EA200300042A1 - Карбаматные соединения для использования при предотвращении или лечении невропатической боли и гистаминовой головной боли и головной боли, связанной с мигренью - Google Patents
Карбаматные соединения для использования при предотвращении или лечении невропатической боли и гистаминовой головной боли и головной боли, связанной с мигреньюInfo
- Publication number
- EA200300042A1 EA200300042A1 EA200300042A EA200300042A EA200300042A1 EA 200300042 A1 EA200300042 A1 EA 200300042A1 EA 200300042 A EA200300042 A EA 200300042A EA 200300042 A EA200300042 A EA 200300042A EA 200300042 A1 EA200300042 A1 EA 200300042A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- headache
- migraine
- neuropathic pain
- phenyl
- alkyl
- Prior art date
Links
- 206010019233 Headaches Diseases 0.000 title abstract 2
- 208000019695 Migraine disease Diseases 0.000 title abstract 2
- 208000018912 cluster headache syndrome Diseases 0.000 title abstract 2
- 231100000869 headache Toxicity 0.000 title abstract 2
- 206010027599 migraine Diseases 0.000 title abstract 2
- 208000004296 neuralgia Diseases 0.000 title abstract 2
- 208000021722 neuropathic pain Diseases 0.000 title abstract 2
- AFCCDDWKHLHPDF-UHFFFAOYSA-M metam-sodium Chemical compound [Na+].CNC([S-])=S AFCCDDWKHLHPDF-UHFFFAOYSA-M 0.000 title 1
- 230000002265 prevention Effects 0.000 title 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- MPVDXIMFBOLMNW-UHFFFAOYSA-N chembl1615565 Chemical compound OC1=CC=C2C=C(S(O)(=O)=O)C=C(S(O)(=O)=O)C2=C1N=NC1=CC=CC=C1 MPVDXIMFBOLMNW-UHFFFAOYSA-N 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 239000011630 iodine Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Настоящее изобретение относится к способу предотвращения или лечения невропатической боли и гистаминовой головной боли и головной боли, связанной с мигренью, включающему введение субъекту, нуждающемуся в этом, терапевтически эффективного количества энантиомера формулы (I), по существу, свободного от других энантиомеров, или энантиомерной смеси, где энантиомер формулы (I) преобладает (см. формулу), где фенил замещен от одного до пяти заместителями X, которые представляют из себя атомы галогена, независимо выбранные из группы, состоящей из фтора, хлора, брома и йода; и Rи Rявляются независимо выбранными из группы, состоящей из водорода и C-Cалкила; где C-Cалкил необязательно замещен фенилом, где фенил необязательно замещен заместителями, независимо выбранными из группы, состоящей из водорода, галогена, C-Cалкила, C-Cалкокси, амино, нитро и циан.Отчет о международном поиске был опубликован 2002.05.30
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21965700P | 2000-07-21 | 2000-07-21 | |
PCT/US2001/022322 WO2002007822A2 (en) | 2000-07-21 | 2001-07-16 | Carbamate compounds for use in preventing or treating neuropathic pain and cluster and migraine headache-associated pain |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200300042A1 true EA200300042A1 (ru) | 2003-06-26 |
EA005648B1 EA005648B1 (ru) | 2005-04-28 |
Family
ID=22820176
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200300042A EA005648B1 (ru) | 2000-07-21 | 2001-07-16 | Карбаматные соединения для использования при предотвращении или лечении невропатической боли, гистаминовой головной боли и головной боли, связанной с мигренью |
Country Status (28)
Country | Link |
---|---|
US (4) | US20020107283A1 (ru) |
EP (1) | EP1305082B1 (ru) |
JP (1) | JP5271473B2 (ru) |
KR (1) | KR100792814B1 (ru) |
CN (1) | CN1250213C (ru) |
AT (1) | ATE267629T1 (ru) |
AU (2) | AU2001273493B2 (ru) |
BG (1) | BG107529A (ru) |
BR (1) | BR0112713A (ru) |
CA (1) | CA2416819C (ru) |
CZ (1) | CZ2003445A3 (ru) |
DE (1) | DE60103546T2 (ru) |
DK (1) | DK1305082T3 (ru) |
EA (1) | EA005648B1 (ru) |
ES (1) | ES2221651T3 (ru) |
HU (1) | HUP0302940A3 (ru) |
IL (2) | IL154052A0 (ru) |
MX (1) | MXPA03000619A (ru) |
MY (1) | MY127317A (ru) |
NO (1) | NO330055B1 (ru) |
NZ (1) | NZ523851A (ru) |
PL (1) | PL365701A1 (ru) |
PT (1) | PT1305082E (ru) |
SK (1) | SK1962003A3 (ru) |
TR (1) | TR200401511T4 (ru) |
UA (1) | UA74195C2 (ru) |
WO (1) | WO2002007822A2 (ru) |
ZA (1) | ZA200301403B (ru) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RS67603A (en) | 2001-02-27 | 2007-02-05 | Ortho-Mcneil Pharmaceutical Inc., | Carbamate compounds for use in the treatment of pain |
KR20040016994A (ko) | 2001-07-16 | 2004-02-25 | 오르토-맥네일 파마슈티칼, 인코퍼레이티드 | 신경병증 통증 및 군발성 및 편두통성 두통-관련 통증의예방 또는 치료를 위해 사용하기 위한 카바메이트 화합물 |
BR0211240A (pt) * | 2001-07-16 | 2004-07-27 | Ortho Mcneil Pharm Inc | Compostos de carbamato para uso na prevenção ou tratamento de dor neuropática e dor associada à cefaléia em cacho e hemicrânia |
US20040087642A1 (en) * | 2002-10-24 | 2004-05-06 | Zeldis Jerome B. | Methods of using and compositions comprising a JNK inhibitor for the treatment, prevention, management and/or modification of pain |
US7323443B2 (en) * | 2002-12-12 | 2008-01-29 | Agennix Inc. | Lactoferrin in the reduction of pain |
US7183381B2 (en) * | 2004-10-26 | 2007-02-27 | Agennix, Inc. | Composition of lactoferrin related peptides and uses thereof |
MX2007008845A (es) * | 2005-01-20 | 2007-11-08 | Johnson & Johnson | Metodos para control del intervalo qt. |
EP2476433A1 (en) | 2006-03-30 | 2012-07-18 | GlaxoSmithKline Biologicals S.A. | Immunogenic composition |
US20080194860A1 (en) * | 2006-10-10 | 2008-08-14 | Transform Pharmaceuticals, Inc. | Novel crystal of (s)-(+)-2-(2-chlorophenyl)-2-hydroxy-ethyl carbamate |
US8609849B1 (en) | 2010-11-30 | 2013-12-17 | Fox Chase Chemical Diversity Center, Inc. | Hydroxylated sulfamides exhibiting neuroprotective action and their method of use |
US20150057351A1 (en) * | 2013-08-22 | 2015-02-26 | Sucampo Ag | Method for treating neuropathic pain |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3278380A (en) * | 1962-02-06 | 1966-10-11 | Armour Pharma | Methods of calming employing diphenyl hydroxy carbamate compounds |
US3265728A (en) * | 1962-07-18 | 1966-08-09 | Armour Pharma | Substituted phenethyl carbamates |
HU191549B (en) * | 1984-04-11 | 1987-03-30 | Richter Gedeon Vegyeszet | Process for producing 1-/6-/2 comma above-substituted-5 comma above, 6 comma above, 7 comma above, 8 comma above-tetrahydro-4 comma above-oxo-quinazolino//-3,4-dihydro-6,7-disubstituted-isoquinoline derivatives |
US4868190A (en) * | 1988-12-27 | 1989-09-19 | Hoechst-Roussel Pharmaceuticals, Inc. | N-pyridinyl-9H-carbazol-9-amines |
GB9518027D0 (en) * | 1995-09-05 | 1995-11-08 | Wellcome Found | Pharmacologically active compound |
US5698588A (en) * | 1996-01-16 | 1997-12-16 | Yukong Limited | Halogen substituted carbamate compounds from 2-phenyl-1,2-ethanediol |
AU8025198A (en) * | 1997-06-05 | 1998-12-21 | Sanofi-Synthelabo | 5-naphthalen-1-yl-1,3-dioxane derivatives, preparation and therapeutic application |
KR100946944B1 (ko) * | 2001-02-27 | 2010-03-15 | 오르토-맥네일 파마슈티칼, 인코퍼레이티드 | 양극성 장애의 예방 또는 치료용 카바메이트 화합물 |
JP4276841B2 (ja) * | 2001-02-27 | 2009-06-10 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | 精神病性障害の予防もしくは治療における使用のためのカルバメート化合物 |
CN1262272C (zh) * | 2001-02-27 | 2006-07-05 | 奥索-麦克尼尔药品公司 | 用于预防或治疗运动障碍的氨基甲酸酯化合物 |
-
2001
- 2001-07-16 WO PCT/US2001/022322 patent/WO2002007822A2/en active IP Right Grant
- 2001-07-16 AU AU2001273493A patent/AU2001273493B2/en not_active Ceased
- 2001-07-16 UA UA2003010559A patent/UA74195C2/ru unknown
- 2001-07-16 CZ CZ2003445A patent/CZ2003445A3/cs unknown
- 2001-07-16 EA EA200300042A patent/EA005648B1/ru not_active IP Right Cessation
- 2001-07-16 NZ NZ523851A patent/NZ523851A/en unknown
- 2001-07-16 PL PL01365701A patent/PL365701A1/xx not_active Application Discontinuation
- 2001-07-16 AT AT01952773T patent/ATE267629T1/de not_active IP Right Cessation
- 2001-07-16 US US09/906,251 patent/US20020107283A1/en not_active Abandoned
- 2001-07-16 DE DE60103546T patent/DE60103546T2/de not_active Expired - Lifetime
- 2001-07-16 HU HU0302940A patent/HUP0302940A3/hu unknown
- 2001-07-16 KR KR1020037000914A patent/KR100792814B1/ko active IP Right Grant
- 2001-07-16 TR TR2004/01511T patent/TR200401511T4/xx unknown
- 2001-07-16 EP EP01952773A patent/EP1305082B1/en not_active Expired - Lifetime
- 2001-07-16 BR BR0112713-6A patent/BR0112713A/pt not_active Application Discontinuation
- 2001-07-16 CA CA2416819A patent/CA2416819C/en not_active Expired - Fee Related
- 2001-07-16 SK SK196-2003A patent/SK1962003A3/sk unknown
- 2001-07-16 AU AU7349301A patent/AU7349301A/xx active Pending
- 2001-07-16 MX MXPA03000619A patent/MXPA03000619A/es active IP Right Grant
- 2001-07-16 JP JP2002513552A patent/JP5271473B2/ja not_active Expired - Lifetime
- 2001-07-16 DK DK01952773T patent/DK1305082T3/da active
- 2001-07-16 ES ES01952773T patent/ES2221651T3/es not_active Expired - Lifetime
- 2001-07-16 PT PT01952773T patent/PT1305082E/pt unknown
- 2001-07-16 IL IL15405201A patent/IL154052A0/xx unknown
- 2001-07-16 CN CNB01815798XA patent/CN1250213C/zh not_active Expired - Fee Related
- 2001-07-20 MY MYPI20013443 patent/MY127317A/en unknown
-
2003
- 2003-01-20 NO NO20030299A patent/NO330055B1/no not_active IP Right Cessation
- 2003-01-20 IL IL154052A patent/IL154052A/en unknown
- 2003-02-05 BG BG107529A patent/BG107529A/bg unknown
- 2003-02-20 ZA ZA200301403A patent/ZA200301403B/en unknown
-
2004
- 2004-06-15 US US10/868,633 patent/US20040266866A1/en not_active Abandoned
-
2005
- 2005-02-18 US US11/194,876 patent/US20060183795A1/en not_active Abandoned
-
2009
- 2009-07-20 US US12/505,765 patent/US20090281179A1/en not_active Abandoned
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM |
|
PD4A | Registration of transfer of a eurasian patent in accordance with the succession in title | ||
TC4A | Change in name of a patent proprietor in a eurasian patent | ||
PC4A | Registration of transfer of a eurasian patent by assignment | ||
MK4A | Patent expired |
Designated state(s): RU |