NO330273B1 - Fremgangsmate ved fremstilling av geminale bifosfonater - Google Patents

Fremgangsmate ved fremstilling av geminale bifosfonater Download PDF

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Publication number
NO330273B1
NO330273B1 NO20023646A NO20023646A NO330273B1 NO 330273 B1 NO330273 B1 NO 330273B1 NO 20023646 A NO20023646 A NO 20023646A NO 20023646 A NO20023646 A NO 20023646A NO 330273 B1 NO330273 B1 NO 330273B1
Authority
NO
Norway
Prior art keywords
acid
substituted
phosphorus
amino
unsubstituted
Prior art date
Application number
NO20023646A
Other languages
English (en)
Norwegian (no)
Other versions
NO20023646D0 (no
NO20023646L (no
Inventor
Frederick Dana Cazer
Gregory Eugene Parry
Dennis Michael Billings
William Douglas Cramer
Original Assignee
Warner Chilcott Co Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Chilcott Co Llc filed Critical Warner Chilcott Co Llc
Publication of NO20023646D0 publication Critical patent/NO20023646D0/no
Publication of NO20023646L publication Critical patent/NO20023646L/no
Publication of NO330273B1 publication Critical patent/NO330273B1/no

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839Polyphosphonic acids
    • C07F9/3873Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839Polyphosphonic acids
    • C07F9/386Polyphosphonic acids containing hydroxy substituents in the hydrocarbon radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576Six-membered rings
    • C07F9/58Pyridine rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NO20023646A 2000-02-01 2002-07-31 Fremgangsmate ved fremstilling av geminale bifosfonater NO330273B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17950600P 2000-02-01 2000-02-01
PCT/US2001/003309 WO2001057052A1 (en) 2000-02-01 2001-02-01 Process for making geminal bisphosphonates

Publications (3)

Publication Number Publication Date
NO20023646D0 NO20023646D0 (no) 2002-07-31
NO20023646L NO20023646L (no) 2002-09-30
NO330273B1 true NO330273B1 (no) 2011-03-14

Family

ID=22656872

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20023646A NO330273B1 (no) 2000-02-01 2002-07-31 Fremgangsmate ved fremstilling av geminale bifosfonater

Country Status (27)

Country Link
US (1) US6562974B2 (es)
EP (1) EP1252169B1 (es)
JP (1) JP4534185B2 (es)
KR (1) KR100681740B1 (es)
CN (1) CN1223598C (es)
AT (1) ATE269343T1 (es)
AU (1) AU784385B2 (es)
BR (1) BRPI0107952B8 (es)
CA (1) CA2399974C (es)
CO (1) CO5430222A1 (es)
CZ (1) CZ304038B6 (es)
DE (1) DE60103851T2 (es)
DK (1) DK1252169T3 (es)
ES (1) ES2221887T3 (es)
HK (1) HK1051045A1 (es)
HU (1) HU228980B1 (es)
IL (2) IL150512A0 (es)
MX (1) MXPA02007418A (es)
NO (1) NO330273B1 (es)
NZ (1) NZ519967A (es)
PE (1) PE20011065A1 (es)
PL (1) PL207617B1 (es)
PT (1) PT1252169E (es)
RU (1) RU2002123362A (es)
SK (1) SK10992002A3 (es)
TR (1) TR200402317T4 (es)
WO (1) WO2001057052A1 (es)

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EP2172192A1 (en) * 2001-12-24 2010-04-07 Teva Pharmaceutical Industries Ltd. Dosage form with a core tablet of active ingredient sheathed in a compressed annular body of powder of granular material, and process and tooling for producing it
US20040052843A1 (en) * 2001-12-24 2004-03-18 Lerner E. Itzhak Controlled release dosage forms
ITMI20020908A1 (it) * 2002-04-29 2003-10-29 Chemi Spa Processo di preparazione di sodio alendronato
WO2003097655A1 (en) * 2002-05-17 2003-11-27 Teva Pharmaceutical Industries Ltd. Use of certain diluents for making bisphosphonic acids
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US20050260272A1 (en) * 2004-05-05 2005-11-24 Alkermes Controlled Therapeutics, Inc. Method of forming microparticles that include a bisphosphonate and a polymer
WO2006039721A2 (en) * 2004-10-08 2006-04-13 The Board Of Trustees Of The University Of Illinois Bisphosphonate compounds and methods for bone resorption diseases, cancer, bone pain, immune disorders, and infectious diseases
US8012949B2 (en) * 2004-10-08 2011-09-06 The Board Of Trustees Of The University Of Illinois Bisphosphonate compounds and methods with enhanced potency for multiple targets including FPPS, GGPPS, and DPPS
US7214818B2 (en) 2004-10-29 2007-05-08 Hoffmann-La Roche Inc. Method for synthesizing bisphosphonate
PL199215B1 (pl) * 2004-12-28 2008-08-29 Politechnika Gdanska Sposób wytwarzania kwasu [1-hydroksy-2-(3-pirydylo)etylidenobisfosfonowego] oraz jego soli monosodowej dwu i pół wodnej
WO2006129056A2 (en) * 2005-05-28 2006-12-07 Pliva Hrvatska D.O.O Process and novel salt
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EP2001486A4 (en) * 2006-03-17 2010-12-29 Univ Illinois BIPHOSPHONATE COMPOUNDS AND CORRESPONDING METHODS
JP5354858B2 (ja) * 2006-05-09 2013-11-27 株式会社Adeka スルホンアミド化合物の金属塩を含有するポリエステル樹脂組成物
US8076483B2 (en) 2006-05-11 2011-12-13 M/S. Ind Swift Laboratories Limited Process for the preparation of pure risedronic acid or salts
SI2144919T1 (sl) 2007-04-11 2016-02-29 F. Hoffmann-La Roche Ag Večstopenjska sinteza ibandronata
WO2008152518A2 (en) * 2007-05-16 2008-12-18 Actavis Group Ptc Ehf Process for the preparation of risedronic acid or risedronate sodium
WO2009050731A2 (en) * 2007-06-20 2009-04-23 Alkem Laboratories Ltd Novel process for preparing risedronic acid
KR100877667B1 (ko) * 2007-06-28 2009-01-08 보령제약 주식회사 리세드로네이트의 제조 방법
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Also Published As

Publication number Publication date
SK10992002A3 (sk) 2003-02-04
AU784385B2 (en) 2006-03-23
DE60103851T2 (de) 2005-06-23
AU3661301A (en) 2001-08-14
IL150512A0 (en) 2003-02-12
DK1252169T3 (da) 2004-10-25
CZ304038B6 (cs) 2013-09-04
WO2001057052A1 (en) 2001-08-09
CA2399974A1 (en) 2001-08-09
HUP0300890A3 (en) 2009-01-28
HU228980B1 (en) 2013-07-29
BR0107952A (pt) 2003-02-25
IL150512A (en) 2006-10-31
RU2002123362A (ru) 2004-01-10
KR20020063622A (ko) 2002-08-03
EP1252169B1 (en) 2004-06-16
NO20023646D0 (no) 2002-07-31
DE60103851D1 (de) 2004-07-22
EP1252169A1 (en) 2002-10-30
NO20023646L (no) 2002-09-30
ATE269343T1 (de) 2004-07-15
BRPI0107952B1 (pt) 2015-09-01
KR100681740B1 (ko) 2007-02-15
PT1252169E (pt) 2004-11-30
CA2399974C (en) 2005-08-16
ES2221887T3 (es) 2005-01-16
CN1396925A (zh) 2003-02-12
CO5430222A1 (es) 2004-06-01
JP4534185B2 (ja) 2010-09-01
TR200402317T4 (tr) 2004-12-21
US6562974B2 (en) 2003-05-13
PL207617B1 (pl) 2011-01-31
PL357116A1 (en) 2004-07-12
US20010041690A1 (en) 2001-11-15
PE20011065A1 (es) 2001-11-21
MXPA02007418A (es) 2002-12-09
JP2003522181A (ja) 2003-07-22
HUP0300890A2 (hu) 2003-08-28
CN1223598C (zh) 2005-10-19
NZ519967A (en) 2004-05-28
HK1051045A1 (zh) 2003-07-18
BRPI0107952B8 (pt) 2021-05-25

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