NO321777B1 - Hybridproteiner som danner heterodimerer, DNA, ekspresjonsvektorer og vertsceller som koder for eller uttrykker disse, samt farmasoytisk sammensetning og anvendelse av hybridproteinene for fremstilling av et medikament for behandling av humane lidelser med behov for inhibering av TNF. - Google Patents

Hybridproteiner som danner heterodimerer, DNA, ekspresjonsvektorer og vertsceller som koder for eller uttrykker disse, samt farmasoytisk sammensetning og anvendelse av hybridproteinene for fremstilling av et medikament for behandling av humane lidelser med behov for inhibering av TNF. Download PDF

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Publication number
NO321777B1
NO321777B1 NO19983799A NO983799A NO321777B1 NO 321777 B1 NO321777 B1 NO 321777B1 NO 19983799 A NO19983799 A NO 19983799A NO 983799 A NO983799 A NO 983799A NO 321777 B1 NO321777 B1 NO 321777B1
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NO
Norway
Prior art keywords
hybrid protein
protein according
sequence
receptor
hcg
Prior art date
Application number
NO19983799A
Other languages
English (en)
Norwegian (no)
Other versions
NO983799L (no
NO983799D0 (no
Inventor
Robert K Campbell
Bradford A Jameson
Scott C Chappel
Original Assignee
Applied Research Systems
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Application filed by Applied Research Systems filed Critical Applied Research Systems
Publication of NO983799D0 publication Critical patent/NO983799D0/no
Publication of NO983799L publication Critical patent/NO983799L/no
Publication of NO321777B1 publication Critical patent/NO321777B1/no

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/04Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups
    • C07C209/22Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of other functional groups
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62DNA sequences coding for fusion proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/24Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/06Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/14Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A61P5/16Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/59Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Reproductive Health (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
NO19983799A 1996-02-20 1998-08-19 Hybridproteiner som danner heterodimerer, DNA, ekspresjonsvektorer og vertsceller som koder for eller uttrykker disse, samt farmasoytisk sammensetning og anvendelse av hybridproteinene for fremstilling av et medikament for behandling av humane lidelser med behov for inhibering av TNF. NO321777B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1193696P 1996-02-20 1996-02-20
PCT/US1997/002315 WO1997030161A1 (en) 1996-02-20 1997-02-20 Hybrid proteins which form heterodimers

Publications (3)

Publication Number Publication Date
NO983799D0 NO983799D0 (no) 1998-08-19
NO983799L NO983799L (no) 1998-10-19
NO321777B1 true NO321777B1 (no) 2006-07-03

Family

ID=21752599

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19983799A NO321777B1 (no) 1996-02-20 1998-08-19 Hybridproteiner som danner heterodimerer, DNA, ekspresjonsvektorer og vertsceller som koder for eller uttrykker disse, samt farmasoytisk sammensetning og anvendelse av hybridproteinene for fremstilling av et medikament for behandling av humane lidelser med behov for inhibering av TNF.

Country Status (25)

Country Link
US (5) US6193972B1 (de)
EP (1) EP0894141B1 (de)
JP (2) JP4140927B2 (de)
KR (1) KR100369985B1 (de)
CN (1) CN1261579C (de)
AT (1) ATE295887T1 (de)
AU (1) AU706504B2 (de)
BG (1) BG64510B1 (de)
BR (1) BR9707589A (de)
CA (1) CA2245877C (de)
CZ (1) CZ291212B6 (de)
DE (1) DE69733309T2 (de)
DK (1) DK0894141T3 (de)
EA (1) EA002474B1 (de)
EE (1) EE04025B1 (de)
ES (1) ES2241040T3 (de)
HU (1) HUP9900619A3 (de)
IL (1) IL125864A (de)
NO (1) NO321777B1 (de)
NZ (1) NZ331539A (de)
PL (1) PL187400B1 (de)
PT (1) PT894141E (de)
SK (1) SK282326B6 (de)
UA (1) UA52646C2 (de)
WO (1) WO1997030161A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ331539A (en) * 1996-02-20 2000-01-28 Applied Research Systems Hybrid proteins from two coexpressed receptors to form a heterodimer
US6635740B1 (en) * 1997-03-27 2003-10-21 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Ligand/lytic peptide compositions and methods of use
CA2301846A1 (en) 1997-09-04 1999-03-11 Gryphon Sciences Modular protein libraries and methods of preparation
EA006605B1 (ru) * 2000-02-22 2006-02-24 Апплайд Резеч Системз Арс Холдинг Н.В. СПОСОБ ОЧИСТКИ РЕКОМБИНАНТНОГО чХГ
US20030228600A1 (en) * 2000-07-14 2003-12-11 Eppendorf 5 Prime, Inc. DNA isolation method and kit
IL147414A0 (en) * 2001-12-31 2002-08-14 Yeda Res & Dev Ifnar2 mutants, their production and use
US20030157091A1 (en) * 2002-02-14 2003-08-21 Dyax Corporation Multi-functional proteins
DE10247755B4 (de) * 2002-10-14 2006-01-19 Pfizenmaier, Klaus, Prof. Dr. Selektive, lokale Aktivierung von Mitgliedern der TNF-Rezeptorfamilie durch systemisch inaktive nicht-Antikörper-TNF-Liganden-Fusionsproteine
AU2005207960A1 (en) * 2004-01-28 2005-08-11 Syntonix Pharmaceuticals, Inc. Heterodimeric follicle stimulating hormone-Fc (FSH-Fc) fusion proteins for the treatment of infertility
JP2008525002A (ja) 2004-12-23 2008-07-17 ラボラトワール セローノ ソシエテ アノニム Bcmaポリペプチド及びその使用
PT1885753E (pt) 2005-06-03 2011-10-06 Ares Trading Sa Produção de proteína recombinante de ligação a il-18
CN108129573B (zh) * 2007-09-21 2021-10-08 加利福尼亚大学董事会 被导靶的干扰素显示强的细胞凋亡和抗肿瘤活性
EP3009513A1 (de) * 2008-02-01 2016-04-20 Chromocell Corporation Neuartige zelllinien und verfahren
CN102002495B (zh) * 2009-08-31 2012-07-18 成都蓉生药业有限责任公司 用于表达异二聚体糖蛋白激素的表达框、表达载体及制备方法
SG10201602371VA (en) * 2011-03-25 2016-04-28 Glenmark Pharmaceuticals Sa Hetero-dimeric immunoglobulins
ES2771478T3 (es) 2013-02-18 2020-07-06 Vegenics Pty Ltd Moléculas de unión a ligando y usos de las mismas
JP7439372B2 (ja) * 2018-06-21 2024-02-28 シャタック ラボ,インコーポレイテッド ヘテロ二量体タンパク質及びその使用
US20220227837A1 (en) * 2019-05-24 2022-07-21 Proviva Therapeutics (Hong Kong) Limited Il-2 compositions and methods of use thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0721983A1 (de) * 1988-01-22 1996-07-17 ZymoGenetics, Inc. Verfahren zur herstellung von biologisch-aktive Dimerpeptiden
US5705478A (en) * 1989-02-21 1998-01-06 Washington University Covalently linked β subunits of the glycoprotein hormones as antagonists
US6225449B1 (en) * 1991-10-04 2001-05-01 Washington University Hormone analogs with multiple CTP extensions
US5116964A (en) * 1989-02-23 1992-05-26 Genentech, Inc. Hybrid immunoglobulins
AU5355790A (en) * 1989-04-19 1990-11-16 Cetus Corporation Multifunctional m-csf proteins and genes encoding therefor
US5650150A (en) * 1990-11-09 1997-07-22 Gillies; Stephen D. Recombinant antibody cytokine fusion proteins
IL99120A0 (en) * 1991-08-07 1992-07-15 Yeda Res & Dev Multimers of the soluble forms of tnf receptors,their preparation and pharmaceutical compositions containing them
US5932448A (en) * 1991-11-29 1999-08-03 Protein Design Labs., Inc. Bispecific antibody heterodimers
ATE242322T1 (de) 1992-03-30 2003-06-15 Immunex Corp Fusionsprotein , das zwei rezeptoren des tumornekrose-faktors enthält
US5447851B1 (en) * 1992-04-02 1999-07-06 Univ Texas System Board Of Dna encoding a chimeric polypeptide comprising the extracellular domain of tnf receptor fused to igg vectors and host cells
IL111125A0 (en) 1994-05-11 1994-12-29 Yeda Res & Dev Soluble oligomeric tnf/ngf super family ligand receptors and their use
NZ331539A (en) * 1996-02-20 2000-01-28 Applied Research Systems Hybrid proteins from two coexpressed receptors to form a heterodimer
US6194177B1 (en) * 1996-02-20 2001-02-27 Applied Research Systems Ars Holding N.V. DNA encoding a hybrid heterodimeric protein

Also Published As

Publication number Publication date
CZ291212B6 (cs) 2003-01-15
UA52646C2 (uk) 2003-01-15
DE69733309T2 (de) 2006-01-19
US20040230034A1 (en) 2004-11-18
SK282326B6 (sk) 2002-01-07
SK114898A3 (en) 1999-07-12
CA2245877A1 (en) 1997-08-21
US7291339B2 (en) 2007-11-06
US20010014333A1 (en) 2001-08-16
CN1212017A (zh) 1999-03-24
DE69733309D1 (de) 2005-06-23
CZ264498A3 (cs) 1998-12-16
KR100369985B1 (ko) 2004-03-26
WO1997030161A1 (en) 1997-08-21
EA002474B1 (ru) 2002-06-27
CA2245877C (en) 2013-09-03
AU2125297A (en) 1997-09-02
EA199800744A1 (ru) 1999-02-25
BG64510B1 (bg) 2005-05-31
EE04025B1 (et) 2003-04-15
EP0894141A1 (de) 1999-02-03
PT894141E (pt) 2005-09-30
ATE295887T1 (de) 2005-06-15
DK0894141T3 (da) 2005-08-22
EP0894141B1 (de) 2005-05-18
US20100075402A1 (en) 2010-03-25
HUP9900619A3 (en) 2001-11-28
AU706504B2 (en) 1999-06-17
US6193972B1 (en) 2001-02-27
PL187400B1 (pl) 2004-06-30
CN1261579C (zh) 2006-06-28
NO983799L (no) 1998-10-19
US20090240039A1 (en) 2009-09-24
HUP9900619A2 (hu) 1999-06-28
EE9800256A (et) 1999-02-15
NZ331539A (en) 2000-01-28
IL125864A0 (en) 1999-04-11
JP4140927B2 (ja) 2008-08-27
JP2008019258A (ja) 2008-01-31
IL125864A (en) 2007-07-04
US6663867B2 (en) 2003-12-16
BG102705A (en) 1999-04-30
KR19990082482A (ko) 1999-11-25
PL328454A1 (en) 1999-02-01
ES2241040T3 (es) 2005-10-16
BR9707589A (pt) 2000-01-04
NO983799D0 (no) 1998-08-19
JP2000504586A (ja) 2000-04-18

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