NO330294B1 - Nye pyrrolidin- og tiazolidinforbindelser, fremgangsmate for deres fremstilling og farmasoytiske sammensetninger inneholdende dem - Google Patents
Nye pyrrolidin- og tiazolidinforbindelser, fremgangsmate for deres fremstilling og farmasoytiske sammensetninger inneholdende dem Download PDFInfo
- Publication number
- NO330294B1 NO330294B1 NO20052414A NO20052414A NO330294B1 NO 330294 B1 NO330294 B1 NO 330294B1 NO 20052414 A NO20052414 A NO 20052414A NO 20052414 A NO20052414 A NO 20052414A NO 330294 B1 NO330294 B1 NO 330294B1
- Authority
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- Norway
- Prior art keywords
- formula
- compound
- group
- acetyl
- pyrrolidinecarbonitrile
- Prior art date
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- 238000000034 method Methods 0.000 title claims description 50
- 238000002360 preparation method Methods 0.000 title claims description 7
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 6
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 title description 7
- 150000003548 thiazolidines Chemical class 0.000 title description 2
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- 150000003839 salts Chemical class 0.000 claims abstract description 29
- 239000002253 acid Substances 0.000 claims abstract description 25
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 25
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims abstract description 5
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims abstract description 5
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims abstract description 5
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- -1 cation salts Chemical class 0.000 claims description 10
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 8
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 7
- 125000003277 amino group Chemical group 0.000 claims description 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 6
- 238000011282 treatment Methods 0.000 claims description 6
- 229910052799 carbon Inorganic materials 0.000 claims description 5
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- 239000007858 starting material Substances 0.000 description 1
- 239000006190 sub-lingual tablet Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- KIRHQHDBUWJHPP-UHFFFAOYSA-N tert-butyl n-(2-carbamoylspiro[3.3]heptan-2-yl)carbamate Chemical compound C1C(NC(=O)OC(C)(C)C)(C(N)=O)CC11CCC1 KIRHQHDBUWJHPP-UHFFFAOYSA-N 0.000 description 1
- GQJYLUCLOMGOSP-UHFFFAOYSA-N tert-butyl n-[2-(2-hydroxypropan-2-yl)spiro[3.3]heptan-2-yl]carbamate Chemical compound C1C(NC(=O)OC(C)(C)C)(C(C)(C)O)CC11CCC1 GQJYLUCLOMGOSP-UHFFFAOYSA-N 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pyrrole Compounds (AREA)
- Pyrane Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0405454A FR2870538B1 (fr) | 2004-05-19 | 2004-05-19 | Nouveaux derives de pyrrolidines et de thiazolidines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20052414D0 NO20052414D0 (no) | 2005-05-19 |
| NO20052414L NO20052414L (no) | 2005-11-21 |
| NO330294B1 true NO330294B1 (no) | 2011-03-21 |
Family
ID=34942306
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20052414A NO330294B1 (no) | 2004-05-19 | 2005-05-19 | Nye pyrrolidin- og tiazolidinforbindelser, fremgangsmate for deres fremstilling og farmasoytiske sammensetninger inneholdende dem |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US7439263B2 (es) |
| EP (1) | EP1598350B1 (es) |
| JP (1) | JP4335171B2 (es) |
| KR (1) | KR100747967B1 (es) |
| CN (1) | CN100381438C (es) |
| AR (1) | AR049278A1 (es) |
| AT (1) | ATE366731T1 (es) |
| AU (1) | AU2005202180B2 (es) |
| BR (1) | BRPI0501769A (es) |
| CA (1) | CA2506491C (es) |
| CY (1) | CY1106878T1 (es) |
| DE (1) | DE602005001576T2 (es) |
| DK (1) | DK1598350T3 (es) |
| EA (1) | EA009292B1 (es) |
| ES (1) | ES2290864T3 (es) |
| FR (1) | FR2870538B1 (es) |
| GE (1) | GEP20074103B (es) |
| HK (1) | HK1086259A1 (es) |
| HR (1) | HRP20070376T3 (es) |
| MX (1) | MXPA05005256A (es) |
| MY (1) | MY139481A (es) |
| NO (1) | NO330294B1 (es) |
| NZ (1) | NZ540108A (es) |
| PL (1) | PL1598350T3 (es) |
| PT (1) | PT1598350E (es) |
| RS (1) | RS50526B (es) |
| SG (1) | SG117551A1 (es) |
| SI (1) | SI1598350T1 (es) |
| ZA (1) | ZA200504050B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2020413A1 (de) * | 2007-08-02 | 2009-02-04 | Bayer CropScience AG | Oxaspirocyclische-spiro-substituierte Tetram- und Tetronsäure-Derivate |
| WO2009037719A1 (en) * | 2007-09-21 | 2009-03-26 | Lupin Limited | Novel compounds as dipeptidyl peptidase iv (dpp iv) inhibitors |
| JP5438028B2 (ja) * | 2008-01-23 | 2014-03-12 | ジエンス ハンセン ファーマセウティカル カンパニー リミテッド | アザビシクロオクタンの誘導体、その製造方法及びそのジペプチジルペプチダーゼｉｖの阻害剤としての用途 |
| GB2483614B (en) | 2009-06-18 | 2014-12-03 | Lupin Ltd | 2-Amino-2- [8-(dimethyl carbamoyl)- 8-aza- bicyclo [3.2.1] oct-3-yl]-exo- ethanoyl derivatives as potent dpp-iv inhibitors |
| US8440710B2 (en) * | 2009-10-15 | 2013-05-14 | Hoffmann-La Roche Inc. | HSL inhibitors useful in the treatment of diabetes |
| WO2014000629A1 (zh) * | 2012-06-25 | 2014-01-03 | 广东东阳光药业有限公司 | 六氢并环戊二烯衍生物、其制备方法及其在医药上的应用 |
| KR102449196B1 (ko) | 2016-01-15 | 2022-09-29 | 삼성전자주식회사 | 비휘발성 메모리 장치 및 비휘발성 메모리 장치의 프로그램 방법 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0618957B2 (ja) * | 1988-01-26 | 1994-03-16 | 日本合成化学工業株式会社 | 成形物の製造方法 |
| CA2046801C (en) * | 1990-08-07 | 2002-02-26 | Peter D. Davis | Substituted pyrroles |
| DE4222459C2 (de) * | 1992-07-08 | 1995-09-14 | Sigma Tau Ind Farmaceuti | 3,9-disubstituierte-Spiro[5.5]undecane, ein Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die diese enthalten |
| ES2167371T3 (es) * | 1993-07-02 | 2002-05-16 | Bayer Ag | Derivados de 1h-3-aril-pirrolidin-2,4-diona espirociclicos substituidos. |
| TW492957B (en) * | 1996-11-07 | 2002-07-01 | Novartis Ag | N-substituted 2-cyanopyrrolidnes |
| US6110949A (en) * | 1999-06-24 | 2000-08-29 | Novartis Ag | N-(substituted glycyl)-4-cyanothiazolidines, pharmaceutical compositions containing them and their use in inhibiting dipeptidyl peptidase-IV |
| TW583185B (en) * | 2000-06-13 | 2004-04-11 | Novartis Ag | N-(substituted glycyl)-2-cyanopyrrolidines and pharmaceutical composition for inhibiting dipeptidyl peptidase-IV (DPP-IV) or for the prevention or treatment of diseases or conditions associated with elevated levels of DPP-IV comprising the same |
| DK1308439T3 (da) * | 2000-08-10 | 2009-01-12 | Mitsubishi Tanabe Pharma Corp | Prolinderivater og anvendelse af disse som lægemidler |
| AU8811401A (en) * | 2000-09-25 | 2002-04-02 | Toray Industries | Spiro compounds and adhesion molecule inhibitors containing the same as the active ingredient |
| FR2824825B1 (fr) * | 2001-05-15 | 2005-05-06 | Servier Lab | Nouveaux derives d'alpha-amino-acides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| WO2003057144A2 (en) * | 2001-12-26 | 2003-07-17 | Guilford Pharmaceuticals | Change inhibitors of dipeptidyl peptidase iv |
| HUP0200849A2 (hu) * | 2002-03-06 | 2004-08-30 | Sanofi-Synthelabo | N-aminoacetil-2-ciano-pirrolidin-származékok, e vegyületeket tartalmazó gyógyszerkészítmények és eljárás előállításukra |
| AU2003214534B2 (en) * | 2002-04-08 | 2006-08-31 | Torrent Pharmaceuticals Ltd. | Thiazolidine-4-carbonitriles and analogues and their use as dipeptidyl-peptidas inhibitors |
| TW200404796A (en) * | 2002-08-19 | 2004-04-01 | Ono Pharmaceutical Co | Nitrogen-containing compound |
| US7262207B2 (en) * | 2002-09-19 | 2007-08-28 | Abbott Laboratories | Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV) |
| PL376822A1 (pl) * | 2002-11-07 | 2006-01-09 | Merck & Co., Inc. | Pochodne fenyloalaniny jako inhibitory dipeptydylopeptydazy do leczenia lub zapobiegania cukrzycy |
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2004
- 2004-05-19 FR FR0405454A patent/FR2870538B1/fr not_active Expired - Fee Related
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- 2005-05-04 SG SG200502766A patent/SG117551A1/en unknown
- 2005-05-05 CA CA002506491A patent/CA2506491C/fr not_active Expired - Fee Related
- 2005-05-17 MX MXPA05005256A patent/MXPA05005256A/es active IP Right Grant
- 2005-05-18 AT AT05291066T patent/ATE366731T1/de active
- 2005-05-18 SI SI200530030T patent/SI1598350T1/sl unknown
- 2005-05-18 NZ NZ540108A patent/NZ540108A/en unknown
- 2005-05-18 EA EA200500683A patent/EA009292B1/ru not_active IP Right Cessation
- 2005-05-18 RS RSP-2007/0392A patent/RS50526B/sr unknown
- 2005-05-18 MY MYPI20052248A patent/MY139481A/en unknown
- 2005-05-18 AR ARP050102045A patent/AR049278A1/es unknown
- 2005-05-18 DE DE602005001576T patent/DE602005001576T2/de active Active
- 2005-05-18 US US11/131,510 patent/US7439263B2/en not_active Expired - Fee Related
- 2005-05-18 EP EP05291066A patent/EP1598350B1/fr active Active
- 2005-05-18 PL PL05291066T patent/PL1598350T3/pl unknown
- 2005-05-18 KR KR1020050041742A patent/KR100747967B1/ko not_active IP Right Cessation
- 2005-05-18 PT PT05291066T patent/PT1598350E/pt unknown
- 2005-05-18 DK DK05291066T patent/DK1598350T3/da active
- 2005-05-18 GE GEAP20058802A patent/GEP20074103B/en unknown
- 2005-05-18 ES ES05291066T patent/ES2290864T3/es active Active
- 2005-05-19 CN CNB200510087845XA patent/CN100381438C/zh not_active Expired - Fee Related
- 2005-05-19 AU AU2005202180A patent/AU2005202180B2/en not_active Ceased
- 2005-05-19 ZA ZA200504050A patent/ZA200504050B/en unknown
- 2005-05-19 JP JP2005146186A patent/JP4335171B2/ja not_active Expired - Fee Related
- 2005-05-19 BR BR0501769-6A patent/BRPI0501769A/pt not_active IP Right Cessation
- 2005-05-19 NO NO20052414A patent/NO330294B1/no not_active IP Right Cessation
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2006
- 2006-05-29 HK HK06106186A patent/HK1086259A1/xx not_active IP Right Cessation
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2007
- 2007-09-03 HR HR20070376T patent/HRP20070376T3/xx unknown
- 2007-09-19 CY CY20071101205T patent/CY1106878T1/el unknown
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