DE60103851D1 - Verfahren zur herstellung von geminalen bisphosphonaten - Google Patents

Verfahren zur herstellung von geminalen bisphosphonaten

Info

Publication number
DE60103851D1
DE60103851D1 DE60103851T DE60103851T DE60103851D1 DE 60103851 D1 DE60103851 D1 DE 60103851D1 DE 60103851 T DE60103851 T DE 60103851T DE 60103851 T DE60103851 T DE 60103851T DE 60103851 D1 DE60103851 D1 DE 60103851D1
Authority
DE
Germany
Prior art keywords
substituted
unsubstituted
unsaturated
saturated
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60103851T
Other languages
English (en)
Other versions
DE60103851T2 (de
Inventor
Fredrick Dana Cazer
Gregory Eugene Perry
Dennis Michael Billings
William Douglas Cramer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Chilcott Co LLC
Original Assignee
Procter and Gamble Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter and Gamble Co filed Critical Procter and Gamble Co
Publication of DE60103851D1 publication Critical patent/DE60103851D1/de
Application granted granted Critical
Publication of DE60103851T2 publication Critical patent/DE60103851T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/3804Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se) not used, see subgroups
    • C07F9/3839Polyphosphonic acids
    • C07F9/3873Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/3804Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se) not used, see subgroups
    • C07F9/3839Polyphosphonic acids
    • C07F9/386Polyphosphonic acids containing hydroxy substituents in the hydrocarbon radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576Six-membered rings
    • C07F9/58Pyridine rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE60103851T 2000-02-01 2001-02-01 Verfahren zur herstellung von geminalen bisphosphonaten Expired - Lifetime DE60103851T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17950600P 2000-02-01 2000-02-01
US179506P 2000-02-01
PCT/US2001/003309 WO2001057052A1 (en) 2000-02-01 2001-02-01 Process for making geminal bisphosphonates

Publications (2)

Publication Number Publication Date
DE60103851D1 true DE60103851D1 (de) 2004-07-22
DE60103851T2 DE60103851T2 (de) 2005-06-23

Family

ID=22656872

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60103851T Expired - Lifetime DE60103851T2 (de) 2000-02-01 2001-02-01 Verfahren zur herstellung von geminalen bisphosphonaten

Country Status (27)

Country Link
US (1) US6562974B2 (de)
EP (1) EP1252169B1 (de)
JP (1) JP4534185B2 (de)
KR (1) KR100681740B1 (de)
CN (1) CN1223598C (de)
AT (1) ATE269343T1 (de)
AU (1) AU784385B2 (de)
BR (1) BRPI0107952B8 (de)
CA (1) CA2399974C (de)
CO (1) CO5430222A1 (de)
CZ (1) CZ304038B6 (de)
DE (1) DE60103851T2 (de)
DK (1) DK1252169T3 (de)
ES (1) ES2221887T3 (de)
HK (1) HK1051045A1 (de)
HU (1) HU228980B1 (de)
IL (2) IL150512A0 (de)
MX (1) MXPA02007418A (de)
NO (1) NO330273B1 (de)
NZ (1) NZ519967A (de)
PE (1) PE20011065A1 (de)
PL (1) PL207617B1 (de)
PT (1) PT1252169E (de)
RU (1) RU2002123362A (de)
SK (1) SK10992002A3 (de)
TR (1) TR200402317T4 (de)
WO (1) WO2001057052A1 (de)

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CA2347330C (en) * 2001-05-10 2002-03-12 Pharmaceutical Partners Of Canada Inc. Liquid injectable formulation of disodium pamidronate
GB0115824D0 (en) * 2001-06-28 2001-08-22 Rhodia Cons Spec Ltd Improved solvent systems
US20040052843A1 (en) * 2001-12-24 2004-03-18 Lerner E. Itzhak Controlled release dosage forms
BR0215413A (pt) * 2001-12-24 2004-12-14 Teva Pharma Formula dosada com um comprimido central de ingrediente ativo encapado em uma capa anular prensada de material em pó ou granulado e processo e conjunto de ferramentas para a sua produção
ITMI20020908A1 (it) * 2002-04-29 2003-10-29 Chemi Spa Processo di preparazione di sodio alendronato
WO2003097655A1 (en) * 2002-05-17 2003-11-27 Teva Pharmaceutical Industries Ltd. Use of certain diluents for making bisphosphonic acids
ATE451380T1 (de) * 2003-08-21 2009-12-15 Sun Pharmaceuticals Ind Ltd Verfahren zur herstellung von bisphosphonsäureverbindungen
US20050260272A1 (en) * 2004-05-05 2005-11-24 Alkermes Controlled Therapeutics, Inc. Method of forming microparticles that include a bisphosphonate and a polymer
WO2008128056A1 (en) * 2004-10-08 2008-10-23 The Board Of Trustees Of The University Of Illinois Bisphosphonate compounds and methods with enhanced potency for multiple targets including fpps, ggpps, and dpps
EP1802641B8 (de) * 2004-10-08 2012-03-07 The Board Of Trustees Of The University Of Illinois Bisphosphonatverbindungen und -verfahren für knochenschwundkrankheiten, krebs, knochenschmerzen, immunstörungen und infektionskrankheiten
WO2007109585A2 (en) * 2006-03-17 2007-09-27 The Board Of Trustees Of The University Of Illinois Bisphosphonate compounds and methods
US7214818B2 (en) 2004-10-29 2007-05-08 Hoffmann-La Roche Inc. Method for synthesizing bisphosphonate
PL199215B1 (pl) * 2004-12-28 2008-08-29 Politechnika Gdanska Sposób wytwarzania kwasu [1-hydroksy-2-(3-pirydylo)etylidenobisfosfonowego] oraz jego soli monosodowej dwu i pół wodnej
WO2006129056A2 (en) * 2005-05-28 2006-12-07 Pliva Hrvatska D.O.O Process and novel salt
WO2006134603A1 (en) 2005-06-13 2006-12-21 Jubilant Organosys Limited Process for producing bisphosphonic acids and forms thereof
EP1775302A1 (de) 2005-10-11 2007-04-18 Sandoz A/S Methode zur Herstellung von kristallinem Natriumrisedronat
KR100860666B1 (ko) 2006-01-06 2008-09-26 삼성전자주식회사 통신 시스템에서 신호 수신 장치 및 방법
JP5354858B2 (ja) * 2006-05-09 2013-11-27 株式会社Adeka スルホンアミド化合物の金属塩を含有するポリエステル樹脂組成物
WO2007132478A2 (en) 2006-05-11 2007-11-22 Ind-Swift Laboratories Limited Process for the preparation of pure risedronic acid or salts
US7662990B2 (en) 2007-04-11 2010-02-16 Hoffmann-La Roche Inc. Process for preparing ibandronate
US20100317859A1 (en) * 2007-05-16 2010-12-16 Actavis Group Ptc Ehf Process for the Preparation of Risedronate Sodium
WO2009050731A2 (en) * 2007-06-20 2009-04-23 Alkem Laboratories Ltd Novel process for preparing risedronic acid
KR100877667B1 (ko) * 2007-06-28 2009-01-08 보령제약 주식회사 리세드로네이트의 제조 방법
JP2011515535A (ja) * 2008-03-17 2011-05-19 キャボット コーポレイション リン酸塩遊離が低減した改質顔料、ならびにそれからの分散体およびインクジェットインク組成物
JP5258370B2 (ja) * 2008-05-08 2013-08-07 ダイト株式会社 リセドロン酸の工業的製造方法
CA2775004A1 (en) 2009-10-02 2011-04-07 Straitmark Holding Ag Method for the manufacture of aminohydroxy diphosphonic acids

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Also Published As

Publication number Publication date
AU784385B2 (en) 2006-03-23
AU3661301A (en) 2001-08-14
US6562974B2 (en) 2003-05-13
CN1223598C (zh) 2005-10-19
CA2399974A1 (en) 2001-08-09
CN1396925A (zh) 2003-02-12
NO330273B1 (no) 2011-03-14
CZ304038B6 (cs) 2013-09-04
NO20023646D0 (no) 2002-07-31
SK10992002A3 (sk) 2003-02-04
EP1252169A1 (de) 2002-10-30
PL357116A1 (en) 2004-07-12
JP4534185B2 (ja) 2010-09-01
RU2002123362A (ru) 2004-01-10
NO20023646L (no) 2002-09-30
CO5430222A1 (es) 2004-06-01
BRPI0107952B1 (pt) 2015-09-01
KR100681740B1 (ko) 2007-02-15
MXPA02007418A (es) 2002-12-09
NZ519967A (en) 2004-05-28
JP2003522181A (ja) 2003-07-22
DE60103851T2 (de) 2005-06-23
BR0107952A (pt) 2003-02-25
CA2399974C (en) 2005-08-16
HK1051045A1 (zh) 2003-07-18
ATE269343T1 (de) 2004-07-15
ES2221887T3 (es) 2005-01-16
KR20020063622A (ko) 2002-08-03
BRPI0107952B8 (pt) 2021-05-25
HUP0300890A2 (hu) 2003-08-28
PE20011065A1 (es) 2001-11-21
IL150512A (en) 2006-10-31
HUP0300890A3 (en) 2009-01-28
PT1252169E (pt) 2004-11-30
HU228980B1 (en) 2013-07-29
WO2001057052A1 (en) 2001-08-09
DK1252169T3 (da) 2004-10-25
TR200402317T4 (tr) 2004-12-21
US20010041690A1 (en) 2001-11-15
PL207617B1 (pl) 2011-01-31
EP1252169B1 (de) 2004-06-16
IL150512A0 (en) 2003-02-12

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Owner name: WARNER CHILCOTT COMPANY, LLC, FAJARDO, P.R., US