NO323611B1 - Fusjonspolypeptidisolert polynukleotid, fremgangsmate for fremstilling, og vektorer, samt farmasoytisk sammensetning og anvendelse av fusjonspolypeptider for fremstilling av medikament for behandling av IgE- eller IgE-reseptormedierte forstyrrelser - Google Patents

Fusjonspolypeptidisolert polynukleotid, fremgangsmate for fremstilling, og vektorer, samt farmasoytisk sammensetning og anvendelse av fusjonspolypeptider for fremstilling av medikament for behandling av IgE- eller IgE-reseptormedierte forstyrrelser Download PDF

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Publication number
NO323611B1
NO323611B1 NO19990328A NO990328A NO323611B1 NO 323611 B1 NO323611 B1 NO 323611B1 NO 19990328 A NO19990328 A NO 19990328A NO 990328 A NO990328 A NO 990328A NO 323611 B1 NO323611 B1 NO 323611B1
Authority
NO
Norway
Prior art keywords
ige
polypeptide
hsa
fusion
cells
Prior art date
Application number
NO19990328A
Other languages
English (en)
Norwegian (no)
Other versions
NO990328D0 (no
NO990328L (no
Inventor
Mary Ellen Digan
Hermann Gram
Philip Lake
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of NO990328D0 publication Critical patent/NO990328D0/no
Publication of NO990328L publication Critical patent/NO990328L/no
Publication of NO323611B1 publication Critical patent/NO323611B1/no

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/64General methods for preparing the vector, for introducing it into the cell or for selecting the vector-containing host
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76Albumins
    • C07K14/765Serum albumin, e.g. HSA
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/70535Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/05Animals comprising random inserted nucleic acids (transgenic)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
NO19990328A 1996-07-26 1999-01-25 Fusjonspolypeptidisolert polynukleotid, fremgangsmate for fremstilling, og vektorer, samt farmasoytisk sammensetning og anvendelse av fusjonspolypeptider for fremstilling av medikament for behandling av IgE- eller IgE-reseptormedierte forstyrrelser NO323611B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69021696A 1996-07-26 1996-07-26
PCT/EP1997/004066 WO1998004718A1 (en) 1996-07-26 1997-07-25 Fusion polypeptides comprising an ige-binding domain and a hsa component, and their diagnostic and therapeutic uses

Publications (3)

Publication Number Publication Date
NO990328D0 NO990328D0 (no) 1999-01-25
NO990328L NO990328L (no) 1999-02-19
NO323611B1 true NO323611B1 (no) 2007-06-18

Family

ID=24771594

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19990328A NO323611B1 (no) 1996-07-26 1999-01-25 Fusjonspolypeptidisolert polynukleotid, fremgangsmate for fremstilling, og vektorer, samt farmasoytisk sammensetning og anvendelse av fusjonspolypeptider for fremstilling av medikament for behandling av IgE- eller IgE-reseptormedierte forstyrrelser

Country Status (28)

Country Link
EP (1) EP0917581B1 (de)
JP (1) JP3681402B2 (de)
KR (1) KR100502879B1 (de)
CN (1) CN1146664C (de)
AR (1) AR008077A1 (de)
AT (1) ATE383429T1 (de)
AU (1) AU722069B2 (de)
BR (1) BR9710605A (de)
CA (1) CA2261562C (de)
CO (1) CO4650184A1 (de)
CZ (1) CZ297634B6 (de)
DE (1) DE69738452T2 (de)
ES (1) ES2300114T3 (de)
HK (1) HK1020352A1 (de)
ID (1) ID19420A (de)
IL (2) IL128094A0 (de)
MY (1) MY120425A (de)
NO (1) NO323611B1 (de)
NZ (1) NZ333908A (de)
PE (1) PE99498A1 (de)
PL (1) PL189415B1 (de)
PT (1) PT917581E (de)
RU (1) RU2209211C2 (de)
SK (1) SK7799A3 (de)
TR (1) TR199900155T2 (de)
TW (1) TW565571B (de)
WO (1) WO1998004718A1 (de)
ZA (1) ZA976666B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1289253A (zh) * 1998-01-29 2001-03-28 泰诺士公司 以lgE拮抗剂治疗特应性皮炎
ES2273497T3 (es) * 1998-06-15 2007-05-01 Gtc Biotherapeutics, Inc. Proteina de fusion de la albumina serica humana de eritropoyetina analoga.
AU6755300A (en) * 1999-08-09 2001-03-05 Genaissance Pharmaceuticals, Inc. Drug target isogenes: polymorphisms in the immunoglobulin e receptor i alpha subunit gene
DE10026998A1 (de) * 2000-05-31 2001-12-13 Fresenius Kabi De Gmbh Verfahren zur Herstellung einer kosmetischen Zusammensetzung, die humanes Serum Albumin umfasst, welches aus transgenen nicht-menschlichen Säugern erhalten wurde
US7271149B2 (en) * 2000-12-07 2007-09-18 Eli Lilly And Company GLP-1 fusion proteins
TW200526779A (en) * 2001-02-08 2005-08-16 Wyeth Corp Modified and stabilized GDF propeptides and uses thereof
ES2545090T3 (es) 2001-12-21 2015-09-08 Human Genome Sciences, Inc. Proteínas de fusión de albúmina y GCSF
US8927694B2 (en) 2008-11-18 2015-01-06 Merrimack Pharmaceuticals, Inc. Human serum albumin linkers and conjugates thereof
BRPI1008762B8 (pt) 2009-02-27 2021-05-25 Novartis Ag métodos para seleção de células de mamífero expressando uma proteína heteróloga, para produzir um produto de interesse e uso de um meio de cultura seletivo
WO2012169735A2 (ko) * 2011-06-07 2012-12-13 (주)네오팜 FCεRI의 수용성 단편을 포함하는 복합체 및 이를 포함하는 IGE 매개 알레르기성 질환 치료용 조성물
RU2506271C2 (ru) * 2011-06-22 2014-02-10 Учреждение Российской Академии Медицинских Наук Научно-исследовательский институт экспериментальной медицины Северо-западного отделения РАМН (НИИЭМ СЗО РАМН) РЕКОМБИНАНТНЫЙ ПОЛИПЕПТИД А2, СЕЛЕКТИВНО СВЯЗЫВАЮЩИЙ HSA, РЕКОМБИНАНТНАЯ ДНК pa2, КОДИРУЮЩАЯ HSA-СВЯЗЫВАЮЩУЮ ЧАСТЬ ПОЛИПЕПТИДА A2, ЕГО ПРОДУЦЕНТ - РЕКОМБИНАНТНЫЙ ШТАММ Escherichia coli M15-A2, СОДЕРЖАЩИЙ РЕКОМБИНАНТНУЮ ПЛАЗМИДНУЮ ДНК pQE 32-pa2, ОБЕСПЕЧИВАЮЩУЮ ПОЛУЧЕНИЕ ПОЛИПЕПТИДА A2 И ПРИМЕНЕНИЕ ПОЛИПЕПТИДА А2 ДЛЯ ДИАГНОСТИКИ МИКРОАЛЬБУМИНУРИИ И ВЫДЕЛЕНИЯ HSA ИЗ СЫВОРОТКИ КРОВИ
US20150202287A1 (en) 2012-08-30 2015-07-23 Merrimack Pharmaceuticals, Inc. Combination therapies comprising anti-erbb3 agents
JP2018515073A (ja) * 2015-05-04 2018-06-14 ラボラトワール フランセ デュ フラクショヌマン エ デ ビオテクノロジーLaboratoire Francais du Fractionnement et des Biotechnologies Fc融合タンパク質のトランスジェニック産生
EP3192806A1 (de) 2016-01-13 2017-07-19 Affiris AG Alpha-kette des hochaffinen ige-rezeptors (fceria)
WO2018089335A1 (en) * 2016-11-09 2018-05-17 North Carolina State University Treatment of allergic diseases with chimeric protein
US12060437B2 (en) 2018-03-23 2024-08-13 North Carolina State University Methods and compositions for antibody to high affinity receptor for IgE
CN114302891A (zh) * 2019-07-08 2022-04-08 普罗根有限公司 新的il-10变体蛋白及其用途
CN111773392B (zh) * 2020-05-25 2023-04-07 河南省生物工程技术研究中心 一种人血白蛋白/寡核苷酸纳米颗粒及其制备方法和用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4962035A (en) * 1987-12-01 1990-10-09 President And Fellows Of Harvard College DNA encoding IgE receptor alpha-subunit or fragment thereof
GB8909916D0 (en) * 1989-04-29 1989-06-14 Delta Biotechnology Ltd Polypeptides
CA2059842A1 (en) * 1991-02-11 1992-08-12 Richard A. Chizzonite Ige-receptor-antibodies

Also Published As

Publication number Publication date
PE99498A1 (es) 1999-01-21
CZ24699A3 (cs) 1999-04-14
EP0917581A1 (de) 1999-05-26
CO4650184A1 (es) 1998-09-03
TW565571B (en) 2003-12-11
NZ333908A (en) 1999-10-28
TR199900155T2 (xx) 2000-08-21
NO990328D0 (no) 1999-01-25
IL128094A (en) 2006-08-20
ZA976666B (en) 1999-01-25
RU2209211C2 (ru) 2003-07-27
KR100502879B1 (ko) 2005-07-25
BR9710605A (pt) 1999-08-17
JP2000516089A (ja) 2000-12-05
AR008077A1 (es) 1999-12-09
ID19420A (id) 1998-07-09
MY120425A (en) 2005-10-31
CA2261562C (en) 2011-04-05
ES2300114T3 (es) 2008-06-01
JP3681402B2 (ja) 2005-08-10
EP0917581B1 (de) 2008-01-09
PL331356A1 (en) 1999-07-05
PL189415B1 (pl) 2005-08-31
HK1020352A1 (en) 2000-04-14
WO1998004718A1 (en) 1998-02-05
AU722069B2 (en) 2000-07-20
ATE383429T1 (de) 2008-01-15
AU4202597A (en) 1998-02-20
IL128094A0 (en) 1999-11-30
KR20000029563A (ko) 2000-05-25
SK7799A3 (en) 1999-07-12
CZ297634B6 (cs) 2007-02-21
CN1146664C (zh) 2004-04-21
CN1229439A (zh) 1999-09-22
DE69738452D1 (de) 2008-02-21
NO990328L (no) 1999-02-19
CA2261562A1 (en) 1998-02-05
PT917581E (pt) 2008-04-11
DE69738452T2 (de) 2008-12-24

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