NO326341B1 - Piperazindion-forbindelser, samt anvendelse derav. - Google Patents
Piperazindion-forbindelser, samt anvendelse derav. Download PDFInfo
- Publication number
- NO326341B1 NO326341B1 NO20025373A NO20025373A NO326341B1 NO 326341 B1 NO326341 B1 NO 326341B1 NO 20025373 A NO20025373 A NO 20025373A NO 20025373 A NO20025373 A NO 20025373A NO 326341 B1 NO326341 B1 NO 326341B1
- Authority
- NO
- Norway
- Prior art keywords
- compound
- dione
- phenyl
- methylidene
- benzyloxypyridin
- Prior art date
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- JTHRRMFZHSDGNJ-UHFFFAOYSA-N piperazine-2,3-dione Chemical class O=C1NCCNC1=O JTHRRMFZHSDGNJ-UHFFFAOYSA-N 0.000 title description 19
- 150000001875 compounds Chemical class 0.000 claims description 47
- -1 2-oxo-indolyl Chemical group 0.000 claims description 40
- 206010028980 Neoplasm Diseases 0.000 claims description 22
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 20
- 125000004076 pyridyl group Chemical group 0.000 claims description 11
- 125000001424 substituent group Chemical group 0.000 claims description 11
- 238000011282 treatment Methods 0.000 claims description 10
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 9
- 229910052736 halogen Inorganic materials 0.000 claims description 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 8
- 125000001041 indolyl group Chemical group 0.000 claims description 5
- 238000002360 preparation method Methods 0.000 claims description 5
- 125000002541 furyl group Chemical group 0.000 claims description 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims description 2
- 125000005843 halogen group Chemical group 0.000 claims 4
- 125000001544 thienyl group Chemical group 0.000 claims 2
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 48
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- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 36
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 30
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- AOSZTAHDEDLTLQ-AZKQZHLXSA-N (1S,2S,4R,8S,9S,11S,12R,13S,19S)-6-[(3-chlorophenyl)methyl]-12,19-difluoro-11-hydroxy-8-(2-hydroxyacetyl)-9,13-dimethyl-6-azapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one Chemical compound C([C@@H]1C[C@H]2[C@H]3[C@]([C@]4(C=CC(=O)C=C4[C@@H](F)C3)C)(F)[C@@H](O)C[C@@]2([C@@]1(C1)C(=O)CO)C)N1CC1=CC=CC(Cl)=C1 AOSZTAHDEDLTLQ-AZKQZHLXSA-N 0.000 description 2
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Devices For Conveying Motion By Means Of Endless Flexible Members (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30419100P | 2000-05-09 | 2000-05-09 | |
| PCT/US2001/014721 WO2001095858A2 (fr) | 2000-05-09 | 2001-05-08 | Composes de piperazinedione |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20025373D0 NO20025373D0 (no) | 2002-11-08 |
| NO20025373L NO20025373L (no) | 2002-12-13 |
| NO326341B1 true NO326341B1 (no) | 2008-11-10 |
Family
ID=23175471
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20025373A NO326341B1 (no) | 2000-05-09 | 2002-11-08 | Piperazindion-forbindelser, samt anvendelse derav. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6635649B2 (fr) |
| EP (1) | EP1282609B1 (fr) |
| JP (1) | JP5101781B2 (fr) |
| KR (1) | KR100852965B1 (fr) |
| CN (1) | CN100522949C (fr) |
| AT (1) | ATE417614T1 (fr) |
| BR (1) | BR0110745A (fr) |
| CZ (1) | CZ301743B6 (fr) |
| DE (1) | DE60137037D1 (fr) |
| HU (1) | HUP0302358A3 (fr) |
| NO (1) | NO326341B1 (fr) |
| RU (1) | RU2269520C2 (fr) |
| WO (1) | WO2001095858A2 (fr) |
| ZA (1) | ZA200209917B (fr) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7288545B2 (en) * | 2000-05-09 | 2007-10-30 | Angiorx Corporation | Piperazinedione compounds |
| CN101632669B (zh) | 2000-08-04 | 2011-05-18 | Dmi生物科学公司 | 二酮基哌嗪和包含它们的组合物的使用方法 |
| US7935704B2 (en) * | 2003-08-01 | 2011-05-03 | Nereus Pharmaceuticals, Inc. | Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof |
| US7919497B2 (en) | 2002-08-02 | 2011-04-05 | Nereus Pharmaceuticals, Inc. | Analogs of dehydrophenylahistins and their therapeutic use |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5973574A (ja) * | 1982-10-21 | 1984-04-25 | Grelan Pharmaceut Co Ltd | 環状ジペプチド類 |
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| DK181687A (da) * | 1986-04-23 | 1987-10-24 | Fujisawa Pharmaceutical Co | Piperazinderivater og fremgangsmaade til fremstiling deraf |
| GB9217331D0 (en) * | 1992-08-14 | 1992-09-30 | Xenova Ltd | Pharmaceutical compounds |
| GB9402807D0 (en) * | 1994-02-14 | 1994-04-06 | Xenova Ltd | Pharmaceutical compounds |
| IL112627A0 (en) * | 1994-02-14 | 1995-05-26 | Xenova Ltd | Diketopiperazines, their preparation and pharmaceutical or veterinary compositions containing them |
| JP3795093B2 (ja) * | 1994-11-25 | 2006-07-12 | キッセイ薬品工業株式会社 | １−ヒドロキシインドール誘導体 |
| JP3131574B2 (ja) * | 1996-09-04 | 2001-02-05 | 新日本製鐵株式会社 | 新規抗腫瘍物質、該物質を製造するための微生物及び方法、並びに該物質を有効成分とする細胞周期阻害剤及び抗腫瘍剤 |
-
2001
- 2001-05-08 HU HU0302358A patent/HUP0302358A3/hu unknown
- 2001-05-08 KR KR1020027015025A patent/KR100852965B1/ko not_active IP Right Cessation
- 2001-05-08 CZ CZ20023693A patent/CZ301743B6/cs not_active IP Right Cessation
- 2001-05-08 CN CNB018125212A patent/CN100522949C/zh not_active Expired - Fee Related
- 2001-05-08 DE DE60137037T patent/DE60137037D1/de not_active Expired - Lifetime
- 2001-05-08 JP JP2002510040A patent/JP5101781B2/ja not_active Expired - Fee Related
- 2001-05-08 BR BR0110745-3A patent/BR0110745A/pt not_active Application Discontinuation
- 2001-05-08 EP EP01975152A patent/EP1282609B1/fr not_active Expired - Lifetime
- 2001-05-08 US US09/851,077 patent/US6635649B2/en not_active Expired - Fee Related
- 2001-05-08 WO PCT/US2001/014721 patent/WO2001095858A2/fr active IP Right Grant
- 2001-05-08 AT AT01975152T patent/ATE417614T1/de not_active IP Right Cessation
- 2001-05-08 RU RU2002132897/04A patent/RU2269520C2/ru not_active IP Right Cessation
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2002
- 2002-11-08 NO NO20025373A patent/NO326341B1/no not_active IP Right Cessation
- 2002-12-06 ZA ZA200209917A patent/ZA200209917B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR0110745A (pt) | 2003-12-30 |
| NO20025373D0 (no) | 2002-11-08 |
| WO2001095858A2 (fr) | 2001-12-20 |
| NO20025373L (no) | 2002-12-13 |
| JP2004510701A (ja) | 2004-04-08 |
| ATE417614T1 (de) | 2009-01-15 |
| CN100522949C (zh) | 2009-08-05 |
| CZ20023693A3 (cs) | 2003-05-14 |
| JP5101781B2 (ja) | 2012-12-19 |
| WO2001095858A3 (fr) | 2002-03-21 |
| RU2269520C2 (ru) | 2006-02-10 |
| ZA200209917B (en) | 2004-04-28 |
| EP1282609A2 (fr) | 2003-02-12 |
| EP1282609A4 (fr) | 2003-06-04 |
| US20020028819A1 (en) | 2002-03-07 |
| EP1282609B1 (fr) | 2008-12-17 |
| DE60137037D1 (de) | 2009-01-29 |
| US6635649B2 (en) | 2003-10-21 |
| HUP0302358A2 (hu) | 2003-11-28 |
| KR20030005336A (ko) | 2003-01-17 |
| CZ301743B6 (cs) | 2010-06-09 |
| CN1441789A (zh) | 2003-09-10 |
| KR100852965B1 (ko) | 2008-08-19 |
| HUP0302358A3 (en) | 2007-09-28 |
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