) 2010-01-07
GEP20115231B (en) 2011-06-10
EP1928875B1 (en) 2011-06-29
AR058072A1 (es) 2008-01-23
EA016152B1 (ru) 2012-02-28
PE20070621A1 (es) 2007-09-06
EP1928875A1 (en) 2008-06-11
PT1928875E (pt) 2011-09-06
HRP20110655T1 (hr) 2011-10-31
JP2009510108A (ja) 2009-03-12
NZ566914A (en) 2011-09-30
KR20080057318A (ko) 2008-06-24
TW200728304A (en) 2007-08-01
ME01952B (en) 2011-12-31
SMP200800029B (it) 2008-05-07
BRPI0616701A2 (pt) 2011-06-28
AU2006297124A1 (en) 2007-04-12
JO2783B1 (en) 2014-03-15
IL190446A0 (en) 2008-11-03
RS51795B (sr) 2011-12-31
WO2007041362A1 (en) 2007-04-12

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