CA2408649C - Composes de piperazinedione - Google Patents

Composes de piperazinedione Download PDF

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Publication number
CA2408649C
CA2408649C CA2408649A CA2408649A CA2408649C CA 2408649 C CA2408649 C CA 2408649C CA 2408649 A CA2408649 A CA 2408649A CA 2408649 A CA2408649 A CA 2408649A CA 2408649 C CA2408649 C CA 2408649C
Authority
CA
Canada
Prior art keywords
compound
aryl
alkyl
dione
methylidene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2408649A
Other languages
English (en)
Other versions
CA2408649A1 (fr
Inventor
Eric I. C. Li
On Lee
Jih-Hwa Guh
Huei-Ting Chen
Yan-Bing Fan
Ya-Lan Chen
Che-Ming Teng
Hui-Po Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AngioRx Corp
Original Assignee
AngioRx Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AngioRx Corp filed Critical AngioRx Corp
Priority claimed from PCT/US2001/014721 external-priority patent/WO2001095858A2/fr
Publication of CA2408649A1 publication Critical patent/CA2408649A1/fr
Application granted granted Critical
Publication of CA2408649C publication Critical patent/CA2408649C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne les composés de pipérazinedione de la formule (I) dans laquelle ---- et ---- représentent indépendamment une simple liaison ou une double liaison; A est H ou CH(R?a¿R?b¿) lorsque ---- est une simple liaison, ou C(R?a¿R?b¿) lorsque ---- est une double liaison; Z est R¿3?O-(Ar)-B avec B étant CH(R?c¿) lorsque ---- est une simple liaison, ou C(R?c¿) lorsque ---- est une double liaison; Ar est hétéroaryle; R¿3? est H, alkyle, aryle, hétéroaryle, C(O)R?d¿, C(O)OR?d¿, C(O)NR?d¿R?e¿, ou SO¿2?R?d¿, R¿1? et R¿2? sont indépendamment H C(O)R?d¿, C(O)OR?d¿, C(O)NR?d¿R?e¿, ou SO¿2?R?d¿; et R?a¿, R?b¿, R?c¿, R?d¿, et R?e¿ sont indépendamment H, alkyle, aryle, hétéroaryle, cyclyle, or hétérocyclyle. Eventuellement, R?a¿ et R?b¿ pris ensemble sont cyclyle ou hétérocyclyle; et également éventuellement, R¿1? et R?a¿ ou R¿1? et R?b¿ pris ensemble sont cyclyle ou hétérocyclyle.
CA2408649A 2000-05-09 2001-05-08 Composes de piperazinedione Expired - Fee Related CA2408649C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US30419100P 2000-05-09 2000-05-09
US56727100A 2000-05-09 2000-05-09
US90/567,211 2000-05-09
US60/304,191 2000-05-09
PCT/US2001/014721 WO2001095858A2 (fr) 2000-05-09 2001-05-08 Composes de piperazinedione

Publications (2)

Publication Number Publication Date
CA2408649A1 CA2408649A1 (fr) 2001-12-20
CA2408649C true CA2408649C (fr) 2010-04-27

Family

ID=26973869

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2408649A Expired - Fee Related CA2408649C (fr) 2000-05-09 2001-05-08 Composes de piperazinedione

Country Status (1)

Country Link
CA (1) CA2408649C (fr)

Also Published As

Publication number Publication date
CA2408649A1 (fr) 2001-12-20

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Effective date: 20130508