NO326612B1 - Variant av human DNase I, isolert nukleinsyre og preparat for reduksjon av viskoelastisiteten til pulmonale sekreter. - Google Patents

Variant av human DNase I, isolert nukleinsyre og preparat for reduksjon av viskoelastisiteten til pulmonale sekreter. Download PDF

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Publication number
NO326612B1
NO326612B1 NO19973876A NO973876A NO326612B1 NO 326612 B1 NO326612 B1 NO 326612B1 NO 19973876 A NO19973876 A NO 19973876A NO 973876 A NO973876 A NO 973876A NO 326612 B1 NO326612 B1 NO 326612B1
Authority
NO
Norway
Prior art keywords
dnase
variant
actin
human dnase
dna
Prior art date
Application number
NO19973876A
Other languages
English (en)
Norwegian (no)
Other versions
NO973876D0 (no
NO973876L (no
Inventor
Robert A Lazarus
Steven Shak
Jana S Ulmer
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Application filed by Genentech Inc filed Critical Genentech Inc
Priority to NO19973876A priority Critical patent/NO326612B1/no
Publication of NO973876D0 publication Critical patent/NO973876D0/no
Publication of NO973876L publication Critical patent/NO973876L/no
Publication of NO326612B1 publication Critical patent/NO326612B1/no

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/16Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22Ribonucleases RNAses, DNAses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/12Mucolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NO19973876A 1995-02-24 1997-08-22 Variant av human DNase I, isolert nukleinsyre og preparat for reduksjon av viskoelastisiteten til pulmonale sekreter. NO326612B1 (no)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NO19973876A NO326612B1 (no) 1995-02-24 1997-08-22 Variant av human DNase I, isolert nukleinsyre og preparat for reduksjon av viskoelastisiteten til pulmonale sekreter.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/US1995/002366 WO1996026278A1 (en) 1995-02-24 1995-02-24 HUMAN DNase I VARIANTS
NO19973876A NO326612B1 (no) 1995-02-24 1997-08-22 Variant av human DNase I, isolert nukleinsyre og preparat for reduksjon av viskoelastisiteten til pulmonale sekreter.

Publications (3)

Publication Number Publication Date
NO973876D0 NO973876D0 (no) 1997-08-22
NO973876L NO973876L (no) 1997-10-24
NO326612B1 true NO326612B1 (no) 2009-01-19

Family

ID=22248728

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19973876A NO326612B1 (no) 1995-02-24 1997-08-22 Variant av human DNase I, isolert nukleinsyre og preparat for reduksjon av viskoelastisiteten til pulmonale sekreter.

Country Status (22)

Country Link
EP (1) EP0811068B1 (xx)
JP (1) JPH11505408A (xx)
AT (1) ATE230027T1 (xx)
AU (1) AU720635B2 (xx)
BG (1) BG64061B1 (xx)
BR (1) BR9510323A (xx)
CA (1) CA2210871C (xx)
CZ (1) CZ288633B6 (xx)
DE (1) DE69529235T2 (xx)
DK (1) DK0811068T3 (xx)
ES (1) ES2188653T3 (xx)
HU (1) HU223272B1 (xx)
MX (1) MX9706428A (xx)
NO (1) NO326612B1 (xx)
PL (1) PL180773B1 (xx)
PT (1) PT811068E (xx)
RU (1) RU2215787C2 (xx)
SI (1) SI9520153B (xx)
SK (1) SK283850B6 (xx)
UA (2) UA66749C2 (xx)
WO (1) WO1996026278A1 (xx)
ZA (1) ZA961419B (xx)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK284191B6 (sk) * 1995-02-24 2004-10-05 Genentech, Inc. Aktín-rezistentný variant humánnej DNázy I
US6391607B1 (en) 1996-06-14 2002-05-21 Genentech, Inc. Human DNase I hyperactive variants
EP1433842B1 (en) 2002-12-18 2011-01-05 Roche Diagnostics GmbH Recombinant bovine pancreatic desoxyribonuclease I with high specific activity
ATE494367T1 (de) 2002-12-18 2011-01-15 Hoffmann La Roche Rekombinante desoxyribonuclease i aus rinder- pankreas mit hoher spezifischer aktivität
WO2013114374A1 (en) * 2012-02-01 2013-08-08 Protalix Ltd. Dnase i polypeptides, polynucleotides encoding same, methods of producing dnase i and uses thereof in therapy

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2130120T3 (es) * 1988-12-23 1999-07-01 Genentech Inc Procedimiento para la preparacion de la adnasa humana.
US5464817A (en) * 1990-04-11 1995-11-07 Brigham And Women's Hospital Method for reducing the viscosity of pathological mucoid airway contents in the respiratory tract comprising administering actin-binding compounds with or without DNASE I

Also Published As

Publication number Publication date
CZ288633B6 (cs) 2001-08-15
EP0811068A1 (en) 1997-12-10
SK114797A3 (en) 1998-02-04
WO1996026278A1 (en) 1996-08-29
BR9510323A (pt) 1997-11-11
MX9706428A (es) 1997-11-29
BG64061B1 (bg) 2003-11-28
RU2215787C2 (ru) 2003-11-10
CA2210871A1 (en) 1996-08-29
JPH11505408A (ja) 1999-05-21
SI9520153B (sl) 2004-10-31
SI9520153A (sl) 1998-06-30
NO973876D0 (no) 1997-08-22
UA65523C2 (en) 2004-04-15
ATE230027T1 (de) 2003-01-15
DE69529235D1 (de) 2003-01-30
SK283850B6 (sk) 2004-03-02
ES2188653T3 (es) 2003-07-01
DK0811068T3 (da) 2003-03-10
ZA961419B (en) 1997-08-22
PT811068E (pt) 2003-04-30
PL180773B1 (pl) 2001-04-30
AU1970395A (en) 1996-09-11
NO973876L (no) 1997-10-24
CZ267797A3 (cs) 1998-01-14
HUT77422A (hu) 1998-04-28
EP0811068B1 (en) 2002-12-18
BG101846A (en) 1998-07-31
PL321890A1 (en) 1997-12-22
CA2210871C (en) 2009-04-07
DE69529235T2 (de) 2003-09-04
HU223272B1 (hu) 2004-04-28
AU720635B2 (en) 2000-06-08
UA66749C2 (en) 2004-06-15

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