NO325392B1 - Kapsel som innkapsler et cytokrom P450 uttrykkende gen, farmasoytisk preparat som inneholder kapselen og anvendelse av kapselen til fremstilling av et medikament - Google Patents

Kapsel som innkapsler et cytokrom P450 uttrykkende gen, farmasoytisk preparat som inneholder kapselen og anvendelse av kapselen til fremstilling av et medikament Download PDF

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Publication number
NO325392B1
NO325392B1 NO19984540A NO984540A NO325392B1 NO 325392 B1 NO325392 B1 NO 325392B1 NO 19984540 A NO19984540 A NO 19984540A NO 984540 A NO984540 A NO 984540A NO 325392 B1 NO325392 B1 NO 325392B1
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Norway
Prior art keywords
capsule
cytochrome
cells
prodrug
cell
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NO19984540A
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English (en)
Norwegian (no)
Other versions
NO984540L (no
NO984540D0 (no
Inventor
Robert Michael Saller
Peter Karle
Walter H Guenzburg
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Gsf Forschungszentrum Umwelt
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Application filed by Gsf Forschungszentrum Umwelt filed Critical Gsf Forschungszentrum Umwelt
Publication of NO984540L publication Critical patent/NO984540L/no
Publication of NO984540D0 publication Critical patent/NO984540D0/no
Publication of NO325392B1 publication Critical patent/NO325392B1/no

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86Viral vectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0071Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0077Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with a reduced iron-sulfur protein as one donor (1.14.15)
    • C12N9/0079Steroid 11 beta monooxygenase (P-450 protein)(1.14.15.4)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/126Immunoprotecting barriers, e.g. jackets, diffusion chambers
    • A61K2035/128Immunoprotecting barriers, e.g. jackets, diffusion chambers capsules, e.g. microcapsules
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00Reverse transcribing RNA viruses
    • C12N2740/00011Details
    • C12N2740/10011Retroviridae
    • C12N2740/10041Use of virus, viral particle or viral elements as a vector
    • C12N2740/10043Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00Reverse transcribing RNA viruses
    • C12N2740/00011Details
    • C12N2740/10011Retroviridae
    • C12N2740/16011Human Immunodeficiency Virus, HIV
    • C12N2740/16041Use of virus, viral particle or viral elements as a vector
    • C12N2740/16043Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
NO19984540A 1996-03-27 1998-09-28 Kapsel som innkapsler et cytokrom P450 uttrykkende gen, farmasoytisk preparat som inneholder kapselen og anvendelse av kapselen til fremstilling av et medikament NO325392B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK35296 1996-03-27
PCT/EP1997/001585 WO1997035994A2 (fr) 1996-03-27 1997-03-27 Vecteurs retroviraux transducteurs du cytochrome p450

Publications (3)

Publication Number Publication Date
NO984540L NO984540L (no) 1998-09-28
NO984540D0 NO984540D0 (no) 1998-09-28
NO325392B1 true NO325392B1 (no) 2008-04-21

Family

ID=8092560

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19984540A NO325392B1 (no) 1996-03-27 1998-09-28 Kapsel som innkapsler et cytokrom P450 uttrykkende gen, farmasoytisk preparat som inneholder kapselen og anvendelse av kapselen til fremstilling av et medikament

Country Status (19)

Country Link
US (1) US6893634B1 (fr)
EP (1) EP0892852B1 (fr)
JP (1) JP4229982B2 (fr)
AT (1) ATE309383T1 (fr)
AU (1) AU713382B2 (fr)
CA (1) CA2250173A1 (fr)
CZ (1) CZ288074B6 (fr)
DE (1) DE69730595D1 (fr)
DK (1) DK0892852T3 (fr)
ES (1) ES2253775T3 (fr)
HU (1) HU221349B1 (fr)
IL (1) IL125795A0 (fr)
NO (1) NO325392B1 (fr)
NZ (1) NZ331765A (fr)
PL (1) PL188323B1 (fr)
RU (2) RU2185821C2 (fr)
SI (1) SI0892852T1 (fr)
SK (1) SK282744B6 (fr)
WO (1) WO1997035994A2 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT835137E (pt) 1995-06-27 2004-12-31 Gsf Forschungszentrum Umwelt U Celulas encapsuladas produtoras de particulas virais
DE69730595D1 (de) 1996-03-27 2004-10-14 Bavarian Nordic As Kvistgaard Verkapselte zellen expremierend cytochrome p450 für die aktivierung einer medikamentenvorstufe
US6540995B1 (en) 1996-03-27 2003-04-01 Bavarian Nordic Research Institute Gmbh Encapsulated cells producing cytochrome P450
JP2002526510A (ja) * 1998-09-21 2002-08-20 トランジェーヌ、ソシエテ、アノニム 薬剤またはプロドラッグを必要とする患者の予備治療のための医薬組成物
GB0400443D0 (en) 2004-01-09 2004-02-11 Oxford Biomedica Ltd Cascade
US7091040B1 (en) * 1999-01-04 2006-08-15 Innovata Plc P450/acetaminophen genetically directed enzyme prodrug therapy (GDEPT)
GB9900009D0 (en) * 1999-01-04 1999-02-24 Ml Lab Plc Gene therapy
GB0010105D0 (en) * 2000-04-26 2000-06-14 Ml Lab Plc Cell ablation
AU2002336162A1 (en) * 2001-09-21 2003-04-01 Oxford Biomedica (Uk) Limited Pseudotyped retroviral vector system
GB201408233D0 (en) 2014-05-09 2014-06-25 Austrianova Singapore Pte Ltd Use of polyanionic composition
MX2015006813A (es) 2015-05-29 2016-11-28 Univ Nac Autónoma De México Nanoparticulas biocataliticas cyp-p22 con actividad citocromo p450 para la activacion de profarmacos.

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0371119B1 (fr) 1988-05-17 1996-09-04 Sloan-Kettering Institute For Cancer Research Vecteur retroviral
WO1994029437A1 (fr) 1993-06-07 1994-12-22 University Of Medicine & Dentistry Of New Jersey Vecteurs retroviraux exempts de region u3, exempts de recombinaison, a auto-inactivation, hautement efficaces
US5688773A (en) * 1994-08-17 1997-11-18 The General Hospital Corporation Method of selectively destroying neoplastic cells
CA2198210C (fr) 1994-09-02 2006-07-11 Walter Henry Gunzburg Vecteurs retroviraux utiles comme vehicules de transfert genique pour therapie genique
PT835137E (pt) 1995-06-27 2004-12-31 Gsf Forschungszentrum Umwelt U Celulas encapsuladas produtoras de particulas virais
AU6987696A (en) * 1995-09-06 1997-03-27 Bavarian Nordic Research Institute A/S The use of the wap of mmtv regulatory sequences for targeted expression of linked heterologous genes in human mammary cells, including human mammary carcinoma cells
DE69730595D1 (de) 1996-03-27 2004-10-14 Bavarian Nordic As Kvistgaard Verkapselte zellen expremierend cytochrome p450 für die aktivierung einer medikamentenvorstufe

Also Published As

Publication number Publication date
CZ305098A3 (cs) 1999-01-13
JP4229982B2 (ja) 2009-02-25
NO984540L (no) 1998-09-28
SK282744B6 (sk) 2002-12-03
DE69730595D1 (de) 2004-10-14
HUP9904116A3 (en) 2001-01-29
SK132398A3 (en) 1999-04-13
SI0892852T1 (sl) 2006-04-30
NO984540D0 (no) 1998-09-28
HU221349B1 (en) 2002-09-28
EP0892852A2 (fr) 1999-01-27
US6893634B1 (en) 2005-05-17
NZ331765A (en) 2000-02-28
DK0892852T3 (da) 2006-03-06
ES2253775T3 (es) 2006-06-01
PL329071A1 (en) 1999-03-15
CZ288074B6 (cs) 2001-04-11
ATE309383T1 (de) 2005-11-15
IL125795A0 (en) 1999-04-11
RU2223788C2 (ru) 2004-02-20
WO1997035994A2 (fr) 1997-10-02
WO1997035994A3 (fr) 1997-11-20
AU713382B2 (en) 1999-12-02
PL188323B1 (pl) 2005-01-31
AU2382797A (en) 1997-10-17
RU2185821C2 (ru) 2002-07-27
HUP9904116A2 (hu) 2000-04-28
JP2000509249A (ja) 2000-07-25
CA2250173A1 (fr) 1997-10-02
EP0892852B1 (fr) 2005-11-09

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