DK1252169T3 - Fremgangsmåde til fremstilling af geminale bisphosphonater - Google Patents

Fremgangsmåde til fremstilling af geminale bisphosphonater

Info

Publication number
DK1252169T3
DK1252169T3 DK01908779T DK01908779T DK1252169T3 DK 1252169 T3 DK1252169 T3 DK 1252169T3 DK 01908779 T DK01908779 T DK 01908779T DK 01908779 T DK01908779 T DK 01908779T DK 1252169 T3 DK1252169 T3 DK 1252169T3
Authority
DK
Denmark
Prior art keywords
substituted
unsubstituted
unsaturated
saturated
hydrogen
Prior art date
Application number
DK01908779T
Other languages
English (en)
Inventor
Fredrick Dana Cazer
Gregory Eugene Perry
Dennis Michael Billings
William Douglas Cramer
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Application granted granted Critical
Publication of DK1252169T3 publication Critical patent/DK1252169T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/3804—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se) not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/3804—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se) not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/386—Polyphosphonic acids containing hydroxy substituents in the hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings
DK01908779T 2000-02-01 2001-02-01 Fremgangsmåde til fremstilling af geminale bisphosphonater DK1252169T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17950600P 2000-02-01 2000-02-01
PCT/US2001/003309 WO2001057052A1 (en) 2000-02-01 2001-02-01 Process for making geminal bisphosphonates

Publications (1)

Publication Number Publication Date
DK1252169T3 true DK1252169T3 (da) 2004-10-25

Family

ID=22656872

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01908779T DK1252169T3 (da) 2000-02-01 2001-02-01 Fremgangsmåde til fremstilling af geminale bisphosphonater

Country Status (27)

Country Link
US (1) US6562974B2 (da)
EP (1) EP1252169B1 (da)
JP (1) JP4534185B2 (da)
KR (1) KR100681740B1 (da)
CN (1) CN1223598C (da)
AT (1) ATE269343T1 (da)
AU (1) AU784385B2 (da)
BR (1) BRPI0107952B8 (da)
CA (1) CA2399974C (da)
CO (1) CO5430222A1 (da)
CZ (1) CZ304038B6 (da)
DE (1) DE60103851T2 (da)
DK (1) DK1252169T3 (da)
ES (1) ES2221887T3 (da)
HK (1) HK1051045A1 (da)
HU (1) HU228980B1 (da)
IL (2) IL150512A0 (da)
MX (1) MXPA02007418A (da)
NO (1) NO330273B1 (da)
NZ (1) NZ519967A (da)
PE (1) PE20011065A1 (da)
PL (1) PL207617B1 (da)
PT (1) PT1252169E (da)
RU (1) RU2002123362A (da)
SK (1) SK10992002A3 (da)
TR (1) TR200402317T4 (da)
WO (1) WO2001057052A1 (da)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2347330C (en) * 2001-05-10 2002-03-12 Pharmaceutical Partners Of Canada Inc. Liquid injectable formulation of disodium pamidronate
GB0115824D0 (en) * 2001-06-28 2001-08-22 Rhodia Cons Spec Ltd Improved solvent systems
US20040052843A1 (en) * 2001-12-24 2004-03-18 Lerner E. Itzhak Controlled release dosage forms
BR0215413A (pt) * 2001-12-24 2004-12-14 Teva Pharma Formula dosada com um comprimido central de ingrediente ativo encapado em uma capa anular prensada de material em pó ou granulado e processo e conjunto de ferramentas para a sua produção
ITMI20020908A1 (it) * 2002-04-29 2003-10-29 Chemi Spa Processo di preparazione di sodio alendronato
WO2003097655A1 (en) * 2002-05-17 2003-11-27 Teva Pharmaceutical Industries Ltd. Use of certain diluents for making bisphosphonic acids
ATE451380T1 (de) * 2003-08-21 2009-12-15 Sun Pharmaceuticals Ind Ltd Verfahren zur herstellung von bisphosphonsäureverbindungen
US20050260272A1 (en) * 2004-05-05 2005-11-24 Alkermes Controlled Therapeutics, Inc. Method of forming microparticles that include a bisphosphonate and a polymer
WO2008128056A1 (en) * 2004-10-08 2008-10-23 The Board Of Trustees Of The University Of Illinois Bisphosphonate compounds and methods with enhanced potency for multiple targets including fpps, ggpps, and dpps
EP1802641B8 (en) * 2004-10-08 2012-03-07 The Board Of Trustees Of The University Of Illinois Bisphosphonate compounds and methods for bone resorption diseases, cancer, bone pain, immune disorders, and infectious diseases
WO2007109585A2 (en) * 2006-03-17 2007-09-27 The Board Of Trustees Of The University Of Illinois Bisphosphonate compounds and methods
US7214818B2 (en) 2004-10-29 2007-05-08 Hoffmann-La Roche Inc. Method for synthesizing bisphosphonate
PL199215B1 (pl) * 2004-12-28 2008-08-29 Politechnika Gdanska Sposób wytwarzania kwasu [1-hydroksy-2-(3-pirydylo)etylidenobisfosfonowego] oraz jego soli monosodowej dwu i pół wodnej
WO2006129056A2 (en) * 2005-05-28 2006-12-07 Pliva Hrvatska D.O.O Process and novel salt
WO2006134603A1 (en) 2005-06-13 2006-12-21 Jubilant Organosys Limited Process for producing bisphosphonic acids and forms thereof
EP1775302A1 (en) 2005-10-11 2007-04-18 Sandoz A/S Method for preparing crystalline sodium risedronate
KR100860666B1 (ko) 2006-01-06 2008-09-26 삼성전자주식회사 통신 시스템에서 신호 수신 장치 및 방법
JP5354858B2 (ja) * 2006-05-09 2013-11-27 株式会社Ａｄｅｋａ スルホンアミド化合物の金属塩を含有するポリエステル樹脂組成物
WO2007132478A2 (en) 2006-05-11 2007-11-22 Ind-Swift Laboratories Limited Process for the preparation of pure risedronic acid or salts
US7662990B2 (en) 2007-04-11 2010-02-16 Hoffmann-La Roche Inc. Process for preparing ibandronate
US20100317859A1 (en) * 2007-05-16 2010-12-16 Actavis Group Ptc Ehf Process for the Preparation of Risedronate Sodium
WO2009050731A2 (en) * 2007-06-20 2009-04-23 Alkem Laboratories Ltd Novel process for preparing risedronic acid
KR100877667B1 (ko) * 2007-06-28 2009-01-08 보령제약 주식회사 리세드로네이트의 제조 방법
JP2011515535A (ja) * 2008-03-17 2011-05-19 キャボット コーポレイション リン酸塩遊離が低減した改質顔料、ならびにそれからの分散体およびインクジェットインク組成物
JP5258370B2 (ja) * 2008-05-08 2013-08-07 ダイト株式会社 リセドロン酸の工業的製造方法
CA2775004A1 (en) 2009-10-02 2011-04-07 Straitmark Holding Ag Method for the manufacture of aminohydroxy diphosphonic acids

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2534391C2 (de) 1975-08-01 1983-01-13 Henkel KGaA, 4000 Düsseldorf 1-Hydroxy-3-aminoalkan-1,1-diphosphonsäuren
DE2658961C3 (de) 1976-12-24 1981-09-24 Joh. A. Benckiser Gmbh, 6700 Ludwigshafen Verfahren zur Herstellung von 1-Hydroxy-3-amino-propan-1,1-diphosphonsäuren
US4447256A (en) 1977-07-20 1984-05-08 Nissan Chemical Industries, Ltd. N-(Unsubstituted or substituted pyridyl)aminomethylene-diphosphonic acids, herbicidal compositions containing same, their use for herbicides, and process for preparing same
DE2745083C2 (de) * 1977-10-07 1985-05-02 Henkel KGaA, 4000 Düsseldorf Hydroxydiphosphonsäuren und Verfahren zu deren Herstellung
US4330537A (en) 1977-12-07 1982-05-18 The Procter & Gamble Company Compositions for inhibiting mobilization of calcium phosphate in animal tissue
JPS5598193A (en) 1979-01-22 1980-07-25 Nissan Chem Ind Ltd Methylenediphosphonic acid derivative and herbicide comprising it as active constituent
DE2943498C2 (de) 1979-10-27 1983-01-27 Henkel KGaA, 4000 Düsseldorf Verfahren zur Herstellung von 3-Amino-1-hydroxypropan-1,1-diphosphonsäure
DE3016289A1 (de) 1980-04-28 1981-10-29 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren
US4304734A (en) 1980-10-16 1981-12-08 Vysoka Skola Chemicko-Technologicka 6-Amino-1-hydroxyhexylidene diphosphonic acid, salts and a process for production thereof
DE3151038A1 (de) 1981-12-23 1983-07-28 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung von 3-amino-1-hydroxypropan-1,1-diphosphonsaeure
IT1201087B (it) 1982-04-15 1989-01-27 Gentili Ist Spa Bifosfonati farmacologicamente attivi,procedimento per la loro preparazione e relative composizioni farmaceutiche
IT1196315B (it) * 1984-10-29 1988-11-16 Gentili Ist Spa Procedimento per la preparazione di acidi difosfonici
IL77243A (en) 1984-12-21 1996-11-14 Procter & Gamble Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds
IT1187750B (it) 1985-10-15 1987-12-23 Eurand Spa Procedimento per la preparazione di compresse,anche a rilascio prolungato,di iscsorbide-5-mononitrato stabilizzato e formulazioni cosi' ottenute
DE3540150A1 (de) 1985-11-13 1987-05-14 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
GB8531071D0 (en) 1985-12-17 1986-01-29 Boots Co Plc Therapeutic compound
ES2031462T3 (es) 1986-03-24 1992-12-16 Nippon Kayaku Kabushiki Kaisha Procedimiento para producir 1-b-d-arabinofuranosilcitosina-5'-estearilfosfato monosodico y monohidrato de la misma, y compuesto farmaceutico que contiene esta ultima.
DE3623397A1 (de) 1986-07-11 1988-01-14 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
DE3626058A1 (de) 1986-08-01 1988-02-11 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
ES2038692T4 (es) 1986-11-21 2012-02-10 Novartis Ag Procedimiento para la obtencion de acidos alcanodifosfonicos substituidos.
DE3700772A1 (de) 1987-01-13 1988-07-21 Inst Khim Kinetiki I Gorenija Verfahren zur herstellung von i-funktionellsubstituierten alkyliden-i,i-diphosphonsaeuren und deren gemischen
US5091525A (en) 1987-10-07 1992-02-25 Eli Lilly And Company Monohydrate and DMF solvates of a new carbacephem antibiotic
US5035898A (en) 1987-11-27 1991-07-30 Schering Corporation Potassium/magnesium supplement
US5110807A (en) 1988-12-01 1992-05-05 Ciba-Geigy Corporation Araliphatylaminoalkanediphosphonic acids
DE3822650A1 (de) * 1988-07-05 1990-02-01 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
DE3917153A1 (de) 1989-05-26 1990-11-29 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
TW208013B (da) 1990-03-01 1993-06-21 Daiichi Co Ltd
JPH06500112A (ja) 1990-08-21 1994-01-06 ジ・アップジョン・カンパニー 抗関節炎剤としてのビスホスホン酸誘導体
US5039819A (en) 1990-09-18 1991-08-13 Merck & Co., Inc. Diphosphonate intermediate for preparing an antihypercalcemic agent
IT1246992B (it) * 1991-01-08 1994-12-12 Gentili Ist Spa Procedimento per la preparazione di acidi difosfonici e loro sali
DK58291D0 (da) 1991-04-02 1991-04-02 Novo Nordisk As Krystalinsk stof og dets fremstilling
SE501389C2 (sv) 1992-04-24 1995-01-30 Leiras Oy Farmaceutiskt preparat och förfarande för dess framställning
US5317015A (en) 1992-05-01 1994-05-31 Rhone-Poulenc Rorer Pharmaceuticals Inc. Azacyclic bisphosphonates as anticholesterolemic agents
CA2137665A1 (en) 1992-06-23 1994-01-06 Yasuo Isomura Novel crystal of monohydrate of heterocyclic bis(phosphonic acid) derivative
FR2694558B1 (fr) 1992-08-05 1994-10-28 Sanofi Elf Monohydrate du sel disodique de l'acide 4-chlorophénylthiométhylène bisphosphonique, sa préparation, les compositions pharmaceutiques en contenant.
US5312925A (en) 1992-09-01 1994-05-17 Pfizer Inc. Monohydrate of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)-ethyl)-6-chloro-1,3-dihydro-2H-indol-2-one-hydrochloride
CZ280195A3 (en) 1993-04-28 1996-02-14 Pfizer Crystalline spirostanyl glycoside, monohydrate thereof, pharmaceutical composition based thereon and process for preparing crystalline steroidal glycoside
US5510517A (en) 1993-08-25 1996-04-23 Merck & Co., Inc. Process for producing N-amino-1-hydroxy-alkylidene-1,1-bisphosphonic acids
US5580977A (en) 1995-03-01 1996-12-03 Eli Lilly And Company Process for preparing loracarbef monohydrate
TW393488B (en) 1995-04-20 2000-06-11 Merck & Co Inc Process for making 1-hydrox-ybisphosphonates
KR100192215B1 (ko) 1996-09-03 1999-06-15 강재헌 3-아미노-1-히드록시프로판-1,1-디포스폰산의 제조방법
CA2197267C (en) 1997-02-11 2000-02-08 Yong Tao Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof

Also Published As

Publication number Publication date
AU784385B2 (en) 2006-03-23
AU3661301A (en) 2001-08-14
US6562974B2 (en) 2003-05-13
CN1223598C (zh) 2005-10-19
CA2399974A1 (en) 2001-08-09
CN1396925A (zh) 2003-02-12
NO330273B1 (no) 2011-03-14
CZ304038B6 (cs) 2013-09-04
NO20023646D0 (no) 2002-07-31
SK10992002A3 (sk) 2003-02-04
EP1252169A1 (en) 2002-10-30
PL357116A1 (en) 2004-07-12
JP4534185B2 (ja) 2010-09-01
RU2002123362A (ru) 2004-01-10
NO20023646L (no) 2002-09-30
CO5430222A1 (es) 2004-06-01
BRPI0107952B1 (pt) 2015-09-01
KR100681740B1 (ko) 2007-02-15
MXPA02007418A (es) 2002-12-09
NZ519967A (en) 2004-05-28
JP2003522181A (ja) 2003-07-22
DE60103851D1 (de) 2004-07-22
DE60103851T2 (de) 2005-06-23
BR0107952A (pt) 2003-02-25
CA2399974C (en) 2005-08-16
HK1051045A1 (zh) 2003-07-18
ATE269343T1 (de) 2004-07-15
ES2221887T3 (es) 2005-01-16
KR20020063622A (ko) 2002-08-03
BRPI0107952B8 (pt) 2021-05-25
HUP0300890A2 (hu) 2003-08-28
PE20011065A1 (es) 2001-11-21
IL150512A (en) 2006-10-31
HUP0300890A3 (en) 2009-01-28
PT1252169E (pt) 2004-11-30
HU228980B1 (en) 2013-07-29
WO2001057052A1 (en) 2001-08-09
TR200402317T4 (tr) 2004-12-21
US20010041690A1 (en) 2001-11-15
PL207617B1 (pl) 2011-01-31
EP1252169B1 (en) 2004-06-16
IL150512A0 (en) 2003-02-12

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