ES2091654T3 - Sistema efervescente que contiene un ingrediente activo farmaceutico sensible a alcalis y/o metales, y procedimiento para su produccion. - Google Patents
Sistema efervescente que contiene un ingrediente activo farmaceutico sensible a alcalis y/o metales, y procedimiento para su produccion.Info
- Publication number
- ES2091654T3 ES2091654T3 ES94105539T ES94105539T ES2091654T3 ES 2091654 T3 ES2091654 T3 ES 2091654T3 ES 94105539 T ES94105539 T ES 94105539T ES 94105539 T ES94105539 T ES 94105539T ES 2091654 T3 ES2091654 T3 ES 2091654T3
- Authority
- ES
- Spain
- Prior art keywords
- acid
- alcalis
- metals
- procedure
- production
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
EN LA PREPARACION FARMACEUTICA DE AL MENOS UNA SUSTANCIA ACTIVA, SENSIBLE, ALCALINA, CON UN SISTEMA DE DUCHA, LA SUSTANCIA ACTIVA ES AL MENOS UNA DE LOS SIGUIENTES COMPUESTOS: UN ACIDO ORGANICO COMESTIBLE, UN ALCOHOL ALTO, UN HIDROCOLOIDE, UN POLIVINILPIRROLIDON DE CADENA LARGA INTRODUCIDO, RECUBIERTO, CON PREFERENCIA CON AL MENOS UNO DE LOS COMPUESTOS CONOCIDOS. CON PREFERENCIA EL COMPONENTE CARBONATICO ESTA AL MENOS TAMBIEN INTRODUCIDO EN UN ACIDO ORGANICO, COMESTIBLE Y CON PREFERENCIA RECUBIERTO DEL MISMO O DE OTRO ACIDO. LA ZONA DE CONTACTO ENTRE LA SUSTANCIA ACTIVA Y EL SISTEMA DE DUCHA DEBE MOSTRAR UN VALOR DE PH COMO MAS ALTO DE 4,5. TANTO EN EL SISTEMA DE DUCHA COMO LAS PARTICULAS DE SUSTANCIA ACTIVA, QUE ESTAN RECUBIERTAS EVENTUALMENTE O INTRODUCIDAS DE ESTE MODO, PUEDEN SER APLICADAS SOBRE CRISTALES SOPORTE O UN OTRO ACIDO. LA MEZCLA ESTA PRENSADA CON PREFERENCIA EN TABLETAS. EL ACIDO UTILIZADO PARA LA INTRODUCCION O RECUBRIMIENTO PUEDE CONTENER DESDE 0,1 HASTA 3 MG DE ETILENDIAMINA ACIDO TETRAACETICO POR TABLETA.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH113793 | 1993-04-15 | ||
CN94193522.1A CN1131910A (zh) | 1993-04-15 | 1994-06-14 | 含碱金属和/或金属敏感性药用活性物质的泡腾体系及其制造方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2091654T3 true ES2091654T3 (es) | 1996-11-01 |
Family
ID=37102585
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94105539T Expired - Lifetime ES2091654T3 (es) | 1993-04-15 | 1994-04-11 | Sistema efervescente que contiene un ingrediente activo farmaceutico sensible a alcalis y/o metales, y procedimiento para su produccion. |
Country Status (10)
Country | Link |
---|---|
US (1) | US5527540A (es) |
EP (1) | EP0624364B1 (es) |
JP (1) | JPH09501955A (es) |
CN (1) | CN1131910A (es) |
AT (1) | ATE140621T1 (es) |
AU (1) | AU7185294A (es) |
CA (1) | CA2169441C (es) |
DE (1) | DE59400446D1 (es) |
ES (1) | ES2091654T3 (es) |
WO (1) | WO1995034283A1 (es) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2091654T3 (es) * | 1993-04-15 | 1996-11-01 | Gergely Gerhard | Sistema efervescente que contiene un ingrediente activo farmaceutico sensible a alcalis y/o metales, y procedimiento para su produccion. |
US5804165A (en) * | 1996-07-24 | 1998-09-08 | Arnold; Michael J. | Antiplaque oral composition |
AU5828098A (en) | 1997-01-31 | 1998-08-25 | Fmc Corporation | Texture and stabilizer composition |
US6225123B1 (en) | 1997-04-30 | 2001-05-01 | Becton Dickinson And Company | Additive preparation and method of use thereof |
US6534016B1 (en) | 1997-04-30 | 2003-03-18 | Richmond Cohen | Additive preparation and method of use thereof |
EP1024787B1 (en) * | 1997-10-21 | 2002-01-23 | Gerhard Gergely | Effervescent base |
DE19811167A1 (de) * | 1998-03-14 | 1999-09-16 | Findusfit Sportdiaetetika Gmbh | Tablette, Lutschtablette zur Kohlenhydratversorgung mit Langzeitwirkung |
DE19814256A1 (de) | 1998-03-31 | 1999-10-07 | Asta Medica Ag | Feste, schnellzerfallende Cetirizin-Formulierungen |
DE19814257A1 (de) * | 1998-03-31 | 1999-10-07 | Asta Medica Ag | Brauseformulierungen |
ATE246915T1 (de) * | 1998-11-23 | 2003-08-15 | E Pharma Trento Spa | Verfahren zur herstellung eines brausegranulats |
US20030225124A1 (en) * | 1999-08-31 | 2003-12-04 | Spiridon Spireas | Stable formulations of ACE inhibitors, and methods for preparation thereof |
US6555551B1 (en) * | 1999-08-31 | 2003-04-29 | Mutual Pharmaceutical Co., Inc. | Stable formulations of ACE inhibitors, and methods for preparation thereof |
US20040157911A1 (en) * | 1999-08-31 | 2004-08-12 | Spiridon Spireas | Storage-stable and bio-stable formulations of ace inhibitors, and methods for preparation thereof |
DE10038364A1 (de) * | 2000-08-05 | 2002-05-02 | Hexal Ag | Pharmazeutische, Ramipril enthaltende Brauseformulierung |
JP2002176934A (ja) * | 2000-12-12 | 2002-06-25 | Pigeon Corp | 顆粒状食品およびその製造方法 |
US20050069590A1 (en) * | 2003-09-30 | 2005-03-31 | Buehler Gail K. | Stable suspensions for medicinal dosages |
US8349361B2 (en) * | 2003-10-15 | 2013-01-08 | Fuji Chemical Industry Co., Ltd. | Composition for rapid disintegrating tablet in oral cavity |
JP3841804B2 (ja) * | 2003-10-15 | 2006-11-08 | 富士化学工業株式会社 | 口腔内速崩壊性錠剤用の組成物 |
AU2005247048B2 (en) * | 2004-05-28 | 2007-12-13 | Imaginot Pty Ltd | Oral therapeutic compound delivery system |
US8216610B2 (en) * | 2004-05-28 | 2012-07-10 | Imaginot Pty Ltd. | Oral paracetamol formulations |
CA2629904C (en) * | 2005-11-28 | 2018-07-10 | Imaginot Pty Ltd. | Oral therapeutic compound delivery system |
US20100120776A1 (en) * | 2008-11-12 | 2010-05-13 | Hall Bioscience Corporation | Carbocysteine medical foods |
MX2014009247A (es) | 2012-02-01 | 2014-10-14 | Intercontinental Great Brands Llc | Tableta para bebida baja en calorias. |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4678661A (en) * | 1983-09-28 | 1987-07-07 | Gerhard Gergely | Effervescent composition and method of making same |
DE3440288A1 (de) * | 1984-11-05 | 1986-05-07 | Gergely, Gerhard, Dr.-Ing., Wien | Pharmazeutische zubereitung mit einem gehalt an mindestens einer schleimhautreizenden substanz oder dergleichen, insbesondere profen, sowie verfahren zu ihrer herstellung |
IT1246350B (it) * | 1990-07-11 | 1994-11-17 | Eurand Int | Metodo per ottenere una rapida sospensione in acqua di farmaci insolubili |
DK0592484T3 (da) * | 1991-07-01 | 1995-06-12 | Gerhard Gergely | Brusetablet |
ES2091654T3 (es) * | 1993-04-15 | 1996-11-01 | Gergely Gerhard | Sistema efervescente que contiene un ingrediente activo farmaceutico sensible a alcalis y/o metales, y procedimiento para su produccion. |
-
1994
- 1994-04-11 ES ES94105539T patent/ES2091654T3/es not_active Expired - Lifetime
- 1994-04-11 AT AT94105539T patent/ATE140621T1/de active
- 1994-04-11 EP EP94105539A patent/EP0624364B1/de not_active Expired - Lifetime
- 1994-04-11 DE DE59400446T patent/DE59400446D1/de not_active Expired - Lifetime
- 1994-04-15 US US08/228,211 patent/US5527540A/en not_active Expired - Lifetime
- 1994-06-14 CN CN94193522.1A patent/CN1131910A/zh active Pending
- 1994-06-14 WO PCT/EP1994/001934 patent/WO1995034283A1/de active Application Filing
- 1994-06-14 JP JP8501515A patent/JPH09501955A/ja not_active Ceased
- 1994-06-14 CA CA002169441A patent/CA2169441C/en not_active Expired - Lifetime
- 1994-06-14 AU AU71852/94A patent/AU7185294A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
ATE140621T1 (de) | 1996-08-15 |
JPH09501955A (ja) | 1997-02-25 |
EP0624364B1 (de) | 1996-07-24 |
CN1131910A (zh) | 1996-09-25 |
AU7185294A (en) | 1996-01-05 |
WO1995034283A1 (de) | 1995-12-21 |
CA2169441A1 (en) | 1995-12-21 |
DE59400446D1 (de) | 1996-08-29 |
US5527540A (en) | 1996-06-18 |
EP0624364A1 (de) | 1994-11-17 |
CA2169441C (en) | 2005-01-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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