NO327982B1 - C(7)-estersubstituerte taxaner, farmasoytiske preparater som omfatter taxanene, preparater for oral administrering som omfatter taxanene, samt anvendelse av taxanene til fremstilling av orale farmasoytiske preparater for inhibering av tumorvekst hos pattedyr - Google Patents
C(7)-estersubstituerte taxaner, farmasoytiske preparater som omfatter taxanene, preparater for oral administrering som omfatter taxanene, samt anvendelse av taxanene til fremstilling av orale farmasoytiske preparater for inhibering av tumorvekst hos pattedyr Download PDFInfo
- Publication number
- NO327982B1 NO327982B1 NO20014759A NO20014759A NO327982B1 NO 327982 B1 NO327982 B1 NO 327982B1 NO 20014759 A NO20014759 A NO 20014759A NO 20014759 A NO20014759 A NO 20014759A NO 327982 B1 NO327982 B1 NO 327982B1
- Authority
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- Norway
- Prior art keywords
- ethyl
- butyl
- taxanes
- xio
- solution
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- 229940123237 Taxane Drugs 0.000 title claims description 41
- 238000002360 preparation method Methods 0.000 title claims description 40
- 239000000825 pharmaceutical preparation Substances 0.000 title claims description 17
- 241000124008 Mammalia Species 0.000 title claims description 5
- 230000004614 tumor growth Effects 0.000 title claims description 4
- 239000008183 oral pharmaceutical preparation Substances 0.000 title claims description 3
- 230000005764 inhibitory process Effects 0.000 title description 3
- -1 tert-amyl Chemical group 0.000 claims description 35
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- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 29
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 23
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 22
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 18
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 11
- 125000000217 alkyl group Chemical group 0.000 claims description 10
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- 125000002541 furyl group Chemical group 0.000 claims description 4
- 230000002401 inhibitory effect Effects 0.000 claims description 3
- 125000001544 thienyl group Chemical group 0.000 claims description 3
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims description 2
- 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 claims 13
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 claims 11
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- XBXCNNQPRYLIDE-UHFFFAOYSA-M n-tert-butylcarbamate Chemical compound CC(C)(C)NC([O-])=O XBXCNNQPRYLIDE-UHFFFAOYSA-M 0.000 description 1
- 229960002446 octanoic acid Drugs 0.000 description 1
- YYZUSRORWSJGET-UHFFFAOYSA-N octanoic acid ethyl ester Natural products CCCCCCCC(=O)OCC YYZUSRORWSJGET-UHFFFAOYSA-N 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
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- 239000006186 oral dosage form Substances 0.000 description 1
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000006201 parenteral dosage form Substances 0.000 description 1
- 235000020232 peanut Nutrition 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 150000002972 pentoses Chemical class 0.000 description 1
- 229940124531 pharmaceutical excipient Drugs 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229920001515 polyalkylene glycol Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920001522 polyglycol ester Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
- 235000010483 polyoxyethylene sorbitan monopalmitate Nutrition 0.000 description 1
- 239000000249 polyoxyethylene sorbitan monopalmitate Substances 0.000 description 1
- 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 description 1
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 description 1
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 description 1
- 239000013630 prepared media Substances 0.000 description 1
- XVSSGIXTKVRGAR-UHFFFAOYSA-N prop-2-enoxycarbonyl prop-2-enyl carbonate Chemical compound C=CCOC(=O)OC(=O)OCC=C XVSSGIXTKVRGAR-UHFFFAOYSA-N 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- RZWZRACFZGVKFM-UHFFFAOYSA-N propanoyl chloride Chemical compound CCC(Cl)=O RZWZRACFZGVKFM-UHFFFAOYSA-N 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
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- 125000004076 pyridyl group Chemical group 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 238000001226 reprecipitation Methods 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 239000004248 saffron Substances 0.000 description 1
- 235000013974 saffron Nutrition 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 239000010686 shark liver oil Substances 0.000 description 1
- 229940069764 shark liver oil Drugs 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 125000003808 silyl group Chemical group [H][Si]([H])([H])[*] 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
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- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 235000017550 sodium carbonate Nutrition 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
- BTURAGWYSMTVOW-UHFFFAOYSA-M sodium dodecanoate Chemical compound [Na+].CCCCCCCCCCCC([O-])=O BTURAGWYSMTVOW-UHFFFAOYSA-M 0.000 description 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
- 229940082004 sodium laurate Drugs 0.000 description 1
- 229940001584 sodium metabisulfite Drugs 0.000 description 1
- 235000010262 sodium metabisulphite Nutrition 0.000 description 1
- 235000010265 sodium sulphite Nutrition 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
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- 239000001593 sorbitan monooleate Substances 0.000 description 1
- 229940035049 sorbitan monooleate Drugs 0.000 description 1
- 229940084106 spermaceti Drugs 0.000 description 1
- 239000012177 spermaceti Substances 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- 229940031439 squalene Drugs 0.000 description 1
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 1
- 239000012086 standard solution Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 230000000707 stereoselective effect Effects 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 150000003892 tartrate salts Chemical class 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 235000007586 terpenes Nutrition 0.000 description 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 description 1
- 150000003538 tetroses Chemical class 0.000 description 1
- 238000011287 therapeutic dose Methods 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 229940033663 thimerosal Drugs 0.000 description 1
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- 125000004665 trialkylsilyl group Chemical group 0.000 description 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
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- 238000009736 wetting Methods 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epoxy Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17979400P | 2000-02-02 | 2000-02-02 | |
| PCT/US2001/003385 WO2001057027A1 (en) | 2000-02-02 | 2001-02-02 | C7 ester substituted taxanes as antitumor agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20014759D0 NO20014759D0 (no) | 2001-10-01 |
| NO20014759L NO20014759L (no) | 2001-11-29 |
| NO327982B1 true NO327982B1 (no) | 2009-11-02 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20014759A NO327982B1 (no) | 2000-02-02 | 2001-10-01 | C(7)-estersubstituerte taxaner, farmasoytiske preparater som omfatter taxanene, preparater for oral administrering som omfatter taxanene, samt anvendelse av taxanene til fremstilling av orale farmasoytiske preparater for inhibering av tumorvekst hos pattedyr |
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| EP (1) | EP1183253B8 (de) |
| JP (1) | JP2003522167A (de) |
| KR (1) | KR100784161B1 (de) |
| CN (1) | CN1362955A (de) |
| AR (1) | AR030188A1 (de) |
| AT (1) | ATE396188T1 (de) |
| AU (1) | AU776051B2 (de) |
| BG (1) | BG65279B1 (de) |
| BR (1) | BR0104749A (de) |
| CA (1) | CA2368993C (de) |
| CO (1) | CO5280224A1 (de) |
| CZ (1) | CZ298484B6 (de) |
| DE (1) | DE60134094D1 (de) |
| DK (1) | DK1183253T3 (de) |
| ES (1) | ES2307588T3 (de) |
| GE (1) | GEP20043322B (de) |
| HK (1) | HK1047938A1 (de) |
| HU (1) | HUP0200917A3 (de) |
| IL (1) | IL145641A0 (de) |
| MX (1) | MXPA01009901A (de) |
| MY (1) | MY137637A (de) |
| NO (1) | NO327982B1 (de) |
| NZ (1) | NZ514409A (de) |
| PL (1) | PL202668B1 (de) |
| PT (1) | PT1183253E (de) |
| RO (1) | RO121777B1 (de) |
| RU (1) | RU2265017C2 (de) |
| SA (1) | SA01220045B1 (de) |
| SK (1) | SK13712001A3 (de) |
| TR (1) | TR200102856T1 (de) |
| TW (1) | TWI291873B (de) |
| UA (1) | UA75573C2 (de) |
| WO (1) | WO2001057027A1 (de) |
| ZA (1) | ZA200108060B (de) |
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| CO5280224A1 (es) * | 2000-02-02 | 2003-05-30 | Univ Florida State Res Found | Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen |
| CZ20013498A3 (cs) * | 2000-02-02 | 2002-04-17 | Florida State University Research Foundation, Inc. | Taxanové formulace mající zlepąenou rozpustnost |
| CA2354486A1 (en) * | 2001-07-31 | 2003-01-31 | Florida State University Research Foundation, Inc. | C7 ester substituted taxanes |
| KR100819578B1 (ko) * | 2001-08-01 | 2008-04-04 | 플로리다 스테이트 유니버시티 리서치 파운데이션, 인크 | Ｃ７ 에스테르 치환된 탁산 |
| SG125889A1 (en) * | 2001-08-01 | 2006-10-30 | Univ Florida State Res Found | C7 ester subsituted taxanes |
| US20030082229A1 (en) * | 2001-11-01 | 2003-05-01 | Board Of Regents, The University Of Texas Systems | Parenteral chlorambucil for treatment of malignant and autoimmune disease and methods of use |
| US8012950B2 (en) * | 2003-08-29 | 2011-09-06 | Wisconsin Alumni Research Foundation | Method to diagnose and treat degenerative joint disease |
| SI1664033T1 (sl) * | 2003-09-25 | 2008-04-30 | Tapestry Pharmaceuticals Inc | Analogi 9,10-alfa,alfa-oh-taksana in postopki za proizvodnjo le-teh |
| CN1886400A (zh) | 2003-09-25 | 2006-12-27 | 泰普斯特医药公司 | 9,10－α,α－OH紫杉烷类似物及其制备方法 |
| SV2006002036A (es) * | 2004-03-05 | 2006-03-16 | Univ Florida State Res Found | Taxanos con sustituyente lactiloxilo en el c7 |
| TW200533339A (en) * | 2004-03-16 | 2005-10-16 | Bristol Myers Squibb Co | Therapeutic synergy of anti-cancer compounds |
| US20090004118A1 (en) * | 2004-10-07 | 2009-01-01 | Shuming Nie | Multifunctional Nanoparticle Conjugates And Their Use |
| KR101292026B1 (ko) | 2004-10-25 | 2013-08-01 | 데크-테크 인코포레이티드 | 종양 치료제로서의 이소포스포르아미드 머스타드 및 이의동족체의 염 |
| US20060216767A1 (en) * | 2005-03-22 | 2006-09-28 | Saladax Biomedical Inc. | Docetaxel immunoassay |
| PL217731B1 (pl) | 2006-06-01 | 2014-08-29 | Tomasz Byrski | Sposób wykrywania genetycznie uwarunkowanej obniżonej odpowiedzi na chemioterapię cytostatykiem taksanowym, zastosowanie mutacji założycielskiej oraz zestawu do wykrywania takiej odpowiedzi |
| WO2008106621A1 (en) | 2007-02-28 | 2008-09-04 | Tapestry Pharmaceuticals, Inc | Taxane analogs for the treatment of brain cancer |
| US11786504B2 (en) | 2006-09-28 | 2023-10-17 | Tapestry Pharmaceuticals, Inc. | Taxane analogs for the treatment of brain cancer |
| WO2008121476A1 (en) | 2007-03-28 | 2008-10-09 | Tapestry Pharmaceuticals, Inc. | Biologically active taxane analogs and methods of treatment by oral administration |
| US11873308B2 (en) | 2006-11-06 | 2024-01-16 | Tapestry Pharmaceuticals, Inc. | Biologically active taxane analogs and methods of treatment by oral administration |
| US20120128657A1 (en) | 2007-02-07 | 2012-05-24 | Bewley Carole A | Synthetic macrocyclic compounds and methods for treating cancer |
| DK2155682T3 (en) | 2007-04-06 | 2015-09-21 | Ziopharm Oncology Inc | SALTS OF isophosphoramide mustard and analogs thereof |
| WO2010014841A1 (en) | 2008-07-31 | 2010-02-04 | Ziopharm Oncology, Inc. | Synthesis and formulations of salts of isophosphoramide mustard and analogs thereof |
| CA2753041A1 (en) | 2009-02-24 | 2010-09-02 | Dekk-Tec, Inc. | Complexes of 4-hydroperoxy ifosfamide as anti-tumor agents |
| WO2010138686A1 (en) | 2009-05-29 | 2010-12-02 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Mdri-inverse agents |
| WO2011112867A1 (en) | 2010-03-10 | 2011-09-15 | The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services | The use of fenoterol and fenoterol analogues in the treatment of glioblastomas and astrocytomas |
| WO2012033601A1 (en) | 2010-08-20 | 2012-03-15 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Thiosemicarbazones with mdr1 - inverse activity |
| CA2841120C (en) | 2011-07-11 | 2020-10-27 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Antibody-ir700 conjugates for photodynamic therapy |
| US20150157580A1 (en) | 2012-05-25 | 2015-06-11 | The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services | Methods of regulating cannabinoid receptor activity-related disorders and diseases |
| CA3178299A1 (en) | 2013-10-11 | 2015-04-16 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Tem8 antibodies and their use |
| US10830678B2 (en) | 2014-08-08 | 2020-11-10 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv | Photo-controlled removal of targets in vitro and in vivo |
| WO2019099615A1 (en) | 2017-11-17 | 2019-05-23 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Use of copeptin to modulate the immune response and hematopoiesis, and stimulate bone growth |
| CN112272676A (zh) | 2018-04-10 | 2021-01-26 | 美国政府(由卫生和人类服务部的部长所代表) | 靶向癌细胞的近红外光免疫疗法与宿主免疫激活的联合使用 |
| EP3994173A1 (de) | 2019-07-02 | 2022-05-11 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Monoklonale egfrviii-bindende antikörper und ihre verwendung |
| US20230057461A1 (en) | 2020-01-27 | 2023-02-23 | The U.S.A., As Represented By The Secretary, Department Of Health And Human Services | Rab13 and net1 antisense oligonucleotides to treat metastatic cancer |
| CA3210086A1 (en) | 2021-01-29 | 2022-08-04 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Near infrared photoimmunotherapy (nir-pit) combination therapy to treat cancer |
| EP4329786A1 (de) | 2021-04-30 | 2024-03-06 | KaliVir Immunotherapeutics, Inc. | Onkolytische viren zur modifizierten mhc-expression |
| WO2024006965A1 (en) | 2022-06-30 | 2024-01-04 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Cd25-specific antibodies and uses thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2601675B1 (fr) * | 1986-07-17 | 1988-09-23 | Rhone Poulenc Sante | Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent |
| US5321128A (en) * | 1988-09-06 | 1994-06-14 | Kabi Pharmacia Ab | Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension |
| US4960790A (en) | 1989-03-09 | 1990-10-02 | University Of Kansas | Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof |
| SE463189B (sv) | 1989-03-13 | 1990-10-22 | Eston Joensson | Preparat avsett att tillfoeras amalgamfyllningar i taender foer att daerigenom hindra eller minska avgaang av kvicksilver eller kvicksilveraanga |
| US5175315A (en) | 1989-05-31 | 1992-12-29 | Florida State University | Method for preparation of taxol using β-lactam |
| FR2679230B1 (fr) | 1991-07-16 | 1993-11-19 | Rhone Poulenc Rorer Sa | Nouveaux derives d'analogues du taxol, leur preparation et les compositions qui les contiennent. |
| US5243045A (en) | 1991-09-23 | 1993-09-07 | Florida State University | Certain alkoxy substituted taxanes and pharmaceutical compositions containing them |
| US5721268A (en) | 1991-09-23 | 1998-02-24 | Florida State University | C7 taxane derivatives and pharmaceutical compositions containing them |
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2001
- 2001-01-31 CO CO01007075A patent/CO5280224A1/es not_active Application Discontinuation
- 2001-01-31 AR ARP010100463A patent/AR030188A1/es not_active Application Discontinuation
- 2001-02-02 NZ NZ514409A patent/NZ514409A/xx unknown
- 2001-02-02 AT AT01905349T patent/ATE396188T1/de not_active IP Right Cessation
- 2001-02-02 EP EP01905349A patent/EP1183253B8/de not_active Expired - Lifetime
- 2001-02-02 RO ROA200101085A patent/RO121777B1/ro unknown
- 2001-02-02 DE DE60134094T patent/DE60134094D1/de not_active Expired - Fee Related
- 2001-02-02 RU RU2001129507/04A patent/RU2265017C2/ru not_active IP Right Cessation
- 2001-02-02 BR BR0104749-3A patent/BR0104749A/pt not_active IP Right Cessation
- 2001-02-02 DK DK01905349T patent/DK1183253T3/da active
- 2001-02-02 JP JP2001557859A patent/JP2003522167A/ja active Pending
- 2001-02-02 CZ CZ20013503A patent/CZ298484B6/cs not_active IP Right Cessation
- 2001-02-02 HU HU0200917A patent/HUP0200917A3/hu unknown
- 2001-02-02 ES ES01905349T patent/ES2307588T3/es not_active Expired - Lifetime
- 2001-02-02 WO PCT/US2001/003385 patent/WO2001057027A1/en active IP Right Grant
- 2001-02-02 MX MXPA01009901A patent/MXPA01009901A/es active IP Right Grant
- 2001-02-02 PT PT01905349T patent/PT1183253E/pt unknown
- 2001-02-02 UA UA2001106734A patent/UA75573C2/uk unknown
- 2001-02-02 CA CA002368993A patent/CA2368993C/en not_active Expired - Fee Related
- 2001-02-02 PL PL350026A patent/PL202668B1/pl not_active IP Right Cessation
- 2001-02-02 KR KR1020017012600A patent/KR100784161B1/ko not_active IP Right Cessation
- 2001-02-02 GE GE4514A patent/GEP20043322B/en unknown
- 2001-02-02 AU AU33239/01A patent/AU776051B2/en not_active Ceased
- 2001-02-02 IL IL14564101A patent/IL145641A0/xx unknown
- 2001-02-02 MY MYPI20010481A patent/MY137637A/en unknown
- 2001-02-02 SK SK1371-2001A patent/SK13712001A3/sk unknown
- 2001-02-02 CN CN01800306A patent/CN1362955A/zh active Pending
- 2001-02-02 TR TR2001/02856T patent/TR200102856T1/xx unknown
- 2001-02-02 US US09/775,851 patent/US6610860B2/en not_active Expired - Fee Related
- 2001-03-06 TW TW090102237A patent/TWI291873B/zh active
- 2001-04-11 SA SA1220045A patent/SA01220045B1/ar unknown
- 2001-10-01 NO NO20014759A patent/NO327982B1/no not_active IP Right Cessation
- 2001-10-01 BG BG105967A patent/BG65279B1/bg unknown
- 2001-10-01 ZA ZA200108060A patent/ZA200108060B/en unknown
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2003
- 2003-01-07 HK HK03100173.6A patent/HK1047938A1/zh unknown
- 2003-06-25 US US10/606,027 patent/US7186849B2/en not_active Expired - Fee Related
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2007
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