NO323059B1 - Antitrombotisk forbindelse, samt fremstilling og anvendelse derav og farmasoytisk preparat. - Google Patents

Antitrombotisk forbindelse, samt fremstilling og anvendelse derav og farmasoytisk preparat. Download PDF

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Publication number
NO323059B1
NO323059B1 NO20022689A NO20022689A NO323059B1 NO 323059 B1 NO323059 B1 NO 323059B1 NO 20022689 A NO20022689 A NO 20022689A NO 20022689 A NO20022689 A NO 20022689A NO 323059 B1 NO323059 B1 NO 323059B1
Authority
NO
Norway
Prior art keywords
compound
mmol
solution
water
concentrated
Prior art date
Application number
NO20022689A
Other languages
English (en)
Norwegian (no)
Other versions
NO20022689L (no
NO20022689D0 (no
Inventor
Constant Adriaan Anton Van Boeckel
Cornelia Maria Tromp
Tamara Theodora Maria Geertsen
Original Assignee
Organon Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organon Nv filed Critical Organon Nv
Publication of NO20022689L publication Critical patent/NO20022689L/no
Publication of NO20022689D0 publication Critical patent/NO20022689D0/no
Publication of NO323059B1 publication Critical patent/NO323059B1/no

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00Processes for the preparation of sugar derivatives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26Acyclic or carbocyclic radicals, substituted by hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K9/00Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NO20022689A 1999-12-07 2002-06-06 Antitrombotisk forbindelse, samt fremstilling og anvendelse derav og farmasoytisk preparat. NO323059B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99204172 1999-12-07
PCT/EP2000/012155 WO2001042262A2 (en) 1999-12-07 2000-12-01 Antithrombotic compound

Publications (3)

Publication Number Publication Date
NO20022689L NO20022689L (no) 2002-06-06
NO20022689D0 NO20022689D0 (no) 2002-06-06
NO323059B1 true NO323059B1 (no) 2006-12-27

Family

ID=8240976

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20022689A NO323059B1 (no) 1999-12-07 2002-06-06 Antitrombotisk forbindelse, samt fremstilling og anvendelse derav og farmasoytisk preparat.

Country Status (23)

Country Link
US (1) US6875755B2 (cs)
EP (1) EP1237897B1 (cs)
JP (1) JP4820517B2 (cs)
KR (1) KR100776607B1 (cs)
CN (1) CN1195767C (cs)
AR (1) AR026726A1 (cs)
AU (1) AU781846B2 (cs)
BR (1) BR0016217A (cs)
CA (1) CA2393042C (cs)
CO (1) CO5251449A1 (cs)
CZ (1) CZ303385B6 (cs)
HK (1) HK1047593A1 (cs)
HU (1) HUP0203471A3 (cs)
IL (2) IL149628A0 (cs)
NO (1) NO323059B1 (cs)
NZ (1) NZ519100A (cs)
PE (1) PE20010935A1 (cs)
PL (1) PL202840B1 (cs)
RU (1) RU2266913C2 (cs)
SK (1) SK287682B6 (cs)
TW (1) TWI289566B (cs)
WO (1) WO2001042262A2 (cs)
ZA (1) ZA200203799B (cs)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2423888T3 (es) * 2001-09-07 2013-09-25 Alchemia Limited Pentasacáridos de heparina sintéticos
ATE451369T1 (de) 2002-07-15 2009-12-15 Merck & Co Inc Piperidinopyrimidindipeptidylpeptidaseinhibitor n zur behandlung von diabetes
JP4491346B2 (ja) 2002-10-07 2010-06-30 メルク・シャープ・エンド・ドーム・コーポレイション 抗糖尿病ベータアミノ複素環ジペプチジルペプチダーゼ阻害剤
MXPA05004890A (es) * 2002-11-07 2005-07-22 Merck & Co Inc Derivados de fenilalanina como inhibidores de dipeptidilpeptidasa para el tratamiento o prevencion de diabetes.
JP4564952B2 (ja) 2003-01-17 2010-10-20 メルク・シャープ・エンド・ドーム・コーポレイション 糖尿病の治療および予防のためのジペプチジルペプチダーゼ阻害薬としての3−アミノ−4−フェニルブタン酸誘導体
US7388019B2 (en) 2003-01-31 2008-06-17 Merck & Co., Inc. 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
DE602004023932D1 (de) 2003-05-14 2009-12-17 Merck & Co Inc 3-amino-4-phenylbutansäurederivate als dipeptidylpeptidase-hemmer zur behandlung oder vorbeugung von diabetes
EP1635818B1 (en) 2003-06-06 2010-04-07 Merck Sharp & Dohme Corp. Fused indoles as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
AU2004249163A1 (en) 2003-06-17 2004-12-29 Merck & Co., Inc. Cyclohexylglycine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
AU2004261186A1 (en) 2003-07-31 2005-02-10 Merck & Co., Inc. Hexahydrodiazepinones as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes
EP1574516A1 (en) 2004-03-05 2005-09-14 Sanofi-Aventis Antithrombotic compound
TW200621794A (en) * 2004-10-06 2006-07-01 Akzo Nobel Nv Pulmonary administration of an antithrombotic compound
TWI403334B (zh) * 2004-12-23 2013-08-01 Merck Sharp & Dohme 包含生物素殘基之抗血栓雙重抑制劑
TWI376234B (en) 2005-02-01 2012-11-11 Msd Oss Bv Conjugates of a polypeptide and an oligosaccharide
AU2006301331B2 (en) * 2005-10-10 2011-12-22 Merck Sharp & Dohme B.V. Anticoagulant antithrombotic dual inhibitors comprising a biotin label
EP2512448B1 (en) 2009-12-18 2016-07-06 Endotis Pharma Pharmaceutical oral dosage form containing a synthetic oligosaccharide

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4115468A1 (de) * 1991-05-11 1992-11-12 Behringwerke Ag Amidinophenylalaninderivate, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel als antikoagulantien
DE4206858A1 (de) * 1992-03-05 1993-09-09 Behringwerke Ag Glycopeptid-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische mittel
FR2704226B1 (fr) * 1993-04-22 1995-07-21 Sanofi Elf 3-desoxy oligosaccharides, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
ES2147216T3 (es) * 1993-09-01 2000-09-01 Akzo Nobel Nv Bisconjugados que comprenden dos sacaridos y un grupo de union.
IL126893A (en) * 1997-11-19 2003-05-29 Akzo Nobel Nv Sulfated pentasaccharide derivatives and pharmaceutical compositions containing them
AU756493B2 (en) * 1998-06-17 2003-01-16 Merck Sharp & Dohme B.V. Antithrombotic compounds

Also Published As

Publication number Publication date
RU2266913C2 (ru) 2005-12-27
AU781846B2 (en) 2005-06-16
NO20022689L (no) 2002-06-06
CN1195767C (zh) 2005-04-06
CA2393042A1 (en) 2001-06-14
PL202840B1 (pl) 2009-07-31
CN1407989A (zh) 2003-04-02
KR100776607B1 (ko) 2007-11-16
US6875755B2 (en) 2005-04-05
ZA200203799B (en) 2003-10-29
BR0016217A (pt) 2002-09-10
IL149628A (en) 2010-04-29
JP4820517B2 (ja) 2011-11-24
SK7942002A3 (en) 2002-09-10
HUP0203471A2 (hu) 2003-02-28
HUP0203471A3 (en) 2003-03-28
US20030114361A1 (en) 2003-06-19
CA2393042C (en) 2011-06-28
CZ303385B6 (cs) 2012-08-29
EP1237897A2 (en) 2002-09-11
EP1237897B1 (en) 2015-01-14
IL149628A0 (en) 2002-11-10
HK1047593A1 (zh) 2003-02-28
JP2003520208A (ja) 2003-07-02
SK287682B6 (sk) 2011-06-06
WO2001042262A3 (en) 2001-12-13
PE20010935A1 (es) 2001-09-20
NZ519100A (en) 2004-09-24
AR026726A1 (es) 2003-02-26
TWI289566B (en) 2007-11-11
NO20022689D0 (no) 2002-06-06
CZ20021958A3 (cs) 2002-08-14
CO5251449A1 (es) 2003-02-28
KR20020070988A (ko) 2002-09-11
WO2001042262A2 (en) 2001-06-14
PL355484A1 (en) 2004-05-04
AU2003801A (en) 2001-06-18

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Legal Events

Date Code Title Description
CHAD Change of the owner's name or address (par. 44 patent law, par. patentforskriften)

Owner name: MERCK SHARP & DOHME BV, NL

MM1K Lapsed by not paying the annual fees