RU2004129573A - Жевательная таблетка с приятным вкусом - Google Patents
Жевательная таблетка с приятным вкусом Download PDFInfo
- Publication number
- RU2004129573A RU2004129573A RU2004129573/15A RU2004129573A RU2004129573A RU 2004129573 A RU2004129573 A RU 2004129573A RU 2004129573/15 A RU2004129573/15 A RU 2004129573/15A RU 2004129573 A RU2004129573 A RU 2004129573A RU 2004129573 A RU2004129573 A RU 2004129573A
- Authority
- RU
- Russia
- Prior art keywords
- tablet
- additional excipients
- cyclodextrin
- combination
- cetirizine
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/282—Organic compounds, e.g. fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/282—Organic compounds, e.g. fats
- A61K9/2826—Sugars or sugar alcohols, e.g. sucrose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (12)
1. Жевательная таблетка с приятным вкусом, включающая:
(а) цетиризин или его фармацевтически приемлемую соль,
(b) подсластитель,
(с) комбинацию виноградного ароматизатора и ванильного ароматизатора в сочетании от примерно 4:1 до 2:1,
(d) циклодекстрин,
(е) один или более дополнительных эксципиентов.
2. Таблетка по п. 1, где указанная фармацевтически приемлемая соль цетиризина представляет собой дигидрохлорид цетиризина.
3. Таблетка по п. 1, дополнительно включающая красный, голубой или пурпурный красители.
4. Таблетка по п. 1, где указанный циклодекстрин представляет собой бета-циклодекстрин.
5. Таблетка по п. 2, где указанный циклодекстрин представляет собой бета-циклодекстрин.
6. Таблетка по п. 1, указанный один или несколько дополнительных эксципиентов выбирают из группы, состоящей из стеарата магния, коллоидного диоксида кремния, безводной лактозы, микрокристаллической целлюлозы, модифицированной гуаровой камедью микрокристаллической целлюлозы, кроскармелозы натрия, маннита, сахарозы и декстринизированной сахарозы.
7. Таблетка по пп. 1, 2, 3, 4, 5 или 6, где указанный подсластитель представляет собой ацесульфам калия.
8. Жевательная двухслойная таблетка с приятным вкусом, включающая:
(а) первый слой, состоящий из:
(i) цетиризина или его фармацевтически приемлемой соли,
(ii) комбинации виноградного ароматизатора и ванильного ароматизатора в сочетании от примерно 4:1 до 2:1,
(iii) бета-циклодекстрина,
(iv) красители;
(v) одного или более дополнительных эксципиентов; и
(b) второй слой, состоящий из:
(i) маннита или декстринизированной сахарозы,
(ii) комбинации виноградного ароматизатора и ванильного ароматизатора в сочетании от примерно 4:1 до 2:1,
(iii) красителей и
(iv) одного или более дополнительных эксципиентов.
9. Таблетка по п. 8, где указанная фармацевтически приемлемая соль цетиризина представляет собой дигидрохлорид цетиризина.
10. Таблетка по п. 8 или 9, где указанный один или несколько дополнительных эксципиентов в указанном первом слое выбирают из группы, состоящей из стеарата магния, коллоидного диоксида кремния, безводной лактозы, микрокристаллической целлюлозы, модифицированной гуаровой камедью микрокристаллической целлюлозы, и кроскармелозы натрия.
11. Таблетка по п. 8 или 9, где указанный один или несколько дополнительных эксципиентов в указанном втором слое представляет собой стеарат магния.
12. Таблетка по п. 10, где указанный один или несколько дополнительных эксципиентов в указанном втором слое представляет собой стеарат магния.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37008602P | 2002-04-04 | 2002-04-04 | |
| US60/370,086 | 2002-04-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2004129573A true RU2004129573A (ru) | 2005-04-10 |
Family
ID=28792024
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2004129573/15A RU2004129573A (ru) | 2002-04-04 | 2003-03-26 | Жевательная таблетка с приятным вкусом |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7482022B2 (ru) |
| EP (1) | EP1494654B1 (ru) |
| JP (1) | JP2005526104A (ru) |
| KR (1) | KR20040098036A (ru) |
| CN (1) | CN100335041C (ru) |
| AR (1) | AR039242A1 (ru) |
| AT (1) | ATE388693T1 (ru) |
| BR (1) | BR0308927A (ru) |
| CA (1) | CA2481025A1 (ru) |
| DE (1) | DE60319685T2 (ru) |
| ES (1) | ES2298540T3 (ru) |
| HN (1) | HN2003000112A (ru) |
| IL (1) | IL164106A0 (ru) |
| MX (1) | MXPA04009617A (ru) |
| NO (1) | NO20044774L (ru) |
| PA (1) | PA8570601A1 (ru) |
| PE (1) | PE20030950A1 (ru) |
| PL (1) | PL372904A1 (ru) |
| RU (1) | RU2004129573A (ru) |
| TW (1) | TW200401651A (ru) |
| UY (1) | UY27746A1 (ru) |
| WO (1) | WO2003084511A1 (ru) |
| ZA (1) | ZA200407537B (ru) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE486587T1 (de) * | 2002-01-15 | 2010-11-15 | Ucb Farchim Sa | Formulierungen zur oralen verabreichung von wirkstoffen |
| US20050232995A1 (en) | 2002-07-29 | 2005-10-20 | Yam Nyomi V | Methods and dosage forms for controlled delivery of paliperidone and risperidone |
| US20080113944A1 (en) | 2004-05-04 | 2008-05-15 | Novo Nordisk A/S | Novel Indole Derivatives |
| ATE464883T1 (de) * | 2004-07-22 | 2010-05-15 | Bend Res Inc | Geschmacksabdeckende formulierung mit einer retardierten wirkstoffformulierung und/oder schnell löslichem cyclodextrin |
| US20070020330A1 (en) | 2004-11-24 | 2007-01-25 | Medpointe Healthcare Inc. | Compositions comprising azelastine and methods of use thereof |
| US8758816B2 (en) | 2004-11-24 | 2014-06-24 | Meda Pharmaceuticals Inc. | Compositions comprising azelastine and methods of use thereof |
| ES2704482T3 (es) | 2004-11-24 | 2019-03-18 | Meda Pharmaceuticals Inc | Composiciones que comprenden azelastina y sus métodos de uso |
| US20090269393A1 (en) * | 2006-06-12 | 2009-10-29 | Jubliant Organosys Limited | Chewable Bilayer Tablet Formulation |
| DK2178521T3 (da) * | 2007-07-11 | 2014-04-28 | Fertin Pharma As | Stabilt medicinsk tyggegummi omfattende cyclodextrin-inklusionskompleks |
| WO2009006892A1 (en) * | 2007-07-11 | 2009-01-15 | Fertin Pharma A/S | Stable medicated chewing gum comprising antioxidant |
| WO2009006899A1 (en) * | 2007-07-11 | 2009-01-15 | Fertin Pharma A/S | Compressed chewing gum tablet comprising taste-masking agent |
| CL2008003230A1 (es) * | 2007-11-01 | 2009-11-27 | Sanofi Aventis Healthcare Pty Ltd | Composicion de recubrimiento de tableta que comprende polimero celulosico, plastificante, edulcorante y composicion de sabor en polvo la que comprende saborizante asociado con portador solido; fluido de recubrimiento de tableta que comprende dicha composicion; tableta farmaceutica; proceso de preparacion de dicha tableta. |
| DK2498758T3 (en) | 2009-11-13 | 2018-10-15 | Astrazeneca Ab | TWO-LAYER TABLET FORMULATIONS |
| WO2011110939A2 (en) | 2010-03-11 | 2011-09-15 | Rubicon Research Private Limited | Pharmaceutical compositions of substituted benzhydrylpiperazines |
| JPWO2013129436A1 (ja) * | 2012-02-29 | 2015-07-30 | 武田薬品工業株式会社 | 経口剤 |
| PT2861236T (pt) | 2012-06-15 | 2019-10-28 | Pharmathen Sa | Composição farmacêutica contendo polímero de ligação a fosfato |
| CN102716099B (zh) * | 2012-07-05 | 2013-10-09 | 湖南千金湘江药业股份有限公司 | 盐酸左西替利嗪咀嚼片及其制备方法 |
| JP6280554B2 (ja) | 2012-09-28 | 2018-02-14 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | Ｅｒｋ阻害剤である新規化合物 |
| WO2016033424A1 (en) | 2014-08-29 | 2016-03-03 | Genzyme Corporation | Methods for the prevention and treatment of major adverse cardiovascular events using compounds that modulate apolipoprotein b |
| JP2016094364A (ja) * | 2014-11-14 | 2016-05-26 | ニプロ株式会社 | 安定化および苦味抑制された口腔内崩壊製剤 |
| EP3061501A1 (en) | 2015-02-27 | 2016-08-31 | Rottapharm Ltd. | Composition for the treatment of acne |
| EP3117825A1 (en) | 2015-07-16 | 2017-01-18 | Rottapharm S.p.A. | Oral formulation comprising berberine and morus alba extract |
| JP2019001730A (ja) * | 2017-06-13 | 2019-01-10 | 武田テバファーマ株式会社 | 安定な経口医薬組成物 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3558600A (en) | 1967-07-28 | 1971-01-26 | Abbott Lab | Alkyl sulfate salts of 1-(p-chlorobenzhydryl)-4-methylhomopiperazines |
| NO155805C (no) | 1981-02-06 | 1987-06-10 | Ucb Sa | Analogifremgangsmaate for fremstilling av terapeutisk virksomme 2-(4-(difenylmethyl)-1-piperazinyl)-eddiksyrer og deres amider og ikke-toksiske salter. |
| US4650663A (en) | 1983-07-20 | 1987-03-17 | Warner-Lambert Company | Magnesium trisilicate suitable for preparation of medicament adsorbates of antitussives |
| US4792448A (en) | 1987-06-11 | 1988-12-20 | Pfizer Inc. | Generic zero order controlled drug delivery system |
| IL91398A (en) | 1988-08-30 | 1994-05-30 | Pfizer | A device for the controlled release of pneumatic substances, including the active substance, surrounded by an asymmetric membrane |
| ES2067957T3 (es) | 1990-08-07 | 1995-04-01 | Pfizer | Uso de membranas polimerizadas interfacialmente en dispositivos de liberacion. |
| AU678561B2 (en) | 1992-10-09 | 1997-06-05 | Procter & Gamble Company, The | Pharmaceutical compositions and methods for treating cold symptoms |
| BE1011045A3 (fr) * | 1997-03-14 | 1999-04-06 | Ucb Sa | Compositions pharmaceutiques pour la liberation controlee de substances actives. |
| US6027746A (en) * | 1997-04-23 | 2000-02-22 | Warner-Lambert Company | Chewable soft gelatin-encapsulated pharmaceutical adsorbates |
| BE1011251A3 (fr) * | 1997-07-03 | 1999-06-01 | Ucb Sa | Compositions pharmaceutiques administrables par voie orale, comprenant une substance active et une cyclodextrine. |
| DE19814256A1 (de) * | 1998-03-31 | 1999-10-07 | Asta Medica Ag | Feste, schnellzerfallende Cetirizin-Formulierungen |
| US6270790B1 (en) | 1998-08-18 | 2001-08-07 | Mxneil-Ppc, Inc. | Soft, convex shaped chewable tablets having reduced friability |
| US7223421B2 (en) * | 2000-06-30 | 2007-05-29 | Mcneil-Ppc, Inc. | Teste masked pharmaceutical particles |
| US20030035839A1 (en) * | 2001-05-15 | 2003-02-20 | Peirce Management, Llc | Pharmaceutical composition for both intraoral and oral administration |
| ATE486587T1 (de) * | 2002-01-15 | 2010-11-15 | Ucb Farchim Sa | Formulierungen zur oralen verabreichung von wirkstoffen |
-
2003
- 2003-03-26 JP JP2003581751A patent/JP2005526104A/ja active Pending
- 2003-03-26 EP EP03745693A patent/EP1494654B1/en not_active Expired - Lifetime
- 2003-03-26 CA CA002481025A patent/CA2481025A1/en not_active Abandoned
- 2003-03-26 RU RU2004129573/15A patent/RU2004129573A/ru not_active Application Discontinuation
- 2003-03-26 KR KR10-2004-7015586A patent/KR20040098036A/ko not_active Application Discontinuation
- 2003-03-26 IL IL16410603A patent/IL164106A0/xx unknown
- 2003-03-26 ES ES03745693T patent/ES2298540T3/es not_active Expired - Lifetime
- 2003-03-26 PL PL03372904A patent/PL372904A1/xx not_active Application Discontinuation
- 2003-03-26 CN CNB038070448A patent/CN100335041C/zh not_active Expired - Fee Related
- 2003-03-26 BR BR0308927-4A patent/BR0308927A/pt not_active IP Right Cessation
- 2003-03-26 WO PCT/IB2003/001130 patent/WO2003084511A1/en active IP Right Grant
- 2003-03-26 MX MXPA04009617A patent/MXPA04009617A/es active IP Right Grant
- 2003-03-26 DE DE60319685T patent/DE60319685T2/de not_active Expired - Lifetime
- 2003-03-26 AT AT03745693T patent/ATE388693T1/de not_active IP Right Cessation
- 2003-04-01 US US10/404,964 patent/US7482022B2/en not_active Expired - Fee Related
- 2003-04-02 PE PE2003000337A patent/PE20030950A1/es not_active Application Discontinuation
- 2003-04-02 TW TW092107552A patent/TW200401651A/zh unknown
- 2003-04-02 UY UY27746A patent/UY27746A1/es not_active Application Discontinuation
- 2003-04-03 AR ARP030101167A patent/AR039242A1/es unknown
- 2003-04-03 HN HN2003000112A patent/HN2003000112A/es unknown
- 2003-04-04 PA PA20038570601A patent/PA8570601A1/es unknown
-
2004
- 2004-09-17 ZA ZA200407537A patent/ZA200407537B/en unknown
- 2004-11-03 NO NO20044774A patent/NO20044774L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003084511A1 (en) | 2003-10-16 |
| CN1642531A (zh) | 2005-07-20 |
| ATE388693T1 (de) | 2008-03-15 |
| JP2005526104A (ja) | 2005-09-02 |
| NO20044774L (no) | 2004-11-03 |
| CN100335041C (zh) | 2007-09-05 |
| DE60319685T2 (de) | 2009-03-26 |
| EP1494654A1 (en) | 2005-01-12 |
| KR20040098036A (ko) | 2004-11-18 |
| DE60319685D1 (de) | 2008-04-24 |
| AU2003209953A1 (en) | 2003-10-20 |
| US7482022B2 (en) | 2009-01-27 |
| ES2298540T3 (es) | 2008-05-16 |
| AR039242A1 (es) | 2005-02-16 |
| CA2481025A1 (en) | 2003-10-16 |
| EP1494654B1 (en) | 2008-03-12 |
| TW200401651A (en) | 2004-02-01 |
| PL372904A1 (en) | 2005-08-08 |
| PA8570601A1 (es) | 2003-12-10 |
| BR0308927A (pt) | 2005-01-04 |
| ZA200407537B (en) | 2006-06-28 |
| PE20030950A1 (es) | 2003-11-12 |
| US20030215503A1 (en) | 2003-11-20 |
| HN2003000112A (es) | 2004-05-05 |
| IL164106A0 (en) | 2005-12-18 |
| MXPA04009617A (es) | 2005-01-11 |
| UY27746A1 (es) | 2003-10-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20060310 |