NO330055B1 - Karbamatforbindelser til anvendelse for fremstilling av et medikament for forebygging eller terapi av neuropatisk smerte samt cluster- og migrenehodepineassosiert smerte - Google Patents
Karbamatforbindelser til anvendelse for fremstilling av et medikament for forebygging eller terapi av neuropatisk smerte samt cluster- og migrenehodepineassosiert smerte Download PDFInfo
- Publication number
- NO330055B1 NO330055B1 NO20030299A NO20030299A NO330055B1 NO 330055 B1 NO330055 B1 NO 330055B1 NO 20030299 A NO20030299 A NO 20030299A NO 20030299 A NO20030299 A NO 20030299A NO 330055 B1 NO330055 B1 NO 330055B1
- Authority
- NO
- Norway
- Prior art keywords
- enantiomer
- formula
- alkyl
- enantiomers
- pain
- Prior art date
Links
- 208000002193 Pain Diseases 0.000 title claims abstract description 47
- 230000036407 pain Effects 0.000 title claims abstract description 45
- 208000004296 neuralgia Diseases 0.000 title claims abstract description 36
- 208000021722 neuropathic pain Diseases 0.000 title claims abstract description 36
- 208000019695 Migraine disease Diseases 0.000 title claims abstract description 29
- 206010027599 migraine Diseases 0.000 title claims abstract description 29
- 208000006561 Cluster Headache Diseases 0.000 title claims abstract description 26
- 208000018912 cluster headache syndrome Diseases 0.000 title claims abstract description 26
- 238000002560 therapeutic procedure Methods 0.000 title claims description 22
- 239000003814 drug Substances 0.000 title claims description 20
- 230000002265 prevention Effects 0.000 title claims description 19
- 238000004519 manufacturing process Methods 0.000 title claims description 9
- 150000004657 carbamic acid derivatives Chemical class 0.000 title description 4
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims abstract description 52
- 239000000203 mixture Substances 0.000 claims abstract description 37
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 27
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 19
- 239000001257 hydrogen Substances 0.000 claims abstract description 19
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract description 16
- 125000001424 substituent group Chemical group 0.000 claims abstract description 12
- 229910052736 halogen Inorganic materials 0.000 claims abstract description 10
- 150000002367 halogens Chemical group 0.000 claims abstract description 10
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims abstract description 10
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims abstract description 10
- 229910052801 chlorine Inorganic materials 0.000 claims abstract description 9
- 239000000460 chlorine Substances 0.000 claims abstract description 9
- 125000004093 cyano group Chemical group *C#N 0.000 claims abstract description 9
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims abstract description 7
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims abstract description 7
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims abstract description 7
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims abstract description 7
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims abstract description 7
- 229910052794 bromium Inorganic materials 0.000 claims abstract description 7
- 229910052731 fluorine Inorganic materials 0.000 claims abstract description 7
- 239000011737 fluorine Substances 0.000 claims abstract description 7
- 125000005843 halogen group Chemical group 0.000 claims abstract description 7
- 229910052740 iodine Inorganic materials 0.000 claims abstract description 6
- 239000011630 iodine Substances 0.000 claims abstract description 6
- 125000000217 alkyl group Chemical group 0.000 claims description 31
- 125000003545 alkoxy group Chemical group 0.000 claims description 7
- 238000000034 method Methods 0.000 abstract description 12
- 150000002431 hydrogen Chemical group 0.000 abstract description 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
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- 235000019483 Peanut oil Nutrition 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- QGMRQYFBGABWDR-UHFFFAOYSA-M Pentobarbital sodium Chemical compound [Na+].CCCC(C)C1(CC)C(=O)NC(=O)[N-]C1=O QGMRQYFBGABWDR-UHFFFAOYSA-M 0.000 description 1
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- VREFGVBLTWBCJP-UHFFFAOYSA-N alprazolam Chemical compound C12=CC(Cl)=CC=C2N2C(C)=NN=C2CN=C1C1=CC=CC=C1 VREFGVBLTWBCJP-UHFFFAOYSA-N 0.000 description 1
- 150000001412 amines Chemical group 0.000 description 1
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- MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
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- RGCLLPNLLBQHPF-HJWRWDBZSA-N phosphamidon Chemical compound CCN(CC)C(=O)C(\Cl)=C(/C)OP(=O)(OC)OC RGCLLPNLLBQHPF-HJWRWDBZSA-N 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
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- OANVFVBYPNXRLD-UHFFFAOYSA-M propyromazine bromide Chemical compound [Br-].C12=CC=CC=C2SC2=CC=CC=C2N1C(=O)C(C)[N+]1(C)CCCC1 OANVFVBYPNXRLD-UHFFFAOYSA-M 0.000 description 1
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- 235000011803 sesame oil Nutrition 0.000 description 1
- AEQFSUDEHCCHBT-UHFFFAOYSA-M sodium valproate Chemical compound [Na+].CCCC(C([O-])=O)CCC AEQFSUDEHCCHBT-UHFFFAOYSA-M 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21965700P | 2000-07-21 | 2000-07-21 | |
| PCT/US2001/022322 WO2002007822A2 (en) | 2000-07-21 | 2001-07-16 | Carbamate compounds for use in preventing or treating neuropathic pain and cluster and migraine headache-associated pain |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20030299D0 NO20030299D0 (no) | 2003-01-20 |
| NO20030299L NO20030299L (no) | 2003-03-12 |
| NO330055B1 true NO330055B1 (no) | 2011-02-14 |
Family
ID=22820176
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20030299A NO330055B1 (no) | 2000-07-21 | 2003-01-20 | Karbamatforbindelser til anvendelse for fremstilling av et medikament for forebygging eller terapi av neuropatisk smerte samt cluster- og migrenehodepineassosiert smerte |
Country Status (28)
| Country | Link |
|---|---|
| US (4) | US20020107283A1 (ja) |
| EP (1) | EP1305082B1 (ja) |
| JP (1) | JP5271473B2 (ja) |
| KR (1) | KR100792814B1 (ja) |
| CN (1) | CN1250213C (ja) |
| AT (1) | ATE267629T1 (ja) |
| AU (2) | AU7349301A (ja) |
| BG (1) | BG107529A (ja) |
| BR (1) | BR0112713A (ja) |
| CA (1) | CA2416819C (ja) |
| CZ (1) | CZ2003445A3 (ja) |
| DE (1) | DE60103546T2 (ja) |
| DK (1) | DK1305082T3 (ja) |
| EA (1) | EA005648B1 (ja) |
| ES (1) | ES2221651T3 (ja) |
| HU (1) | HUP0302940A3 (ja) |
| IL (2) | IL154052A0 (ja) |
| MX (1) | MXPA03000619A (ja) |
| MY (1) | MY127317A (ja) |
| NO (1) | NO330055B1 (ja) |
| NZ (1) | NZ523851A (ja) |
| PL (1) | PL365701A1 (ja) |
| PT (1) | PT1305082E (ja) |
| SK (1) | SK1962003A3 (ja) |
| TR (1) | TR200401511T4 (ja) |
| UA (1) | UA74195C2 (ja) |
| WO (1) | WO2002007822A2 (ja) |
| ZA (1) | ZA200301403B (ja) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2283106C2 (ru) | 2001-02-27 | 2006-09-10 | Орто-Макнейл Фармасьютикал, Инк. | Производные карбаматов для использования для лечения боли |
| PT1408954E (pt) | 2001-07-16 | 2009-07-28 | Ortho Mcneil Janssen Pharm | Compostos carbamatos para utilização na prevenção ou tratamento da dor neuropática |
| DE60217493T2 (de) * | 2001-07-16 | 2007-11-15 | Ortho-Mcneil Pharmaceutical, Inc. | Verwendung von carbamat-verbindungen zur prävention oder behandlung von neuropathischen schmerzen und migräneartigen kopfschmerzen |
| US20040087642A1 (en) * | 2002-10-24 | 2004-05-06 | Zeldis Jerome B. | Methods of using and compositions comprising a JNK inhibitor for the treatment, prevention, management and/or modification of pain |
| WO2004054608A2 (en) * | 2002-12-12 | 2004-07-01 | Agennix Incorporated | Lactoferrin in the reduction of pain |
| US7183381B2 (en) * | 2004-10-26 | 2007-02-27 | Agennix, Inc. | Composition of lactoferrin related peptides and uses thereof |
| US7846968B2 (en) * | 2005-01-20 | 2010-12-07 | Janssen Pharmaceutica, N.V. | Methods for QT interval control |
| KR101541383B1 (ko) | 2006-03-30 | 2015-08-03 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 면역원성 조성물 |
| WO2008063284A2 (en) * | 2006-10-10 | 2008-05-29 | Janssen Pharmaceutica Nv | Novel crystal of (s)-(+)-2-(2-chlorophenyl)-2-hydroxy-ethyl carbamate |
| US8609849B1 (en) | 2010-11-30 | 2013-12-17 | Fox Chase Chemical Diversity Center, Inc. | Hydroxylated sulfamides exhibiting neuroprotective action and their method of use |
| US20150057351A1 (en) * | 2013-08-22 | 2015-02-26 | Sucampo Ag | Method for treating neuropathic pain |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3278380A (en) * | 1962-02-06 | 1966-10-11 | Armour Pharma | Methods of calming employing diphenyl hydroxy carbamate compounds |
| US3265728A (en) * | 1962-07-18 | 1966-08-09 | Armour Pharma | Substituted phenethyl carbamates |
| HU191549B (en) * | 1984-04-11 | 1987-03-30 | Richter Gedeon Vegyeszet | Process for producing 1-/6-/2 comma above-substituted-5 comma above, 6 comma above, 7 comma above, 8 comma above-tetrahydro-4 comma above-oxo-quinazolino//-3,4-dihydro-6,7-disubstituted-isoquinoline derivatives |
| US4868190A (en) * | 1988-12-27 | 1989-09-19 | Hoechst-Roussel Pharmaceuticals, Inc. | N-pyridinyl-9H-carbazol-9-amines |
| GB9518027D0 (en) * | 1995-09-05 | 1995-11-08 | Wellcome Found | Pharmacologically active compound |
| US5698588A (en) * | 1996-01-16 | 1997-12-16 | Yukong Limited | Halogen substituted carbamate compounds from 2-phenyl-1,2-ethanediol |
| PL337234A1 (en) * | 1997-06-05 | 2000-08-14 | Sanofi Synthelabo | Derivatives of 5-naphtalen-1-yl-1,3-dioxane, their production and therapeutic application |
| ATE324108T1 (de) * | 2001-02-27 | 2006-05-15 | Ortho Mcneil Pharm Inc | Carbamatverbindungen zur verwendung bei der prävention oder behandlung der bipolaren erkrankung |
| PT1401424E (pt) * | 2001-02-27 | 2007-02-28 | Ortho Mcneil Pharm Inc | Compostos carbamato para utilização na prevenção ou tratamento de distúrbios psicóticos |
| CN1262272C (zh) * | 2001-02-27 | 2006-07-05 | 奥索-麦克尼尔药品公司 | 用于预防或治疗运动障碍的氨基甲酸酯化合物 |
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2001
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- 2001-07-16 CZ CZ2003445A patent/CZ2003445A3/cs unknown
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- 2001-07-16 DE DE60103546T patent/DE60103546T2/de not_active Expired - Lifetime
- 2001-07-16 NZ NZ523851A patent/NZ523851A/en unknown
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- 2001-07-16 WO PCT/US2001/022322 patent/WO2002007822A2/en active IP Right Grant
- 2001-07-16 KR KR1020037000914A patent/KR100792814B1/ko active IP Right Grant
- 2001-07-16 UA UA2003010559A patent/UA74195C2/uk unknown
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- 2001-07-16 MX MXPA03000619A patent/MXPA03000619A/es active IP Right Grant
- 2001-07-16 EA EA200300042A patent/EA005648B1/ru not_active IP Right Cessation
- 2001-07-16 DK DK01952773T patent/DK1305082T3/da active
- 2001-07-16 AU AU7349301A patent/AU7349301A/xx active Pending
- 2001-07-16 AT AT01952773T patent/ATE267629T1/de not_active IP Right Cessation
- 2001-07-16 JP JP2002513552A patent/JP5271473B2/ja not_active Expired - Lifetime
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- 2001-07-16 ES ES01952773T patent/ES2221651T3/es not_active Expired - Lifetime
- 2001-07-16 US US09/906,251 patent/US20020107283A1/en not_active Abandoned
- 2001-07-16 SK SK196-2003A patent/SK1962003A3/sk unknown
- 2001-07-16 AU AU2001273493A patent/AU2001273493B2/en not_active Ceased
- 2001-07-16 PL PL01365701A patent/PL365701A1/xx not_active Application Discontinuation
- 2001-07-16 CN CNB01815798XA patent/CN1250213C/zh not_active Expired - Fee Related
- 2001-07-16 BR BR0112713-6A patent/BR0112713A/pt not_active Application Discontinuation
- 2001-07-16 EP EP01952773A patent/EP1305082B1/en not_active Expired - Lifetime
- 2001-07-20 MY MYPI20013443 patent/MY127317A/en unknown
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2003
- 2003-01-20 NO NO20030299A patent/NO330055B1/no not_active IP Right Cessation
- 2003-01-20 IL IL154052A patent/IL154052A/en unknown
- 2003-02-05 BG BG107529A patent/BG107529A/bg unknown
- 2003-02-20 ZA ZA200301403A patent/ZA200301403B/en unknown
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2004
- 2004-06-15 US US10/868,633 patent/US20040266866A1/en not_active Abandoned
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2005
- 2005-02-18 US US11/194,876 patent/US20060183795A1/en not_active Abandoned
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2009
- 2009-07-20 US US12/505,765 patent/US20090281179A1/en not_active Abandoned
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