NO324525B1 - Preparat for behandling av svekket gastro-intestinalfunksjon, fremgangsmate for fremstilling samt anvendelse derav. - Google Patents
Preparat for behandling av svekket gastro-intestinalfunksjon, fremgangsmate for fremstilling samt anvendelse derav. Download PDFInfo
- Publication number
- NO324525B1 NO324525B1 NO20024743A NO20024743A NO324525B1 NO 324525 B1 NO324525 B1 NO 324525B1 NO 20024743 A NO20024743 A NO 20024743A NO 20024743 A NO20024743 A NO 20024743A NO 324525 B1 NO324525 B1 NO 324525B1
- Authority
- NO
- Norway
- Prior art keywords
- preparation
- preparation according
- amino acids
- patients
- treatment
- Prior art date
Links
- 230000001771 impaired effect Effects 0.000 title claims abstract description 12
- 238000000034 method Methods 0.000 title claims abstract description 7
- 238000002360 preparation method Methods 0.000 title claims description 117
- 230000007661 gastrointestinal function Effects 0.000 title claims description 5
- 235000001014 amino acid Nutrition 0.000 claims abstract description 40
- 150000001413 amino acids Chemical class 0.000 claims abstract description 40
- 230000002265 prevention Effects 0.000 claims abstract description 6
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims abstract description 5
- 235000013922 glutamic acid Nutrition 0.000 claims abstract description 5
- 239000004220 glutamic acid Substances 0.000 claims abstract description 5
- 235000016709 nutrition Nutrition 0.000 claims description 24
- 239000000203 mixture Substances 0.000 claims description 21
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims description 16
- 235000018417 cysteine Nutrition 0.000 claims description 16
- 230000035764 nutrition Effects 0.000 claims description 15
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims description 9
- 239000004475 Arginine Substances 0.000 claims description 5
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 5
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims description 3
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims description 3
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims description 3
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims description 3
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims description 3
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims description 3
- 235000003704 aspartic acid Nutrition 0.000 claims description 3
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims description 3
- 239000003814 drug Substances 0.000 claims description 3
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 2
- 239000004472 Lysine Substances 0.000 claims description 2
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims description 2
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims description 2
- 239000004473 Threonine Substances 0.000 claims description 2
- 239000003085 diluting agent Substances 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract description 5
- 230000008901 benefit Effects 0.000 description 17
- 235000018102 proteins Nutrition 0.000 description 13
- 108090000623 proteins and genes Proteins 0.000 description 13
- 102000004169 proteins and genes Human genes 0.000 description 13
- 150000002632 lipids Chemical class 0.000 description 10
- 229940057917 medium chain triglycerides Drugs 0.000 description 10
- 150000001720 carbohydrates Chemical class 0.000 description 8
- 235000014633 carbohydrates Nutrition 0.000 description 8
- 230000035876 healing Effects 0.000 description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
- 229930003231 vitamin Natural products 0.000 description 7
- 235000013343 vitamin Nutrition 0.000 description 7
- 239000011782 vitamin Substances 0.000 description 7
- 229940088594 vitamin Drugs 0.000 description 7
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
- 238000010521 absorption reaction Methods 0.000 description 6
- 235000005911 diet Nutrition 0.000 description 6
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 6
- 229910052500 inorganic mineral Inorganic materials 0.000 description 6
- 239000011707 mineral Substances 0.000 description 6
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 description 5
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 description 5
- 235000013734 beta-carotene Nutrition 0.000 description 5
- 239000011648 beta-carotene Substances 0.000 description 5
- 229960002747 betacarotene Drugs 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 5
- 230000037213 diet Effects 0.000 description 5
- 201000010099 disease Diseases 0.000 description 5
- 230000006870 function Effects 0.000 description 5
- 230000002757 inflammatory effect Effects 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 5
- 229920002774 Maltodextrin Polymers 0.000 description 4
- 239000005913 Maltodextrin Substances 0.000 description 4
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 4
- 230000002496 gastric effect Effects 0.000 description 4
- 229940035034 maltodextrin Drugs 0.000 description 4
- 230000002503 metabolic effect Effects 0.000 description 4
- 238000003786 synthesis reaction Methods 0.000 description 4
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 4
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 3
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 3
- 108010024636 Glutathione Proteins 0.000 description 3
- 206010049645 Hypercatabolism Diseases 0.000 description 3
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 3
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 3
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 3
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 3
- 229930003268 Vitamin C Natural products 0.000 description 3
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 3
- 208000038016 acute inflammation Diseases 0.000 description 3
- 230000006022 acute inflammation Effects 0.000 description 3
- 235000021466 carotenoid Nutrition 0.000 description 3
- 150000001747 carotenoids Chemical class 0.000 description 3
- 229960003180 glutathione Drugs 0.000 description 3
- 239000011777 magnesium Substances 0.000 description 3
- 229910052749 magnesium Inorganic materials 0.000 description 3
- 210000003205 muscle Anatomy 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- 235000015097 nutrients Nutrition 0.000 description 3
- 230000036470 plasma concentration Effects 0.000 description 3
- 229910052711 selenium Inorganic materials 0.000 description 3
- 239000011669 selenium Substances 0.000 description 3
- 238000001356 surgical procedure Methods 0.000 description 3
- 150000003626 triacylglycerols Chemical class 0.000 description 3
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 3
- 235000019154 vitamin C Nutrition 0.000 description 3
- 239000011718 vitamin C Substances 0.000 description 3
- 239000011701 zinc Substances 0.000 description 3
- 229910052725 zinc Inorganic materials 0.000 description 3
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 description 2
- 208000017667 Chronic Disease Diseases 0.000 description 2
- 229920002261 Corn starch Polymers 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 description 2
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 102000008934 Muscle Proteins Human genes 0.000 description 2
- 108010074084 Muscle Proteins Proteins 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 2
- 240000008042 Zea mays Species 0.000 description 2
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 2
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 230000000747 cardiac effect Effects 0.000 description 2
- 230000001925 catabolic effect Effects 0.000 description 2
- 235000005822 corn Nutrition 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 235000004626 essential fatty acids Nutrition 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 230000004968 inflammatory condition Effects 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 235000020888 liquid diet Nutrition 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 235000006180 nutrition needs Nutrition 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- 238000004806 packaging method and process Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000001243 protein synthesis Methods 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 229960003080 taurine Drugs 0.000 description 2
- 230000017423 tissue regeneration Effects 0.000 description 2
- 235000021476 total parenteral nutrition Nutrition 0.000 description 2
- 230000014616 translation Effects 0.000 description 2
- 230000008733 trauma Effects 0.000 description 2
- 235000019155 vitamin A Nutrition 0.000 description 2
- 239000011719 vitamin A Substances 0.000 description 2
- 229940045997 vitamin a Drugs 0.000 description 2
- 150000003722 vitamin derivatives Chemical class 0.000 description 2
- 208000030507 AIDS Diseases 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 208000028399 Critical Illness Diseases 0.000 description 1
- 208000011231 Crohn disease Diseases 0.000 description 1
- 201000003883 Cystic fibrosis Diseases 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 206010062016 Immunosuppression Diseases 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
- LEVWYRKDKASIDU-IMJSIDKUSA-N L-cystine Chemical compound [O-]C(=O)[C@@H]([NH3+])CSSC[C@H]([NH3+])C([O-])=O LEVWYRKDKASIDU-IMJSIDKUSA-N 0.000 description 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 206010025476 Malabsorption Diseases 0.000 description 1
- 208000004155 Malabsorption Syndromes Diseases 0.000 description 1
- 208000002720 Malnutrition Diseases 0.000 description 1
- 101710137760 Malonyl-CoA-acyl carrier protein transacylase, mitochondrial Proteins 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 208000008425 Protein deficiency Diseases 0.000 description 1
- 206010039921 Selenium deficiency Diseases 0.000 description 1
- 206010040047 Sepsis Diseases 0.000 description 1
- 206010049416 Short-bowel syndrome Diseases 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 239000005864 Sulphur Substances 0.000 description 1
- 125000002252 acyl group Chemical group 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000000828 canola oil Substances 0.000 description 1
- 235000019519 canola oil Nutrition 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 206010008129 cerebral palsy Diseases 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 239000003240 coconut oil Substances 0.000 description 1
- 235000019864 coconut oil Nutrition 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000002285 corn oil Substances 0.000 description 1
- 235000005687 corn oil Nutrition 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 229960003067 cystine Drugs 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 235000014105 formulated food Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000007160 gastrointestinal dysfunction Effects 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000000265 homogenisation Methods 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 230000001506 immunosuppresive effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 230000003871 intestinal function Effects 0.000 description 1
- 208000028867 ischemia Diseases 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 150000004668 long chain fatty acids Chemical class 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 235000000824 malnutrition Nutrition 0.000 description 1
- 230000001071 malnutrition Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 239000011785 micronutrient Substances 0.000 description 1
- 235000013369 micronutrients Nutrition 0.000 description 1
- 235000021243 milk fat Nutrition 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 235000021590 normal diet Nutrition 0.000 description 1
- 235000015816 nutrient absorption Nutrition 0.000 description 1
- 235000006286 nutrient intake Nutrition 0.000 description 1
- 208000015380 nutritional deficiency disease Diseases 0.000 description 1
- 235000020665 omega-6 fatty acid Nutrition 0.000 description 1
- 229940033080 omega-6 fatty acid Drugs 0.000 description 1
- 235000016236 parenteral nutrition Nutrition 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 description 1
- 235000003784 poor nutrition Nutrition 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 238000005057 refrigeration Methods 0.000 description 1
- 229960003471 retinol Drugs 0.000 description 1
- 235000020944 retinol Nutrition 0.000 description 1
- 239000011607 retinol Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000008347 soybean phospholipid Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000000153 supplemental effect Effects 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/175—Amino acids
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pediatric Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0009056.3A GB0009056D0 (en) | 2000-04-12 | 2000-04-12 | Composition comprising free amino acids |
PCT/EP2001/003188 WO2001078532A1 (en) | 2000-04-12 | 2001-03-21 | Composition comprising free amino acids |
Publications (3)
Publication Number | Publication Date |
---|---|
NO20024743D0 NO20024743D0 (no) | 2002-10-02 |
NO20024743L NO20024743L (no) | 2002-12-03 |
NO324525B1 true NO324525B1 (no) | 2007-11-12 |
Family
ID=9889802
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20024743A NO324525B1 (no) | 2000-04-12 | 2002-10-02 | Preparat for behandling av svekket gastro-intestinalfunksjon, fremgangsmate for fremstilling samt anvendelse derav. |
Country Status (17)
Country | Link |
---|---|
US (3) | US20040096478A1 (de) |
EP (1) | EP1274322B1 (de) |
JP (1) | JP5600232B2 (de) |
KR (1) | KR20020089448A (de) |
CN (1) | CN1243542C (de) |
AT (1) | ATE326867T1 (de) |
CA (1) | CA2404005C (de) |
DE (1) | DE60119919T2 (de) |
ES (1) | ES2263602T3 (de) |
GB (1) | GB0009056D0 (de) |
HK (1) | HK1054489A1 (de) |
HU (1) | HUP0300299A3 (de) |
MX (1) | MXPA02010058A (de) |
NO (1) | NO324525B1 (de) |
PL (1) | PL358876A1 (de) |
RU (1) | RU2002130204A (de) |
WO (1) | WO2001078532A1 (de) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030105104A1 (en) * | 2001-11-27 | 2003-06-05 | Burzynski Stanislaw R. | Formulation of amino acids and riboflavin useful to reduce toxic effects of cytotoxic chemotherapy |
DE10221403A1 (de) * | 2002-05-14 | 2003-12-04 | Kyberg Pharma Vertriebs Gmbh & | Diätetische und pharmazeutische Zusammensetzungen, ihre Herstellung und ihre Verwendung |
US6592908B1 (en) * | 2002-09-23 | 2003-07-15 | Albert Crum | Nutritional or therapeutic compositions |
CA2532473C (en) | 2003-06-23 | 2013-08-06 | Nestec S.A. | Amino acid supplementation for a healthy microbiota ecosystem |
US20050053673A1 (en) * | 2003-09-05 | 2005-03-10 | Shrirang Netke | Composition and method for facilitating bone healing |
EP1543735B1 (de) * | 2003-12-20 | 2015-10-07 | Nestec S.A. | Lebensmittelzusammensetzung für die wundheilung |
WO2005110124A1 (en) * | 2004-04-15 | 2005-11-24 | Abbott Laboratories | Composition and methods for nutritional management of patients with hepatic disease |
EP1767201B8 (de) * | 2004-06-28 | 2012-02-29 | Ajinomoto Co., Inc. | Nährstoffzusammensetzung und zusammensetzung zur prävention/mitigation von verdauungstraktdepression |
KR101153242B1 (ko) | 2004-09-17 | 2012-06-08 | 아지노모토 가부시키가이샤 | 기능성 소화관 장해 예방 또는 개선제 및 식품 |
WO2006134135A2 (en) * | 2005-06-14 | 2006-12-21 | Nestec S.A. | Nutritional method for elderly people |
JPWO2007004613A1 (ja) * | 2005-07-01 | 2009-01-29 | 味の素株式会社 | 炎症性腸疾患治療薬及びTNF−α産生抑制剤 |
JP4916143B2 (ja) * | 2005-08-04 | 2012-04-11 | サッポロビール株式会社 | ビール酵母で発酵させたアルコール飲料からコラーゲン産生促進作用を有する組成物を製造する方法及びその組成物 |
EP2668957A1 (de) | 2005-08-29 | 2013-12-04 | Ajinomoto Co., Inc. | Nährstoffzusammensetzung |
US8722120B2 (en) | 2006-08-02 | 2014-05-13 | Mead Johnson Nutrition Company | Amino acid-based nutritional formulations |
EP2263666A4 (de) * | 2008-03-11 | 2011-11-09 | Ajinomoto Kk | Mittel und nahrungsmittel zur prävention/linderung von funktionalen magen-darm-erkrankungen |
WO2011021926A1 (en) * | 2009-08-21 | 2011-02-24 | N.V. Nutricia | Regulating the amino acid pool used for the acute-phase protein synthesis |
EP2503906B1 (de) * | 2009-11-25 | 2016-03-30 | Nestec S.A. | Ernährungszusammensetzungen mit einem bestandteil mit hohem proteingehalt und exogenen nukleotiden |
JP2011121888A (ja) * | 2009-12-09 | 2011-06-23 | En Otsuka Pharmaceutical Co Ltd | 炎症性腸疾患用アミノ酸組成物 |
JP2011121887A (ja) * | 2009-12-09 | 2011-06-23 | En Otsuka Pharmaceutical Co Ltd | 炎症性腸疾患用アミノ酸組成物 |
JP2011121889A (ja) * | 2009-12-09 | 2011-06-23 | En Otsuka Pharmaceutical Co Ltd | 炎症性腸疾患用アミノ酸組成物 |
JP2011144116A (ja) * | 2010-01-12 | 2011-07-28 | En Otsuka Pharmaceutical Co Ltd | 炎症性腸疾患用添加剤 |
EP4406557A2 (de) * | 2010-09-24 | 2024-07-31 | University of Florida Research Foundation, Inc. | Materialien und verfahren zur verbesserung der magen-darm-funktion |
US8183227B1 (en) | 2011-07-07 | 2012-05-22 | Chemo S. A. France | Compositions, kits and methods for nutrition supplementation |
US8168611B1 (en) | 2011-09-29 | 2012-05-01 | Chemo S.A. France | Compositions, kits and methods for nutrition supplementation |
ES2708756T3 (es) | 2013-03-11 | 2019-04-11 | Univ Florida | Materiales y métodos para mejorar la función pulmonar y para la prevención y/o el tratamiento de complicaciones pulmonares inducidas por radiación |
JP6450689B2 (ja) * | 2014-01-17 | 2019-01-09 | 株式会社明治 | 食後早期飽満感または胃食道逆流症の予防または改善剤 |
JP6693413B2 (ja) * | 2014-04-30 | 2020-05-13 | 味の素株式会社 | 消化管障害を改善する組成物 |
US20170326088A1 (en) | 2014-11-24 | 2017-11-16 | Entrinsic Health Solutions, Llc | Amino acid compositions for the treatment of symptoms of disease |
PL3294279T3 (pl) * | 2015-05-14 | 2020-06-29 | Professional Dietetics International S.R.L. | Kompozycje zawierające aminokwasy do zastosowania w leczeniu zapalenia błony śluzowej u pacjentów cierpiących na neoplazję poddawanych radioterapii i/lub chemioterapii |
TW201717931A (zh) | 2015-06-10 | 2017-06-01 | Ajinomoto Kk | 運動誘發性的消化管障礙之改善劑 |
EP3310354A4 (de) | 2015-06-17 | 2018-12-12 | Dispersol Technologies, LLC | Verbesserte formulierungen von deferasirox und verfahren zur herstellung davon |
CN105747214A (zh) * | 2016-02-26 | 2016-07-13 | 四川安益生物科技有限公司 | 一种支链氨基酸组合物 |
WO2018067717A1 (en) | 2016-10-04 | 2018-04-12 | University Of Florida Research Foundation, Incorporated | Amino acid compositions and uses thereof |
JOP20190146A1 (ar) | 2016-12-19 | 2019-06-18 | Axcella Health Inc | تركيبات حمض أميني وطرق لمعالجة أمراض الكبد |
EP3357352B1 (de) | 2017-02-02 | 2021-03-24 | artgerecht GmbH | Zusammensetzung mit aminosäuren |
DE102017201713A1 (de) | 2017-02-02 | 2018-08-02 | artgerecht GmbH | Zusammensetzung mit Aminosäuren |
US11224582B2 (en) * | 2017-04-25 | 2022-01-18 | Almeda Labs Llc | Amino acid formulations for pancreatic viability |
JP7266581B2 (ja) | 2017-08-14 | 2023-04-28 | アクセラ・ヘルス・インコーポレイテッド | 肝疾患の治療のためのアミノ酸組成物 |
JP2019058140A (ja) * | 2017-09-27 | 2019-04-18 | 味の素株式会社 | 栄養組成物 |
TW201932483A (zh) * | 2018-01-16 | 2019-08-16 | 林文欽 | 用於形成膠原蛋白的氨基酸組成物 |
US10596136B2 (en) | 2018-06-20 | 2020-03-24 | Axcella Health Inc. | Compositions and methods for the treatment of fat infiltration in muscle |
CN114007438A (zh) * | 2019-05-08 | 2022-02-01 | 麦可科技有限公司 | 用于生产菌丝化的增量组合物的方法 |
CN111067885A (zh) * | 2020-02-20 | 2020-04-28 | 杨益文 | 一种消除幽门螺旋螺杆菌及治疗胃及十二指肠溃疡的药物 |
US20230089723A1 (en) * | 2020-03-06 | 2023-03-23 | Axcella Health Inc. | Amino acid compositions and methods for muscle and myotube modulation |
WO2023066831A1 (en) * | 2021-10-21 | 2023-04-27 | Société des Produits Nestlé S.A. | Composition |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT945910B (it) * | 1971-04-08 | 1973-05-10 | Erra C Spa | Prodotto dietetico impiegabile quale intergratore dell alimenta zione umana con particolare riferi mento all infanzia agli stati di convalescenza di gravidanza d allat tamento e dell eta senile e procedi mento per la sua fabbricazione |
US4042687A (en) * | 1975-11-24 | 1977-08-16 | Control Drug, Inc. | Method of treating obesity by the oral administration of a predigested protein composition |
US4053589A (en) * | 1975-11-24 | 1977-10-11 | Control Drug Inc. | Method of treating nutritional deficiency during cardiac cachexia, diabetes, hypoglycemia, gastroenterology, lipid, cell glycogen and keratin-related skin conditions and alcoholism |
US4414238A (en) * | 1981-12-24 | 1983-11-08 | Cutter Laboratories, Inc. | Liquid elemental diet |
FR2556594B1 (fr) * | 1983-12-20 | 1988-09-09 | Synthelabo | Solutions d'acides amines |
GB2223925A (en) * | 1988-09-09 | 1990-04-25 | Stiff John Edward | Dietary supplements |
US5292773A (en) * | 1990-02-14 | 1994-03-08 | Hirsch Gerald P | Treating aids and HIV infection with methionine |
US5106836A (en) * | 1991-02-22 | 1992-04-21 | Clintec Nutrition Co. | Enteral diet |
CA2143420C (en) * | 1992-12-23 | 1999-01-19 | Phyllis J. B. Acosta | Medical foods for the nutritional support of infant/toddler metabolic diseases |
US5438042B1 (en) * | 1993-10-08 | 1997-08-26 | Sandoz Nutrition Ltd | Enteral nutritional composition having amino acid profile |
RU2091067C1 (ru) * | 1994-05-30 | 1997-09-27 | Мыслицкая Людмила Николаевна | Способ лечения желудочно-кишечных заболеваний |
RU2080871C1 (ru) * | 1994-05-30 | 1997-06-10 | Макаров Николай Васильевич | Средство, обладающее регенеративной активностью |
US5719133A (en) * | 1994-09-21 | 1998-02-17 | Novartis Nutrition Ag | Adolescent dietary composition |
ES2132021B1 (es) * | 1997-05-28 | 2000-02-16 | Riera Simon Schwartz | Formulas de aminoacidos para personas de la tercera edad y procedimiento para el calculo de las mismas. |
AU7764798A (en) | 1997-06-02 | 1998-12-21 | Societe Des Produits Nestle S.A. | Product and method for providing glutamine |
EP1024709B1 (de) | 1997-09-16 | 2006-06-14 | Societe Des Produits Nestle S.A. | Verwendung eines organspezifischen ernährungmittels |
-
2000
- 2000-04-12 GB GBGB0009056.3A patent/GB0009056D0/en not_active Ceased
-
2001
- 2001-03-21 CN CNB018079431A patent/CN1243542C/zh not_active Expired - Fee Related
- 2001-03-21 US US10/240,025 patent/US20040096478A1/en not_active Abandoned
- 2001-03-21 HU HU0300299A patent/HUP0300299A3/hu not_active Application Discontinuation
- 2001-03-21 EP EP01915386A patent/EP1274322B1/de not_active Expired - Lifetime
- 2001-03-21 ES ES01915386T patent/ES2263602T3/es not_active Expired - Lifetime
- 2001-03-21 WO PCT/EP2001/003188 patent/WO2001078532A1/en active IP Right Grant
- 2001-03-21 DE DE60119919T patent/DE60119919T2/de not_active Expired - Lifetime
- 2001-03-21 PL PL01358876A patent/PL358876A1/xx not_active Application Discontinuation
- 2001-03-21 KR KR1020027013614A patent/KR20020089448A/ko not_active Application Discontinuation
- 2001-03-21 AT AT01915386T patent/ATE326867T1/de not_active IP Right Cessation
- 2001-03-21 MX MXPA02010058A patent/MXPA02010058A/es unknown
- 2001-03-21 RU RU2002130204/15A patent/RU2002130204A/ru unknown
- 2001-03-21 CA CA002404005A patent/CA2404005C/en not_active Expired - Fee Related
- 2001-03-21 JP JP2001575843A patent/JP5600232B2/ja not_active Expired - Fee Related
-
2002
- 2002-10-02 NO NO20024743A patent/NO324525B1/no not_active IP Right Cessation
-
2003
- 2003-07-15 HK HK03105128.1A patent/HK1054489A1/zh unknown
-
2006
- 2006-04-28 US US11/380,841 patent/US8067471B2/en not_active Expired - Fee Related
-
2011
- 2011-10-18 US US13/275,996 patent/US8383680B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ES2263602T3 (es) | 2006-12-16 |
MXPA02010058A (es) | 2003-03-10 |
US8383680B2 (en) | 2013-02-26 |
US20120035234A1 (en) | 2012-02-09 |
DE60119919T2 (de) | 2007-04-26 |
HUP0300299A3 (en) | 2005-01-28 |
CN1422125A (zh) | 2003-06-04 |
NO20024743D0 (no) | 2002-10-02 |
CN1243542C (zh) | 2006-03-01 |
EP1274322A1 (de) | 2003-01-15 |
JP5600232B2 (ja) | 2014-10-01 |
CA2404005A1 (en) | 2001-10-25 |
GB0009056D0 (en) | 2000-05-31 |
CA2404005C (en) | 2009-12-08 |
RU2002130204A (ru) | 2004-03-27 |
EP1274322B1 (de) | 2006-05-24 |
JP2003530411A (ja) | 2003-10-14 |
HK1054489A1 (zh) | 2003-12-05 |
KR20020089448A (ko) | 2002-11-29 |
US20040096478A1 (en) | 2004-05-20 |
NO20024743L (no) | 2002-12-03 |
US20060247312A1 (en) | 2006-11-02 |
HUP0300299A2 (hu) | 2003-07-28 |
PL358876A1 (en) | 2004-08-23 |
US8067471B2 (en) | 2011-11-29 |
WO2001078532A1 (en) | 2001-10-25 |
ATE326867T1 (de) | 2006-06-15 |
DE60119919D1 (de) | 2006-06-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO324525B1 (no) | Preparat for behandling av svekket gastro-intestinalfunksjon, fremgangsmate for fremstilling samt anvendelse derav. | |
EP0705542B1 (de) | Diätetische Zusammensetzung für Jugendliche | |
US6544547B2 (en) | Nutritional composition containing methionine | |
US5635199A (en) | Support of pediatric patients | |
EP0764405B1 (de) | Ernährungszusammensetzung | |
US4920098A (en) | Nutritional support or therapy for individuals at risk or under treatment for atherosclerotic vascular, cardiovascular, and/or thrombotic diseases | |
CA2234398C (en) | Composition and method for providing nutrition to diabetics | |
US5723446A (en) | Enteral formulation designed for optimized nutrient absorption and wound healing | |
CA2320991C (en) | Calorically dense nutritional composition | |
PT1112006E (pt) | Produto nutricional entérico elementar contendo proteína de soja hidrolizada e caseinato parcialmente hidrolizado | |
CA2384859C (en) | High lipid diet | |
AU8152087A (en) | Liquid nutritional compositions | |
WO2005110124A1 (en) | Composition and methods for nutritional management of patients with hepatic disease | |
EP4110086A2 (de) | Ernährungszusammensetzungen zur förderung der gesundheitserhaltung in der pädiatrie | |
WO2023282316A1 (ja) | 経腸栄養製剤 | |
MXPA00007799A (en) | Calorically dense nutritional composition |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM1K | Lapsed by not paying the annual fees |