NO323960B1 - Fremgangsmate for analgesi - Google Patents

Fremgangsmate for analgesi Download PDF

Info

Publication number
NO323960B1
NO323960B1 NO20030915A NO20030915A NO323960B1 NO 323960 B1 NO323960 B1 NO 323960B1 NO 20030915 A NO20030915 A NO 20030915A NO 20030915 A NO20030915 A NO 20030915A NO 323960 B1 NO323960 B1 NO 323960B1
Authority
NO
Norway
Prior art keywords
pain
tetrodotoxin
cancer
ttx
injection
Prior art date
Application number
NO20030915A
Other languages
English (en)
Norwegian (no)
Other versions
NO20030915D0 (no
NO20030915L (no
Inventor
Qingbin Dong
Frank Haykong Shum
Original Assignee
Wex Medical Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wex Medical Ltd filed Critical Wex Medical Ltd
Publication of NO20030915D0 publication Critical patent/NO20030915D0/no
Publication of NO20030915L publication Critical patent/NO20030915L/no
Publication of NO323960B1 publication Critical patent/NO323960B1/no

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00Anaesthetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00Anaesthetics
    • A61P23/02Local anaesthetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Anesthesiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Electrotherapy Devices (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Laser Surgery Devices (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO20030915A 2000-09-18 2003-02-27 Fremgangsmate for analgesi NO323960B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CNB001245171A CN1284536C (zh) 2000-09-18 2000-09-18 河豚毒素或蛤蚌毒素及其类似物在制备用于全身镇痛的镇痛药中的应用
PCT/CN2001/001391 WO2002022129A1 (en) 2000-09-18 2001-09-11 A method of analgesia

Publications (3)

Publication Number Publication Date
NO20030915D0 NO20030915D0 (no) 2003-02-27
NO20030915L NO20030915L (no) 2003-04-25
NO323960B1 true NO323960B1 (no) 2007-07-23

Family

ID=4590472

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20030915A NO323960B1 (no) 2000-09-18 2003-02-27 Fremgangsmate for analgesi

Country Status (26)

Country Link
US (1) US6407088B1 (bg)
EP (3) EP1320369B1 (bg)
JP (1) JP2004508404A (bg)
KR (2) KR20070112864A (bg)
CN (1) CN1284536C (bg)
AT (2) ATE447959T1 (bg)
AU (1) AU2002213785A1 (bg)
BG (1) BG107690A (bg)
BR (1) BR0113961A (bg)
CA (1) CA2421562C (bg)
DE (1) DE60140466D1 (bg)
EA (1) EA004870B1 (bg)
EE (1) EE200300106A (bg)
ES (1) ES2435463T3 (bg)
HR (1) HRP20030202A2 (bg)
HU (1) HUP0302677A3 (bg)
IL (1) IL154342A0 (bg)
IS (1) IS6719A (bg)
MX (1) MXPA03002389A (bg)
NO (1) NO323960B1 (bg)
PL (1) PL360616A1 (bg)
SK (1) SK3732003A3 (bg)
UA (1) UA76960C2 (bg)
WO (1) WO2002022129A1 (bg)
YU (1) YU17103A (bg)
ZA (1) ZA200301852B (bg)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2287255A1 (en) 1997-04-22 1998-10-29 Cocensys, Inc. Carbocyclic and heterocyclic substituted semicarbazones and thiosemicarbazones and the use thereof
CN1236773C (zh) * 2000-11-22 2006-01-18 南宁枫叶药业有限公司 用于镇痛、麻醉或治疗药物依赖性的制剂
US7119062B1 (en) 2001-02-23 2006-10-10 Neucoll, Inc. Methods and compositions for improved articular surgery using collagen
CN1269482C (zh) * 2001-05-18 2006-08-16 威克斯医药有限公司 钠离子通道阻断剂和阿片类镇痛剂在制备用于对哺乳动物进行协同镇痛的药物中的应用
CN1203860C (zh) * 2001-06-22 2005-06-01 威克斯医药有限公司 钠离子通道阻断剂和阿司匹林在制备用于对哺乳动物进行协同镇痛的药物中的应用
KR20100135884A (ko) 2001-11-15 2010-12-27 마이크로 알제 코포레이션 3, 4-프로피온퍼하이드로퓨린을 포함하는 약학 조성물 및 상기 조성물을 이용한 신경 전달의 블로킹 방법
WO2004013637A1 (en) * 2002-08-01 2004-02-12 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with g-protein coupled receptor 37 (gpr37)
US20040209960A1 (en) * 2003-01-30 2004-10-21 Dynogen Pharmaceuticals, Inc. Methods of treating lower urinary tract disorders using sodium channell modulators
CN1568999A (zh) 2003-07-14 2005-01-26 南宁枫叶药业有限公司 稳定的医药用河豚毒素冷冻干燥制剂
JP2005154368A (ja) * 2003-11-27 2005-06-16 Teikoku Seiyaku Co Ltd ジソピラミド含有神経因性疼痛の鎮痛剤
WO2005110417A1 (en) * 2004-05-07 2005-11-24 Phytotox Limited Phycotoxins and uses thereof
ES2568953T3 (es) * 2004-05-07 2016-05-05 Phytotox Limited Administración transdérmica de ficotoxinas
US20050282836A1 (en) * 2004-06-22 2005-12-22 Weiyang Lin Solid orally ingestible formulations of tetrodotoxin
US20060034823A1 (en) * 2004-08-13 2006-02-16 Paul Reid Method of production and use of crotoxin as an analgesic
CN100363006C (zh) * 2004-08-20 2008-01-23 厦门朝阳生物工程有限公司 一种戒毒制剂及其制备方法
JP2008513407A (ja) * 2004-09-21 2008-05-01 ウェックス ファーマシューティカルズ インコーポレイテッド 中枢神経由来の神経障害性疼痛の治療用テトロドトキシンおよびその誘導体
KR20070092698A (ko) * 2004-09-22 2007-09-13 라보라토리오스 델 드라. 에스테브.에스.에이. 말초 신경적으로 유발된 신경병증성 통증을 치료하기 위한테트로도톡신 및 그것의 유도체
AR053811A1 (es) * 2005-02-11 2007-05-23 Esteve Labor Dr Utilizacion de un bloqueador del canal de sodio y sus analogos para el tratamiento de la dependencia de la nicotina
EP1690541A1 (en) * 2005-02-11 2006-08-16 Laboratorios Del Dr. Esteve, S.A. Use of a sodium channel blocker and their analogues for the treatment of nicotine dependency
EP1714655A1 (en) * 2005-04-22 2006-10-25 Laboratorios Del Dr. Esteve, S.A. Use of sodium channel blockers and their analogues for the treatment of nicotine dependency
EP1702627A1 (en) * 2005-03-18 2006-09-20 Laboratorios Del Dr. Esteve, S.A. Analgesic combination of sodium channel blockers with opioid antagonists
EP1928452A4 (en) * 2005-08-25 2010-09-01 Wex Medical Ltd USE OF SODIUM CHANNEL BLOCKS FOR THE TREATMENT OF VISCERAL PAIN OR PAIN THROUGH CANCER TREATMENT
WO2007025213A2 (en) * 2005-08-25 2007-03-01 Wex Pharmaceuticals, Inc. Use of sodium channel blockers for the management of musculoskeletal pain
US20070148159A1 (en) * 2005-12-22 2007-06-28 Reid Paul F Use of crotoxin as an analgesic - CIP
GB0603008D0 (en) * 2006-02-14 2006-03-29 Portela & Ca Sa Method
EP1844781A1 (en) 2006-02-22 2007-10-17 Wex Pharmaceuticals Inc. Use of sodium channel blockers for the treatment of preterm labor
EP2394646B1 (en) 2006-03-27 2018-07-25 Wex Medical Limited Use of sodium channel blockers for the treatment of neuropathic pain developing as a consequence of chemotherapy
WO2007110220A1 (en) * 2006-03-27 2007-10-04 Wex Pharmaceuticals Inc. USE OF 4,9-ANHYDRO-TETRODOTOXIN FOR THE TREATMENT OF DISEASES RELATED TO THE VOLTAGE-GATED SODIUM CHANNEL α SUBUNIT NAV 1.6
EP1844783A1 (en) * 2006-03-27 2007-10-17 Wex Pharmaceuticals, Inc Use of 4,9-anhydro-tetrodotoxin for the treatment of diseases related to the voltage-gated sodium channel - subunit Nav1.6
EP1844782A1 (en) * 2006-03-27 2007-10-17 Wex Pharmaceuticals, Inc Use of 4,9-anhydro-tetrodotoxin for the treatment of diseases related to the voltage-gated sodium channel subunit Nav1.6
CN100438873C (zh) * 2006-06-26 2008-12-03 黄致强 将河鲀毒素作为镇痛药的耐受抑制剂在制备复方镇痛制剂中的应用
EP1882692A1 (en) * 2006-07-28 2008-01-30 Wex Pharmaceuticals Inc. Dimethano-[1,3]dioxocino[6,5-D]pyrimidine-spiro derivatives of tetrodotoxin, process for their synthesis and uses thereof in the treatment of pain
WO2009008997A2 (en) * 2007-07-06 2009-01-15 Nuon Therapeutics, Inc. Treatment of neuropathic pain
CN101352422B (zh) * 2008-09-17 2011-04-20 厦门朝阳生物工程有限公司 河豚毒素冻干粉针制剂及其制备方法
US8952152B2 (en) 2009-03-24 2015-02-10 Proteus S.A. Methods for purifying phycotoxins, pharmaceutical compositions containing purified phycotoxins, and methods of use thereof
WO2010117996A1 (en) * 2009-04-08 2010-10-14 Children's Medical Center Corporation Prolonged duration local anesthesia with minimal toxicity
JP6112867B2 (ja) * 2010-02-10 2017-04-12 ファイトトックス リミテッドPhytotox Limited サキシトキシン誘導体での触覚の喪失の処置
CN103328038A (zh) 2010-12-01 2013-09-25 史拜诺莫度雷森公司 向神经解剖结构直接递送药剂
MX2015010749A (es) 2013-03-14 2015-11-30 Regeneron Pharma Anticuerpos humanos para nav1.7.
JP6313420B2 (ja) * 2013-03-15 2018-04-18 ザ チルドレンズ メディカル センター コーポレイション 持続する局所麻酔のためのネオサキシトキシン併用製剤
US8986694B1 (en) 2014-07-15 2015-03-24 Kymab Limited Targeting human nav1.7 variants for treatment of pain
US8992927B1 (en) 2014-07-15 2015-03-31 Kymab Limited Targeting human NAV1.7 variants for treatment of pain
GB201403775D0 (en) 2014-03-04 2014-04-16 Kymab Ltd Antibodies, uses & methods
US11779604B2 (en) 2016-11-03 2023-10-10 Kymab Limited Antibodies, combinations comprising antibodies, biomarkers, uses and methods
CN107198689A (zh) * 2017-07-11 2017-09-26 东新皓特(北京)生化科技有限公司 用于治疗疼痛病症的河豚毒素药物组合物及外用药

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4022899A (en) 1973-06-12 1977-05-10 Astra Pharmaceutical Products, Inc. Synergistic local anesthetic compositions
US4029793A (en) 1973-06-12 1977-06-14 Astra Pharmaceutical Products, Inc. Synergistic local anesthetic compositions
AU1888195A (en) * 1994-03-17 1995-10-03 Nanning Maple Leaf Pharmaceutical Co. Ltd. The use of amino hydrogenated quinazoline compounds and derivatives thereof for abstaining from drug dependence
CN1072486C (zh) * 1996-09-24 2001-10-10 王维国 用于戒毒、镇痛的药剂及其制法
WO1998043619A2 (en) * 1997-04-02 1998-10-08 The Regents Of The University Of California Method of local anesthesia
WO1998051290A2 (en) * 1997-05-16 1998-11-19 Children's Medical Center Corporation Local anesthetic formulations comprising a site 1 sodium channel blocker combined with a second active agent
CN1236773C (zh) * 2000-11-22 2006-01-18 南宁枫叶药业有限公司 用于镇痛、麻醉或治疗药物依赖性的制剂
CN1269482C (zh) * 2001-05-18 2006-08-16 威克斯医药有限公司 钠离子通道阻断剂和阿片类镇痛剂在制备用于对哺乳动物进行协同镇痛的药物中的应用

Also Published As

Publication number Publication date
KR20070112864A (ko) 2007-11-27
BR0113961A (pt) 2004-01-13
IS6719A (is) 2003-02-14
EP1320369A1 (en) 2003-06-25
CA2421562C (en) 2011-05-24
CA2421562A1 (en) 2002-03-21
EP1320369B1 (en) 2009-11-11
EE200300106A (et) 2005-04-15
ES2435463T3 (es) 2013-12-19
ATE542534T1 (de) 2012-02-15
AU2002213785A1 (en) 2002-03-26
EP1563839A1 (en) 2005-08-17
NO20030915D0 (no) 2003-02-27
EP2298306B1 (en) 2013-09-11
HRP20030202A2 (en) 2005-02-28
ATE447959T1 (de) 2009-11-15
HUP0302677A2 (hu) 2003-11-28
EP1563839B1 (en) 2012-01-25
WO2002022129A1 (en) 2002-03-21
EA004870B1 (ru) 2004-08-26
DE60140466D1 (de) 2009-12-24
EA200300172A1 (ru) 2003-12-25
EP1320369A4 (en) 2003-07-02
EP2298306A1 (en) 2011-03-23
SK3732003A3 (sk) 2005-05-05
MXPA03002389A (es) 2004-03-12
JP2004508404A (ja) 2004-03-18
KR100891568B1 (ko) 2009-04-03
ZA200301852B (en) 2004-06-21
CN1356104A (zh) 2002-07-03
BG107690A (bg) 2004-01-30
PL360616A1 (en) 2004-09-20
UA76960C2 (en) 2006-10-16
HUP0302677A3 (en) 2005-01-28
YU17103A (sh) 2006-03-03
IL154342A0 (en) 2003-09-17
NO20030915L (no) 2003-04-25
CN1284536C (zh) 2006-11-15
KR20030034181A (ko) 2003-05-01
US6407088B1 (en) 2002-06-18

Similar Documents

Publication Publication Date Title
NO323960B1 (no) Fremgangsmate for analgesi
JP5775300B2 (ja) カンナビノイド含有植物抽出物の新規な用途
JP6254090B2 (ja) 軸索再生および神経機能を促進するための方法および組成物
CN107820425A (zh) 用于治疗神经肌肉病症的化合物
Brain et al. A review of the history, actions, and legitimate uses of cocaine
Bobyrov et al. Pharmacology
El-Haddad et al. Neuronal NO modulates spontaneous and ANG II-stimulated fetal swallowing behavior in the near-term ovine fetus
BR112020017835A2 (pt) Agente de tratamento de epilepsia
JP4864259B2 (ja) 性機能障害および血管収縮に関する疾患の予防および治療におけるイカリンの使用
JP2022523885A (ja) 疼痛管理のための製剤
US6916845B2 (en) Method for prevention and treatment of male and female sexual dysfunction
US20160000804A1 (en) Inhibitors of na(v) 1.9 channel activity and uses thereof for treating pain
AU2007200073B2 (en) A Method of Analgesia
Seth et al. Effect of propranolol on the airway response to prostaglandin E2 in normal man.
Yadav Pharmacology & Toxicology
Smith et al. Involvement of the α4β2 nicotinic receptor subtype in nicotine-induced attenuation of Δ9-THC cerebellar ataxia: Role of cerebellar nitric oxide
RU2776109C1 (ru) Лекарственный препарат для лечения хронического кашля
WO2021063387A1 (zh) 伊马替尼及其衍生物的组合物在制备预防、治疗及防治成瘾复吸药物中的应用
Frajmund Functional Effects of the Relaxin-3/RXFP-3 Pathway on the Affective Dimension of Chronic Pain
KR20230067418A (ko) Lcn2 단백질 또는 그를 코딩하는 폴리뉴클레오티드를 유효성분으로 포함하는 발기부전 예방 또는 치료용 약학 조성물
CN115745890A (zh) 一种酯键化合物及其制备方法和应用、镇痛药物
Doggrell et al. Pharmacology in one semester [Version 3, Semester 1, 2014]
Yadav et al. NEUROPROTECTIVE ROLE AND ANTI-AMNESIC EFFECT OF DOCOSAHEXAENOIC ACID AND GAMMA-LINOLENIC ACID IN LEAD INDUCED NEUROLOGICAL DEFICIT AND AMNESIA IN SWISS ALBINO MICE.
WO2010120203A1 (ru) Применение органических красителей в качестве обезболивающих средств