NO321478B1 - Arylpiperaziner, fremgangsmate for fremstilling og anvendelse derav, samt farmasoytisk preparat. - Google Patents

Arylpiperaziner, fremgangsmate for fremstilling og anvendelse derav, samt farmasoytisk preparat. Download PDF

Info

Publication number
NO321478B1
NO321478B1 NO20011023A NO20011023A NO321478B1 NO 321478 B1 NO321478 B1 NO 321478B1 NO 20011023 A NO20011023 A NO 20011023A NO 20011023 A NO20011023 A NO 20011023A NO 321478 B1 NO321478 B1 NO 321478B1
Authority
NO
Norway
Prior art keywords
compound
formula
pharmaceutically acceptable
acceptable salt
precursor
Prior art date
Application number
NO20011023A
Other languages
English (en)
Norwegian (no)
Other versions
NO20011023L (no
NO20011023D0 (no
Inventor
David Waterson
Howard Tucker
Nicholas John Newcombe
Bernard Christophe Barlaam
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of NO20011023D0 publication Critical patent/NO20011023D0/no
Publication of NO20011023L publication Critical patent/NO20011023L/no
Publication of NO321478B1 publication Critical patent/NO321478B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/42—Radicals substituted by singly-bound nitrogen atoms having hetero atoms attached to the substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Electroluminescent Light Sources (AREA)
NO20011023A 1998-08-31 2001-02-28 Arylpiperaziner, fremgangsmate for fremstilling og anvendelse derav, samt farmasoytisk preparat. NO321478B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP98402144 1998-08-31
EP99401351 1999-06-04
PCT/GB1999/002801 WO2000012478A1 (fr) 1998-08-31 1999-08-25 Arylpiperazines et leur emploi comme inhibiteurs des metalloproteinases

Publications (3)

Publication Number Publication Date
NO20011023D0 NO20011023D0 (no) 2001-02-28
NO20011023L NO20011023L (no) 2001-04-25
NO321478B1 true NO321478B1 (no) 2006-05-15

Family

ID=26151689

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20011023A NO321478B1 (no) 1998-08-31 2001-02-28 Arylpiperaziner, fremgangsmate for fremstilling og anvendelse derav, samt farmasoytisk preparat.

Country Status (33)

Country Link
US (2) US6734184B1 (fr)
EP (1) EP1109787B1 (fr)
JP (1) JP4776778B2 (fr)
KR (1) KR100771454B1 (fr)
CN (1) CN1183119C (fr)
AT (1) ATE326448T1 (fr)
AU (1) AU764367B2 (fr)
BG (1) BG65426B1 (fr)
BR (1) BR9913255A (fr)
CA (1) CA2339761C (fr)
CY (1) CY1106139T1 (fr)
DE (1) DE69931375T2 (fr)
DK (1) DK1109787T3 (fr)
EE (1) EE05005B1 (fr)
ES (1) ES2263284T3 (fr)
GB (1) GB9919776D0 (fr)
HK (1) HK1036060A1 (fr)
HU (1) HUP0103344A3 (fr)
ID (1) ID28786A (fr)
IL (2) IL141410A0 (fr)
IS (1) IS5849A (fr)
MX (1) MXPA01001847A (fr)
MY (1) MY129409A (fr)
NO (1) NO321478B1 (fr)
NZ (2) NZ509730A (fr)
PL (1) PL199894B1 (fr)
PT (1) PT1109787E (fr)
RU (1) RU2220967C2 (fr)
SI (1) SI1109787T1 (fr)
SK (1) SK286658B6 (fr)
TR (1) TR200100605T2 (fr)
TW (1) TWI240722B (fr)
WO (1) WO2000012478A1 (fr)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60033809T2 (de) * 1999-06-04 2007-12-06 Astrazeneca Ab Inhibitoren von metalloproteinasen
JP2003524007A (ja) * 2000-02-21 2003-08-12 アストラゼネカ・アクチエボラーグ アリールピペラジン類およびそれらのメタロプロテイナーゼ阻害剤（ｍｍｐ）としての使用
SK287071B6 (sk) * 2000-02-21 2009-11-05 Astrazeneca Ab Deriváty N-hydroxyformamidov substituované piperidínom a piperazínom, farmaceutická kompozícia, ktorá ich obsahuje, spôsob ich prípravy a ich použitie
AU3385401A (en) * 2000-02-21 2001-09-03 Astrazeneca Ab Arylpiperazines and arylpiperidines and their use as metalloproteinase inhibiting agents
WO2001087844A1 (fr) * 2000-05-15 2001-11-22 Darwin Discovery Limited Derives d'acides hydroxamique et carboxylique presentant une activite inhibitrice de mmp et de tnf
WO2001087883A1 (fr) * 2000-05-15 2001-11-22 Darwin Discovery Limited Derives d'acides hydroxamique et carboxylique possedant une activite inhibitrice des metalloproteinases et du facteur de necrose tumorale
US20040024066A1 (en) * 2000-05-25 2004-02-05 Best Desmond John Bicyclyl or heterobicyclylmethanesulfonylamino-substituted n-hydroxyformamides
SE0100902D0 (sv) 2001-03-15 2001-03-15 Astrazeneca Ab Compounds
ATE319703T1 (de) 2001-07-02 2006-03-15 Piperidinverbindungen, die sich als modulatoren der chemokinrezeptoraktivität eignen
GB0119472D0 (en) * 2001-08-09 2001-10-03 Astrazeneca Ab Compounds
GB0119474D0 (en) 2001-08-09 2001-10-03 Astrazeneca Ab Compounds
GB0119473D0 (en) * 2001-08-09 2001-10-03 Astrazeneca Compounds
GB0120461D0 (en) 2001-08-22 2001-10-17 Astrazeneca Ab Novel compounds
DE60230781D1 (en) 2001-09-07 2009-02-26 Kaken Pharma Co Ltd Reverse hydroxamsäurederivate
GB0122503D0 (en) 2001-09-18 2001-11-07 Astrazeneca Ab Chemical compounds
WO2003040103A1 (fr) * 2001-11-02 2003-05-15 Bristol-Myers Squibb Company Derives $g(b)-sulfone utilises comme inhibiteurs de metalloproteinases matricielles et/ou enzyme de conversion de tnf-$g(a) (tace)
SE0103710D0 (sv) 2001-11-07 2001-11-07 Astrazeneca Ab Compounds
TW200303304A (en) 2002-02-18 2003-09-01 Astrazeneca Ab Chemical compounds
SE0200844D0 (sv) 2002-03-19 2002-03-19 Astrazeneca Ab Chemical compounds
SE0200843D0 (sv) 2002-03-19 2002-03-19 Astrazeneca Ab Chemical compounds
CA2479906C (fr) * 2002-04-03 2011-02-08 Topotarget Uk Limited Composes d'acide carbamique comprenant un chainon de piperazine tels que les inhibiteurs hdac
GB0216382D0 (en) * 2002-07-13 2002-08-21 Astrazeneca Ab Compounds
GB0216379D0 (en) * 2002-07-13 2002-08-21 Astrazeneca Ab Compounds
GB0216383D0 (en) * 2002-07-13 2002-08-21 Astrazeneca Ab Compounds
SE0202539D0 (sv) 2002-08-27 2002-08-27 Astrazeneca Ab Compounds
GB0221250D0 (en) * 2002-09-13 2002-10-23 Astrazeneca Ab Compounds
US7465719B2 (en) 2003-01-17 2008-12-16 Topotarget Uk Limited Carbamic acid compounds comprising an ester or ketone linkage as HDAC inhibitors
SE0300957D0 (sv) 2003-04-01 2003-04-01 Astrazeneca Ab Chemical compounds
CA2528317A1 (fr) * 2003-06-19 2004-12-29 Celltech R & D Limited Sulfonamides d'hydroxamate servant d'inhibiteurs d'elimination du virus cd23
SE0301922D0 (sv) * 2003-06-27 2003-06-27 Astrazeneca Ab Novel compounds
SE0400208D0 (sv) 2004-02-02 2004-02-02 Astrazeneca Ab Chemical compounds
US7648992B2 (en) 2004-07-05 2010-01-19 Astrazeneca Ab Hydantoin derivatives for the treatment of obstructive airway diseases
GB0427403D0 (en) 2004-12-15 2005-01-19 Astrazeneca Ab Novel compounds I
SE0403085D0 (sv) 2004-12-17 2004-12-17 Astrazeneca Ab Novel componds
SE0403086D0 (sv) 2004-12-17 2004-12-17 Astrazeneca Ab Compounds
ES2379367T3 (es) 2004-12-21 2012-04-25 Merck Serono Sa Derivados cíclicos de sulfonilamino y uso de los mismos como inhibidores de MMP.
FR2885615B1 (fr) * 2005-05-12 2007-06-22 Servier Lab Nouveaux derives de phenylpyridinylpiperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2885616B1 (fr) * 2005-05-12 2007-06-22 Servier Lab Nouveaux derives de phenylpyridinylpiperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
KR20080037655A (ko) 2005-07-21 2008-04-30 아스트라제네카 아베 신규 피페리딘 유도체
PL1951674T3 (pl) * 2005-10-26 2012-04-30 Merck Serono Sa Pochodne sulfonamidowe i ich zastosowania do modulowania metaloproteinaz
JP5199109B2 (ja) * 2005-11-24 2013-05-15 メルク セローノ ソシエテ アノニム Ｎ−ヒドロキシアミド誘導体およびその使用
LT1976828T (lt) 2005-12-29 2017-04-25 Celtaxsys, Inc. Diamino dariniai, kaip leukotrieno a4 hidrolazės inhibitoriai
CA2804918C (fr) 2010-07-08 2018-03-06 Kaken Pharmaceutical Co., Ltd. Derive de n-hydroxyformamide et produit pharmaceutique le contenant
CN104955806B (zh) 2013-02-06 2018-09-14 默克专利股份公司 用于治疗骨关节炎的作为聚蛋白聚糖酶抑制剂的取代羧酸衍生物
ES2864862T3 (es) 2013-03-12 2021-10-14 Celltaxis Llc Métodos de inhibición de la leucotrieno A4 hidrolasa
AU2014239585B2 (en) 2013-03-14 2019-04-04 Celtaxsys, Inc. Inhibitors of leukotriene A4 hydrolase
AU2014240042C1 (en) 2013-03-14 2019-09-05 Celltaxis, Llc Inhibitors of leukotriene A4 hydrolase
EP2970309A4 (fr) 2013-03-14 2016-11-09 Celtaxsys Inc Inhibiteurs de la leucotriène a4 hydrolase
US10898484B2 (en) 2018-05-31 2021-01-26 Celltaxis, Llc Method of reducing pulmonary exacerbations in respiratory disease patients
AU2019282274A1 (en) 2018-06-07 2021-01-28 Idorsia Pharmaceuticals Ltd Alkoxy-substituted pyridinyl derivatives as LPA1 receptor antagonists and their use in the treatment of fibrosis
WO2020070239A1 (fr) 2018-10-04 2020-04-09 INSERM (Institut National de la Santé et de la Recherche Médicale) Inhibiteurs de l'egfr pour traiter les kératodermies

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3532340A (en) * 1967-08-11 1970-10-06 Vincent Nardiello Spring type abdominal exercising device
ES426195A1 (es) * 1973-05-18 1976-07-01 Mega Produc U Verpackungsentwi Perfeccionamientos en aparatos para entrenamiento muscular.
US4480831A (en) * 1982-03-12 1984-11-06 Mueller Deinhardt Friedhelm Exercise hoop having a counter
BE897714A (nl) * 1983-09-09 1984-01-02 Nelissen Koenraad Ring met elastiek en handvat
US4607625A (en) * 1985-01-10 1986-08-26 Schenck Robert R Dynamic traction device
US4724827A (en) * 1985-01-10 1988-02-16 Schenck Robert R Dynamic traction device
GB9411598D0 (en) * 1994-06-09 1994-08-03 Hoffmann La Roche Hydroxamic acid derivatives
US5674162A (en) * 1995-06-07 1997-10-07 Ellingson; Richard L. Biomechanical stabilizer apparatus and methods for strengthening unstable joints and improving muscle coordination
AU730464B2 (en) * 1996-08-07 2001-03-08 Darwin Discovery Limited Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activity
WO1998016514A1 (fr) * 1996-10-16 1998-04-23 American Cyanamid Company Acides ortho-sulfonamido-bicycliques-heteroaryl hydroxamiques en tant qu'inhibiteurs des metalloproteinases matricielles et de tace
JP2001506257A (ja) * 1996-12-17 2001-05-15 藤沢薬品工業株式会社 Ｍｍｐまたはｔｎｆ阻害剤としてのピペラジン化合物
ZA98376B (en) 1997-01-23 1998-07-23 Hoffmann La Roche Sulfamide-metalloprotease inhibitors
US6376506B1 (en) 1997-01-23 2002-04-23 Syntex (U.S.A.) Llc Sulfamide-metalloprotease inhibitors
CA2278694C (fr) * 1997-01-23 2006-09-26 F. Hoffmann-La Roche Ag Inhibiteurs de sulfamide-metalloprotease
US6482827B1 (en) 1997-07-10 2002-11-19 Pharmacia & Upjohn S.P.A. Matrix metalloproteinase inhibitors
JP2001500533A (ja) * 1997-07-10 2001-01-16 フアルマシア・エ・アツプジヨン・エツセ・ピー・アー マトリックスメタロプロテイナーゼ・インヒビター
KR20010022413A (ko) * 1997-07-31 2001-03-15 진 엠. 듀발 Ｖｌａ-4에 의해 매개되는 백혈구 부착을 억제하는 벤질화합물
US6294573B1 (en) 1997-08-06 2001-09-25 Abbott Laboratories Reverse hydroxamate inhibitors of matrix metalloproteinases
US6235786B1 (en) 1997-08-06 2001-05-22 Abbott Laboratories Reverse hydroxamate inhibitors of matrix metalloproteinases
US6130220A (en) 1997-10-16 2000-10-10 Syntex (Usa) Inc. Sulfamide-metalloprotease inhibitors
CA2317455C (fr) 1998-01-30 2011-01-25 Darwin Discovery Limited Derives d'acide carboxylique et hydroxamique
EP1087937A1 (fr) * 1998-06-17 2001-04-04 Du Pont Pharmaceuticals Company Acides hydroxamiques cycliques utilises en tant qu'inhibiteurs de metalloproteases
EP1107953A1 (fr) 1998-08-29 2001-06-20 British Biotech Pharmaceuticals Limited Derives d'acide hydroxamique comme inhibiteurs de proteinase

Also Published As

Publication number Publication date
CY1106139T1 (el) 2011-06-08
NZ524921A (en) 2004-10-29
EE200100106A (et) 2002-06-17
EP1109787A1 (fr) 2001-06-27
JP4776778B2 (ja) 2011-09-21
DK1109787T3 (da) 2006-08-21
MY129409A (en) 2007-03-30
TWI240722B (en) 2005-10-01
US7342020B2 (en) 2008-03-11
HK1036060A1 (en) 2001-12-21
DE69931375D1 (de) 2006-06-22
TR200100605T2 (tr) 2001-08-21
KR20010073000A (ko) 2001-07-31
PL346344A1 (en) 2002-02-11
PT1109787E (pt) 2006-09-29
BR9913255A (pt) 2001-05-22
BG105369A (en) 2001-12-29
CN1183119C (zh) 2005-01-05
SK286658B6 (sk) 2009-03-05
US6734184B1 (en) 2004-05-11
US20040171641A1 (en) 2004-09-02
ES2263284T3 (es) 2006-12-01
WO2000012478A1 (fr) 2000-03-09
CA2339761A1 (fr) 2000-03-09
EP1109787B1 (fr) 2006-05-17
HUP0103344A3 (en) 2002-03-28
HUP0103344A2 (hu) 2002-02-28
IS5849A (is) 2001-02-16
NO20011023L (no) 2001-04-25
GB9919776D0 (en) 1999-10-27
CN1324347A (zh) 2001-11-28
CA2339761C (fr) 2010-10-12
MXPA01001847A (es) 2002-04-08
IL141410A0 (en) 2002-03-10
IL141410A (en) 2007-06-03
NO20011023D0 (no) 2001-02-28
BG65426B1 (bg) 2008-07-31
DE69931375T2 (de) 2007-05-24
KR100771454B1 (ko) 2007-10-31
AU764367B2 (en) 2003-08-14
RU2220967C2 (ru) 2004-01-10
AU5524799A (en) 2000-03-21
EE05005B1 (et) 2008-04-15
JP2002523493A (ja) 2002-07-30
PL199894B1 (pl) 2008-11-28
ID28786A (id) 2001-07-05
SI1109787T1 (sl) 2006-10-31
ATE326448T1 (de) 2006-06-15
NZ509730A (en) 2003-05-30
SK2702001A3 (en) 2001-08-06

Similar Documents

Publication Publication Date Title
NO321478B1 (no) Arylpiperaziner, fremgangsmate for fremstilling og anvendelse derav, samt farmasoytisk preparat.
US20060229313A1 (en) Arylpiperazines and arylpiperidines and their use as metalloproteinase inhibiting agents
EP1187811B1 (fr) Inhibiteurs de metalloproteases
EP1261590B1 (fr) N-hydroxyformamides substitues par piperidine et piperazine utilises comme inhibiteurs de metalloproteinase
US20030139419A1 (en) Arylpiperazines and arylpiperidines and their use as metalloproteinase inhibiting agents
AU2003262101B2 (en) Arylpiperazines and their use as metalloproteinase inhibiting agents (MMP)
CZ2001687A3 (cs) Arylpiperaziny a jejich použití jako činidel inhibujících metaloproteinázu (MMP)

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees