NO328848B1 - Variolinderivater og deres anvendelse som antitumormidler - Google Patents

Variolinderivater og deres anvendelse som antitumormidler Download PDF

Info

Publication number
NO328848B1
NO328848B1 NO20040113A NO20040113A NO328848B1 NO 328848 B1 NO328848 B1 NO 328848B1 NO 20040113 A NO20040113 A NO 20040113A NO 20040113 A NO20040113 A NO 20040113A NO 328848 B1 NO328848 B1 NO 328848B1
Authority
NO
Norway
Prior art keywords
compound
mmol
solution
hydrogen
nmr
Prior art date
Application number
NO20040113A
Other languages
English (en)
Norwegian (no)
Other versions
NO20040113L (no
Inventor
Carmen Cuevas
Andres Francesch
Ignacio Manzanares
Simon Munt
Modesto Remuinan
Juan Jose Gonzalez
Carlos Del Pozo
Regan James Anderson
Jonathan Charles Morris
Original Assignee
Pharma Mar Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharma Mar Sa filed Critical Pharma Mar Sa
Publication of NO20040113L publication Critical patent/NO20040113L/no
Publication of NO328848B1 publication Critical patent/NO328848B1/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62Oxygen or sulfur atoms
    • C07D213/63One oxygen atom
    • C07D213/64One oxygen atom attached in position 2 or 6
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32One oxygen, sulfur or nitrogen atom
    • C07D239/38One sulfur atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06Peri-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Carbon And Carbon Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO20040113A 2001-07-11 2004-01-12 Variolinderivater og deres anvendelse som antitumormidler NO328848B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0116966.3A GB0116966D0 (en) 2001-07-11 2001-07-11 Anittumoral compounds
PCT/GB2002/003197 WO2003006457A1 (en) 2001-07-11 2002-07-11 Variolin derivatives and their use as antitumor agents

Publications (2)

Publication Number Publication Date
NO20040113L NO20040113L (no) 2004-03-09
NO328848B1 true NO328848B1 (no) 2010-05-31

Family

ID=9918335

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20040113A NO328848B1 (no) 2001-07-11 2004-01-12 Variolinderivater og deres anvendelse som antitumormidler

Country Status (20)

Country Link
US (2) US7495000B2 (ru)
EP (2) EP1867645B1 (ru)
JP (1) JP4369225B2 (ru)
KR (1) KR100929616B1 (ru)
CN (1) CN1553906B (ru)
AT (2) ATE396987T1 (ru)
AU (1) AU2002317329B2 (ru)
CA (1) CA2453418C (ru)
DE (2) DE60237652D1 (ru)
ES (2) ES2307768T3 (ru)
GB (1) GB0116966D0 (ru)
HK (1) HK1060354A1 (ru)
HU (1) HUP0402658A2 (ru)
IL (2) IL159792A0 (ru)
MX (1) MXPA04000355A (ru)
NO (1) NO328848B1 (ru)
NZ (1) NZ530556A (ru)
PL (1) PL366894A1 (ru)
RU (1) RU2302419C2 (ru)
WO (1) WO2003006457A1 (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2327210T3 (es) 2000-07-11 2009-10-27 Pharma Mar, S.A. Derivados de variolina como agentes anticancerigenos.
GB0019117D0 (en) * 2000-08-03 2000-09-27 Univ Barcelona Derivatives of variolin B
GB0116966D0 (en) 2001-07-11 2001-09-05 Pharma Mar Sa Anittumoral compounds
US8501765B2 (en) * 2008-06-11 2013-08-06 Genentech, Inc. Diazacarbazoles and methods of use
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2327210T3 (es) * 2000-07-11 2009-10-27 Pharma Mar, S.A. Derivados de variolina como agentes anticancerigenos.
GB0019117D0 (en) * 2000-08-03 2000-09-27 Univ Barcelona Derivatives of variolin B
GB0116966D0 (en) 2001-07-11 2001-09-05 Pharma Mar Sa Anittumoral compounds

Also Published As

Publication number Publication date
JP4369225B2 (ja) 2009-11-18
ES2307768T3 (es) 2008-12-01
CA2453418C (en) 2011-05-17
KR20040023649A (ko) 2004-03-18
CN1553906A (zh) 2004-12-08
US20090197901A1 (en) 2009-08-06
JP2004536850A (ja) 2004-12-09
US20060235223A1 (en) 2006-10-19
US7495000B2 (en) 2009-02-24
EP1867645B1 (en) 2010-09-08
EP1404668B1 (en) 2008-05-28
NO20040113L (no) 2004-03-09
PL366894A1 (en) 2005-02-07
MXPA04000355A (es) 2005-03-07
NZ530556A (en) 2005-07-29
CA2453418A1 (en) 2003-01-23
US7772241B2 (en) 2010-08-10
DE60226869D1 (de) 2008-07-10
AU2002317329B2 (en) 2008-10-02
IL159792A (en) 2009-08-03
GB0116966D0 (en) 2001-09-05
ES2354991T3 (es) 2011-03-21
HK1060354A1 (en) 2004-08-06
HUP0402658A2 (hu) 2005-04-28
EP1404668A1 (en) 2004-04-07
CN1553906B (zh) 2010-04-28
IL159792A0 (en) 2004-06-20
KR100929616B1 (ko) 2009-12-03
RU2302419C2 (ru) 2007-07-10
ATE480533T1 (de) 2010-09-15
EP1867645A1 (en) 2007-12-19
RU2004103857A (ru) 2005-06-20
DE60237652D1 (de) 2010-10-21
WO2003006457A1 (en) 2003-01-23
ATE396987T1 (de) 2008-06-15

Similar Documents

Publication Publication Date Title
AU2019201352B2 (en) Bromodomain inhibitors
CA2504385C (en) Thiadiazine compounds and uses thereof
EP3016951B1 (en) Tricyclic pyrido-carboxamide derivatives as rock inhibitors
AU2008274099B2 (en) Derivatives of 7-alkynyl-1,8-naphthyridones, preparation method thereof and use of same in therapeutics
NO178029B (no) Analogifremgangsmåte ved fremstilling av terapeutisk aktive pyrazolopyrimidinoner
CN111148740B (zh) 用作自噬调节剂的化合物及其制备方法和用途
KR20190080951A (ko) 피리미도[5,4-b]인돌리진 또는 피리미도[5,4-b]피롤리진 화합물, 그의 제조방법 및 용도
JP2019526577A (ja) イミダゾール誘導体及び自己免疫性疾患若しくは炎症性疾患又は癌の治療におけるそれらの使用
EP1329454A1 (en) Thienopyrimidine compounds and their salts and process for preparation of both
WO2003077857A2 (en) N-(substituted benzyl)-8-hydroxy-1,6-naphthyridine-7- carboxamides useful as hiv integrase inhibitors
Shatsauskas et al. Synthesis of benzo [c][1, 7] naphthyridine derivatives
FI85484B (fi) Foerfarande foer framstaellning av antipsykotiska pyridinylpiperazinderivat som innehaoller en kondenserad ring.
NO328848B1 (no) Variolinderivater og deres anvendelse som antitumormidler
IL153682A (en) History of variolins, processes for their preparation and pharmaceutical preparations containing them
EA007226B1 (ru) Производные имидазохинолина
PT1560827E (pt) Agentes anti-infecciosos
AU2002317329A1 (en) Variolin derivatives and their use as antitumor agents
Abdel-Mohsen et al. A convenient synthesis of pyrrolo [2, 3-b] pyridines and pyrido [2′, 3′: 5, 4] pyrrolo [2, 3-d] pyrimidines
EP0218423B1 (en) 9-(Substituted thio)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives, their manufacture and use
RU2229475C1 (ru) 6-сульфамоилхинолин-4-карбоновые кислоты, их производные и комбинаторная библиотека
AU2013351550A1 (en) Specific carboxamides as KCNQ2/3 modulators
JPS63146884A (ja) ピリドピリミジン誘導体
KR20050024358A (ko) 비만증, 타입 ⅱ 당뇨병 및 cns 장애의 치료에 유용한신규 화합물
AU2013351551A1 (en) Heteroquinoline-3-carboxamides as KCNQ2/3 modulators

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees