NO329005B1 - Heksasykliske forbindelser, farmasoytiske preparater som omfatter forbindelsene, anvendelser av forbindelsene til fremstilling av medikamenter samt fremgangsmate for fremstilling av forbindelsene og fremgangsmater for fremstilling av mellomprodukter - Google Patents
Heksasykliske forbindelser, farmasoytiske preparater som omfatter forbindelsene, anvendelser av forbindelsene til fremstilling av medikamenter samt fremgangsmate for fremstilling av forbindelsene og fremgangsmater for fremstilling av mellomprodukter Download PDFInfo
- Publication number
- NO329005B1 NO329005B1 NO20042729A NO20042729A NO329005B1 NO 329005 B1 NO329005 B1 NO 329005B1 NO 20042729 A NO20042729 A NO 20042729A NO 20042729 A NO20042729 A NO 20042729A NO 329005 B1 NO329005 B1 NO 329005B1
- Authority
- NO
- Norway
- Prior art keywords
- ethyl
- pyrano
- pyrido
- indolizino
- quinazoline
- Prior art date
Links
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- 238000002360 preparation method Methods 0.000 title claims description 126
- 238000000034 method Methods 0.000 title claims description 120
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- 239000000543 intermediate Substances 0.000 title description 2
- 239000008194 pharmaceutical composition Substances 0.000 title description 2
- 150000003839 salts Chemical class 0.000 claims abstract description 33
- 230000002062 proliferating effect Effects 0.000 claims abstract description 5
- -1 hydroxy, amino Chemical group 0.000 claims description 107
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- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 80
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- LNOPIUAQISRISI-UHFFFAOYSA-N n'-hydroxy-2-propan-2-ylsulfonylethanimidamide Chemical compound CC(C)S(=O)(=O)CC(N)=NO LNOPIUAQISRISI-UHFFFAOYSA-N 0.000 description 1
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- MUMZUERVLWJKNR-UHFFFAOYSA-N oxoplatinum Chemical compound [Pt]=O MUMZUERVLWJKNR-UHFFFAOYSA-N 0.000 description 1
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- 229910052700 potassium Inorganic materials 0.000 description 1
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- 239000003755 preservative agent Substances 0.000 description 1
- 150000003141 primary amines Chemical class 0.000 description 1
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- 239000002356 single layer Substances 0.000 description 1
- 230000005783 single-strand break Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- VSIVTUIKYVGDCX-UHFFFAOYSA-M sodium;4-[2-(2-methoxy-4-nitrophenyl)-3-(4-nitrophenyl)tetrazol-2-ium-5-yl]benzene-1,3-disulfonate Chemical compound [Na+].COC1=CC([N+]([O-])=O)=CC=C1[N+]1=NC(C=2C(=CC(=CC=2)S([O-])(=O)=O)S([O-])(=O)=O)=NN1C1=CC=C([N+]([O-])=O)C=C1 VSIVTUIKYVGDCX-UHFFFAOYSA-M 0.000 description 1
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- 239000007858 starting material Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000007940 sugar coated tablet Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000001973 tert-pentyl group Chemical group [H]C([H])([H])C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- AHJWSRRHTXRLAQ-UHFFFAOYSA-N tetramethoxymethane Chemical compound COC(OC)(OC)OC AHJWSRRHTXRLAQ-UHFFFAOYSA-N 0.000 description 1
- ZWZVWGITAAIFPS-UHFFFAOYSA-N thiophosgene Chemical compound ClC(Cl)=S ZWZVWGITAAIFPS-UHFFFAOYSA-N 0.000 description 1
- AXZWODMDQAVCJE-UHFFFAOYSA-L tin(II) chloride (anhydrous) Chemical compound [Cl-].[Cl-].[Sn+2] AXZWODMDQAVCJE-UHFFFAOYSA-L 0.000 description 1
- XJDNKRIXUMDJCW-UHFFFAOYSA-J titanium tetrachloride Chemical compound Cl[Ti](Cl)(Cl)Cl XJDNKRIXUMDJCW-UHFFFAOYSA-J 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01128361 | 2001-11-30 | ||
| PCT/EP2002/013216 WO2003045952A2 (en) | 2001-11-30 | 2002-11-25 | Condensed camptothecins as antitumor agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20042729L NO20042729L (no) | 2004-08-27 |
| NO329005B1 true NO329005B1 (no) | 2010-07-19 |
Family
ID=8179394
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20042729A NO329005B1 (no) | 2001-11-30 | 2004-06-29 | Heksasykliske forbindelser, farmasoytiske preparater som omfatter forbindelsene, anvendelser av forbindelsene til fremstilling av medikamenter samt fremgangsmate for fremstilling av forbindelsene og fremgangsmater for fremstilling av mellomprodukter |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US6825194B2 (OSRAM) |
| EP (1) | EP1480984B9 (OSRAM) |
| JP (1) | JP4305909B2 (OSRAM) |
| KR (1) | KR100895746B1 (OSRAM) |
| CN (1) | CN100338066C (OSRAM) |
| AT (1) | ATE398131T1 (OSRAM) |
| AU (1) | AU2002356720B2 (OSRAM) |
| BR (1) | BR0214615A (OSRAM) |
| CA (1) | CA2468824C (OSRAM) |
| DE (1) | DE60227113D1 (OSRAM) |
| ES (1) | ES2307830T3 (OSRAM) |
| GT (1) | GT200200250A (OSRAM) |
| HU (1) | HUP0500062A3 (OSRAM) |
| IL (1) | IL162058A0 (OSRAM) |
| MX (1) | MXPA04005185A (OSRAM) |
| MY (1) | MY136138A (OSRAM) |
| NO (1) | NO329005B1 (OSRAM) |
| NZ (1) | NZ533568A (OSRAM) |
| PA (1) | PA8558901A1 (OSRAM) |
| PE (1) | PE20030725A1 (OSRAM) |
| PL (1) | PL207510B1 (OSRAM) |
| RS (1) | RS51051B (OSRAM) |
| RU (1) | RU2299212C2 (OSRAM) |
| TW (1) | TWI258481B (OSRAM) |
| UA (1) | UA80409C2 (OSRAM) |
| UY (1) | UY27560A1 (OSRAM) |
| WO (1) | WO2003045952A2 (OSRAM) |
| ZA (1) | ZA200404522B (OSRAM) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1777611A (zh) * | 2003-02-21 | 2006-05-24 | 中外制药株式会社 | 制备六环喜树碱衍生物的方法 |
| MXPA06011679A (es) | 2004-04-09 | 2007-01-23 | Chugai Pharmaceutical Co Ltd | Novedosos profarmacos solubles en agua. |
| TW200744603A (en) * | 2005-08-22 | 2007-12-16 | Chugai Pharmaceutical Co Ltd | Novel anticancer concomitant drug |
| US20090118271A1 (en) * | 2005-10-19 | 2009-05-07 | Chugai Seiyaku Kabushiki Kaisha | Preventive or Therapeutic Agents for Pancreatic Cancer, Ovarian Cancer, or Liver Cancer Comprising a Novel Water-Soluble Prodrug |
| RU2439073C1 (ru) * | 2010-07-13 | 2012-01-10 | Государственное образовательное учреждение высшего профессионального образования "Кубанский государственный технологический университет" (ГОУ ВПО "КубГТУ") | СПОСОБ ПОЛУЧЕНИЯ ПРОИЗВОДНЫХ ИНДОЛИЗИНО[7,6-b]ИНДОЛА |
| EP3946464B1 (en) | 2019-03-29 | 2022-08-31 | MedImmune Limited | Compounds and conjugates thereof |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4473692A (en) | 1981-09-04 | 1984-09-25 | Kabushiki Kaisha Yakult Honsha | Camptothecin derivatives and process for preparing same |
| US4939255A (en) * | 1987-06-24 | 1990-07-03 | Daiichi Pharmaceutical Co., Ltd. | Hexa-cyclic camptothecin derivatives |
| HU213136B (en) * | 1990-08-14 | 1997-02-28 | Kyorin Seiyaku Kk | Process for producing fluoroethyl camptothecin derivatives and pharmaceutical compositions containing them |
| JP3008226B2 (ja) * | 1991-01-16 | 2000-02-14 | 第一製薬株式会社 | 六環性化合物 |
| JP3359955B2 (ja) * | 1992-07-16 | 2002-12-24 | 第一製薬株式会社 | 抗腫瘍剤 |
| GB9402934D0 (en) * | 1994-02-16 | 1994-04-06 | Erba Carlo Spa | Camptothecin derivatives and process for their preparation |
| US5663177A (en) * | 1995-05-31 | 1997-09-02 | Smithkline Beecham Corporation | Water soluble camptothecin analogs |
| WO1998035940A1 (en) | 1997-02-14 | 1998-08-20 | Bionumerik Pharmaceuticals, Inc. | Highly lipophilic camptothecin derivatives |
| GB9715821D0 (en) * | 1997-07-25 | 1997-10-01 | Pharmacia & Upjohn Spa | Amidino-camptothecin derivatives |
-
2002
- 2002-11-25 AU AU2002356720A patent/AU2002356720B2/en not_active Ceased
- 2002-11-25 ES ES02803790T patent/ES2307830T3/es not_active Expired - Lifetime
- 2002-11-25 DE DE60227113T patent/DE60227113D1/de not_active Expired - Lifetime
- 2002-11-25 MX MXPA04005185A patent/MXPA04005185A/es active IP Right Grant
- 2002-11-25 CA CA2468824A patent/CA2468824C/en not_active Expired - Fee Related
- 2002-11-25 BR BR0214615-0A patent/BR0214615A/pt not_active IP Right Cessation
- 2002-11-25 IL IL16205802A patent/IL162058A0/xx not_active IP Right Cessation
- 2002-11-25 RS YUP-470/04A patent/RS51051B/sr unknown
- 2002-11-25 UA UA20040605013A patent/UA80409C2/uk unknown
- 2002-11-25 NZ NZ533568A patent/NZ533568A/en not_active IP Right Cessation
- 2002-11-25 JP JP2003547402A patent/JP4305909B2/ja not_active Expired - Fee Related
- 2002-11-25 PL PL370479A patent/PL207510B1/pl not_active IP Right Cessation
- 2002-11-25 EP EP02803790A patent/EP1480984B9/en not_active Expired - Lifetime
- 2002-11-25 WO PCT/EP2002/013216 patent/WO2003045952A2/en not_active Ceased
- 2002-11-25 HU HU0500062A patent/HUP0500062A3/hu unknown
- 2002-11-25 CN CNB028277465A patent/CN100338066C/zh not_active Expired - Fee Related
- 2002-11-25 AT AT02803790T patent/ATE398131T1/de not_active IP Right Cessation
- 2002-11-25 RU RU2004119841/04A patent/RU2299212C2/ru not_active IP Right Cessation
- 2002-11-25 KR KR1020047008223A patent/KR100895746B1/ko not_active Expired - Fee Related
- 2002-11-26 US US10/304,672 patent/US6825194B2/en not_active Expired - Fee Related
- 2002-11-27 TW TW091134463A patent/TWI258481B/zh not_active IP Right Cessation
- 2002-11-28 PE PE2002001148A patent/PE20030725A1/es not_active Application Discontinuation
- 2002-11-28 PA PA20028558901A patent/PA8558901A1/es unknown
- 2002-11-28 MY MYPI20024479A patent/MY136138A/en unknown
- 2002-11-29 GT GT200200250A patent/GT200200250A/es unknown
- 2002-11-29 UY UY27560A patent/UY27560A1/es not_active Application Discontinuation
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2004
- 2004-06-08 ZA ZA200404522A patent/ZA200404522B/en unknown
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