NO329071B1 - Faste, hurtig desintegrerende cetirizin-formuleringer - Google Patents
Faste, hurtig desintegrerende cetirizin-formuleringer Download PDFInfo
- Publication number
- NO329071B1 NO329071B1 NO20004722A NO20004722A NO329071B1 NO 329071 B1 NO329071 B1 NO 329071B1 NO 20004722 A NO20004722 A NO 20004722A NO 20004722 A NO20004722 A NO 20004722A NO 329071 B1 NO329071 B1 NO 329071B1
- Authority
- NO
- Norway
- Prior art keywords
- soda
- formulations according
- acid
- base
- cetirizine
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims description 36
- ZKLPARSLTMPFCP-UHFFFAOYSA-N Cetirizine Chemical compound C1CN(CCOCC(=O)O)CCN1C(C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 ZKLPARSLTMPFCP-UHFFFAOYSA-N 0.000 title claims description 27
- 238000009472 formulation Methods 0.000 title claims description 27
- 229960001803 cetirizine Drugs 0.000 title claims description 25
- 239000007787 solid Substances 0.000 title claims description 9
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 42
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 33
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 20
- 239000002585 base Substances 0.000 claims description 15
- 239000002253 acid Substances 0.000 claims description 12
- 150000003839 salts Chemical class 0.000 claims description 12
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 10
- 229910052784 alkaline earth metal Inorganic materials 0.000 claims description 9
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 9
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 claims description 8
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 7
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims description 6
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 6
- 235000014214 soft drink Nutrition 0.000 claims description 6
- 239000000126 substance Substances 0.000 claims description 6
- -1 alkaline earth metal carbonates Chemical class 0.000 claims description 5
- 239000008187 granular material Substances 0.000 claims description 5
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 4
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 4
- 239000001361 adipic acid Substances 0.000 claims description 4
- 239000003513 alkali Substances 0.000 claims description 4
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 4
- 239000001630 malic acid Substances 0.000 claims description 4
- 239000011975 tartaric acid Substances 0.000 claims description 4
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 4
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical class OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 claims description 3
- HFVMEOPYDLEHBR-UHFFFAOYSA-N (2-fluorophenyl)-phenylmethanol Chemical compound C=1C=CC=C(F)C=1C(O)C1=CC=CC=C1 HFVMEOPYDLEHBR-UHFFFAOYSA-N 0.000 claims description 2
- QISOBCMNUJQOJU-UHFFFAOYSA-N 4-bromo-1h-pyrazole-5-carboxylic acid Chemical compound OC(=O)C=1NN=CC=1Br QISOBCMNUJQOJU-UHFFFAOYSA-N 0.000 claims description 2
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 claims description 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Natural products OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 2
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims description 2
- 235000011037 adipic acid Nutrition 0.000 claims description 2
- 239000011668 ascorbic acid Substances 0.000 claims description 2
- 229910001424 calcium ion Inorganic materials 0.000 claims description 2
- 239000001530 fumaric acid Substances 0.000 claims description 2
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims description 2
- 239000011976 maleic acid Substances 0.000 claims description 2
- 229940124531 pharmaceutical excipient Drugs 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 239000000377 silicon dioxide Substances 0.000 claims description 2
- 235000012239 silicon dioxide Nutrition 0.000 claims description 2
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 2
- 239000004299 sodium benzoate Substances 0.000 claims description 2
- 235000010234 sodium benzoate Nutrition 0.000 claims description 2
- 239000001384 succinic acid Substances 0.000 claims description 2
- 235000002906 tartaric acid Nutrition 0.000 claims description 2
- 239000003826 tablet Substances 0.000 description 14
- 239000004480 active ingredient Substances 0.000 description 12
- 235000019658 bitter taste Nutrition 0.000 description 8
- 238000002360 preparation method Methods 0.000 description 8
- 239000000243 solution Substances 0.000 description 8
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 6
- 235000019640 taste Nutrition 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 5
- 229910052791 calcium Inorganic materials 0.000 description 5
- 239000011575 calcium Substances 0.000 description 5
- 230000000873 masking effect Effects 0.000 description 5
- 150000007524 organic acids Chemical class 0.000 description 5
- 238000000034 method Methods 0.000 description 4
- 235000017557 sodium bicarbonate Nutrition 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000007937 lozenge Substances 0.000 description 3
- 210000000214 mouth Anatomy 0.000 description 3
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 3
- 208000019698 Cutaneous collagenous vasculopathy Diseases 0.000 description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 150000001720 carbohydrates Chemical class 0.000 description 2
- 235000014633 carbohydrates Nutrition 0.000 description 2
- 201000009911 cataract 8 multiple types Diseases 0.000 description 2
- 229960004342 cetirizine hydrochloride Drugs 0.000 description 2
- 239000007910 chewable tablet Substances 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 235000011090 malic acid Nutrition 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 235000010755 mineral Nutrition 0.000 description 2
- 235000005985 organic acids Nutrition 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
- 239000000600 sorbitol Substances 0.000 description 2
- 230000009747 swallowing Effects 0.000 description 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
- 239000004135 Bone phosphate Substances 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- 206010013911 Dysgeusia Diseases 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 229910000288 alkali metal carbonate Inorganic materials 0.000 description 1
- 150000008041 alkali metal carbonates Chemical class 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 229940125715 antihistaminic agent Drugs 0.000 description 1
- 239000000739 antihistaminic agent Substances 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 229920002301 cellulose acetate Polymers 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- 235000019262 disodium citrate Nutrition 0.000 description 1
- 239000002526 disodium citrate Substances 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- CEYULKASIQJZGP-UHFFFAOYSA-L disodium;2-(carboxymethyl)-2-hydroxybutanedioate Chemical compound [Na+].[Na+].[O-]C(=O)CC(O)(C(=O)O)CC([O-])=O CEYULKASIQJZGP-UHFFFAOYSA-L 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000007941 film coated tablet Substances 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 229960001680 ibuprofen Drugs 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- 239000013081 microcrystal Substances 0.000 description 1
- XONPDZSGENTBNJ-UHFFFAOYSA-N molecular hydrogen;sodium Chemical compound [Na].[H][H] XONPDZSGENTBNJ-UHFFFAOYSA-N 0.000 description 1
- 235000018342 monosodium citrate Nutrition 0.000 description 1
- 239000002524 monosodium citrate Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 150000007519 polyprotic acids Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000002048 spasmolytic effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- WCTAGTRAWPDFQO-UHFFFAOYSA-K trisodium;hydrogen carbonate;carbonate Chemical compound [Na+].[Na+].[Na+].OC([O-])=O.[O-]C([O-])=O WCTAGTRAWPDFQO-UHFFFAOYSA-K 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19814256A DE19814256A1 (de) | 1998-03-31 | 1998-03-31 | Feste, schnellzerfallende Cetirizin-Formulierungen |
| PCT/DE1999/000799 WO1999049843A1 (de) | 1998-03-31 | 1999-03-20 | Feste, schnellzerfallende cetirizin-formulierungen |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20004722D0 NO20004722D0 (no) | 2000-09-21 |
| NO20004722L NO20004722L (no) | 2000-09-21 |
| NO329071B1 true NO329071B1 (no) | 2010-08-16 |
Family
ID=7863014
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20004722A NO329071B1 (no) | 1998-03-31 | 2000-09-21 | Faste, hurtig desintegrerende cetirizin-formuleringer |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US6245353B1 (zh) |
| EP (1) | EP1067904B1 (zh) |
| JP (1) | JP2002509873A (zh) |
| KR (1) | KR100653568B1 (zh) |
| CN (1) | CN1136838C (zh) |
| AR (1) | AR018828A1 (zh) |
| AT (1) | ATE209899T1 (zh) |
| AU (1) | AU750140B2 (zh) |
| BG (1) | BG64741B1 (zh) |
| BR (1) | BR9909233A (zh) |
| CA (1) | CA2326809C (zh) |
| CY (1) | CY1107331T1 (zh) |
| CZ (1) | CZ300704B6 (zh) |
| DE (2) | DE19814256A1 (zh) |
| DK (1) | DK1067904T3 (zh) |
| ES (1) | ES2168013T3 (zh) |
| HK (1) | HK1036217A1 (zh) |
| HU (1) | HU227477B1 (zh) |
| IL (1) | IL138606A (zh) |
| NO (1) | NO329071B1 (zh) |
| NZ (1) | NZ506988A (zh) |
| PL (1) | PL191266B1 (zh) |
| PT (1) | PT1067904E (zh) |
| RU (1) | RU2216318C2 (zh) |
| SI (1) | SI1067904T1 (zh) |
| SK (1) | SK284476B6 (zh) |
| TR (1) | TR200002809T2 (zh) |
| TW (1) | TWI233808B (zh) |
| UA (1) | UA57615C2 (zh) |
| WO (1) | WO1999049843A1 (zh) |
| ZA (1) | ZA200005134B (zh) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001271055B2 (en) | 2000-07-17 | 2005-07-07 | Astellas Pharma Inc. | Pharmaceutical composition improved in peroral absorbability |
| CN101632642B (zh) * | 2002-01-15 | 2011-06-08 | Ucb法奇姆股份有限公司 | 口感和稳定性改善的配方 |
| RU2004129573A (ru) * | 2002-04-04 | 2005-04-10 | Пфайзер Продактс Инк. (Us) | Жевательная таблетка с приятным вкусом |
| ES2624585T3 (es) | 2004-05-28 | 2017-07-17 | Imaginot Pty Ltd. | Sistema de suministro de compuesto terapéutico oral |
| US8216610B2 (en) | 2004-05-28 | 2012-07-10 | Imaginot Pty Ltd. | Oral paracetamol formulations |
| US8758816B2 (en) * | 2004-11-24 | 2014-06-24 | Meda Pharmaceuticals Inc. | Compositions comprising azelastine and methods of use thereof |
| MX2007006233A (es) | 2004-11-24 | 2007-11-23 | Medpointe Healthcare Inc | Composiciones que comprenden azelastina y metodos de uso de la misma. |
| US20070020330A1 (en) | 2004-11-24 | 2007-01-25 | Medpointe Healthcare Inc. | Compositions comprising azelastine and methods of use thereof |
| US20060198885A1 (en) * | 2005-02-22 | 2006-09-07 | Sun Pharmaceutical Industries Ltd. | Oral pharmaceutical composition |
| JP2009517346A (ja) | 2005-11-28 | 2009-04-30 | イメイジノット ピーティーワイ エルティーディー | 治療用化合物の経口送達系 |
| ES2564056T3 (es) * | 2008-09-05 | 2016-03-17 | Johnson & Johnson Consumer Inc. | Método para hacer pastillas de cetirizina |
| EP2405747A4 (en) * | 2009-03-13 | 2013-01-16 | Nucitec Sa De Cv | COMPOSITIONS AND METHODS FOR TREATMENT AND PREVENTION OF CARDIOVASCULAR DISEASES |
| WO2011146032A2 (en) * | 2010-05-18 | 2011-11-24 | Mahmut Bilgic | Effervescent formulations |
| US20140371174A1 (en) | 2013-06-12 | 2014-12-18 | The Procter & Gamble Company | Effervescent Dosage Form |
| CA2876062C (en) | 2012-06-12 | 2017-09-12 | The Procter & Gamble Company | Effervescent dosage form |
| JP5945191B2 (ja) * | 2012-08-09 | 2016-07-05 | 株式会社ファンケル | 口腔内速崩錠 |
| JP6092672B2 (ja) * | 2013-03-21 | 2017-03-08 | 株式会社ファンケル | 口腔内速崩壊性錠剤 |
| KR101591319B1 (ko) * | 2013-12-03 | 2016-02-18 | 에프엔바이오 주식회사 | 홍삼 발포정의 제조방법 |
| TWI705814B (zh) * | 2014-06-20 | 2020-10-01 | 美商梅琳塔有限責任公司 | 醫藥組成物及其用途 |
| TW201605447A (zh) * | 2014-06-20 | 2016-02-16 | 美林塔治療學有限公司 | 處理感染的方法 |
| EP3061501A1 (en) | 2015-02-27 | 2016-08-31 | Rottapharm Ltd. | Composition for the treatment of acne |
| EP3117825A1 (en) | 2015-07-16 | 2017-01-18 | Rottapharm S.p.A. | Oral formulation comprising berberine and morus alba extract |
| CN106109422A (zh) * | 2016-07-28 | 2016-11-16 | 北京万全德众医药生物技术有限公司 | 盐酸左西替利嗪泡腾颗粒及其制备方法 |
| US10624921B2 (en) | 2016-11-15 | 2020-04-21 | Berkeley Nox Limited | Dietary supplements |
| JP2018108950A (ja) * | 2016-12-28 | 2018-07-12 | 沢井製薬株式会社 | レボセチリジン塩酸塩含有口腔内崩壊錠 |
| WO2019099003A2 (en) * | 2017-11-15 | 2019-05-23 | Berkeley Nox Limited | Novel dietary supplements |
| ES2945809T3 (es) | 2019-10-02 | 2023-07-07 | Intas Pharmaceuticals Ltd | Composiciones farmacéuticas sólidas efervescentes prácticamente sin sodio |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK154078C (da) * | 1981-02-06 | 1989-05-22 | Ucb Sa | Analogifremgangsmaade til fremstilling af 2-(2-(4-(diphenyl-methyl)-1-piperazinyl)ethoxy)-acetamider eller syreadditionssalte heraf |
| US4678661A (en) * | 1983-09-28 | 1987-07-07 | Gerhard Gergely | Effervescent composition and method of making same |
| US4792448A (en) * | 1987-06-11 | 1988-12-20 | Pfizer Inc. | Generic zero order controlled drug delivery system |
| IL91398A (en) * | 1988-08-30 | 1994-05-30 | Pfizer | A device for the controlled release of pneumatic substances, including the active substance, surrounded by an asymmetric membrane |
| US5178878A (en) | 1989-10-02 | 1993-01-12 | Cima Labs, Inc. | Effervescent dosage form with microparticles |
| JPH0794379B2 (ja) * | 1990-08-07 | 1995-10-11 | ファイザー・インコーポレーテッド | 放出製剤における界面重合膜の使用方法 |
| US6525214B1 (en) * | 1991-05-13 | 2003-02-25 | Bernard John Armitage | Therapeutic agent |
| MX9300110A (es) * | 1992-01-13 | 1994-07-29 | Gerhard Gergely | Preparacion farmaceutica en la forma de una tableta de efervescencia o de desintegracion o de un granulado de tipo instanteneo y procedimiento para su preparacion. |
| EP0662840A1 (en) * | 1992-10-09 | 1995-07-19 | The Procter & Gamble Company | Pharmaceutical compositions and methods for treating cold symptoms |
| GB9224021D0 (en) * | 1992-11-16 | 1993-01-06 | Boots Co Plc | Effervescent compositions |
| FR2698788B1 (fr) * | 1992-12-09 | 1995-03-03 | Union Pharma Scient Appl | Composition pharmaceutique effervescente contenant de l'ibuprofène et son procédé de préparation. |
| TW401300B (en) * | 1992-12-25 | 2000-08-11 | Senju Pharma Co | Antiallergic composition for ophthalmic or nasal use |
| ES2091654T3 (es) * | 1993-04-15 | 1996-11-01 | Gergely Gerhard | Sistema efervescente que contiene un ingrediente activo farmaceutico sensible a alcalis y/o metales, y procedimiento para su produccion. |
| EP0695175A1 (en) * | 1993-04-30 | 1996-02-07 | The Procter & Gamble Company | Coated pharmaceutical compositions |
| US5458879A (en) * | 1994-03-03 | 1995-10-17 | The Procter & Gamble Company | Oral vehicle compositions |
-
1998
- 1998-03-31 DE DE19814256A patent/DE19814256A1/de not_active Withdrawn
-
1999
- 1999-03-20 PT PT99922050T patent/PT1067904E/pt unknown
- 1999-03-20 JP JP2000540809A patent/JP2002509873A/ja active Pending
- 1999-03-20 DK DK99922050T patent/DK1067904T3/da active
- 1999-03-20 EP EP99922050A patent/EP1067904B1/de not_active Expired - Lifetime
- 1999-03-20 AT AT99922050T patent/ATE209899T1/de active
- 1999-03-20 IL IL13860699A patent/IL138606A/xx not_active IP Right Cessation
- 1999-03-20 HU HU0102676A patent/HU227477B1/hu not_active IP Right Cessation
- 1999-03-20 TR TR2000/02809T patent/TR200002809T2/xx unknown
- 1999-03-20 CA CA002326809A patent/CA2326809C/en not_active Expired - Fee Related
- 1999-03-20 UA UA2000106082A patent/UA57615C2/uk unknown
- 1999-03-20 SI SI9930029T patent/SI1067904T1/xx unknown
- 1999-03-20 BR BR9909233-6A patent/BR9909233A/pt not_active Application Discontinuation
- 1999-03-20 DE DE59900501T patent/DE59900501D1/de not_active Expired - Lifetime
- 1999-03-20 CZ CZ20003481A patent/CZ300704B6/cs not_active IP Right Cessation
- 1999-03-20 SK SK1431-2000A patent/SK284476B6/sk not_active IP Right Cessation
- 1999-03-20 AU AU39253/99A patent/AU750140B2/en not_active Ceased
- 1999-03-20 PL PL343199A patent/PL191266B1/pl unknown
- 1999-03-20 CN CNB998046736A patent/CN1136838C/zh not_active Expired - Fee Related
- 1999-03-20 ES ES99922050T patent/ES2168013T3/es not_active Expired - Lifetime
- 1999-03-20 NZ NZ506988A patent/NZ506988A/en unknown
- 1999-03-20 RU RU2000127709/14A patent/RU2216318C2/ru not_active IP Right Cessation
- 1999-03-20 WO PCT/DE1999/000799 patent/WO1999049843A1/de active IP Right Grant
- 1999-03-20 KR KR1020007010848A patent/KR100653568B1/ko not_active IP Right Cessation
- 1999-03-25 TW TW088104724A patent/TWI233808B/zh not_active IP Right Cessation
- 1999-03-26 US US09/277,403 patent/US6245353B1/en not_active Expired - Lifetime
- 1999-03-31 AR ARP990101499A patent/AR018828A1/es not_active Application Discontinuation
-
2000
- 2000-09-21 NO NO20004722A patent/NO329071B1/no not_active IP Right Cessation
- 2000-09-26 ZA ZA200005134A patent/ZA200005134B/xx unknown
- 2000-10-11 BG BG104843A patent/BG64741B1/bg unknown
-
2001
- 2001-09-25 HK HK01106751A patent/HK1036217A1/xx not_active IP Right Cessation
-
2002
- 2002-03-04 CY CY20021100045T patent/CY1107331T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO329071B1 (no) | Faste, hurtig desintegrerende cetirizin-formuleringer | |
| ES2462536T3 (es) | Comprimido orodispersable multicapa | |
| KR101020809B1 (ko) | 펙소페나딘을 함유하는 구강 분산성 정제 | |
| ES2229483T3 (es) | Composiciones farmaceuticas para la liberacion controlada de sustancias activas. | |
| US20070082048A1 (en) | Sleep aid formulations | |
| US20020001617A1 (en) | Rapidly disintegrating tablet and process for the manufacture thereof | |
| US5880106A (en) | Oral dosing formulations of dideoxy purine nucleosides | |
| US20040166162A1 (en) | Novel pharmaceutical formulation containing a proton pump inhibitor and an antacid | |
| AU2002364468B2 (en) | Solid orally-dispersible pharmaceutical formulation | |
| US20110300216A1 (en) | Chewable, swallowable and effervescent solid dosage form for oral delivery of pharmaceutical actives | |
| JP2009539895A (ja) | ＡＣｈＥ−ＮＭＤＡ組み合わせウェーハ | |
| US20110046115A1 (en) | Mirtazapine Solid Dosage Forms | |
| WO1995003785A1 (en) | Pleasant tasting effervescent cold/allergy medications | |
| WO2013098399A1 (en) | Mozavaptan formulations | |
| MXPA00009349A (en) | Solid, quick dissolving cetirizine formulations | |
| US20030228370A1 (en) | Orodispersible solid pharmaceutical form |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |