CO4650184A1 - POLIPEPTIDOS DE FUSION QUE COMPRENDEN UN DOMINIO DE UNION DE IgE Y UN COMPONENTE DE SEROALBUMINA HUMANA - Google Patents
POLIPEPTIDOS DE FUSION QUE COMPRENDEN UN DOMINIO DE UNION DE IgE Y UN COMPONENTE DE SEROALBUMINA HUMANAInfo
- Publication number
- CO4650184A1 CO4650184A1 CO97042651A CO97042651A CO4650184A1 CO 4650184 A1 CO4650184 A1 CO 4650184A1 CO 97042651 A CO97042651 A CO 97042651A CO 97042651 A CO97042651 A CO 97042651A CO 4650184 A1 CO4650184 A1 CO 4650184A1
- Authority
- CO
- Colombia
- Prior art keywords
- polypeptide
- ige
- component
- physiologically functional
- fusion polypeptides
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 8
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 8
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 8
- 230000004927 fusion Effects 0.000 title abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 102000008100 Human Serum Albumin Human genes 0.000 abstract 2
- 108091006905 Human Serum Albumin Proteins 0.000 abstract 2
- 108060003951 Immunoglobulin Proteins 0.000 abstract 1
- 102000018358 immunoglobulin Human genes 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000001131 transforming effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/64—General methods for preparing the vector, for introducing it into the cell or for selecting the vector-containing host
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
- C07K14/765—Serum albumin, e.g. HSA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Un polipéptido de fusión o una sal del mismo, que comprende almenos un dominio de unión de inmunoglobulina E (IgE) fusionado a al menos un componente de seroalbúmina humas (HSA), o un equivalente fisiológicamente funcional del mismo.Un proceso para la preparación de un polipéptido o sal del mismo, de acuerdo a la reivindicación 1, el cual comprende (a) transformar una célula huésped con un vector que comprende el ADN que codifica para un polipéptido de acuerdo a la reivindicación 1 o un equivalente fisiológicamente funcional del mismo; (b) expresar el polipéptido o su equivalente fisiológicamente funcional en esa célula, por lo que el polipéptido equivalente fisiológicamente funcional se modifica para producir un polipéptido de fusión de acuerdo a lo definido en la reivindicación 1; y (c) recuperar el polipéptido resultante de la célula huésped opcionalmente en forma de una sal del mismo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69021696A | 1996-07-26 | 1996-07-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO4650184A1 true CO4650184A1 (es) | 1998-09-03 |
Family
ID=24771594
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO97042651A CO4650184A1 (es) | 1996-07-26 | 1997-07-25 | POLIPEPTIDOS DE FUSION QUE COMPRENDEN UN DOMINIO DE UNION DE IgE Y UN COMPONENTE DE SEROALBUMINA HUMANA |
Country Status (28)
| Country | Link |
|---|---|
| EP (1) | EP0917581B1 (es) |
| JP (1) | JP3681402B2 (es) |
| KR (1) | KR100502879B1 (es) |
| CN (1) | CN1146664C (es) |
| AR (1) | AR008077A1 (es) |
| AT (1) | ATE383429T1 (es) |
| AU (1) | AU722069B2 (es) |
| BR (1) | BR9710605A (es) |
| CA (1) | CA2261562C (es) |
| CO (1) | CO4650184A1 (es) |
| CZ (1) | CZ297634B6 (es) |
| DE (1) | DE69738452T2 (es) |
| ES (1) | ES2300114T3 (es) |
| HK (1) | HK1020352A1 (es) |
| ID (1) | ID19420A (es) |
| IL (2) | IL128094A0 (es) |
| MY (1) | MY120425A (es) |
| NO (1) | NO323611B1 (es) |
| NZ (1) | NZ333908A (es) |
| PE (1) | PE99498A1 (es) |
| PL (1) | PL189415B1 (es) |
| PT (1) | PT917581E (es) |
| RU (1) | RU2209211C2 (es) |
| SK (1) | SK7799A3 (es) |
| TR (1) | TR199900155T2 (es) |
| TW (1) | TW565571B (es) |
| WO (1) | WO1998004718A1 (es) |
| ZA (1) | ZA976666B (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1056471A4 (en) * | 1998-01-29 | 2001-05-30 | Tanox Inc | TREATMENT OF ATOPIC DERMATITIS USING IgE ANTAGONISTS |
| WO1999066054A2 (en) * | 1998-06-15 | 1999-12-23 | Genzyme Transgenics Corp. | Erythropoietin analog-human serum albumin fusion protein |
| JP2003506074A (ja) * | 1999-08-09 | 2003-02-18 | ジェネッサンス ファーマシューティカルズ，インコーポレイティド | 薬剤標的同質遺伝子：免疫グロブリンｅ受容体ｉａｌｐｈａサブユニット遺伝子における多型 |
| DE10026998A1 (de) * | 2000-05-31 | 2001-12-13 | Fresenius Kabi De Gmbh | Verfahren zur Herstellung einer kosmetischen Zusammensetzung, die humanes Serum Albumin umfasst, welches aus transgenen nicht-menschlichen Säugern erhalten wurde |
| BR0116024A (pt) * | 2000-12-07 | 2005-12-13 | Lilly Co Eli | Proteìna de fusão heteróloga e uso da mesma |
| TW200526779A (en) * | 2001-02-08 | 2005-08-16 | Wyeth Corp | Modified and stabilized GDF propeptides and uses thereof |
| ES2500918T3 (es) | 2001-12-21 | 2014-10-01 | Human Genome Sciences, Inc. | Proteínas de fusión de albúmina e interferón beta |
| US8927694B2 (en) | 2008-11-18 | 2015-01-06 | Merrimack Pharmaceuticals, Inc. | Human serum albumin linkers and conjugates thereof |
| RU2551229C2 (ru) * | 2009-02-27 | 2015-05-20 | Новартис Аг | Способы селекции эукариотических клеток, экспрессирующих гетерологичный белок |
| WO2012169735A2 (ko) * | 2011-06-07 | 2012-12-13 | (주)네오팜 | FCεRI의 수용성 단편을 포함하는 복합체 및 이를 포함하는 IGE 매개 알레르기성 질환 치료용 조성물 |
| RU2506271C2 (ru) * | 2011-06-22 | 2014-02-10 | Учреждение Российской Академии Медицинских Наук Научно-исследовательский институт экспериментальной медицины Северо-западного отделения РАМН (НИИЭМ СЗО РАМН) | РЕКОМБИНАНТНЫЙ ПОЛИПЕПТИД А2, СЕЛЕКТИВНО СВЯЗЫВАЮЩИЙ HSA, РЕКОМБИНАНТНАЯ ДНК pa2, КОДИРУЮЩАЯ HSA-СВЯЗЫВАЮЩУЮ ЧАСТЬ ПОЛИПЕПТИДА A2, ЕГО ПРОДУЦЕНТ - РЕКОМБИНАНТНЫЙ ШТАММ Escherichia coli M15-A2, СОДЕРЖАЩИЙ РЕКОМБИНАНТНУЮ ПЛАЗМИДНУЮ ДНК pQE 32-pa2, ОБЕСПЕЧИВАЮЩУЮ ПОЛУЧЕНИЕ ПОЛИПЕПТИДА A2 И ПРИМЕНЕНИЕ ПОЛИПЕПТИДА А2 ДЛЯ ДИАГНОСТИКИ МИКРОАЛЬБУМИНУРИИ И ВЫДЕЛЕНИЯ HSA ИЗ СЫВОРОТКИ КРОВИ |
| US20150202287A1 (en) | 2012-08-30 | 2015-07-23 | Merrimack Pharmaceuticals, Inc. | Combination therapies comprising anti-erbb3 agents |
| CN107979973A (zh) * | 2015-05-04 | 2018-05-01 | 法国化学与生物科技实验室 | Fc融合蛋白质的转基因生产 |
| EP3192806A1 (en) | 2016-01-13 | 2017-07-19 | Affiris AG | Alpha chain of the high-affinity ige receptor (fceria) |
| EP3538558A4 (en) * | 2016-11-09 | 2020-07-15 | North Carolina State University | TREATMENT OF ALLERGIC DISEASES WITH A CHIMERAL PROTEIN |
| US20220267396A1 (en) * | 2019-07-08 | 2022-08-25 | Progen Co., Ltd. | Novel il-10 variant protein and use thereof |
| CN111773392B (zh) * | 2020-05-25 | 2023-04-07 | 河南省生物工程技术研究中心 | 一种人血白蛋白/寡核苷酸纳米颗粒及其制备方法和用途 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4962035A (en) * | 1987-12-01 | 1990-10-09 | President And Fellows Of Harvard College | DNA encoding IgE receptor alpha-subunit or fragment thereof |
| GB8909916D0 (en) * | 1989-04-29 | 1989-06-14 | Delta Biotechnology Ltd | Polypeptides |
| CA2059842A1 (en) * | 1991-02-11 | 1992-08-12 | Richard A. Chizzonite | Ige-receptor-antibodies |
-
1997
- 1997-07-24 MY MYPI97003371A patent/MY120425A/en unknown
- 1997-07-24 PE PE1997000662A patent/PE99498A1/es not_active Application Discontinuation
- 1997-07-24 AR ARP970103340A patent/AR008077A1/es active IP Right Grant
- 1997-07-25 ZA ZA976666A patent/ZA976666B/xx unknown
- 1997-07-25 EP EP97940030A patent/EP0917581B1/en not_active Expired - Lifetime
- 1997-07-25 SK SK77-99A patent/SK7799A3/sk unknown
- 1997-07-25 AT AT97940030T patent/ATE383429T1/de active
- 1997-07-25 CN CNB971976597A patent/CN1146664C/zh not_active Expired - Fee Related
- 1997-07-25 RU RU99103326/13A patent/RU2209211C2/ru not_active IP Right Cessation
- 1997-07-25 PT PT97940030T patent/PT917581E/pt unknown
- 1997-07-25 WO PCT/EP1997/004066 patent/WO1998004718A1/en active IP Right Grant
- 1997-07-25 AU AU42025/97A patent/AU722069B2/en not_active Ceased
- 1997-07-25 TR TR1999/00155T patent/TR199900155T2/xx unknown
- 1997-07-25 IL IL12809497A patent/IL128094A0/xx active IP Right Grant
- 1997-07-25 BR BR9710605A patent/BR9710605A/pt not_active IP Right Cessation
- 1997-07-25 JP JP50850498A patent/JP3681402B2/ja not_active Expired - Fee Related
- 1997-07-25 CA CA2261562A patent/CA2261562C/en not_active Expired - Fee Related
- 1997-07-25 ID IDP972592A patent/ID19420A/id unknown
- 1997-07-25 ES ES97940030T patent/ES2300114T3/es not_active Expired - Lifetime
- 1997-07-25 DE DE69738452T patent/DE69738452T2/de not_active Expired - Lifetime
- 1997-07-25 NZ NZ333908A patent/NZ333908A/en unknown
- 1997-07-25 KR KR10-1999-7000621A patent/KR100502879B1/ko not_active IP Right Cessation
- 1997-07-25 CO CO97042651A patent/CO4650184A1/es unknown
- 1997-07-25 CZ CZ0024699A patent/CZ297634B6/cs not_active IP Right Cessation
- 1997-08-08 TW TW086111356A patent/TW565571B/zh not_active IP Right Cessation
-
1999
- 1999-01-18 IL IL128094A patent/IL128094A/en not_active IP Right Cessation
- 1999-01-25 PL PL97331356A patent/PL189415B1/pl not_active IP Right Cessation
- 1999-01-25 NO NO19990328A patent/NO323611B1/no not_active IP Right Cessation
- 1999-11-24 HK HK99105437A patent/HK1020352A1/xx not_active IP Right Cessation
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