PA8558901A1 - Nuevos compuestos hexaciclicos - Google Patents

Nuevos compuestos hexaciclicos

Info

Publication number
PA8558901A1
PA8558901A1 PA20028558901A PA8558901A PA8558901A1 PA 8558901 A1 PA8558901 A1 PA 8558901A1 PA 20028558901 A PA20028558901 A PA 20028558901A PA 8558901 A PA8558901 A PA 8558901A PA 8558901 A1 PA8558901 A1 PA 8558901A1
Authority
PA
Panama
Prior art keywords
compounds
hexaciclic
new
haxaciclic
reivindications
Prior art date
Application number
PA20028558901A
Other languages
English (en)
Inventor
Nobuo Shimma
Takeshi Murata
Satoshi Niizuma
Hitomi Suda
Masao Tsukazaki
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PA8558901A1 publication Critical patent/PA8558901A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A UN COMPUESTO HAXACICLICO DE FORMULA 1, EN DONDE Z, R1, R2, R3 Y R4 SON COMO SE DEFINIO EN LA DESCRIPCION Y REIVINDICACIONES Y SALES FARMACEUTICAMENTE ACEPTABLES DE LAS MISMAS. ESTOS COMPUESTOS SON UTILES EN EL TRATAMIENTO DE TRASTORNOS CELULARES PROLIFERATIVOS.
PA20028558901A 2001-11-30 2002-11-28 Nuevos compuestos hexaciclicos PA8558901A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP01128361 2001-11-30

Publications (1)

Publication Number Publication Date
PA8558901A1 true PA8558901A1 (es) 2003-06-30

Family

ID=8179394

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20028558901A PA8558901A1 (es) 2001-11-30 2002-11-28 Nuevos compuestos hexaciclicos

Country Status (29)

Country Link
US (2) US6825194B2 (es)
EP (1) EP1480984B9 (es)
JP (1) JP4305909B2 (es)
KR (1) KR100895746B1 (es)
CN (1) CN100338066C (es)
AT (1) ATE398131T1 (es)
AU (1) AU2002356720B2 (es)
BR (1) BR0214615A (es)
CA (1) CA2468824C (es)
DE (1) DE60227113D1 (es)
ES (1) ES2307830T3 (es)
GT (1) GT200200250A (es)
HK (2) HK1072935A1 (es)
HU (1) HUP0500062A3 (es)
IL (1) IL162058A0 (es)
MX (1) MXPA04005185A (es)
MY (1) MY136138A (es)
NO (1) NO329005B1 (es)
NZ (1) NZ533568A (es)
PA (1) PA8558901A1 (es)
PE (1) PE20030725A1 (es)
PL (1) PL207510B1 (es)
RS (1) RS51051B (es)
RU (1) RU2299212C2 (es)
TW (1) TWI258481B (es)
UA (1) UA80409C2 (es)
UY (1) UY27560A1 (es)
WO (1) WO2003045952A2 (es)
ZA (1) ZA200404522B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1599484A2 (en) 2003-02-21 2005-11-30 Chugai Seiyaku Kabushiki Kaisha Process for the preparation of hexacyclic camptothecin derivatives
MXPA06011679A (es) 2004-04-09 2007-01-23 Chugai Pharmaceutical Co Ltd Novedosos profarmacos solubles en agua.
TW200744603A (en) 2005-08-22 2007-12-16 Chugai Pharmaceutical Co Ltd Novel anticancer concomitant drug
BRPI0617730A2 (pt) * 2005-10-19 2011-08-02 Chugai Pharmaceutical Co Ltd agente para prevenir ou tratar cáncer do páncreas, cáncer de ovário ou cáncer hepático contendo nova pró-fármaco hidrossolúvel
KR102498681B1 (ko) 2019-03-29 2023-02-09 메디뮨 리미티드 화합물 및 이의 접합체

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4473692A (en) 1981-09-04 1984-09-25 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives and process for preparing same
US4939255A (en) * 1987-06-24 1990-07-03 Daiichi Pharmaceutical Co., Ltd. Hexa-cyclic camptothecin derivatives
HU213136B (en) * 1990-08-14 1997-02-28 Kyorin Seiyaku Kk Process for producing fluoroethyl camptothecin derivatives and pharmaceutical compositions containing them
JP3008226B2 (ja) * 1991-01-16 2000-02-14 第一製薬株式会社 六環性化合物
JP3359955B2 (ja) * 1992-07-16 2002-12-24 第一製薬株式会社 抗腫瘍剤
GB9402934D0 (en) * 1994-02-16 1994-04-06 Erba Carlo Spa Camptothecin derivatives and process for their preparation
US5663177A (en) * 1995-05-31 1997-09-02 Smithkline Beecham Corporation Water soluble camptothecin analogs
WO1998035940A1 (en) 1997-02-14 1998-08-20 Bionumerik Pharmaceuticals, Inc. Highly lipophilic camptothecin derivatives
GB9715821D0 (en) * 1997-07-25 1997-10-01 Pharmacia & Upjohn Spa Amidino-camptothecin derivatives

Also Published As

Publication number Publication date
TW200408642A (en) 2004-06-01
PE20030725A1 (es) 2003-08-28
NO329005B1 (no) 2010-07-19
TWI258481B (en) 2006-07-21
NO20042729L (no) 2004-08-27
GT200200250A (es) 2004-01-15
KR100895746B1 (ko) 2009-04-30
BR0214615A (pt) 2004-09-14
US6825194B2 (en) 2004-11-30
ES2307830T3 (es) 2008-12-01
MXPA04005185A (es) 2004-08-11
PL207510B1 (pl) 2010-12-31
KR20040062976A (ko) 2004-07-09
RS47004A (en) 2007-02-05
PL370479A1 (en) 2005-05-30
HK1077303A1 (en) 2006-02-10
HK1072935A1 (en) 2005-09-16
MY136138A (en) 2008-08-29
EP1480984B9 (en) 2009-03-11
AU2002356720A1 (en) 2003-06-10
CA2468824C (en) 2011-01-11
EP1480984B1 (en) 2008-06-11
JP4305909B2 (ja) 2009-07-29
CN100338066C (zh) 2007-09-19
JP2005511643A (ja) 2005-04-28
CA2468824A1 (en) 2003-06-05
CN1617874A (zh) 2005-05-18
HUP0500062A2 (hu) 2005-04-28
ATE398131T1 (de) 2008-07-15
DE60227113D1 (de) 2008-07-24
UY27560A1 (es) 2003-05-30
ZA200404522B (en) 2005-01-04
UA80409C2 (en) 2007-09-25
IL162058A0 (en) 2005-11-20
HUP0500062A3 (en) 2012-12-28
AU2002356720B2 (en) 2009-01-29
RU2299212C2 (ru) 2007-05-20
EP1480984A2 (en) 2004-12-01
US20050059679A1 (en) 2005-03-17
RS51051B (sr) 2010-10-31
WO2003045952A3 (en) 2003-10-16
US7109195B2 (en) 2006-09-19
RU2004119841A (ru) 2005-03-27
US20030144304A1 (en) 2003-07-31
WO2003045952A2 (en) 2003-06-05
NZ533568A (en) 2006-01-27

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