NO325611B1 - Laktosefrie, ikke-hygroskopiske og vannfrie farmasoytiske sammensetninger av deskarboetoksyloratadin, samt anvendelse derav ved behandling av sykdommer og forstyrrelser - Google Patents
Laktosefrie, ikke-hygroskopiske og vannfrie farmasoytiske sammensetninger av deskarboetoksyloratadin, samt anvendelse derav ved behandling av sykdommer og forstyrrelser Download PDFInfo
- Publication number
- NO325611B1 NO325611B1 NO19992157A NO992157A NO325611B1 NO 325611 B1 NO325611 B1 NO 325611B1 NO 19992157 A NO19992157 A NO 19992157A NO 992157 A NO992157 A NO 992157A NO 325611 B1 NO325611 B1 NO 325611B1
- Authority
- NO
- Norway
- Prior art keywords
- pharmaceutical composition
- pharmaceutically acceptable
- descarboethoxyloratadine
- composition according
- acceptable salt
- Prior art date
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Landscapes
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- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
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US3732597P | 1997-02-07 | 1997-02-07 | |
US4518497P | 1997-04-30 | 1997-04-30 | |
US5305097P | 1997-07-21 | 1997-07-21 | |
PCT/US1998/002328 WO1998034614A1 (en) | 1997-02-07 | 1998-02-06 | Lactose-free, non-hygroscopic and anhydrous pharmaceutical compositions of descarboethoxyloratadine |
Publications (3)
Publication Number | Publication Date |
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NO992157D0 NO992157D0 (no) | 1999-05-04 |
NO992157L NO992157L (no) | 1999-05-04 |
NO325611B1 true NO325611B1 (no) | 2008-06-23 |
Family
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Application Number | Title | Priority Date | Filing Date |
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NO19992157A NO325611B1 (no) | 1997-02-07 | 1999-05-04 | Laktosefrie, ikke-hygroskopiske og vannfrie farmasoytiske sammensetninger av deskarboetoksyloratadin, samt anvendelse derav ved behandling av sykdommer og forstyrrelser |
NO20075846A NO20075846L (no) | 1997-02-07 | 2007-11-14 | Laktosefrie, ikke-hygroskopiske og vannfrie farmasoytiske sammensetninger av deskarboetoksyloratadin, samt anvendelse derav ved behandling av sykdommer og forstyrrelser |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
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NO20075846A NO20075846L (no) | 1997-02-07 | 2007-11-14 | Laktosefrie, ikke-hygroskopiske og vannfrie farmasoytiske sammensetninger av deskarboetoksyloratadin, samt anvendelse derav ved behandling av sykdommer og forstyrrelser |
Country Status (29)
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US (2) | US20020123504A1 (es) |
EP (2) | EP0969836B1 (es) |
JP (1) | JP2001511184A (es) |
KR (5) | KR20080003012A (es) |
CN (1) | CN1132579C (es) |
AR (3) | AR011114A1 (es) |
AT (1) | ATE345133T1 (es) |
AU (1) | AU6271998A (es) |
BR (1) | BR9806157A (es) |
CA (1) | CA2267136C (es) |
CO (1) | CO4940445A1 (es) |
CZ (1) | CZ119499A3 (es) |
DE (1) | DE69836424T2 (es) |
DK (1) | DK0969836T3 (es) |
ES (1) | ES2271986T3 (es) |
HK (1) | HK1024187A1 (es) |
HU (1) | HUP0001527A3 (es) |
MY (1) | MY136999A (es) |
NO (2) | NO325611B1 (es) |
NZ (1) | NZ335041A (es) |
PE (1) | PE71699A1 (es) |
PL (1) | PL192075B1 (es) |
PT (1) | PT969836E (es) |
RU (1) | RU2209627C2 (es) |
SK (1) | SK286035B6 (es) |
TW (1) | TW522014B (es) |
UA (1) | UA70290C2 (es) |
WO (1) | WO1998034614A1 (es) |
ZA (1) | ZA98977B (es) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SK288240B6 (sk) * | 1998-07-10 | 2015-02-03 | Merck Sharp & Dohme Corp. | Farmaceutický prostriedok na orálne podávanie |
US6100274A (en) * | 1999-07-07 | 2000-08-08 | Schering Corporation | 8-chloro-6,11-dihydro-11- ](4-piperidylidine)-5H-benzo[5,6]cyclohepta[1,2-bpyridine oral compositions |
JP2003509459A (ja) * | 1999-09-22 | 2003-03-11 | シェーリング コーポレイション | アレルギー状態および炎症状態の処置 |
US6114346A (en) * | 1999-10-22 | 2000-09-05 | Schering Corporation | Treating sleep disorders using desloratadine |
MY125516A (en) | 1999-11-16 | 2006-08-30 | Smithkline Beecham Plc | Novel composition based on thiazolidinedione and metformin and use |
SK287684B6 (sk) * | 1999-12-20 | 2011-06-06 | Schering Corporation | Pevná orálna farmaceutická dávková forma s predĺženým uvoľňovaním |
WO2001045676A2 (en) | 1999-12-20 | 2001-06-28 | Schering Corporation | Extended release oral dosage composition |
KR101199654B1 (ko) * | 1999-12-20 | 2012-11-08 | 머크 샤프 앤드 돔 코포레이션 | 안정한 서방출형의 경구 투여용 조성물 |
US7405223B2 (en) | 2000-02-03 | 2008-07-29 | Schering Corporation | Treating allergic and inflammatory conditions |
US20040242619A1 (en) * | 2003-03-12 | 2004-12-02 | Toth Zoltan G. | Processes for preparation of polymorphic forms of desloratadine |
US20060135547A1 (en) * | 2003-03-12 | 2006-06-22 | Toth Zoltan G | Stable pharmaceutical compositions of desloratadine and processes for preparation of polymorphic forms of desloratadine |
US7390503B1 (en) | 2003-08-22 | 2008-06-24 | Barr Laboratories, Inc. | Ondansetron orally disintegrating tablets |
EP1696881A2 (en) * | 2003-12-23 | 2006-09-06 | Sun Pharmaceutical Industries Limited | Stable oral composition |
TWI354569B (en) | 2004-05-28 | 2011-12-21 | Bristol Myers Squibb Co | Coated tablet formulation and method |
CA2574188A1 (en) * | 2004-07-16 | 2006-01-26 | Cipla Limited | Anti-histaminic composition |
US20100129310A1 (en) * | 2004-08-09 | 2010-05-27 | Pavak Rajnikanth Mehta | Stabilized desloratadine composition |
US20070004671A1 (en) * | 2005-05-20 | 2007-01-04 | Agarwal Sudeep K | Stable desloratadine compositions |
EP1728513A3 (en) * | 2005-05-20 | 2007-10-31 | Dr. Reddy's Laboratories, Inc. | Stable desloratadine compositions |
US20070014855A1 (en) * | 2005-07-12 | 2007-01-18 | Rahul Gawande S | Stable desloratadine compositions |
US20080118555A1 (en) * | 2005-10-20 | 2008-05-22 | Glenmark Pharmaceuticals Limited | Stable pharmaceutical composition containing desloratadine |
CA2541045A1 (en) * | 2006-03-24 | 2007-09-24 | Pharmascience Inc. | A descarbonylethoxyloratadine containing pharmaceutical composition |
US20070244144A1 (en) * | 2006-04-10 | 2007-10-18 | Ranbaxy Laboratories Limited | Process for the preparation of desloratadine |
WO2007140987A1 (en) * | 2006-06-07 | 2007-12-13 | Sandoz Ag | Stable and bioavailable formulations and a novel form of desloratadine |
ECSP077628A (es) | 2007-05-03 | 2008-12-30 | Smithkline Beechman Corp | Nueva composición farmacéutica |
TR200806298A2 (tr) | 2008-08-22 | 2010-03-22 | Bi̇lgi̇ç Mahmut | Farmasötik formülasyon |
WO2010094471A1 (en) | 2009-02-17 | 2010-08-26 | Krka, D. D., Novo Mesto | Pharmaceutical compositions comprising prasugrel base or its pharmaceutically acceptable acid addition salts and processes for their preparation |
EP2269586B1 (en) | 2009-07-01 | 2011-09-21 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Pharmaceutical composition comprising desloratadine |
EP2568970B1 (en) | 2010-05-10 | 2018-12-05 | Laboratorios Lesvi, S.L. | Stable pharmaceutical formulations containing an antihistaminic |
TR201009396A2 (tr) | 2010-11-11 | 2012-05-21 | Bi̇lgi̇ç Mahmut | Desloratadin granüller |
CN102813640B (zh) * | 2012-09-06 | 2016-12-21 | 无锡万全医药技术有限公司 | 一种含地氯雷他定的软胶囊及其制备方法 |
US20170135969A1 (en) | 2015-11-12 | 2017-05-18 | Jds Therapeutics, Llc | Topical arginine-silicate-inositol for wound healing |
AU2017318672B2 (en) * | 2016-09-01 | 2022-03-10 | Nutrition 21, Llc | Magnesium biotinate compositions and methods of use |
CN113230235B (zh) * | 2021-04-15 | 2022-11-11 | 海南普利制药股份有限公司 | 含地氯雷他定的复方缓释胶囊及其制备方法 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1548022A (en) * | 1976-10-06 | 1979-07-04 | Wyeth John & Brother Ltd | Pharmaceutial dosage forms |
WO1985003707A1 (en) * | 1984-02-15 | 1985-08-29 | Schering Corporation | 8-CHLORO-6,11-DIHYDRO-11-(4-PIPERIDYLIDENE)-5H-BENZO AD5,6 BDCYCLOHEPTA AD1,2-b BDPYRIDINE AND ITS SALTS, PROCESSES FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS |
US4990535A (en) * | 1989-05-03 | 1991-02-05 | Schering Corporation | Pharmaceutical composition comprising loratadine, ibuprofen and pseudoephedrine |
AU665341B2 (en) * | 1990-12-18 | 1996-01-04 | Wellcome Foundation Limited, The | Agents for potentiating the effects of antitumor agents and combating multiple drug resistance |
RU2068689C1 (ru) * | 1992-09-24 | 1996-11-10 | Товарищество с ограниченной ответственностью "Лекрон" | Способ получения таблеток парацетамола |
US5314697A (en) * | 1992-10-23 | 1994-05-24 | Schering Corporation | Stable extended release oral dosage composition comprising loratadine and pseudoephedrine |
DE4442999A1 (de) * | 1994-12-02 | 1996-06-05 | Hexal Pharma Gmbh | Pharmazeutische Zusammensetzung mit einem aktiven Loratidin-Metaboliten |
US5595997A (en) * | 1994-12-30 | 1997-01-21 | Sepracor Inc. | Methods and compositions for treating allergic rhinitis and other disorders using descarboethoxyloratadine |
US5939426A (en) * | 1997-02-28 | 1999-08-17 | Sepracor Inc. | Methods for treating urinary incontinence using descarboethoxyloratadine |
US6162829A (en) * | 1997-10-17 | 2000-12-19 | Atlantic Pharmaceuticals, Inc. | (3R,4R)-Δ8 -tetrahydrocannabinol-11-oic acids useful as antiinflammatory agents and analgesics |
US5997905A (en) * | 1998-09-04 | 1999-12-07 | Mcneil-Ppc | Preparation of pharmaceutically active particles |
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