NO331618B1 - Nye 3-(4-okso-4H-kromen-2-yl)-(1H)-kinolin-4-on-forbindelser, en fremgangsmate for deres fremstilling og farmasoytisk sammensetninger inneholdende dem - Google Patents
Nye 3-(4-okso-4H-kromen-2-yl)-(1H)-kinolin-4-on-forbindelser, en fremgangsmate for deres fremstilling og farmasoytisk sammensetninger inneholdende dem Download PDFInfo
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- NO331618B1 NO331618B1 NO20045540A NO20045540A NO331618B1 NO 331618 B1 NO331618 B1 NO 331618B1 NO 20045540 A NO20045540 A NO 20045540A NO 20045540 A NO20045540 A NO 20045540A NO 331618 B1 NO331618 B1 NO 331618B1
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- Norway
- Prior art keywords
- compound
- formula
- phenyl
- oxo
- give
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- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
- 229940071870 hydroiodic acid Drugs 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- SXWRTZOXMUOJER-UHFFFAOYSA-N hydron;piperidin-4-one;chloride;hydrate Chemical compound O.Cl.O=C1CCNCC1 SXWRTZOXMUOJER-UHFFFAOYSA-N 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 229940098779 methanesulfonic acid Drugs 0.000 description 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 239000010502 orange oil Substances 0.000 description 1
- 239000012074 organic phase Substances 0.000 description 1
- 210000001672 ovary Anatomy 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 229920000137 polyphosphoric acid Polymers 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- AOJFQRQNPXYVLM-UHFFFAOYSA-N pyridin-1-ium;chloride Chemical compound [Cl-].C1=CC=[NH+]C=C1 AOJFQRQNPXYVLM-UHFFFAOYSA-N 0.000 description 1
- 229940107700 pyruvic acid Drugs 0.000 description 1
- VSGPVHSTVTXREH-UHFFFAOYSA-N quinolin-4-one Chemical compound C1=CC=C[C]2C(=O)C=CN=C21 VSGPVHSTVTXREH-UHFFFAOYSA-N 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 239000013558 reference substance Substances 0.000 description 1
- BOLDJAUMGUJJKM-LSDHHAIUSA-N renifolin D Natural products CC(=C)[C@@H]1Cc2c(O)c(O)ccc2[C@H]1CC(=O)c3ccc(O)cc3O BOLDJAUMGUJJKM-LSDHHAIUSA-N 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000006190 sub-lingual tablet Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 229960001603 tamoxifen Drugs 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
- FBUBVLUPUDBFME-UHFFFAOYSA-N xanthoxylline Natural products COC1=CC(O)=C(C(C)=O)C(OC)=C1 FBUBVLUPUDBFME-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0207536A FR2841243B1 (fr) | 2002-06-19 | 2002-06-19 | Nouveaux derives de 3-(4-oxo-4h-chromen-2yl)-(1h)-quinolein- 4-ones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| PCT/FR2003/001849 WO2004000834A1 (fr) | 2002-06-19 | 2003-06-18 | Nouveaux derives de 3-(4-oxo-4h-chromen-2-yl)-(1h)-quinolein-4-ones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20045540L NO20045540L (no) | 2004-12-17 |
| NO331618B1 true NO331618B1 (no) | 2012-02-06 |
Family
ID=29719853
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20045540A NO331618B1 (no) | 2002-06-19 | 2004-12-17 | Nye 3-(4-okso-4H-kromen-2-yl)-(1H)-kinolin-4-on-forbindelser, en fremgangsmate for deres fremstilling og farmasoytisk sammensetninger inneholdende dem |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US7339061B2 (de) |
| EP (1) | EP1513833B1 (de) |
| JP (1) | JP4252035B2 (de) |
| KR (1) | KR100645138B1 (de) |
| CN (1) | CN1313462C (de) |
| AR (1) | AR040276A1 (de) |
| AT (1) | ATE323698T1 (de) |
| AU (1) | AU2003269003B2 (de) |
| BR (1) | BR0311956A (de) |
| CA (1) | CA2489136C (de) |
| DE (1) | DE60304703T2 (de) |
| DK (1) | DK1513833T3 (de) |
| EA (1) | EA008285B1 (de) |
| ES (1) | ES2263013T3 (de) |
| FR (1) | FR2841243B1 (de) |
| GE (1) | GEP20084296B (de) |
| HK (1) | HK1081191A1 (de) |
| MA (1) | MA27260A1 (de) |
| MX (1) | MXPA04012795A (de) |
| NO (1) | NO331618B1 (de) |
| NZ (1) | NZ537314A (de) |
| PL (1) | PL210722B1 (de) |
| PT (1) | PT1513833E (de) |
| UA (1) | UA78808C2 (de) |
| WO (1) | WO2004000834A1 (de) |
| ZA (1) | ZA200410048B (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070287699A1 (en) * | 2006-05-01 | 2007-12-13 | Virobay, Inc. | Antiviral agents |
| FR2912145B1 (fr) * | 2007-02-02 | 2009-03-06 | Servier Lab | Nouveaux derives tricycliques,leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| KR20190024983A (ko) * | 2016-06-29 | 2019-03-08 | 오토노미, 인코포레이티드 | 트리글리세라이드 귀 제제 및 이의 용도 |
| RU2642426C1 (ru) * | 2017-03-21 | 2018-01-25 | Федеральное государственное бюджетное учреждение науки Институт органического синтеза им. И.Я. Постовского Уральского отделения Российской академии наук (ИОС УрО РАН) | 1-Этил-6-фтор-4-оксо-7-(8-этокси-2-оксо-2Н-хромен-3-ил)-1,4-дигидрохинолин-3-карбоновая кислота, обладающая противотуберкулезной активностью |
| CN112225744A (zh) * | 2020-08-31 | 2021-01-15 | 兰州大学 | 一种6H-苯并吡喃并[3,4-b]喹啉类化合物及其制备方法和用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0733743A (ja) * | 1993-07-22 | 1995-02-03 | Kyorin Pharmaceut Co Ltd | ２−アリール−４−キノリノール誘導体 |
| CA2182932A1 (en) * | 1995-08-10 | 1997-02-11 | Koju Watanabe | Chromone derivative, process for preparing same and pharmaceutical composition |
| TW349948B (en) * | 1995-10-31 | 1999-01-11 | Janssen Pharmaceutica Nv | Farnesyl transferase inhibiting 2-quinolone derivatives |
| DE19850131A1 (de) * | 1998-10-30 | 2000-05-04 | Merck Patent Gmbh | Chromenon- und Chromanonderivate |
-
2002
- 2002-06-19 FR FR0207536A patent/FR2841243B1/fr not_active Expired - Fee Related
-
2003
- 2003-06-18 DE DE60304703T patent/DE60304703T2/de not_active Expired - Lifetime
- 2003-06-18 EP EP03750780A patent/EP1513833B1/de not_active Expired - Lifetime
- 2003-06-18 MX MXPA04012795A patent/MXPA04012795A/es active IP Right Grant
- 2003-06-18 WO PCT/FR2003/001849 patent/WO2004000834A1/fr active IP Right Grant
- 2003-06-18 AT AT03750780T patent/ATE323698T1/de active
- 2003-06-18 UA UAA200500487A patent/UA78808C2/uk unknown
- 2003-06-18 PL PL372984A patent/PL210722B1/pl not_active IP Right Cessation
- 2003-06-18 DK DK03750780T patent/DK1513833T3/da active
- 2003-06-18 CA CA2489136A patent/CA2489136C/fr not_active Expired - Fee Related
- 2003-06-18 CN CNB038140500A patent/CN1313462C/zh not_active Expired - Fee Related
- 2003-06-18 PT PT03750780T patent/PT1513833E/pt unknown
- 2003-06-18 KR KR1020047020594A patent/KR100645138B1/ko not_active IP Right Cessation
- 2003-06-18 BR BR0311956-4A patent/BR0311956A/pt not_active IP Right Cessation
- 2003-06-18 JP JP2004514935A patent/JP4252035B2/ja not_active Expired - Fee Related
- 2003-06-18 NZ NZ537314A patent/NZ537314A/en not_active IP Right Cessation
- 2003-06-18 EA EA200500028A patent/EA008285B1/ru not_active IP Right Cessation
- 2003-06-18 ES ES03750780T patent/ES2263013T3/es not_active Expired - Lifetime
- 2003-06-18 US US10/519,208 patent/US7339061B2/en not_active Expired - Fee Related
- 2003-06-18 AU AU2003269003A patent/AU2003269003B2/en not_active Ceased
- 2003-06-18 GE GEAP20038592A patent/GEP20084296B/en unknown
- 2003-06-19 AR ARP030102176A patent/AR040276A1/es active IP Right Grant
-
2004
- 2004-12-13 ZA ZA200410048A patent/ZA200410048B/xx unknown
- 2004-12-17 NO NO20045540A patent/NO331618B1/no not_active IP Right Cessation
-
2005
- 2005-01-18 MA MA28047A patent/MA27260A1/fr unknown
-
2006
- 2006-01-26 HK HK06101208A patent/HK1081191A1/xx not_active IP Right Cessation
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| MM1K | Lapsed by not paying the annual fees |