NO324680B1 - Mikrogranuler, som inneholder diltiazem som aktivt prinsipp, for vedvarende frigjoring og gelatinkapsler som omfatter mikrogranulene. - Google Patents
Mikrogranuler, som inneholder diltiazem som aktivt prinsipp, for vedvarende frigjoring og gelatinkapsler som omfatter mikrogranulene. Download PDFInfo
- Publication number
- NO324680B1 NO324680B1 NO19982738A NO982738A NO324680B1 NO 324680 B1 NO324680 B1 NO 324680B1 NO 19982738 A NO19982738 A NO 19982738A NO 982738 A NO982738 A NO 982738A NO 324680 B1 NO324680 B1 NO 324680B1
- Authority
- NO
- Norway
- Prior art keywords
- layer
- microgranules according
- microgranules
- active principle
- surfactant
- Prior art date
Links
- 238000013268 sustained release Methods 0.000 title claims 8
- 239000012730 sustained-release form Substances 0.000 title claims 8
- HSUGRBWQSSZJOP-RTWAWAEBSA-N diltiazem Chemical compound C1=CC(OC)=CC=C1[C@H]1[C@@H](OC(C)=O)C(=O)N(CCN(C)C)C2=CC=CC=C2S1 HSUGRBWQSSZJOP-RTWAWAEBSA-N 0.000 title claims 4
- 229960004166 diltiazem Drugs 0.000 title claims 4
- 239000007903 gelatin capsule Substances 0.000 title claims 2
- 239000004014 plasticizer Substances 0.000 claims 10
- 239000011230 binding agent Substances 0.000 claims 9
- 239000004094 surface-active agent Substances 0.000 claims 9
- 230000007935 neutral effect Effects 0.000 claims 6
- 239000011248 coating agent Substances 0.000 claims 5
- -1 alkylbenzene sulfonates Chemical class 0.000 claims 4
- 239000000314 lubricant Substances 0.000 claims 4
- 229910052783 alkali metal Inorganic materials 0.000 claims 3
- 150000001340 alkali metals Chemical class 0.000 claims 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- XNGIFLGASWRNHJ-UHFFFAOYSA-N o-dicarboxybenzene Natural products OC(=O)C1=CC=CC=C1C(O)=O XNGIFLGASWRNHJ-UHFFFAOYSA-N 0.000 claims 3
- 239000003945 anionic surfactant Substances 0.000 claims 2
- 239000000969 carrier Substances 0.000 claims 2
- FLKPEMZONWLCSK-UHFFFAOYSA-N diethyl phthalate Chemical compound CCOC(=O)C1=CC=CC=C1C(=O)OCC FLKPEMZONWLCSK-UHFFFAOYSA-N 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- CXMXRPHRNRROMY-UHFFFAOYSA-N sebacic acid Chemical compound OC(=O)CCCCCCCCC(O)=O CXMXRPHRNRROMY-UHFFFAOYSA-N 0.000 claims 2
- PYGXAGIECVVIOZ-UHFFFAOYSA-N Dibutyl decanedioate Chemical compound CCCCOC(=O)CCCCCCCCC(=O)OCCCC PYGXAGIECVVIOZ-UHFFFAOYSA-N 0.000 claims 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims 1
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 150000008051 alkyl sulfates Chemical class 0.000 claims 1
- 229940045714 alkyl sulfonate alkylating agent Drugs 0.000 claims 1
- 150000008052 alkyl sulfonates Chemical class 0.000 claims 1
- 239000002280 amphoteric surfactant Substances 0.000 claims 1
- 125000000129 anionic group Chemical group 0.000 claims 1
- 125000002091 cationic group Chemical group 0.000 claims 1
- 239000003093 cationic surfactant Substances 0.000 claims 1
- 238000000576 coating method Methods 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 229930195729 fatty acid Natural products 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000002736 nonionic surfactant Substances 0.000 claims 1
- 150000007524 organic acids Chemical class 0.000 claims 1
- 229920000193 polymethacrylate Polymers 0.000 claims 1
- 229950008882 polysorbate Drugs 0.000 claims 1
- 229920000136 polysorbate Polymers 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims 1
- 239000000454 talc Substances 0.000 claims 1
- 229910052623 talc Inorganic materials 0.000 claims 1
- 239000001069 triethyl citrate Substances 0.000 claims 1
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 claims 1
- 235000013769 triethyl citrate Nutrition 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9515361A FR2742660B1 (fr) | 1995-12-22 | 1995-12-22 | Nouvelles formes de microgranules a liberation prolongee contenant du diltiazem comme principe actif |
| PCT/FR1996/002040 WO1997023219A1 (fr) | 1995-12-22 | 1996-12-23 | Microgranules a liberation prolongee contenant du diltiazem comme principe actif |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO982738D0 NO982738D0 (no) | 1998-06-12 |
| NO982738L NO982738L (no) | 1998-08-21 |
| NO324680B1 true NO324680B1 (no) | 2007-12-03 |
Family
ID=9485856
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19982738A NO324680B1 (no) | 1995-12-22 | 1998-06-12 | Mikrogranuler, som inneholder diltiazem som aktivt prinsipp, for vedvarende frigjoring og gelatinkapsler som omfatter mikrogranulene. |
Country Status (27)
| Country | Link |
|---|---|
| US (3) | US6228395B1 (ko) |
| EP (1) | EP0868184B1 (ko) |
| JP (1) | JP2000506500A (ko) |
| KR (1) | KR100354054B1 (ko) |
| CN (1) | CN1145488C (ko) |
| AR (1) | AR004410A1 (ko) |
| AT (1) | ATE238798T1 (ko) |
| AU (1) | AU721949B2 (ko) |
| BG (1) | BG63770B1 (ko) |
| BR (1) | BR9612225A (ko) |
| CA (1) | CA2242224C (ko) |
| DE (1) | DE69627880T2 (ko) |
| DK (1) | DK0868184T3 (ko) |
| EA (1) | EA001721B1 (ko) |
| EE (1) | EE04045B1 (ko) |
| ES (1) | ES2198505T3 (ko) |
| FR (1) | FR2742660B1 (ko) |
| GE (1) | GEP20022629B (ko) |
| HK (1) | HK1018400A1 (ko) |
| HU (1) | HU224214B1 (ko) |
| IL (1) | IL125047A (ko) |
| NO (1) | NO324680B1 (ko) |
| NZ (1) | NZ324739A (ko) |
| PL (1) | PL186621B1 (ko) |
| PT (1) | PT868184E (ko) |
| WO (1) | WO1997023219A1 (ko) |
| ZA (1) | ZA9610776B (ko) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2742660B1 (fr) * | 1995-12-22 | 1998-04-03 | Ethypharm Lab Prod Ethiques | Nouvelles formes de microgranules a liberation prolongee contenant du diltiazem comme principe actif |
| US6162463A (en) * | 1997-05-01 | 2000-12-19 | Dov Pharmaceutical Inc | Extended release formulation of diltiazem hydrochloride |
| FR2790668B1 (fr) * | 1999-03-12 | 2002-07-26 | D B F | Granules contenant une substance vegetale et leur procede de preparation |
| EP1064937A1 (en) * | 1999-06-28 | 2001-01-03 | Sanofi-Synthelabo | Timed dual release dosage forms comprising a short acting hypnotic or a salt thereof |
| EP1064938A1 (en) * | 1999-06-28 | 2001-01-03 | Sanofi-Synthelabo | Pharmaceutical dosage forms for controlled release producing at least a timed pulse |
| US7179483B2 (en) | 2000-04-26 | 2007-02-20 | Watson Pharmaceuticals, Inc. | Compositions and methods for transdermal oxybutynin therapy |
| FR2831546B1 (fr) * | 2001-10-31 | 2007-03-23 | Atofina | Materiau polymere thermoplastique pour supports d'enregistrement d'informations audio et/ou optiques |
| JP5171038B2 (ja) * | 2003-10-10 | 2013-03-27 | エティファルム | イチョウ・エキスを含む放出持続性の微小顆粒およびそのような顆粒の製造方法 |
| WO2005065715A1 (ja) * | 2003-12-25 | 2005-07-21 | Takeda Pharmaceutical Company Limited | 造粒性改善方法 |
| JP2005306778A (ja) * | 2004-04-21 | 2005-11-04 | Basf Ag | 徐放性製剤及びその製造方法 |
| WO2006013431A1 (en) * | 2004-07-29 | 2006-02-09 | Pfizer Limited | Stable controlled-release pharmaceutical formulation of eletriptan |
| US8778395B2 (en) * | 2005-08-11 | 2014-07-15 | Andrx Labs, Llc | Diltiazem controlled release formulation and method of manufacture |
| SI2484346T1 (sl) * | 2006-06-19 | 2017-05-31 | Alpharma Pharmaceuticals Llc | Farmacevtski sestavki |
| ITFI20110172A1 (it) | 2011-08-08 | 2013-02-09 | Valpharma Sa | Formulazione multiparticolata a rilascio modificato di diltiazem hcl. |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE56999B1 (en) * | 1983-12-22 | 1992-03-11 | Elan Corp Plc | Pharmaceutical formulation |
| IT1200217B (it) * | 1986-09-30 | 1989-01-05 | Valducci Roberto | Membrana per uso farmaceutico ed industriale |
| DK173505B1 (da) * | 1987-02-20 | 2001-01-15 | Pharmatec Internat S R L | Fremgangsmåde til fremstilling af en diltiazempellet med langsom afgivelse og anvendelse af således fremstillede pelleter t |
| JPH07552B2 (ja) * | 1987-11-06 | 1995-01-11 | 田辺製薬株式会社 | 持効性製剤 |
| FR2623714B1 (fr) * | 1987-11-26 | 1990-04-20 | Ethypharm Sa | Forme a liberation prolongee du diltiazem, et son medicament ainsi obtenu |
| FR2624732B1 (fr) * | 1987-12-21 | 1991-02-15 | Synthelabo | Formulation pharmaceutique a liberation prolongee |
| FR2630647B1 (fr) * | 1988-04-27 | 1991-08-16 | Sanofi Sa | Microbilles de diltiazem, leur procede de fabrication et compositions pharmaceutiques a liberation prolongee les contenant |
| US5288505A (en) | 1991-06-26 | 1994-02-22 | Galephar P.R., Inc., Ltd. | Extended release form of diltiazem |
| US5229135A (en) * | 1991-11-22 | 1993-07-20 | Prographarm Laboratories | Sustained release diltiazem formulation |
| US5376384A (en) | 1992-12-23 | 1994-12-27 | Kinaform Technology, Inc. | Delayed, sustained-release pharmaceutical preparation |
| US5834024A (en) * | 1995-01-05 | 1998-11-10 | Fh Faulding & Co. Limited | Controlled absorption diltiazem pharmaceutical formulation |
| FR2742660B1 (fr) * | 1995-12-22 | 1998-04-03 | Ethypharm Lab Prod Ethiques | Nouvelles formes de microgranules a liberation prolongee contenant du diltiazem comme principe actif |
-
1995
- 1995-12-22 FR FR9515361A patent/FR2742660B1/fr not_active Expired - Lifetime
-
1996
- 1996-12-20 ZA ZA9610776A patent/ZA9610776B/xx unknown
- 1996-12-23 AR ARP960105884A patent/AR004410A1/es unknown
- 1996-12-23 HU HU9904129A patent/HU224214B1/hu active IP Right Grant
- 1996-12-23 US US09/091,646 patent/US6228395B1/en not_active Expired - Fee Related
- 1996-12-23 PL PL96327567A patent/PL186621B1/pl unknown
- 1996-12-23 ES ES96943156T patent/ES2198505T3/es not_active Expired - Lifetime
- 1996-12-23 PT PT96943156T patent/PT868184E/pt unknown
- 1996-12-23 WO PCT/FR1996/002040 patent/WO1997023219A1/fr active IP Right Grant
- 1996-12-23 CA CA002242224A patent/CA2242224C/fr not_active Expired - Lifetime
- 1996-12-23 IL IL12504796A patent/IL125047A/xx not_active IP Right Cessation
- 1996-12-23 EE EE9800197A patent/EE04045B1/xx unknown
- 1996-12-23 KR KR10-1998-0704833A patent/KR100354054B1/ko not_active IP Right Cessation
- 1996-12-23 EA EA199800593A patent/EA001721B1/ru not_active IP Right Cessation
- 1996-12-23 JP JP9523365A patent/JP2000506500A/ja active Pending
- 1996-12-23 AT AT96943156T patent/ATE238798T1/de active
- 1996-12-23 GE GEAP19964360A patent/GEP20022629B/en unknown
- 1996-12-23 DE DE69627880T patent/DE69627880T2/de not_active Expired - Lifetime
- 1996-12-23 BR BR9612225A patent/BR9612225A/pt not_active IP Right Cessation
- 1996-12-23 DK DK96943156T patent/DK0868184T3/da active
- 1996-12-23 AU AU11983/97A patent/AU721949B2/en not_active Expired
- 1996-12-23 EP EP96943156A patent/EP0868184B1/fr not_active Expired - Lifetime
- 1996-12-23 CN CNB961997648A patent/CN1145488C/zh not_active Expired - Lifetime
- 1996-12-23 NZ NZ324739A patent/NZ324739A/xx not_active IP Right Cessation
-
1998
- 1998-06-12 NO NO19982738A patent/NO324680B1/no not_active IP Right Cessation
- 1998-06-18 BG BG102555A patent/BG63770B1/bg unknown
-
1999
- 1999-08-10 HK HK99103442A patent/HK1018400A1/xx not_active IP Right Cessation
-
2001
- 2001-01-11 US US09/757,628 patent/US6383516B1/en not_active Expired - Lifetime
- 2001-12-03 US US09/998,911 patent/US6660296B2/en not_active Expired - Lifetime
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO324680B1 (no) | Mikrogranuler, som inneholder diltiazem som aktivt prinsipp, for vedvarende frigjoring og gelatinkapsler som omfatter mikrogranulene. | |
| EP1051174B1 (fr) | Microgranules d'omeprazole gastroproteges, procede d'obtention et preparations pharmaceutiques | |
| US7067151B1 (en) | Controlled absorption diltiazem pharmaceutical formulation | |
| US4894240A (en) | Controlled absorption diltiazem formulation for once-daily administration | |
| CA2480826A1 (fr) | Formulation pharmaceutique orale sous forme de suspension aqueuse de microcapsules permettant la liberation modifiee de principe(s) actif(s) | |
| PT89276B (pt) | Processo para a preparacao de uma formulacao farmaceutica de libertacao prolongada constituida por microgranulos revestidos com etilcelulose e eudragit rs (resina acrilica, polimerizado de esteres dos acidos acrilico e metacrilico) | |
| CA2500390A1 (en) | Compositions having an inner core and at least two surrounding layers | |
| CA2299130A1 (en) | Acd tier based routing | |
| CA2476496A1 (en) | Controlled release dosage forms | |
| MX2008001282A (es) | Tratamiento con bloqueadores del canal del calcio de dihidropiridina y acidos grasos omega-3 y un producto de combinacion de los mismos. | |
| HUP0101178A2 (hu) | Gyomorfekély elleni 2-{[(2-piridinil)-metil]-szulfinil}-benzimidazolt tartalmazó gyógyszerkészítmény és eljárás gyógyszerkészítmény előállítására | |
| CA2473200A1 (en) | Extended release compositions comprising as active compound venlafaxine hydrochloride | |
| CA2497197A1 (en) | A tooth whitening product comprising a film and whitening agent and process for making it | |
| CA2377605A1 (en) | Stable benzimidazole formulation | |
| EP1365748B1 (en) | Particulate composition of eletriptan hydrobromide showing a sigmoidal pattern of controlled release | |
| CA2373972C (fr) | Microgranules gastroproteges, procede d'obtention et preparations pharmaceutiques | |
| EP1627631A3 (fr) | Microgranules de sulfate de morphine, procédé de préparation et composition les contenant | |
| CA2520020A1 (en) | Venlafaxine compositions comprising pellets with double layer coating | |
| EP1677779A1 (fr) | Nouvelle association d'un anti-atherothrombotique et d'un antiagregant plaquettaire | |
| CA2280980A1 (fr) | Composition pharmaceutique pour la liberation programmee de dexfenfluramine |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1K | Patent expired |