NO318850B1 - Fremgangsmate for fremstilling av et magnesiumsalt av en substituert sulfinylheterocyklisk forbindelse - Google Patents

Fremgangsmate for fremstilling av et magnesiumsalt av en substituert sulfinylheterocyklisk forbindelse Download PDF

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Publication number
NO318850B1
NO318850B1 NO19984903A NO984903A NO318850B1 NO 318850 B1 NO318850 B1 NO 318850B1 NO 19984903 A NO19984903 A NO 19984903A NO 984903 A NO984903 A NO 984903A NO 318850 B1 NO318850 B1 NO 318850B1
Authority
NO
Norway
Prior art keywords
magnesium
alkyl
methoxy
sulfinyl
hydrogen
Prior art date
Application number
NO19984903A
Other languages
English (en)
Norwegian (no)
Other versions
NO984903D0 (no
NO984903L (no
Inventor
Jan-Ake Hogberg
Panagiotis Ioannidis
Anders Mattson
Original Assignee
Astrazeneca Ab Global Ip
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20402358&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO318850(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab Global Ip filed Critical Astrazeneca Ab Global Ip
Publication of NO984903D0 publication Critical patent/NO984903D0/no
Publication of NO984903L publication Critical patent/NO984903L/no
Publication of NO318850B1 publication Critical patent/NO318850B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO19984903A 1996-04-26 1998-10-21 Fremgangsmate for fremstilling av et magnesiumsalt av en substituert sulfinylheterocyklisk forbindelse NO318850B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9601598A SE508669C2 (sv) 1996-04-26 1996-04-26 Nytt förfarande
PCT/SE1997/000674 WO1997041114A1 (en) 1996-04-26 1997-04-22 Process for the preparation of a magnesium salt of a substituted sulphinyl heterocycle

Publications (3)

Publication Number Publication Date
NO984903D0 NO984903D0 (no) 1998-10-21
NO984903L NO984903L (no) 1998-10-21
NO318850B1 true NO318850B1 (no) 2005-05-18

Family

ID=20402358

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19984903A NO318850B1 (no) 1996-04-26 1998-10-21 Fremgangsmate for fremstilling av et magnesiumsalt av en substituert sulfinylheterocyklisk forbindelse

Country Status (39)

Country Link
US (1) US6124464A (cs)
EP (1) EP0897386B1 (cs)
JP (1) JP4233115B2 (cs)
KR (1) KR100468331B1 (cs)
CN (1) CN1100776C (cs)
AR (1) AR006640A1 (cs)
AT (1) ATE222904T1 (cs)
BR (1) BR9708829A (cs)
CA (1) CA2251636C (cs)
CZ (1) CZ295067B6 (cs)
DE (1) DE69714987T2 (cs)
DK (1) DK0897386T3 (cs)
DZ (1) DZ2209A1 (cs)
EE (1) EE03485B1 (cs)
EG (1) EG23874A (cs)
ES (1) ES2180981T3 (cs)
HR (1) HRP970210B1 (cs)
HU (1) HUP9901798A3 (cs)
ID (1) ID16685A (cs)
IL (1) IL126716A (cs)
IS (1) IS1984B (cs)
MA (1) MA24143A1 (cs)
MY (1) MY119011A (cs)
NO (1) NO318850B1 (cs)
NZ (1) NZ332154A (cs)
PL (1) PL188824B1 (cs)
PT (1) PT897386E (cs)
RS (1) RS49718B (cs)
RU (1) RU2163238C2 (cs)
SA (1) SA97170759B1 (cs)
SE (1) SE508669C2 (cs)
SI (1) SI0897386T1 (cs)
SK (1) SK282752B6 (cs)
TN (1) TNSN97068A1 (cs)
TR (1) TR199802156T2 (cs)
TW (1) TW420676B (cs)
UA (1) UA51699C2 (cs)
WO (1) WO1997041114A1 (cs)
ZA (1) ZA973153B (cs)

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SE9301830D0 (sv) * 1993-05-28 1993-05-28 Ab Astra New compounds
US6875872B1 (en) * 1993-05-28 2005-04-05 Astrazeneca Compounds
US6645988B2 (en) 1996-01-04 2003-11-11 Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US5840737A (en) 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
US6489346B1 (en) 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US6699885B2 (en) 1996-01-04 2004-03-02 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and methods of using same
DE19843413C1 (de) * 1998-08-18 2000-03-30 Byk Gulden Lomberg Chem Fab Neue Salzform von Pantoprazol
PT1131316E (pt) * 1998-11-18 2004-10-29 Astrazeneca Ab Processo quimico e formulacao farmaceutica melhorados
CA2290893C (en) 1999-11-16 2007-05-01 Bernard Charles Sherman Magnesium omeprazole
ATE342263T1 (de) 2000-08-04 2006-11-15 Takeda Pharmaceutical Salze von benzimidazol-derivaten und deren verwendung
US20040006111A1 (en) * 2002-01-25 2004-01-08 Kenneth Widder Transmucosal delivery of proton pump inhibitors
PT1487818E (pt) * 2002-03-05 2007-07-18 Astrazeneca Ab Sais de alquilamónio de omeprazole e esomeprazole
DE10234617B4 (de) * 2002-07-29 2013-04-04 Nycomed Gmbh Neues Salz von (S)-Pantoprazol
TW200410955A (en) 2002-07-29 2004-07-01 Altana Pharma Ag Novel salt of (S)-PANTOPRAZOLE
EA200500673A1 (ru) * 2002-10-22 2005-12-29 Рэнбакси Лабораториз Лимитед Аморфная форма соли эзомепразола, способ ее получения и фармацевтическая композиция на её основе
US20040242642A1 (en) * 2002-11-18 2004-12-02 Dr. Reddy's Laboratories Limited Crystalline esomeprazole compounds and process for the preparation thereof
CA2510849A1 (en) * 2002-12-19 2004-07-08 Teva Pharmaceutical Industries Ltd Solid states of pantoprazole sodium, processes for preparing them and processes for preparing known pantoprazole sodium hydrates
EP1606279A1 (en) * 2003-02-28 2005-12-21 Ranbaxy Laboratories, Ltd. Polymorphs of s-omeprazole
CL2004000983A1 (es) 2003-05-08 2005-03-04 Altana Pharma Ag Composicion farmaceutica oral en forma de tableta que comprende a pantoprazol magnetico dihidratado, en donde la forma de tableta esta compuesto por un nucleo, una capa intermedia y una capa exterior; y uso de la composicion farmaceutica en ulceras y
PE20050150A1 (es) 2003-05-08 2005-03-22 Altana Pharma Ag Una forma de dosificacion que contiene (s)-pantoprazol como ingrediente activo
WO2005012289A1 (en) * 2003-07-17 2005-02-10 Altana Pharma Ag Novel salt of (r) - pantoprazole
US8993599B2 (en) 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
SE0302382D0 (sv) 2003-09-04 2003-09-04 Astrazeneca Ab New salts II
SE0302381D0 (sv) 2003-09-04 2003-09-04 Astrazeneca Ab New salts I
ITMI20031813A1 (it) * 2003-09-23 2005-03-24 Dinamite Dipharma S P A In Forma A Bbreviata Diph Procedimento per la preparazione di pantoprazolo e suoi sali.
WO2005082888A1 (en) * 2004-03-01 2005-09-09 Milen Merkez Ilac Endustrisi A.S. Process for the preparation of magnesium salt of omeprazole
US8815916B2 (en) 2004-05-25 2014-08-26 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8906940B2 (en) 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
ES2246149B1 (es) * 2004-07-02 2007-06-01 Esteve Quimica, S.A. Formas solidas de la sal magnesica de s-omeprazol y procedimientos para su preparacion.
US8779175B2 (en) 2004-10-25 2014-07-15 Synthonics, Inc. Coordination complexes, pharmaceutical solutions comprising coordination complexes, and methods of treating patients
US20060141054A1 (en) 2004-10-25 2006-06-29 Thomas Piccariello Metal coordinated compositions
US7799937B2 (en) 2004-10-25 2010-09-21 Synthonics, Inc. Metal coordinated compositions
EP1801110A1 (en) 2005-12-22 2007-06-27 KRKA, tovarna zdravil, d.d., Novo mesto Esomeprazole arginine salt
US7553857B2 (en) 2005-12-23 2009-06-30 Lek Pharmaceuticals D.D. S-omeprazole magnesium
EP1954691A2 (en) 2006-06-12 2008-08-13 Teva Pharmaceutical Industries Ltd Amorphous and crystalline forms of pantoprazole magnesium salt
EP1947099A1 (en) 2007-01-18 2008-07-23 LEK Pharmaceuticals D.D. Process for solvent removal from omeprazole salts
EP2186807B1 (en) 2007-02-21 2015-01-07 Cipla Limited Process for the preparation of esomeprazole magnesium dihydrate
EP2195309A4 (en) * 2007-10-08 2013-04-24 Hetero Drugs Ltd SALT POLYMORPHS OF THE ESOMEPRAZOLE
EP2147918A1 (en) 2008-07-21 2010-01-27 LEK Pharmaceuticals D.D. Process for the preparation of S-omeprazole magnesium in a stable form
WO2010097583A1 (en) 2009-02-24 2010-09-02 Cipla Limited Esomeprazole potassium polymorph and its preparation
US20110207779A1 (en) * 2010-02-25 2011-08-25 Glenmark Generics Ltd Process for the preparation of esomeprazole magnesium
EP2426111A1 (en) 2010-08-09 2012-03-07 Laboratorios Del. Dr. Esteve, S.A. 4-[-2-[[5-methyl-1-(2-naphtalenyl)-1h-pyrazol-3-yl]oxy]ethyl]morpholine hydrochloride amorphous solid forms
CN103467453A (zh) * 2013-09-13 2013-12-25 上海海虹实业(集团)巢湖今辰药业有限公司 一种奥美拉唑镁原料药制备方法
CN106397399A (zh) * 2015-07-29 2017-02-15 陕西合成药业股份有限公司 一种泮托拉唑镁的精制方法

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SE8301182D0 (sv) * 1983-03-04 1983-03-04 Haessle Ab Novel compounds
GB8307865D0 (en) * 1983-03-22 1983-04-27 Fujisawa Pharmaceutical Co Benzimidazole derivatives
IL76837A0 (en) * 1984-10-31 1986-02-28 Byk Gulden Lomberg Chem Fab Benzimidazole derivatives,processes for the preparation thereof and pharmaceutical compositions containing them
FI861772L (fi) * 1985-05-07 1986-11-08 Chemie Linz Ag Nya tieno(2,3-d)imidazolderivat och foerfarande for deras framstaellning.
US4851419A (en) * 1985-10-16 1989-07-25 Fisons Plc Certain 2-pyridinyl-phenylsulfinyl-benzoxazoles, the corresponding benzothiazoles or benzimidazoles having anti-inflammatory or gastric acid secretion inhibition activity
DD290192A5 (de) * 1986-11-13 1991-05-23 Eisai Co. Ltd,Jp Pyridinderivat mit antiulzeroeser wirkung
NZ222495A (en) * 1986-11-21 1991-04-26 Haessle Ab Benzimidazole derivatives and pharmaceutical compositions
WO1989000566A1 (fr) * 1987-07-21 1989-01-26 Yoshitomi Pharmaceutical Industries, Ltd. Composes de pyridine et leurs utilisations en medecine
SE9002043D0 (sv) * 1990-06-07 1990-06-07 Astra Ab Improved method for synthesis
WO1993006097A1 (en) * 1991-09-20 1993-04-01 Merck & Co., Inc. Novel process for the preparation of anti-ulcer agents
CA2136993A1 (en) * 1992-06-01 1993-12-09 Takeshi Kawakita Pyridine compound and pharmaceutical use thereof
SE9301830D0 (sv) * 1993-05-28 1993-05-28 Ab Astra New compounds
SE9302396D0 (sv) * 1993-07-09 1993-07-09 Ab Astra A novel compound form
SE9302395D0 (sv) * 1993-07-09 1993-07-09 Ab Astra New pharmaceutical formulation
US5374730A (en) * 1993-11-04 1994-12-20 Torcan Chemical Ltd. Preparation of omeprazole and lansoprazole
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Also Published As

Publication number Publication date
SE508669C2 (sv) 1998-10-26
YU44898A (sh) 1999-07-28
KR100468331B1 (ko) 2005-03-16
NO984903D0 (no) 1998-10-21
AR006640A1 (es) 1999-09-08
NO984903L (no) 1998-10-21
SK282752B6 (sk) 2002-12-03
JP4233115B2 (ja) 2009-03-04
AU2719397A (en) 1997-11-19
HK1016978A1 (en) 1999-11-12
RS49718B (sr) 2007-12-31
CZ339898A3 (cs) 1999-03-17
ES2180981T3 (es) 2003-02-16
PT897386E (pt) 2002-12-31
HUP9901798A3 (en) 2003-02-28
PL188824B1 (pl) 2005-04-29
CN1100776C (zh) 2003-02-05
SK140798A3 (en) 1999-04-13
IL126716A (en) 2003-10-31
UA51699C2 (uk) 2002-12-16
AU711345B2 (en) 1999-10-14
ATE222904T1 (de) 2002-09-15
KR20000065018A (ko) 2000-11-06
HUP9901798A2 (hu) 2000-04-28
IS4872A (is) 1998-10-19
WO1997041114A1 (en) 1997-11-06
TNSN97068A1 (fr) 1999-12-31
DK0897386T3 (da) 2002-10-28
MA24143A1 (fr) 1997-12-31
MY119011A (en) 2005-03-31
TW420676B (en) 2001-02-01
BR9708829A (pt) 1999-08-03
PL329683A1 (en) 1999-04-12
CZ295067B6 (cs) 2005-05-18
IL126716A0 (en) 1999-08-17
IS1984B (is) 2005-02-15
CA2251636C (en) 2001-04-10
ID16685A (id) 1997-10-30
NZ332154A (en) 2002-03-01
SA97170759B1 (ar) 2006-09-25
SE9601598L (sv) 1997-10-27
US6124464A (en) 2000-09-26
HRP970210B1 (en) 2002-06-30
EP0897386B1 (en) 2002-08-28
EE9800363A (et) 1999-04-15
RU2163238C2 (ru) 2001-02-20
HRP970210A2 (en) 1998-04-30
DZ2209A1 (fr) 2002-12-03
CA2251636A1 (en) 1997-11-06
EE03485B1 (et) 2001-08-15
SI0897386T1 (en) 2002-12-31
DE69714987D1 (de) 2002-10-02
CN1216989A (zh) 1999-05-19
DE69714987T2 (de) 2003-04-30
SE9601598D0 (sv) 1996-04-26
EP0897386A1 (en) 1999-02-24
EG23874A (en) 2007-11-27
TR199802156T2 (xx) 1999-02-22
ZA973153B (en) 1997-10-27
JP2000509067A (ja) 2000-07-18

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