NO328218B1 - Kinuklidinforbindelser, anvendelse derav, fremgangsmater for fremstilling derav, og medisinske preparater omfattende slike - Google Patents

Kinuklidinforbindelser, anvendelse derav, fremgangsmater for fremstilling derav, og medisinske preparater omfattende slike Download PDF

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Publication number
NO328218B1
NO328218B1 NO20021528A NO20021528A NO328218B1 NO 328218 B1 NO328218 B1 NO 328218B1 NO 20021528 A NO20021528 A NO 20021528A NO 20021528 A NO20021528 A NO 20021528A NO 328218 B1 NO328218 B1 NO 328218B1
Authority
NO
Norway
Prior art keywords
group
benzyl
pyridyl
quinuclidinol
ethynyl
Prior art date
Application number
NO20021528A
Other languages
English (en)
Norwegian (no)
Other versions
NO20021528L (no
NO20021528D0 (no
Inventor
Hironori Ikuta
Takao Saeki
Toshimi Okada
Hironobu Hiyoshi
Kazuki Miyazaki
Nobuyuki Kurusu
Keigo Tanaka
Daisuke Shinmyo
Hiroyuki Sugumi
Mamoru Yanagimachi
Masashi Ito
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Publication of NO20021528D0 publication Critical patent/NO20021528D0/no
Publication of NO20021528L publication Critical patent/NO20021528L/no
Publication of NO328218B1 publication Critical patent/NO328218B1/no

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D453/00Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO20021528A 1999-09-28 2002-03-26 Kinuklidinforbindelser, anvendelse derav, fremgangsmater for fremstilling derav, og medisinske preparater omfattende slike NO328218B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP27390599 1999-09-28
JP2000179352 2000-06-15
PCT/JP2000/006665 WO2001023383A1 (fr) 1999-09-28 2000-09-27 Composes de quinuclidine et medicaments contenant ces composes comme principe actif

Publications (3)

Publication Number Publication Date
NO20021528D0 NO20021528D0 (no) 2002-03-26
NO20021528L NO20021528L (no) 2002-05-28
NO328218B1 true NO328218B1 (no) 2010-01-11

Family

ID=26550809

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20021528A NO328218B1 (no) 1999-09-28 2002-03-26 Kinuklidinforbindelser, anvendelse derav, fremgangsmater for fremstilling derav, og medisinske preparater omfattende slike

Country Status (20)

Country Link
US (1) US6599917B1 (fr)
EP (1) EP1217001B1 (fr)
JP (1) JP4206212B2 (fr)
KR (1) KR100694687B1 (fr)
CN (1) CN100334085C (fr)
AT (1) ATE312100T1 (fr)
AU (1) AU782114B2 (fr)
BR (1) BR0014331A (fr)
CA (1) CA2385995C (fr)
DE (1) DE60024651T2 (fr)
DK (1) DK1217001T3 (fr)
ES (1) ES2252063T3 (fr)
HU (1) HUP0203514A3 (fr)
IL (2) IL148631A0 (fr)
MX (1) MXPA02003167A (fr)
NO (1) NO328218B1 (fr)
NZ (1) NZ517788A (fr)
RU (1) RU2266905C2 (fr)
TW (1) TWI282794B (fr)
WO (1) WO2001023383A1 (fr)

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US7361671B2 (en) * 2001-11-15 2008-04-22 The Institute For Pharmaceutical Discovery, Inc. Substituted heteroarylalkanoic acids
DE10225537A1 (de) * 2002-06-10 2003-12-18 Bayer Ag N-alkylierte Thiazoliumsalze und Verfahren zu deren Herstellung
GB0218876D0 (en) * 2002-08-13 2002-09-25 Merck Sharp & Dohme Therapeutic agents
CA2499128C (fr) 2002-09-25 2012-07-31 Memory Pharmaceuticals Corporation Indazoles, benzothiazoles et benzoisothiazoles, leur preparation et leurs utilisations
DE10334724A1 (de) * 2003-07-30 2005-02-24 Bayer Healthcare Ag N-Biarylamide
JP4667384B2 (ja) * 2003-10-07 2011-04-13 レノビス, インコーポレイテッド イオンチャネルリガンドとしてのアミド誘導体および薬学的組成物、ならびにこれらを使用する方法
MXPA06010852A (es) 2004-03-25 2007-01-16 Memory Pharm Corp Indazoles, benzotiazoles, benzoisotiazoles, bencisoxazoles y preparacion y usos de los mismos.
US8106066B2 (en) 2005-09-23 2012-01-31 Memory Pharmaceuticals Corporation Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof
JP2010519328A (ja) 2007-02-26 2010-06-03 ファイザー・プロダクツ・インク H−pgdsの阻害剤としてのニコチンアミド誘導体およびプロスタグランジンd2が媒介する疾患の治療のためのそれらの使用
TW201111385A (en) 2009-08-27 2011-04-01 Biocryst Pharm Inc Heterocyclic compounds as janus kinase inhibitors
US8420661B2 (en) * 2010-04-13 2013-04-16 Hoffmann-La Roche Inc. Arylethynyl derivatives
AU2011258005A1 (en) 2010-05-28 2013-01-17 Biocryst Pharmaceuticals, Inc. Heterocyclic compounds as Janus kinase inhibitors
SG11201403645VA (en) 2011-12-28 2014-07-30 Global Blood Therapeutics Inc Substituted benzaldehyde compounds and methods for their use in increasing tissue oxygenation
EP2797597B1 (fr) 2011-12-28 2020-02-26 Global Blood Therapeutics, Inc. Composés d'aldéhydes hétéroaryles substitués et leurs procédés d'utilisation dans l'accroissement de l'oxygénation tissulaire
WO2014060381A1 (fr) 2012-10-18 2014-04-24 Bayer Cropscience Ag Composés hétérocycliques pour la lutte contre les nuisibles
EP2914587A1 (fr) 2012-10-31 2015-09-09 Bayer CropScience AG Nouveaux composés hétérocycliques utilisés comme agents de lutte contre les nuisibles
US9802900B2 (en) 2013-03-15 2017-10-31 Global Blood Therapeutics, Inc. Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin
US9422279B2 (en) 2013-03-15 2016-08-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US20140274961A1 (en) 2013-03-15 2014-09-18 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9604999B2 (en) 2013-03-15 2017-03-28 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US10266551B2 (en) 2013-03-15 2019-04-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
CA2902711C (fr) 2013-03-15 2021-07-06 Global Blood Therapeutics, Inc. Derives de pyridinyl-6-methoxy-2-hydroxybenzaldehyde substitues et compositions pharmaceutiques de ceux-ci pour utilisation dans la modulation de l'hemoglobine
US8952171B2 (en) 2013-03-15 2015-02-10 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
AU2014237340C1 (en) 2013-03-15 2018-11-08 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
EA033555B1 (ru) 2013-03-15 2019-10-31 Global Blood Therapeutics Inc Фармацевтические композиции для лечения серповидно-клеточного нарушения
US9458139B2 (en) 2013-03-15 2016-10-04 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
WO2014145040A1 (fr) 2013-03-15 2014-09-18 Global Blood Therapeutics, Inc. Composés aldéhydes substitués et leurs procédés d'utilisation pour accroître l'oxygénation tissulaire
EA201992707A1 (ru) 2013-11-18 2020-06-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
AP2016009261A0 (en) 2014-02-07 2016-06-30 Global Blood Therapeutics Inc Crystalline polymorphs of the free base of 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde
MA41841A (fr) 2015-03-30 2018-02-06 Global Blood Therapeutics Inc Composés aldéhyde pour le traitement de la fibrose pulmonaire, de l'hypoxie, et de maladies auto-immunes et des tissus conjonctifs
PT3303316T (pt) 2015-06-03 2020-04-27 Hoffmann La Roche Derivados de etinilo
WO2017096230A1 (fr) 2015-12-04 2017-06-08 Global Blood Therapeutics, Inc. Régimes posologiques pour 2-hydroxy-6-((2- (1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)méthoxy)benzaldéhyde
TWI825524B (zh) 2016-05-12 2023-12-11 美商全球血液治療公司 用於合成2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)-吡啶-3-基)甲氧基)苯甲醛之方法
TWI778983B (zh) 2016-10-12 2022-10-01 美商全球血液治療公司 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑
US20200115389A1 (en) 2018-09-18 2020-04-16 Nikang Therapeutics, Inc. Fused tricyclic ring derivatives as src homology-2 phosphatase inhibitors
ES2966707T3 (es) 2018-10-01 2024-04-23 Global Blood Therapeutics Inc Moduladores de la hemoglobina para el tratamiento de la drepanocitosis

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GB9226573D0 (en) 1992-12-21 1993-02-17 Ici Plc Heterocyclic compounds
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JPH08134067A (ja) * 1994-11-11 1996-05-28 Yamanouchi Pharmaceut Co Ltd キヌクリジン誘導体
JPH08269056A (ja) * 1995-03-29 1996-10-15 Chugai Pharmaceut Co Ltd スクアレンシンセターゼ阻害作用を有するキヌクリジン誘導体
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WO1997044339A1 (fr) * 1996-05-20 1997-11-27 Merck & Co., Inc. Antagonistes de la gonadoliberine

Also Published As

Publication number Publication date
KR100694687B1 (ko) 2007-03-13
RU2266905C2 (ru) 2005-12-27
HUP0203514A2 (hu) 2003-03-28
KR20020034197A (ko) 2002-05-08
DE60024651D1 (de) 2006-01-12
ATE312100T1 (de) 2005-12-15
CN100334085C (zh) 2007-08-29
TWI282794B (en) 2007-06-21
HUP0203514A3 (en) 2004-01-28
NZ517788A (en) 2003-11-28
IL148631A0 (en) 2002-09-12
WO2001023383A1 (fr) 2001-04-05
JP4206212B2 (ja) 2009-01-07
EP1217001A4 (fr) 2002-12-18
IL148631A (en) 2010-04-29
NO20021528L (no) 2002-05-28
AU782114B2 (en) 2005-07-07
CN1377349A (zh) 2002-10-30
NO20021528D0 (no) 2002-03-26
ES2252063T3 (es) 2006-05-16
CA2385995C (fr) 2009-06-16
CA2385995A1 (fr) 2001-04-05
AU7446400A (en) 2001-04-30
DK1217001T3 (da) 2006-03-20
MXPA02003167A (es) 2003-10-06
BR0014331A (pt) 2003-06-10
EP1217001A1 (fr) 2002-06-26
DE60024651T2 (de) 2006-09-28
EP1217001B1 (fr) 2005-12-07
US6599917B1 (en) 2003-07-29

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