PL1928875T3 - 2-Amino-7,8-dihydro-6H-pirydo(4,3-d)pirymidyn-5-ony, sposoby ich otrzymywania oraz kompozycje farmaceutyczne je zawierające - Google Patents

2-Amino-7,8-dihydro-6H-pirydo(4,3-d)pirymidyn-5-ony, sposoby ich otrzymywania oraz kompozycje farmaceutyczne je zawierające

Info

Publication number
PL1928875T3
PL1928875T3 PL06825272T PL06825272T PL1928875T3 PL 1928875 T3 PL1928875 T3 PL 1928875T3 PL 06825272 T PL06825272 T PL 06825272T PL 06825272 T PL06825272 T PL 06825272T PL 1928875 T3 PL1928875 T3 PL 1928875T3
Authority
PL
Poland
Prior art keywords
pyrido
pyrimidin
dihydro
ones
amino
Prior art date
Application number
PL06825272T
Other languages
English (en)
Inventor
Timothy D Machajewski
Cynthia M Shafer
Christopher Mcbride
William Antonios-Mccrea
Brandon M Doughan
Barry H Levine
Yi Xia
Maureen Mckenna
X Michael Wang
Kris Mendenhall
Yasheen Zhou
Baoqing Gong
Dan Gu
John Dolan
John Tulinsky
Kristin Brinner
Zhenhai Gao
Paul A Renhowe
Daniel Poon
Paul A Barsanti
Xiaodong Lin
Teresa Pick
Abran Costales
Nathan Brammeier
Alice Rico
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PL1928875T3 publication Critical patent/PL1928875T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/86—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
PL06825272T 2005-09-30 2006-09-28 2-Amino-7,8-dihydro-6H-pirydo(4,3-d)pirymidyn-5-ony, sposoby ich otrzymywania oraz kompozycje farmaceutyczne je zawierające PL1928875T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US72279605P 2005-09-30 2005-09-30
US83688606P 2006-08-09 2006-08-09
EP06825272A EP1928875B1 (en) 2005-09-30 2006-09-28 2-amino-7,8-dihydro-6H-pyrido(4,3-d)pyrimidin-5-ones, process for their preparation and pharmaceutical compositions containing the same
PCT/US2006/038181 WO2007041362A1 (en) 2005-09-30 2006-09-28 2-amino-7,8-dihydro-6h-pyrido[4,3-d] pyrimidin-5-ones

Publications (1)

Publication Number Publication Date
PL1928875T3 true PL1928875T3 (pl) 2011-11-30

Family

ID=37661234

Family Applications (1)

Application Number Title Priority Date Filing Date
PL06825272T PL1928875T3 (pl) 2005-09-30 2006-09-28 2-Amino-7,8-dihydro-6H-pirydo(4,3-d)pirymidyn-5-ony, sposoby ich otrzymywania oraz kompozycje farmaceutyczne je zawierające

Country Status (32)

Country Link
US (2) US7671059B2 (pl)
EP (1) EP1928875B1 (pl)
JP (2) JP5036002B2 (pl)
KR (1) KR101311757B1 (pl)
AR (1) AR058072A1 (pl)
AT (1) ATE514694T1 (pl)
AU (1) AU2006297124B2 (pl)
BR (1) BRPI0616701A2 (pl)
CA (1) CA2624253C (pl)
CR (1) CR9846A (pl)
CY (1) CY1112028T1 (pl)
DK (1) DK1928875T3 (pl)
EA (1) EA016152B1 (pl)
EC (1) ECSP088324A (pl)
GE (1) GEP20115231B (pl)
HK (1) HK1118823A1 (pl)
HR (1) HRP20110655T1 (pl)
IL (1) IL190446A0 (pl)
JO (1) JO2783B1 (pl)
MA (1) MA29885B1 (pl)
ME (1) ME01952B (pl)
MY (1) MY143604A (pl)
NO (1) NO342258B1 (pl)
NZ (1) NZ566914A (pl)
PE (1) PE20070621A1 (pl)
PL (1) PL1928875T3 (pl)
PT (1) PT1928875E (pl)
RS (1) RS51795B (pl)
SM (1) SMP200800029B (pl)
TN (1) TNSN08143A1 (pl)
TW (1) TWI373471B (pl)
WO (1) WO2007041362A1 (pl)

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CL2007002994A1 (es) * 2006-10-19 2008-02-08 Wyeth Corp Compuestos derivados heterociclicos que contienen sulfamoilo, inhibidores de hsp90; composicion farmaceutica; y uso para el tratamiento del cancer, tal como cancer de mama, de colon y prostata, entre otros.
CN101225083A (zh) * 2007-01-16 2008-07-23 北京摩力克科技有限公司 四氢喹唑啉酮类化合物及其用于制备治疗和预防病毒性疾病的药物的用途
GB2449293A (en) 2007-05-17 2008-11-19 Evotec Compounds having Hsp90 inhibitory activity
GEP20125718B (en) * 2008-02-01 2012-12-25 Takeda Pharmaceuticals Co Oxim derivatives as hsp90 inhibitors
US8759010B2 (en) 2008-09-26 2014-06-24 Inserm (Institut National De La Sante Et De La Recherche Medicale) Host cell kinases as targets for antiviral therapies against HCV infection
RU2532375C2 (ru) * 2008-11-28 2014-11-10 Новартис Аг ФАРМАЦЕВТИЧЕСКИЕ КОМБИНАЦИИ, ВКЛЮЧАЮЩИЕ ПРОИЗВОДНЫЕ ПИРИДО [4,3-d]ПИРИМИДИНА В КАЧЕСТВЕ ИНГИБИТОРА HSP90 И ИНГИБИТОРА HER2
MX2011005667A (es) * 2008-11-28 2011-06-16 Novartis Ag Combinacion farmaceutica que comprende un inhibidor de hsp90 y un inhibidor de mtor.
CA2743722A1 (en) * 2008-11-28 2010-06-03 Novartis Ag Hsp90 inhibitors for therapeutic treatment
AR075180A1 (es) 2009-01-29 2011-03-16 Novartis Ag Formulaciones orales solidas de una pirido-pirimidinona
AR077405A1 (es) 2009-07-10 2011-08-24 Sanofi Aventis Derivados del indol inhibidores de hsp90, composiciones que los contienen y utilizacion de los mismos para el tratamiento del cancer
FR2949467B1 (fr) 2009-09-03 2011-11-25 Sanofi Aventis Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation
CA2779105C (en) * 2009-10-29 2016-08-16 Hong Woo Kim Kinase inhibitors
WO2012104823A2 (en) 2011-02-04 2012-08-09 Novartis Ag Pyridopyrimidinone compounds in the treatment of neurodegenerative diseases
KR20140078656A (ko) 2011-10-14 2014-06-25 노파르티스 아게 증식성 질환의 치료를 위한 hsp90 억제제와 조합된 2-카르복스아미드 시클로아미노 우레아 유도체
ITTO20111013A1 (it) 2011-11-03 2013-05-04 Dac Srl Composti farmaceutici
CN103664938A (zh) * 2012-09-12 2014-03-26 山东亨利医药科技有限责任公司 含有嘧啶并环的syk抑制剂
CN105120868A (zh) 2012-11-07 2015-12-02 诺华股份有限公司 组合治疗
US9677907B2 (en) * 2013-03-14 2017-06-13 Itron Inc Intelligent receptacle
GB201306610D0 (en) * 2013-04-11 2013-05-29 Almac Discovery Ltd Pharmaceutical compounds
US9694001B2 (en) 2013-09-30 2017-07-04 Taiho Pharmaceutical Co., Ltd. Combination therapy using azabicyclo compound for cancer
EP3189051A1 (en) * 2014-09-02 2017-07-12 Pierre Fabre Medicament Isoquinolinone derivatives useful in the treatment of cancer
KR20160035411A (ko) * 2014-09-23 2016-03-31 주식회사 오스코텍 LRRK2 (Leucine Rich Repeat Kinase 2) 키나제 억제제로서의 피리도피리미딘 유도체 화합물
KR101653560B1 (ko) * 2016-02-02 2016-09-12 한국화학연구원 신규한 화합물 또는 이의 약학적으로 허용가능한 염, 및 이를 유효성분으로 함유하는 인플루엔자 바이러스 감염으로 인한 질환의 예방 또는 치료용 약학적 조성물
RU2629599C1 (ru) * 2016-09-28 2017-08-30 Государственное бюджетное учреждение здравоохранения Московской области "Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского" (ГБУЗ МО МОНИКИ им. М.Ф. Владимирского) Способ химиолучевого лечения опухолей прямой кишки и анального канала
BR112022025816A2 (pt) * 2020-06-26 2023-01-10 Nihon Nohyaku Co Ltd Derivado de ariltetra-hidropiridina ou sal do mesmo, agente inseticida contendo o composto e método de uso do mesmo

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6165873A (ja) * 1984-09-07 1986-04-04 Mitsui Petrochem Ind Ltd ２−ピペラジノピリミジン誘導体
CA1307786C (en) 1984-12-14 1992-09-22 Keiichi Yokoyama Quinazoline derivatives and antihypertensive preparations containing same as effective components
MA21177A1 (fr) * 1987-02-11 1988-10-01 May & Baker Ltd Diones cycliques.
WO2002064594A2 (en) * 2001-02-12 2002-08-22 F. Hoffmann-La Roche Ag 6-substituted pyrido-pyrimidines
DE102004018198A1 (de) 2004-04-15 2005-11-03 Merck Patent Gmbh Sulfonamide
CA2584507C (en) 2004-10-20 2016-04-26 Resverlogix Corp. Flavanoids and isoflavanoids for the prevention and treatment of cardiovascular diseases
US20100152206A1 (en) * 2005-01-07 2010-06-17 Ralph Mazitschek Bicyclic Dihydropyrimidines and Uses Thereof
MX2007012836A (es) 2005-04-14 2008-01-11 Novartis Vaccines & Diagnostic 2-amino-quinazolin-5-onas como inhibidores de la familia hsp90 que son utiles en el tratamiento de enfermedades de proliferacion.

Also Published As

Publication number Publication date
JP2012158611A (ja) 2012-08-23
SMAP200800029A (it) 2008-05-07
PE20070621A1 (es) 2007-09-06
NO20082069L (no) 2008-06-09
TWI373471B (en) 2012-10-01
SMP200800029B (it) 2008-05-07
EP1928875B1 (en) 2011-06-29
AU2006297124A1 (en) 2007-04-12
GEP20115231B (en) 2011-06-10
HK1118823A1 (pl) 2009-02-20
US20070123546A1 (en) 2007-05-31
ATE514694T1 (de) 2011-07-15
AU2006297124B2 (en) 2011-12-08
HRP20110655T1 (hr) 2011-10-31
EP1928875A1 (en) 2008-06-11
NO342258B1 (no) 2018-04-30
CY1112028T1 (el) 2015-11-04
JP5036002B2 (ja) 2012-09-26
BRPI0616701A2 (pt) 2011-06-28
RS51795B (en) 2011-12-31
WO2007041362A1 (en) 2007-04-12
PT1928875E (pt) 2011-09-06
EA200800992A1 (ru) 2008-10-30
MY143604A (en) 2011-06-15
CA2624253C (en) 2015-06-16
CR9846A (es) 2008-08-01
US20100004237A1 (en) 2010-01-07
ECSP088324A (es) 2008-04-28
EA016152B1 (ru) 2012-02-28
KR101311757B1 (ko) 2013-09-26
CA2624253A1 (en) 2007-04-12
TW200728304A (en) 2007-08-01
JO2783B1 (en) 2014-03-15
TNSN08143A1 (en) 2009-07-14
DK1928875T3 (da) 2011-10-03
IL190446A0 (en) 2008-11-03
ME01952B (en) 2011-12-31
MA29885B1 (fr) 2008-10-03
KR20080057318A (ko) 2008-06-24
AR058072A1 (es) 2008-01-23
JP2009510108A (ja) 2009-03-12
NZ566914A (en) 2011-09-30
US7671059B2 (en) 2010-03-02

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