DK0892852T3 - Indkapslede celler, som udtrykker cytochrom-P450 til pro-drug-aktivering - Google Patents
Indkapslede celler, som udtrykker cytochrom-P450 til pro-drug-aktiveringInfo
- Publication number
- DK0892852T3 DK0892852T3 DK97919307T DK97919307T DK0892852T3 DK 0892852 T3 DK0892852 T3 DK 0892852T3 DK 97919307 T DK97919307 T DK 97919307T DK 97919307 T DK97919307 T DK 97919307T DK 0892852 T3 DK0892852 T3 DK 0892852T3
- Authority
- DK
- Denmark
- Prior art keywords
- pro
- cells expressing
- encapsulated cells
- drug activation
- cytochrome
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C12N9/0077—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with a reduced iron-sulfur protein as one donor (1.14.15)
- C12N9/0079—Steroid 11 beta monooxygenase (P-450 protein)(1.14.15.4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/126—Immunoprotecting barriers, e.g. jackets, diffusion chambers
- A61K2035/128—Immunoprotecting barriers, e.g. jackets, diffusion chambers capsules, e.g. microcapsules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/10041—Use of virus, viral particle or viral elements as a vector
- C12N2740/10043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16041—Use of virus, viral particle or viral elements as a vector
- C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Public Health (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Enzymes And Modification Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK35296 | 1996-03-27 | ||
EP97919307A EP0892852B1 (fr) | 1996-03-27 | 1997-03-27 | Cellules encapsulees exrimant le cytochrome p450 pour l'activation des pro-drogues |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0892852T3 true DK0892852T3 (da) | 2006-03-06 |
Family
ID=8092560
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK97919307T DK0892852T3 (da) | 1996-03-27 | 1997-03-27 | Indkapslede celler, som udtrykker cytochrom-P450 til pro-drug-aktivering |
Country Status (19)
Country | Link |
---|---|
US (1) | US6893634B1 (fr) |
EP (1) | EP0892852B1 (fr) |
JP (1) | JP4229982B2 (fr) |
AT (1) | ATE309383T1 (fr) |
AU (1) | AU713382B2 (fr) |
CA (1) | CA2250173A1 (fr) |
CZ (1) | CZ288074B6 (fr) |
DE (1) | DE69730595D1 (fr) |
DK (1) | DK0892852T3 (fr) |
ES (1) | ES2253775T3 (fr) |
HU (1) | HU221349B1 (fr) |
IL (1) | IL125795A0 (fr) |
NO (1) | NO325392B1 (fr) |
NZ (1) | NZ331765A (fr) |
PL (1) | PL188323B1 (fr) |
RU (2) | RU2185821C2 (fr) |
SI (1) | SI0892852T1 (fr) |
SK (1) | SK282744B6 (fr) |
WO (1) | WO1997035994A2 (fr) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT835137E (pt) | 1995-06-27 | 2004-12-31 | Gsf Forschungszentrum Umwelt U | Celulas encapsuladas produtoras de particulas virais |
DE69730595D1 (de) | 1996-03-27 | 2004-10-14 | Bavarian Nordic As Kvistgaard | Verkapselte zellen expremierend cytochrome p450 für die aktivierung einer medikamentenvorstufe |
US6540995B1 (en) | 1996-03-27 | 2003-04-01 | Bavarian Nordic Research Institute Gmbh | Encapsulated cells producing cytochrome P450 |
JP2002526510A (ja) * | 1998-09-21 | 2002-08-20 | トランジェーヌ、ソシエテ、アノニム | 薬剤またはプロドラッグを必要とする患者の予備治療のための医薬組成物 |
GB0400443D0 (en) | 2004-01-09 | 2004-02-11 | Oxford Biomedica Ltd | Cascade |
US7091040B1 (en) * | 1999-01-04 | 2006-08-15 | Innovata Plc | P450/acetaminophen genetically directed enzyme prodrug therapy (GDEPT) |
GB9900009D0 (en) * | 1999-01-04 | 1999-02-24 | Ml Lab Plc | Gene therapy |
GB0010105D0 (en) * | 2000-04-26 | 2000-06-14 | Ml Lab Plc | Cell ablation |
AU2002336162A1 (en) * | 2001-09-21 | 2003-04-01 | Oxford Biomedica (Uk) Limited | Pseudotyped retroviral vector system |
GB201408233D0 (en) | 2014-05-09 | 2014-06-25 | Austrianova Singapore Pte Ltd | Use of polyanionic composition |
MX2015006813A (es) | 2015-05-29 | 2016-11-28 | Univ Nac Autónoma De México | Nanoparticulas biocataliticas cyp-p22 con actividad citocromo p450 para la activacion de profarmacos. |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0371119B1 (fr) | 1988-05-17 | 1996-09-04 | Sloan-Kettering Institute For Cancer Research | Vecteur retroviral |
WO1994029437A1 (fr) | 1993-06-07 | 1994-12-22 | University Of Medicine & Dentistry Of New Jersey | Vecteurs retroviraux exempts de region u3, exempts de recombinaison, a auto-inactivation, hautement efficaces |
US5688773A (en) * | 1994-08-17 | 1997-11-18 | The General Hospital Corporation | Method of selectively destroying neoplastic cells |
CA2198210C (fr) | 1994-09-02 | 2006-07-11 | Walter Henry Gunzburg | Vecteurs retroviraux utiles comme vehicules de transfert genique pour therapie genique |
PT835137E (pt) | 1995-06-27 | 2004-12-31 | Gsf Forschungszentrum Umwelt U | Celulas encapsuladas produtoras de particulas virais |
AU6987696A (en) * | 1995-09-06 | 1997-03-27 | Bavarian Nordic Research Institute A/S | The use of the wap of mmtv regulatory sequences for targeted expression of linked heterologous genes in human mammary cells, including human mammary carcinoma cells |
DE69730595D1 (de) | 1996-03-27 | 2004-10-14 | Bavarian Nordic As Kvistgaard | Verkapselte zellen expremierend cytochrome p450 für die aktivierung einer medikamentenvorstufe |
-
1997
- 1997-03-27 DE DE69730595T patent/DE69730595D1/de not_active Expired - Lifetime
- 1997-03-27 CA CA002250173A patent/CA2250173A1/fr not_active Abandoned
- 1997-03-27 NZ NZ331765A patent/NZ331765A/en not_active IP Right Cessation
- 1997-03-27 HU HU9904116A patent/HU221349B1/hu not_active IP Right Cessation
- 1997-03-27 EP EP97919307A patent/EP0892852B1/fr not_active Expired - Lifetime
- 1997-03-27 RU RU98119459/14A patent/RU2185821C2/ru not_active IP Right Cessation
- 1997-03-27 AT AT97919307T patent/ATE309383T1/de not_active IP Right Cessation
- 1997-03-27 ES ES97919307T patent/ES2253775T3/es not_active Expired - Lifetime
- 1997-03-27 JP JP53405197A patent/JP4229982B2/ja not_active Expired - Lifetime
- 1997-03-27 PL PL97329071A patent/PL188323B1/pl not_active IP Right Cessation
- 1997-03-27 SI SI9730726T patent/SI0892852T1/sl unknown
- 1997-03-27 IL IL12579597A patent/IL125795A0/xx not_active IP Right Cessation
- 1997-03-27 DK DK97919307T patent/DK0892852T3/da active
- 1997-03-27 SK SK1323-98A patent/SK282744B6/sk not_active IP Right Cessation
- 1997-03-27 CZ CZ19983050A patent/CZ288074B6/cs not_active IP Right Cessation
- 1997-03-27 RU RU2002103465/15A patent/RU2223788C2/ru not_active IP Right Cessation
- 1997-03-27 AU AU23827/97A patent/AU713382B2/en not_active Expired
- 1997-03-27 WO PCT/EP1997/001585 patent/WO1997035994A2/fr active IP Right Grant
-
1998
- 1998-09-24 US US09/160,067 patent/US6893634B1/en not_active Expired - Lifetime
- 1998-09-28 NO NO19984540A patent/NO325392B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CZ305098A3 (cs) | 1999-01-13 |
JP4229982B2 (ja) | 2009-02-25 |
NO984540L (no) | 1998-09-28 |
SK282744B6 (sk) | 2002-12-03 |
DE69730595D1 (de) | 2004-10-14 |
HUP9904116A3 (en) | 2001-01-29 |
SK132398A3 (en) | 1999-04-13 |
SI0892852T1 (sl) | 2006-04-30 |
NO984540D0 (no) | 1998-09-28 |
HU221349B1 (en) | 2002-09-28 |
EP0892852A2 (fr) | 1999-01-27 |
US6893634B1 (en) | 2005-05-17 |
NZ331765A (en) | 2000-02-28 |
ES2253775T3 (es) | 2006-06-01 |
NO325392B1 (no) | 2008-04-21 |
PL329071A1 (en) | 1999-03-15 |
CZ288074B6 (cs) | 2001-04-11 |
ATE309383T1 (de) | 2005-11-15 |
IL125795A0 (en) | 1999-04-11 |
RU2223788C2 (ru) | 2004-02-20 |
WO1997035994A2 (fr) | 1997-10-02 |
WO1997035994A3 (fr) | 1997-11-20 |
AU713382B2 (en) | 1999-12-02 |
PL188323B1 (pl) | 2005-01-31 |
AU2382797A (en) | 1997-10-17 |
RU2185821C2 (ru) | 2002-07-27 |
HUP9904116A2 (hu) | 2000-04-28 |
JP2000509249A (ja) | 2000-07-25 |
CA2250173A1 (fr) | 1997-10-02 |
EP0892852B1 (fr) | 2005-11-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MY114889A (en) | 1-phenyl-3-dimethylamino-propane derivatives having pharmacological activity | |
SE9801336L (sv) | Enterala fluoxetin-piller | |
NO20020055L (no) | Blanding egnet for a danne en myk kapsel, samt spiselig myk kapsel. | |
DK0892852T3 (da) | Indkapslede celler, som udtrykker cytochrom-P450 til pro-drug-aktivering | |
AU1534699A (en) | Osmotic dosage form comprising first and second coats | |
AR035500A1 (es) | Uso de clorpromazina y pentamidina para la fabricacion de medicamentos, composicion farmaceutica y paquete farmaceutico que comprenden clorpromazina y pentamidina. | |
DE69808130T2 (de) | Adamantan-derivate | |
MX27046A (es) | 5-arilalquil-4-alcoxy-2(5h)-furanonas, productos intermedios y procedimiento para su preparacion asi como su aplicacion como sustancia activa terapeutica. | |
IL147220A0 (en) | Indanyl-substituted benzole carbonamide, method for the production of the same, use thereof as a medicament and pharmaceutical preparations containing the same | |
NO942835L (no) | 1-benzensulfonyl-1,3-dihydro-2H-benzimidazol-2-on-derivater, fremstilling derav og farmasöytiske blandinger som inneholder dem | |
SE9704546D0 (sv) | Novel compounds | |
CA2294783A1 (fr) | Compositions pharmaceutiques administrables par voie orale, comprenant une substance active et une cyclodextrine | |
AR008991A1 (es) | Compuestos de dimetil-(3-aril-but-3-enil)-amina, procedimientos para su preparacion y aplicacion de los mismos | |
NO973850D0 (no) | Fenylsubstituerte alkenylkarboksylsyreguanidider; fremgangsmåter for deres fremstilling, deres anvendelse som medikament eller diagnostika såvel som medikamenter inneholdende dem | |
DE68908313D1 (de) | Klebverbaende, ihre herstellung und anwendung. | |
AU6211501A (en) | Dental care agents provided in the form of single-portion capsules | |
WO1991015512A3 (fr) | Polypeptides d'enveloppe du vih | |
WO2000008007A3 (fr) | Derives de cyclopentabenzofuranne et leur utilisation | |
DE3776620D1 (de) | 3-propenylcephemderivate, ihre herstellung, zwischenverbindungen, pharmazeutische praeparate und anwendung. | |
DE60043442D1 (de) | Ner aktiven phase und einer inaktiven phase | |
NO985571L (no) | Legemiddel for autoimmunsykdommer | |
NO992999L (no) | Farmasöytisk blanding for oral administrering | |
ES2139332T3 (es) | Procedimiento para la preparacion del trihidrato del (2r,3s)-3-benzoilamino-2-hidroxi-3-fenilpropionato de 4,10-diacetoxi-2alfa-benzoiloxi-5beta,20-epoxi-1,7beta-dihidroxi-9-oxo-tax-11-en-13alfa-ilo. | |
PT1001942E (pt) | Poli-hidroxibutilpirazinas sua preparacao e medicamentos que as contem | |
WO2000017366A3 (fr) | Composition pharmaceutique de pretraitement d'un patient necessitant un medicament ou un promedicament |