UA80409C2 - Hexacyclic compounds - Google Patents

Hexacyclic compounds Download PDF

Info

Publication number
UA80409C2
UA80409C2 UA20040605013A UA20040605013A UA80409C2 UA 80409 C2 UA80409 C2 UA 80409C2 UA 20040605013 A UA20040605013 A UA 20040605013A UA 20040605013 A UA20040605013 A UA 20040605013A UA 80409 C2 UA80409 C2 UA 80409C2
Authority
UA
Ukraine
Prior art keywords
ethyl
hydroxy
pyrano
dione
quinazoline
Prior art date
Application number
UA20040605013A
Other languages
English (en)
Ukrainian (uk)
Inventor
Nobuo Shimma
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of UA80409C2 publication Critical patent/UA80409C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
UA20040605013A 2001-11-30 2002-11-25 Hexacyclic compounds UA80409C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01128361 2001-11-30
PCT/EP2002/013216 WO2003045952A2 (en) 2001-11-30 2002-11-25 Condensed camptothecins as antitumor agents

Publications (1)

Publication Number Publication Date
UA80409C2 true UA80409C2 (en) 2007-09-25

Family

ID=8179394

Family Applications (1)

Application Number Title Priority Date Filing Date
UA20040605013A UA80409C2 (en) 2001-11-30 2002-11-25 Hexacyclic compounds

Country Status (28)

Country Link
US (2) US6825194B2 (OSRAM)
EP (1) EP1480984B9 (OSRAM)
JP (1) JP4305909B2 (OSRAM)
KR (1) KR100895746B1 (OSRAM)
CN (1) CN100338066C (OSRAM)
AT (1) ATE398131T1 (OSRAM)
AU (1) AU2002356720B2 (OSRAM)
BR (1) BR0214615A (OSRAM)
CA (1) CA2468824C (OSRAM)
DE (1) DE60227113D1 (OSRAM)
ES (1) ES2307830T3 (OSRAM)
GT (1) GT200200250A (OSRAM)
HU (1) HUP0500062A3 (OSRAM)
IL (1) IL162058A0 (OSRAM)
MX (1) MXPA04005185A (OSRAM)
MY (1) MY136138A (OSRAM)
NO (1) NO329005B1 (OSRAM)
NZ (1) NZ533568A (OSRAM)
PA (1) PA8558901A1 (OSRAM)
PE (1) PE20030725A1 (OSRAM)
PL (1) PL207510B1 (OSRAM)
RS (1) RS51051B (OSRAM)
RU (1) RU2299212C2 (OSRAM)
TW (1) TWI258481B (OSRAM)
UA (1) UA80409C2 (OSRAM)
UY (1) UY27560A1 (OSRAM)
WO (1) WO2003045952A2 (OSRAM)
ZA (1) ZA200404522B (OSRAM)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1777611A (zh) * 2003-02-21 2006-05-24 中外制药株式会社 制备六环喜树碱衍生物的方法
MXPA06011679A (es) 2004-04-09 2007-01-23 Chugai Pharmaceutical Co Ltd Novedosos profarmacos solubles en agua.
TW200744603A (en) * 2005-08-22 2007-12-16 Chugai Pharmaceutical Co Ltd Novel anticancer concomitant drug
US20090118271A1 (en) * 2005-10-19 2009-05-07 Chugai Seiyaku Kabushiki Kaisha Preventive or Therapeutic Agents for Pancreatic Cancer, Ovarian Cancer, or Liver Cancer Comprising a Novel Water-Soluble Prodrug
RU2439073C1 (ru) * 2010-07-13 2012-01-10 Государственное образовательное учреждение высшего профессионального образования "Кубанский государственный технологический университет" (ГОУ ВПО "КубГТУ") СПОСОБ ПОЛУЧЕНИЯ ПРОИЗВОДНЫХ ИНДОЛИЗИНО[7,6-b]ИНДОЛА
EP3946464B1 (en) 2019-03-29 2022-08-31 MedImmune Limited Compounds and conjugates thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4473692A (en) 1981-09-04 1984-09-25 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives and process for preparing same
US4939255A (en) * 1987-06-24 1990-07-03 Daiichi Pharmaceutical Co., Ltd. Hexa-cyclic camptothecin derivatives
HU213136B (en) * 1990-08-14 1997-02-28 Kyorin Seiyaku Kk Process for producing fluoroethyl camptothecin derivatives and pharmaceutical compositions containing them
JP3008226B2 (ja) * 1991-01-16 2000-02-14 第一製薬株式会社 六環性化合物
JP3359955B2 (ja) * 1992-07-16 2002-12-24 第一製薬株式会社 抗腫瘍剤
GB9402934D0 (en) * 1994-02-16 1994-04-06 Erba Carlo Spa Camptothecin derivatives and process for their preparation
US5663177A (en) * 1995-05-31 1997-09-02 Smithkline Beecham Corporation Water soluble camptothecin analogs
WO1998035940A1 (en) 1997-02-14 1998-08-20 Bionumerik Pharmaceuticals, Inc. Highly lipophilic camptothecin derivatives
GB9715821D0 (en) * 1997-07-25 1997-10-01 Pharmacia & Upjohn Spa Amidino-camptothecin derivatives

Also Published As

Publication number Publication date
RS47004A (sr) 2007-02-05
HUP0500062A3 (en) 2012-12-28
TWI258481B (en) 2006-07-21
HK1077303A1 (en) 2006-02-10
KR20040062976A (ko) 2004-07-09
EP1480984A2 (en) 2004-12-01
AU2002356720A1 (en) 2003-06-10
US20030144304A1 (en) 2003-07-31
RS51051B (sr) 2010-10-31
ES2307830T3 (es) 2008-12-01
CA2468824A1 (en) 2003-06-05
MY136138A (en) 2008-08-29
BR0214615A (pt) 2004-09-14
US6825194B2 (en) 2004-11-30
EP1480984B1 (en) 2008-06-11
WO2003045952A3 (en) 2003-10-16
ZA200404522B (en) 2005-01-04
US20050059679A1 (en) 2005-03-17
HUP0500062A2 (hu) 2005-04-28
NZ533568A (en) 2006-01-27
UY27560A1 (es) 2003-05-30
PL370479A1 (en) 2005-05-30
US7109195B2 (en) 2006-09-19
CN1617874A (zh) 2005-05-18
KR100895746B1 (ko) 2009-04-30
JP2005511643A (ja) 2005-04-28
PE20030725A1 (es) 2003-08-28
HK1072935A1 (en) 2005-09-16
TW200408642A (en) 2004-06-01
PL207510B1 (pl) 2010-12-31
CA2468824C (en) 2011-01-11
EP1480984B9 (en) 2009-03-11
PA8558901A1 (es) 2003-06-30
RU2004119841A (ru) 2005-03-27
AU2002356720B2 (en) 2009-01-29
JP4305909B2 (ja) 2009-07-29
ATE398131T1 (de) 2008-07-15
RU2299212C2 (ru) 2007-05-20
NO20042729L (no) 2004-08-27
DE60227113D1 (de) 2008-07-24
GT200200250A (es) 2004-01-15
NO329005B1 (no) 2010-07-19
WO2003045952A2 (en) 2003-06-05
IL162058A0 (en) 2005-11-20
CN100338066C (zh) 2007-09-19
MXPA04005185A (es) 2004-08-11

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